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Friday, February 27, 2026

FinCEN’s Warning—And The Predictable Failure Of Prohibition – OpEd


Removal of liquor during Prohibition in the United States. 
Photo Credit: Author unknown, Wikipedia Commons


February 27, 2026 
By Roger Bate


Over the past few years, quiet but extraordinary warnings have emerged from the US Treasury Department. The Financial Crimes Enforcement Network reports that illicit e-cigarettes are being used as part of trade-based money-laundering schemes linked to fentanyl trafficking. Illegal vaping products are no longer just a regulatory nuisance or a youth-use talking point. They have become a financial instrument in the cartel economy.

The finding matters because it exposes a reality many policymakers have spent years denying—prohibition does not eliminate markets, it reorganizes them. And when demand persists, prohibition reliably hands control to the most ruthless and well-organized suppliers.

We are now watching that process unfold in real time in the US vaping market. And let’s be clear where the blame lies: The CDC’s Office on Smoking and Health and the FDA’s Center for Tobacco Products have deliberately obscured relative risk and forced nicotine markets underground, where criminal supply now thrives beyond any meaningful oversight.

From Regulation to Underground Supply


Vaping emerged as a harm-reduction alternative for smokers. In the UK and New Zealand and other countries that allowed regulated products to compete openly with cigarettes, smoking rates declined rapidly.

In the United States, by contrast, legal vaping has been squeezed by a combination of bans, frozen approvals, and enforcement-first regulation. The result is not a smaller market. It is a market that has largely gone underground.


By the government’s own admissions, only a small fraction of vaping products currently sold in the US are formally authorized. In practical terms, this means that most adults who vape are buying products that exist outside the legal framework, often without realizing it. In many local markets—especially convenience stores that I’ve personally investigated—illegal disposable vapes appear to make up the majority of sales.

This is not a fringe phenomenon. It is a parallel national supply chain.

What enforcement is actually finding

Recent enforcement actions give a sense of scale. Federal agencies have seized hundreds of thousands—and in some cases millions—of illegal vaping devices in single operations. Entire warehouses have been cleared of products that were never approved and were often deliberately mislabeled to evade customs scrutiny.

Authorities have acknowledged that thousands of distinct unauthorized vaping products are circulating in the US market. Most are manufactured overseas and enter the country through misdeclared shipping, freight forwarding, or informal cross-border routes. Once inside, distribution frequently overlaps with existing smuggling corridors linked to Mexico—routes long used for narcotics, weapons, and cash.

In several cases, vape shops raided by law enforcement turned out to be fronts for broader criminal activity, including drug distribution and money laundering. This is what happens when a consumer market is forced into the shadows: it is absorbed into criminal infrastructure that already knows how to move goods and money at scale.

Why Prohibition Fails—Every Time

None of this is surprising. Prohibition has a long and well-documented track record.

When governments criminalize supply while demand persists, they do not create safer markets. They create markets optimized for secrecy, intimidation, and profit maximization. Compliance-oriented firms exit. Criminal organizations enter. Oversight disappears.

This is not a failure of enforcement. It is the economic logic of prohibition.

Alcohol prohibition produced bootleg liquor, poisonings, and organized crime. The war on drugs professionalized trafficking and entrenched violent networks. High-tax cigarette regimes fueled smuggling and counterfeiting. Illicit vaping follows the same pattern, only faster.

The Danger of Illicit Products

One deeply uncomfortable consequence of this policy choice is now becoming harder to ignore: some illicit vaping products may be genuinely dangerous.

Devices of unknown origin may contain contaminants, inconsistent nicotine delivery, or poorly designed heating elements that generate toxic byproducts. Consumers have no reliable way to know what they are inhaling. There are no ingredient disclosures, no enforceable product standards, no recalls, and no liability.

When harms emerge, prohibition advocates predictably blame vaping itself. That conclusion reverses responsibility.

If an illicit vape injures someone, the fault does not lie with legal manufacturers who were barred from selling regulated products. It does not lie with compliant retailers shut out of the market. And it does not lie with consumers responding rationally to demand.

The responsibility lies with the policy decision that forced supply underground.

Regulatory Theater—and Real Victims

The current response—more raids, more seizures, more press conferences—does not address the underlying problem. It merely treats the symptoms.

Consumers know illegal vapes remain easy to find. Retailers face inconsistent and selective enforcement. Criminal networks adapt faster than regulators can respond. Each seizure is followed by replenishment through new channels.

This is not effective governance. It is regulatory theater with a massive human cost.

If unsafe illicit vaping products cause injuries or deaths, responsibility does not end with smugglers or foreign manufacturers. FDA and CDC officials who spent years demonizing harm reduction, blocking lawful products, and insisting on abstinence-only nicotine policy cannot plausibly claim clean hands.

They were warned. They were shown the incentives. They ignored the evidence.

