Saturday, January 24, 2026

  

To make AI more fair, tame complexity



Biases in AI models can be reduced by better reflecting the complexities of the real world



University of Texas at Austin





In April 2025, OpenAI’s popular ChatGPT hit a milestone of a billion active weekly users, as artificial intelligence continued its explosion in popularity.

But with that popularity has come a dark side. Biases in AI’s models and algorithms can actively harm some of its users and promote social injustice. Documented biases have led to different medical treatments due to patients’ demographics and corporate hiring tools that discriminate against female and Black candidates.

New research from Texas McCombs suggests both a previously unexplored source of AI biases and some ways to correct for them: complexity.

“There’s a complex set of issues that the algorithm has to deal with, and it’s infeasible to deal with those issues well,” says Hüseyin Tanriverdi, associate professor of information, risk, and operations management. “Bias could be an artifact of that complexity rather than other explanations that people have offered.”

With John-Patrick Akinyemi, a McCombs Ph.D. candidate in IROM, Tanriverdi studied a set of 363 algorithms that researchers and journalists had identified as biased. The algorithms came from a repository called AI Algorithmic and Automation Incidents and Controversies.

The researchers compared each problematic algorithm with one that was similar in nature but had not been called out for bias. They examined not only the algorithms but also the organizations that created and used them.

Prior research has assumed that bias can be reduced by making algorithms more accurate. But that assumption, Tanriverdi found, did not tell the whole story. He found three additional factors, all related to a similar problem: not properly modeling for complexity.

Ground truth. Some algorithms are asked to make decisions when there’s no established ground truth: the reference against which the algorithm’s outcomes are evaluated. An algorithm might be asked to guess the age of a bone from an X-ray image, even though in medical practice, there’s no established way for doctors to do so.

In other cases, AI may mistakenly treat opinions as objective truths — for example, when social media users are evenly split on whether a post constitutes hate speech or protected free speech.

AI should only automate decisions for which ground truth is clear, Tanriverdi says. “If there is not a well-established ground truth, then the likelihood that bias will emerge significantly increases.”

Real-world complexity. AI models inevitably simplify the situations they describe. Problems can arise when they miss important components of reality.

Tanriverdi points to a case in which Arkansas replaced home visits by nurses with automated rulings on Medicaid benefits. It had the effect of cutting off disabled people from assistance with eating and showering.

“If a nurse goes and walks around to the house, they will be able to understand more about what kind of support this person needs,” he says. “But algorithms were using only a subset of those variables, because data was not available on everything.

“Because of omission of the relevant variables in the model, that model was no longer a good enough representation of reality.”

Stakeholder involvement.  When a model serving a diverse population is designed mostly by members of a single demographic, it becomes more susceptible to bias. One way to counter this risk is to ensure that all stakeholder groups have a voice in the development process.

By involving stakeholders who may have conflicting goals and expectations, an organization can determine whether it’s possible to meet them all. If it’s not, Tanriverdi says, “It may be feasible to reach compromise solutions that everyone is OK with.”

The research concludes that taming AI bias involves much more than making algorithms more accurate. Developers need to open up their black boxes to account for real-world complexities, input from diverse groups, and ground truths.

“The factors we focus on have a direct effect on the fairness outcome,” Tanriverdi says. “These are the missing pieces that data scientists seem to be ignoring.”

“Algorithmic Social Injustice: Antecedents and Mitigations”  is published in MIS Quarterly.

 

Generative AI use and depressive symptoms among US adults



JAMA Network




About The Study: 

This survey study found that artificial intelligence (AI) use was significantly associated with greater depressive symptoms, with magnitude of differences varying by age group. Further work is needed to understand whether these associations are causal and explain heterogeneous effects.


Corresponding Author: To contact the corresponding author, Roy H. Perlis, MD, MSc, email rperlis@mgb.org.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.54820)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

Embed this link to provide your readers free access to the full-text article 

 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.54820?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=012126

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 IT'S A QUANTUM UNIVERSE

Researchers publish new guide to measuring spacetime fluctuations



Signatures of Correlation of Spacetime Fluctuations in Laser Interferometers




University of Warwick

Image of tabletop QUEST setup for measuring spacetime fluctuations 

image: 

Cardiff's Gravity Exploration Institute team working on QUEST experiment. Credit: H Grote, Cardiff University.

