It’s possible that I shall make an ass of myself. But in that case one can always get out of it with a little dialectic. I have, of course, so worded my proposition as to be right either way (K.Marx, Letter to F.Engels on the Indian Mutiny)
Thursday, June 19, 2025
Prescribing fewer antibiotics might not be enough to combat threat of 'superbugs,' says new research
Antimicrobial resistance is still spreading in the environment despite a reduction in the amounts of antibiotic drugs prescribed, according to a new study led by the University of Bath. Researchers warn that multiple approaches will be required to tackle the increasing threat of antimicrobial resistance to public health.
Antimicrobial resistance (AMR) happens when bacteria evolves over time and doesn’t respond to treatment with antibiotics. It’s been highlighted by the World Health Organization as one of the world’s biggest killers, causing over five million deaths per year.
AMR can develop through several routes: over-use or misuse of antibiotics to treat or prevent bacterial infections; using antibiotics in farm animals to improve meat production; bacteria can also acquire resistance directly by swapping genes with resistant microbes in the environment.
They took samples from four wastewater treatment plants in southwest England over two years during the COVID-19 pandemic and compared them with previous data collected before 2019.
They matched these data with the number of prescriptions for antibiotics during the same time period. They found that despite a seasonal drop in the amount of antibiotics prescribed in years 2017-19 and lower amounts of antibiotic drugs identified in wastewater, there was no corresponding drop in the levels of AMR genes in the environment.
In 2020, a significant reduction in antibiotics and AMR genes was observed during lockdowns due to COVID pandemic social distancing measures that lead to the reduction in the spread of resistant bacteria. After lockdowns, when social interactions increased, both antibiotic presence/prescription and AMR genes increased indicating increased pathogen spread by infected individuals.
Professor Barbara Kasprzyk-Hordern, Director of CWBE, said: “The spread of antimicrobial resistance is a huge threat to all our lives – we rely on antibiotics for treating common infections and to safely carry out surgical procedures.
“The main focus globally on combatting AMR has been to reduce the amount of antibiotics used, but our research findings show that this alone might not be enough to tackle the problem.
“Once resistance genes are out there in the environment, they can be transferred between bacteria, making more and more of them resistant to treatment with antibiotics.
“This is really worrying because we had previously assumed that less usage would result in less AMR, but our results show the problem is more complex than that.”
The researchers suggest that governments and policymakers must take a ‘One Health’ approach to tackling AMR – not just looking at how antibiotics are used in human health, but also how they are used in animals and the effects of antibiotics on the wider environment.
They are establishing first living lab facility that will enable longitudinal studies spanning from early warning for pathogen exposure though to chemical exposure and associated health outcomes.
Dr Like Xu, first author of the study, said: “Antimicrobial resistance is a growing concern, as antibiotics and antibiotic-resistant genes persist in the environment, leading to serious and widespread issues.
“Our work shows that wastewater-based epidemiology is an innovative and cost-effective monitoring tool that can be used to understand antibiotics usage and how antibiotic-resistant genes spread.
“Through wastewater analysis, this approach helps identify new resistance patterns, understand their transmission and establish baselines at community level.
“This evidence can support decision makers in developing coordinated interventions and assessing their effectiveness in near-real time.”
Building bridges to operationalize One Health — A longitudinal two years’ AMR study in England using clinical and wastewater-based surveillance approaches
No comments:
Post a Comment