When agencies deliberately eliminate regulated supply and then express shock that unregulated products fill the gap, they are not passive observers. They are participants. And when the foreseeable consequences include criminal enrichment and consumer harm, there is no moral distance to hide behind.

Owning the Consequences

FinCEN’s warnings should have forced a reckoning. Instead, they have been treated as an inconvenience.

But the lesson is unavoidable: prohibition does not protect public health from organized crime. It funds it. It empowers it. And it makes consumers less safe in the name of protecting them.

If illicit vaping products turn out to be dangerous, that fact does not vindicate prohibition. It indicts it. Dangerous underground markets are not evidence that harm reduction failed. They are evidence that regulation was abandoned.

And the harms that follow are not accidents. They are outcomes—ones that the FDA and CDC helped engineer, and for which they should be held accountable.

This article was published by Brownstone Institute

Roger Bate

Roger Bate is a Brownstone Fellow, Senior Fellow at the International Center for Law and Economics (Jan 2023-present), Board member of Africa Fighting Malaria (September 2000-present), and Fellow at the Institute of Economic Affairs (January 2000-present).

Sunday, February 01, 2026

 

Second-hand vape plumes could form lung-damaging radicals




American Chemical Society





Electronic cigarettes — or vapes — can release puffs of vapor in aromatic clouds. The health risks of breathing in this secondhand or passive vapor aren’t fully understood. So, researchers reporting in ACS’ Environmental Science & Technology conducted a preliminary study on lingering vape plumes in indoor environments. They found that aged vapor contained fine particles with several metals and highly reactive compounds, which together produce radicals that might damage lung tissue if inhaled.

“Our study reveals that the chemical cocktail of metal nanoparticles and reactive peroxides in aged e-cigarette aerosols creates a unique profile of respiratory health risks, highlighting that secondhand vapor is something by-standers shouldn't have to breathe,” says Ying-Hsuan Lin, the corresponding author of the study from the University of California, Riverside.

Unlike traditional cigarettes, e-cigarettes don’t create smoke; they create vapors that could expose non-users to harmful substances. Early studies showed that these secondhand vape aerosols contain volatile organic compounds that react with indoor ozone, creating new compounds, such as peroxides. Additionally, vape liquids and puffs commonly contain heavy metals, as well as other metals that could easily react with peroxides to produce potentially damaging compounds like free radicals.

In another step toward understanding the potential health effects of secondhand vape plumes, Lin and colleagues examined how  ozone indoors impacts the metal and peroxide composition of vape aerosols. They also wanted to see what happens when these substances react in wet environments, simulating what might happen inside the lungs.

For their experiments, the researchers created a simplified vape liquid with one flavoring ingredient (a floral-smelling terpene) and no nicotine, loaded it into two different vape pens with refillable cartridges, and puffed it into a chamber with ozone in the air. After 90 minutes, they collected the aged aerosols for analysis. The particles from both pens contained iron, aluminum and zinc ions, as well as trace amounts of heavy metals such as lead, arsenic and tin. And the two sets of aged aerosols had similar levels of peroxides. The smallest particles, classified as ultrafine particles, contained higher percentages of metals and peroxide compounds compared to larger aerosols.

To preliminarily understand how aged aerosols react with lung fluids, the researchers placed the samples in a water-based solution. The aged aerosols created radicals with the ultrafine particles producing 100 times more radicals relative to their weight as compared to larger particles. Because ultrafine particles can get deep into humans’ lungs and enter the sensitive, fluid-lined alveoli, the researchers say the results indicate these particles’ potential to damage lung tissues and lower respiratory function.

The researchers acknowledge that the study was done under controlled laboratory conditions, and more research is needed using real-world indoor environments and commercially available e-cigarette liquids. Regardless, these results suggest that repeated exposure to aged vape plumes could negatively impact lung health, especially for individuals with pre-existing lung conditions such as asthma or chronic obstructive pulmonary disease, commonly referred to as COPD.

The authors acknowledge funding from the University of California, the Office of the President Tobacco-Related Disease Research Program and a NRSA T32 training grant.

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The American Chemical Society (ACS) is a nonprofit organization founded in 1876 and chartered by the U.S. Congress. ACS is committed to improving all lives through the transforming power of chemistry. Its mission is to advance scientific knowledge, empower a global community and champion scientific integrity, and its vision is a world built on science. The Society is a global leader in promoting excellence in science education and providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, e-books and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research. As a leader in scientific information solutions, its CAS division partners with global innovators to accelerate breakthroughs by curating, connecting and analyzing the world’s scientific knowledge. ACS’ main offices are in Washington, D.C., and Columbus, Ohio.

Registered journalists can subscribe to the ACS journalist news portal on EurekAlert! to access embargoed and public science press releases. For media inquiries, contact newsroom@acs.org.