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Credit: H Grote, Cardiff University




A team of researchers led by the University of Warwick has developed the first unified framework for detecting “spacetime fluctuations” - tiny, random distortions in the fabric of spacetime that appear in many attempts to unite quantum physics and gravity.

These subtle fluctuations, first envisaged by physicist John Wheeler, are thought to arise naturally in several leading theories of quantum gravity. But because different models of gravity predict different forms of these fluctuations, experimental teams have until now lacked clear guidance on what to look for.

The new study, published in Nature Communications addresses this challenge by sorting spacetime fluctuations into three broad categories, each defined by how organised the fluctuations are in space and time. For each category, the researchers mapped out the distinct, measurable signatures that would appear in laser interferometers - from the 4km long LIGO, to compact laboratory systems such as QUEST and GQuEST being developed in the UK (Cardiff University) and USA (Caltech) respectively.

Dr. Sharmila Balamurugan, Assistant Professor, University of Warwick and first author said: “Different models of gravity predict very different underlying trends in the random spacetime fluctuations, and that has left experimentalists without a clear target. Our work provides the first unified guide that translates these abstract, theoretical predictions into concrete, measurable signals.

“It means we can now test a whole class of quantum-gravity predictions using existing interferometers, rather than waiting for entirely new technologies. This is an important step towards bringing some of the most fundamental questions in physics firmly into the realm of experiment.”

The study found that:

  • Tabletop interferometers beat LIGO in bandwidth
     Despite being far smaller than LIGO, QUEST and GQuEST could provide more detailed information about the nature of spacetime fluctuations. Their wide frequency coverage allows them to detect all the characteristic signatures.
  • LIGO is an excellent “yes/no” detector.
     Thanks to its long arm cavities, LIGO is highly sensitive to the mere presence of spacetime fluctuations — although the relevant frequencies lie above the range currently available in public data.
  • A long-running debate is resolved.
     A debate about whether arm cavities help or hinder detection has been answered as here arm cavities do enhance an interferometer’s sensitivity to spacetime fluctuations, depending on the type of fluctuation being tested.

Dr. Sander Vermeulen, Caltech, co-author of the study said: “Interferometers can measure spacetime with extraordinary precision. However, to measure spacetime fluctuations with an interferometer, we need to know where - i.e. at what frequency - to look, and what the signal will look like. With our framework we can now predict this for a wide range of theories. Our results show that interferometers are powerful and versatile tools in the quest for quantum gravity.”

Crucially, the new framework developed here is agnostic of the underlying mechanism for the fluctuations: it requires only the mathematical description of the hypothesised fluctuations and the geometry of the instrument. This makes it a powerful tool not only for quantum-gravity tests but also for searches for stochastic gravitational waves, dark-matter signatures, and certain forms of instrumental noise.

Prof Animesh Datta, Professor of Theoretical Physics at Warwick concluded: “With this methodology, we can now treat any proposed model of spacetime fluctuations in a consistent, comparable way. In the coming years, we can use this to design smarter tabletop interferometers to confirm or refute possible theories of quantum or semiclassical gravity and even test new ideas about dark matter and stochastic gravitational waves.”

ENDS

Notes to Editors

Image Credits: H Grote, Cardiff University.

About the paper and funding:

The paper ‘Signatures of Correlation of Spacetime Fluctuations in Laser Interferometers’ has been published in Nature Communications. DOI: https://doi.org/10.1038/s41467-025-67313-3

This work was funded by the UK STFC “Quantum Technologies for Fundamental Physics” program (Grant Numbers ST/T006404/1, ST/W006308/1 and ST/Y004493/1) and the Leverhulme Trust under research grant ECF-2024-124 and RPG-2019-022.

 About the University of Warwick

Founded in 1965, the University of Warwick is a world-leading institution known for its commitment to era-defining innovation across research and education. A connected ecosystem of staff, students and alumni, the University fosters transformative learning, interdisciplinary collaboration, and bold industry partnerships across state-of-the-art facilities in the UK and global satellite hubs. Here, spirited thinkers push boundaries, experiment, and challenge conventions to create a better world.

 

A Genetic tug-of-war shapes the biosynthesis of bioactive saponins




Nanjing Agricultural University The Academy of Science
Mechanism of EsOSC regulation of E. senticosus saponin synthesis. 

image: 

Mechanism of EsOSC regulation of E. senticosus saponin synthesis.

