Fentanyl inhalation may cause potentially irreversible brain damage, warn doctors
Toxic leukoencephalopathy seen with heroin inhalation, but this is first reported fentanyl case
BMJ
Inhaling the synthetic opioid fentanyl may cause potentially irreversible brain damage (toxic leukoencephalopathy), warn doctors in the journal BMJ Case Reports, after treating a middle aged man found unresponsive in his hotel room after snorting the drug.
Leukoencephalopathy refers to inflammation and damage to the brain’s white matter—the network of nerve fibres that enable the exchange of information and communication between different areas of the brain’s grey matter.
Toxic leukoencephalopathy is a sudden or longstanding neurological syndrome, which has been reported after heroin inhalation, known as ‘chasing the dragon’. But this is the first reported case associated with fentanyl, say the report authors.
The condition is manifest in various signs and symptoms, the most obvious of which are neurological and behavioural changes, ranging from mild confusion to stupor, coma, and death.
The outlook for those affected generally depends on the extent of white matter injury, explain the report authors: some people will recover fully; others will progressively get worse.
In this case, the man had no previous medical problems of any note, and had been unconscious for an unknown period of time in his hotel room, where unidentified crushed pills and a white residue were found on a nearby table.
On arrival at hospital, he wasn’t able to answer questions or follow commands. He responded to pain stimuli to his legs, but not his arms.
A brain scan revealed white matter inflammation and swelling and cerebellar injury. The cerebellum is the part of the brain responsible for gait and balance. He tested negative for epilepsy.
A drug screen returned negative results, but a separate urine test indicated a very high level of fentanyl, prompting a diagnosis of toxic leukoencephalopathy induced by fentanyl inhalation.
Eighteen days later, he remained bedbound and still required tube feeding. He was given several different drugs to treat urinary incontinence, kidney injury, cognitive impairment, suspected opioid withdrawal, pain and agitation, and pneumonia.
After 26 days he was discharged to a rehabilitation facility, and after another month returned home with the support of outpatient physiotherapy and occupational therapy.
Less than a year after his hospital admission he had fully recovered and had returned to work full time.
Commenting on the incident, he describes his recovery as “miraculous”, adding: “Early on it was looking like I would need 24 hour care after being discharged, but I focused and worked hard in my therapy session and was determined not to leave the hospital only to be checked into a group facility for ongoing care.”
Expressing gratitude to all the healthcare professionals who not only saved his life, but enabled him to get back to the life he had before, he says: “I have regrets often about what I did to myself, my wife, and my family.”
The report authors conclude: “This case illustrates the need for inclusion of fentanyl in routine urine drug screens for earlier identification and appropriate management.”
JOURNAL
BMJ Case Reports
METHOD OF RESEARCH
Case study
SUBJECT OF RESEARCH
People
ARTICLE TITLE
Clinical and neuro radiographic features of fentanyl inhalation-induced Leukoencephalopathy
ARTICLE PUBLICATION DATE
29-Apr-2024
OHSU patient is world’s first documented case of brain disease from fentanyl inhalation
Case study highlights added danger of illicit fentanyl, especially to first-time users
The man arrived unconscious and near death.
Previously healthy with no known medical history, the 47-year-old arrived by ambulance to the emergency department at Oregon Health & Science University on Feb. 25, 2023. He was found collapsed in his hotel room, where he was staying during a business trip. As clinicians began administering life-saving treatment, they searched for the cause.
In a case report published online today in the journal BMJ Case Reports, clinicians laid out the surprising and unprecedented diagnosis: toxic leukoencephalopathy by fentanyl inhalation.
In other words, inhaling fentanyl caused large sections of white matter in the patient’s brain to become inflamed to the point where he had lost consciousness and risked irreversible loss of brain function, or possibly death.
Medical experts had documented previous cases caused by inhaling heroin, but the OHSU patient is believed to be the first documented case involving inhalation of illicit fentanyl. The lead author of the study says it should be taken as a warning about the danger of a substance that is cheap, readily available and 50 times more potent than heroin.
“Opioid use, especially fentanyl, has become very stigmatized,” said lead author Chris Eden, M.D., now a second-year resident in internal medicine in the OHSU School of Medicine who was part of the patient’s treatment team. “This is a case of a middle-class man, in his late 40s, with kids, who used fentanyl for the first time. It demonstrates that fentanyl can affect everyone in our society.”
Although this is the first documented case, Eden said it’s likely other cases simply weren’t recognized due in part to the fact that relatively little is known about the syndrome’s physiology. In addition, he said hospitals haven’t traditionally included fentanyl in their standard urinalysis drug screens.
At the same time, fatal and nonfatal overdoses due to fentanyl and other opioids are all too common.
“We know very well the classic opiate side effects: respiratory depression, loss of consciousness, disorientation,” Eden noted. “But we don’t classically think of it causing possibly irreversible brain damage and affecting the brain, as it did in this case.”
Magnetic resonance imaging revealed inflammation in the brain. However, the patient’s lingering loss of consciousness, memory and function could have been due to any number of causes — stroke, carbon monoxide exposure or metabolic disease among them. Ultimately, a nonstandard drug test revealed the presence of fentanyl in his system.
Slow recovery
Fortunately for the patient, he slowly recovered after 26 days in the hospital, followed by a stay in a skilled nursing facility to help regain his speech and function. He is now home with his family in the Seattle area and back to work. To this day, he has no memory of the episode.
The successful outcome involved wraparound treatment with numerous clinicians and support at Oregon’s academic health center and single largest hospital, all operating with a patient-centered approach.
“This case involved internal medicine, neurology, neuroradiology and palliative care physicians, in addition to nurses, social workers, discharge planners, physical therapists, dieticians and pharmacists,” Eden said. “I’m proud of these multidisciplinary teams at OHSU working together to take care of complex patients, both from a medical and social perspective.”
Today’s publication in BMJ Case Reports also includes a perspective from the patient.
“I have regrets often about what I did to myself, my wife and my family,” he said. “I’m grateful to all the doctors, nurses and EMTs who saved my life, and the therapists who got me back to a functioning member of society.”
In addition to Eden, co-authors include Duna Alkhalaileh, D.O., M.P.H., David Pettersson, M.D., and Alan Hunter M.D., of OHSU; and Asad Arastu, M.D., previously of OHSU and now with Penn Medicine.
JOURNAL
BMJ Case Reports
METHOD OF RESEARCH
Case study
SUBJECT OF RESEARCH
People
ARTICLE TITLE
Clinical and neuroradiographic features of fentanyl inhalation-induced leukoencephalopathy
ARTICLE PUBLICATION DATE
29-Apr-2024
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