Note: ACS does not conduct research but publishes and publicizes peer-reviewed scientific studies.

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Thursday, January 29, 2026

WAIT,WHAT?!

Vaping zebrafish suggest E-cigarette exposure disrupts gut microbial networks and neurobehavior



Researchers at Kyushu University hope to spark broader public discussion on the health risks of e-cigarettes and provide scientific evidence to support a reassessment of existing regulations



Kyushu University

Vaping Zebra fish suggest E-cigarette exposure disrupts gut microbial networks and neurobehavior 

image: 

Using a zebrafish model, researchers at Kyushu University found that exposure to e-cigarette vapor—regardless of nicotine content—disrupted the gut microbiome, reducing microbial network stability and altering community composition. At the same time, the fish showed weakened behavioral inhibition and impaired escape responses.

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Credit: Laboratory of Developmental Disorders and Toxicology, Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University




Fukuoka, Japan—Electronic cigarettes (e-cigarettes), widely marketed as a safer alternative to traditional cigarettes, are now hooking younger generations. World Health Organization data from 2025 show that at least 15 million adolescents aged 13–15 now vape. As colorful, fruit-flavored devices become a new social norm on playgrounds and campuses, we must rethink whether they are truly harmless as advertised.

A recent study from Kyushu University, with collaborators from Hong Kong and Taiwan, published in Science of The Total Environment, offers biological insights into the potential health risks of vaping. Using a zebrafish model, the researchers show that exposure to e-cigarettes alters gut microbiota composition and affects neurobehavior.

“The gut microbiome is sensitive to environmental exposure, and its balance and stability are closely linked to overall health,” notes Tse Ka Fai William, Associate Professor at Kyushu University's Faculty of Agriculture. “We therefore investigated how e-cigarette vapor changes bacterial communities and what that might mean for the organism.”

The researchers turned to zebrafish, a commonly used model in toxicology and biomedical research that shares approximately 80% of human disease-causing genes. They designed a water-based exposure system, bubbling e-cigarette liquid—with and without nicotine—into fish tanks over seven days. Doses and device settings mimicked typical vaping conditions, with unexposed tanks used as controls.

Chemical analysis revealed that heating e-cigarette liquids produced harmful byproducts, including formaldehyde and acetaldehyde, which are classified as carcinogens and can cause respiratory and skin irritation.

Following exposure, the researchers found disruptions in the zebrafish gut microbiome, with reduced microbial network stability and altered community composition.

“Some bacteria become dominant and replace others, forming a new microbial community,” explains the paper’s first author Thi Ngoc Mai Dong, a master's student at Kyushu University's Graduate School of Bioresource and Bioenvironmental Sciences. “The changes suggest that the fish, or rather the bacteria, can ‘feel’ the toxic substances in the water and want to adapt to the new environment.”

For instance, in nicotine-exposed fish, Fusobacteriaceae, key contributors to gut health and mucosal integrity declined significantly, while Sphingomonadaceae, bacteria that known for their ability to degrade xenobiotic compounds, became dominant. In nicotine-free vapor exposures, Shewanellaceae and Barnesiellaceae were enriched, potentially reflecting responses to environmental stresses and altered immune regulation. Bioinformatics analysis further showed enrichment of microbial pathways involved in xenobiotic degradation and oxidative stress responses, suggesting both direct chemical metabolism and secondary stress adaptation.

“We also see that the microbiome is actively breaking down flavoring chemicals in vaping liquids,” adds Carl Andersen Macaraeg Tan, an undergraduate student who joined the dual-degree program at Kyushu University's School of Agriculture and the second author. The researchers expressed concern that the chemical compositions of many e-cigarette flavors are not fully disclosed, limiting evidence-based risk assessment.

Given that gut microbial metabolites may influence neurological function, the team further studied zebrafish behavior. They found that regardless of nicotine content, e-cigarette exposure caused behavioral changes and impaired escape responses. The team is now exploring the underlying biological mechanisms and, drawing on its expertise in developmental biology, plans to examine whether vaping exposure of adult fish may affect the health of their offspring.

While based on an animal model and cannot be directly extrapolated to humans, the study aims to raise awareness among the public, educators, and policymakers of the need for further investigation of the potential risks posed by vaping.

“This research was partly motivated by our international students, who noticed e-cigarette use becoming more common among their peers, not only in Japan but worldwide,” says Tse. Through the English-taught International Undergraduate Program at the Faculty of Agriculture, Kyushu University provides young students with early research opportunities, and students from diverse cultural backgrounds bring fresh perspectives to global health concerns.

“We hope these findings can make consumers aware that e-cigarettes produce harmful substances, and support more transparent risk communication and regulation,” Tse concludes.