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Credit: Horticulture Research




Triterpenoid saponins are key bioactive compounds responsible for the medicinal value of many plants, yet how plants regulate the balance between saponin production and sterol biosynthesis has remained unclear. This study identifies two closely related enzymes that compete for the same metabolic precursor but drive it toward distinct biochemical outcomes. By uncovering how these enzymes function, interact, and are differentially regulated, the research reveals a molecular mechanism that determines whether metabolic flux is directed toward pharmacologically valuable saponins or essential sterols. The findings provide a mechanistic framework for understanding saponin biosynthesis and offer new molecular targets for improving the quality and yield of medicinal plant products.

Triterpenoid saponins are widely valued for their diverse pharmacological activities and also play important defensive roles in plants. These compounds are synthesized through the cyclization of a common precursor, 2,3-oxidosqualene, a reaction catalyzed by the 2,3-oxidosqualene cyclase (OSC) enzyme family. Different OSCs can channel this precursor into either saponin or sterol biosynthetic pathways, but the regulatory logic governing this metabolic branching has remained poorly understood. Previous studies mainly focused on enzyme structure or downstream modifications, while gene-level regulation received less attention. Based on these challenges, it is necessary to conduct in-depth research on how specific OSC genes and their regulators coordinate saponin biosynthesis.

Researchers from North China University of Science and Technology reported (DOI: 10.1093/hr/uhaf133) on May 21, 2025, in Horticulture Research a comprehensive molecular analysis of saponin biosynthesis in Eleutherococcus senticosus. The study identified two key OSC genes that determine whether metabolic flux is directed toward triterpenoid saponins or sterols. By combining genome-wide screening, biochemical assays, promoter analysis, and transcription factor studies, the research clarifies how enzyme competition and gene regulation together shape the accumulation of medicinally important saponins.

The researchers first identified ten OSC genes in the E. senticosus genome and narrowed them down to two functionally dominant candidates through expression profiling and metabolite correlation analysis. Functional assays confirmed that one enzyme acts exclusively as a β-amyrin synthase, directing metabolism toward oleanane-type saponins, while the other functions as a cycloartenol synthase that feeds sterol biosynthesis. Both enzymes localize primarily to the cytoplasm and compete for the same substrate, creating a metabolic trade-off.

Detailed structural analyses revealed distinct conserved amino acid triplets that define the catalytic specificity of each enzyme. Site-directed mutagenesis demonstrated that even single amino acid changes could dramatically alter product profiles or abolish enzyme activity. Beyond enzyme function, the study showed that gene expression is finely regulated by light quality, DNA methylation, and multiple transcription factors. Importantly, several transcription factors were found to exert opposite regulatory effects on the two competing genes, simultaneously promoting saponin synthesis while repressing sterol formation, or vice versa. This coordinated regulation provides a molecular explanation for how plants optimize secondary metabolite production.

According to the researchers, the most significant insight of this work is the discovery of a coordinated regulatory system that controls metabolic direction at both enzymatic and transcriptional levels. They note that identifying transcription factors capable of oppositely regulating two competing biosynthetic genes is particularly striking, as such dual control has rarely been documented in plants. This mechanism allows the plant to fine-tune resource allocation between growth-related sterols and defense- or health-related saponins, offering a powerful strategy for metabolic optimization.

The findings have important implications for medicinal plant improvement and metabolic engineering. By targeting specific OSC genes or their regulatory transcription factors, it may be possible to enhance the accumulation of valuable saponins without compromising plant viability. This strategy could support the development of higher-quality herbal medicines and functional plant products. More broadly, the study provides a conceptual model for controlling metabolic branch points in plant secondary metabolism. Such insights may be applied to other medicinal or industrial crops, enabling more precise manipulation of bioactive compound synthesis through genetic and environmental regulation.

###

References

DOI

10.1093/hr/uhaf133

Original Source URL

https://doi.org/10.1093/hr/uhaf133

Funding information

This work was financially supported by the National Natural Science Foundation of China (32470398), the Central Guidance for Local Science and Technology Development Fund Projects (236Z2501G), and Natural Science Foundation of Hebei Province (H2020209033).

About Horticulture Research

Horticulture Research is an open access journal of Nanjing Agricultural University and ranked number one in the Horticulture category of the Journal Citation Reports ™ from Clarivate, 2023. The journal is committed to publishing original research articles, reviews, perspectives, comments, correspondence articles and letters to the editor related to all major horticultural plants and disciplines, including biotechnology, breeding, cellular and molecular biology, evolution, genetics, inter-species interactions, physiology, and the origination and domestication of crops.