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For more information about this research, see "E-cigarette vapor alters gut microbiota composition in zebrafish," Thi Ngoc Mai Dong, Delbert Almerick T. Boncan, Carl Andersen Macaraeg Tan, Da-Wei Liu, Hsin-Yu Sun, Ting-Wei Huang, Chen Hsu, Kuo-Chang Chu, Zulvikar Syambani Ulhaq, Keng Po Lai, Douglas Robert Drummond, Yukiko Ogino, Yun-Jin Jiang, May-Su You, Jen-Kun Chen, Ting Fung Chan, William Ka Fai Tse, Science of The Total Environment,  https://doi.org/10.1016/j.scitotenv.2025.181199

About Kyushu University 
Founded in 1911, Kyushu University is one of Japan's leading research-oriented institutions of higher education, consistently ranking as one of the top ten Japanese universities in the Times Higher Education World University Rankings and the QS World Rankings. Located in Fukuoka, on the island of Kyushu—the most southwestern of Japan’s four main islands—Kyushu U sits in a coastal metropolis frequently ranked among the world’s most livable cities and historically known as Japan’s gateway to Asia. Its multiple campuses are home to around 19,000 students and 8,000 faculty and staff. Through its VISION 2030, Kyushu U will “drive social change with integrative knowledge.” By fusing the spectrum of knowledge, from the humanities and arts to engineering and medical sciences, Kyushu U will strengthen its research in the key areas of decarbonization, medicine and health, and environment and food, to tackle society’s most pressing issues.

Tuesday, January 20, 2026


Irradiated cannabis might still harbour toxic fungi and residues, McGill study finds



Researchers raise concerns about possible health risks for vulnerable users, point to a need for better methods and safeguards



McGill University





Gamma irradiation, an industry-standard sterilization method for medicinal and recreational cannabis, does not fully eliminate toxic fungi or their chemical residues, a McGill University study has found. Current testing practices may also miss contamination, raising concerns about health risks for vulnerable users, particularly those with weakened immune systems. 

The researchers said this is especially significant given that 70 per cent of cannabis is consumed by smoking or vaping, which may deliver toxins directly into the lungs and exacerbate smoking-related injury to lung tissues. 

These findings point to a need for stricter testing and better safeguards, they said.

Major health hazards

Gamma irradiation works by damaging the DNA and RNA of microbes and degrading mycotoxins – harmful compounds produced by certain fungi. While this process significantly reduces microbial loads, researchers found viable spores of mycotoxigenic fungi, DNA fragments and traces of toxins remained after irradiation.  

These remnants pose major health hazards, with heightened risk for such populations as cancer patients, transplant recipients and individuals with HIV/AIDS. However, the study also cites multiple case reports of fungal lung infections and other opportunistic infections in healthy people exposed to contaminated cannabis products. 

Combined methods can improve testing 

Researchers analyzed dried cannabis buds from a licensed producer and ready-to-use products from a licensed producer that were legally on the market. They used three complementary approaches: 

  • Culture-based methods to grow and identify living fungi and bacteria. 

  • Molecular tests (PCR and qPCR) to detect fungal DNA and toxin-producing genes. 

  • Antibody-based ELISA assays to measure mycotoxins such as aflatoxins and ochratoxins. 

The team found that ELISA, the current industry standard, is not sensitive enough on its own to detect trace amounts of mycotoxins left after irradiation, nor is mass spectrometry when used in isolation. Adding molecular and culture-based methods allows testers to track smaller fragments that ELISA or mass spectrometry alone might miss. 

“A single spore can cause disease, so we had to go beyond the ELISA limit to see. To the general population, this may not have much significance, but immunocompromised people will be at much higher risk,” said Saji George, study co-author and Professor at the Department of Food Science and Agricultural Chemistry. 

Industry collaboration and next steps 

The researchers stressed that once contamination occurs, it is extremely difficult to remove, so prevention is key. They are working with industry partners on such solutions as beneficial bacteria that prevent harmful fungi from establishing on the crop. 

“Cannabis buds have sticky resins, so they are really susceptible to contamination. These fungi are everywhere, so we need to be more careful at every stage, from growing and harvesting to processing and storage,” said Mamta Rani, study co-author and Research Associate at the Laboratory for Sustainable Agricultural Food and Environmental Applications of Nanotechnology (SAFE-Nano lab) at McGill.  

“It is possible to produce clean cannabis. Some companies we work with have achieved this through strict hygiene practices and controlled environments,” she said.  

Added George: “We are not trying to tarnish the industry, but to help make it more sustainable and provide guidelines for safer products. We need stricter safety standards, especially for medicinal cannabis.” 

About this study

Detection of Mycotoxigenic Fungi and Residual Mycotoxins in Cannabis Buds Following Gamma Irradiation,” by Mamta Rani, Mohammad Jamil Kaddoura, Jamil Samsatly, Guy Chamberland, Suha Jabaj and Saji George, was published in Toxins

The research was funded by Tetra Biopharma Inc. (G253375).