Tuesday, August 17, 2021

Opinion: Enough with Western hypocrisy over Afghanistan

Europe has long been ignoring the deteriorating security situation in Afghanistan. 
But now that the Taliban has seized power, some Western countries act stunned. 
This hypocrisy must stop, says DW's Waslat Hasrat-Nazimi.


Germany's Bundeswehr prepared to evacuate German citizens from Kabul on Monday — but what about Afghan civilians seeking safety?

Within just a few days of the US troop withdrawal from Afghanistan, the Taliban began capturing one province after another. As the provincial capitals fell like dominos, thousands of Afghans fled their homes and headed for what they thought would be the safe haven of Kabul. But now the Taliban has taken the capital, too.

Meanwhile, the Western world is looking on, stunned as the Islamic Republic of Afghanistan is transformed into an emirate governed by the Taliban. I've been inundated with calls and messages from friends and colleagues expressing their sympathy.

A mission based on lies


The reason why this recent development has shocked so many is that they now realize that their governments launched a mission in Afghanistan 20 years ago not to defend human rights — but for reasons of political expediency.

But now that political priorities have changed and the cost-benefit equation no longer adds up, they wanted out. As fast as possible.


Waslat Hasrat-Nazimi is DW's head of Dari-Pashto service


The mission was one big lie. Joe Biden is determined to see that the mission overseen by four US presidents won't be handed on to a fifth. Human rights? Women's rights? Democracy? That's no longer the West's problem, it seems, it's suddenly for Afghans to sort out among themselves. "Afghan leaders have to come together," said Biden recently. "They've got to fight for themselves, fight for their nation."
Betrayed and abandoned

But what Biden fails to mention is that the US did not only invade Afghanistan back in 2001 in order to fight the Taliban and al-Qaida. The US also promised the Afghan people that it would bring democracy to their country.

Protecting the rights of Afghan women was one of the main arguments for the US-led war on Afghanistan. But two decades on, it's clear that this was all just empty rhetoric; neither women's rights nor democracy were the top priorities.

The same women who supposedly stood up a bit too vehemently for their rights in recent years were placated with promises that democracy and rule of law would always triumph, are now being cast back into the darkness in which they existed prior to 2001. They have been betrayed and abandoned. Many women's rights activists now fear for their lives.

Refugees must be taken in


The EU and Germany's asylum policy is no less hypocritical. Recent years have seen millions of Afghans flee their home country for years. No one makes this decision lightly. They fled because the security situation in Afghanistan had continued to worsen; their plight was ignored. Afghanistan was deemed a "safe country."

Many refugees were deported, others were only tolerated. Thousands of Afghans are living in appalling conditions in Greece, Turkey and the Balkans. EU politicians have refused to acknowledge the gravity of the security situation in Afghanistan and that the international mission has failed.

But now that it's too late, politicians, the media and academics are professing their shock. Western countries — including Germany — have a responsibility to Afghanistan. Instead of supporting warlords and corrupt politicians in recent years, they should have made concerted efforts to understand and engage with the Afghan people, their culture and society. They should have listened to the women's warnings instead of fobbing them off with meaningless promises. Rather than helping build an army, they should have been helping the Afghan people build a future.

So what happens next? Western countries must guarantee Afghan refugees asylum, as fast and as unbureacratically as possible. They must take in the Afghan refugees waiting for decisions on their status and living in terrible conditions in EU countries. They must also take in the Afghans who will arrive in the next few months and years, having fled a devastated country left high and dry by the West. That's the least Europe owes the people of Afghanistan.


Taliban surge in Afghanistan: EU and NATO in state of shock

Following the Taliban's recapture of Afghanistan, NATO and the EU have largely remained silent. The national governments are the ones reacting.


Nato headquarters in Brussels


EU diplomats appear to have been caught unaware by the Taliban's advance and the rapid collapse of the Afghan government. On Thursday, EU foreign policy chief Josep Borrell urged the Taliban to "immediately resume substantive, regular and structured talks," and agree to a cease-fire. He said the EU encourages "the Islamic Republic of Afghanistan to settle political differences, increase representation of all stakeholders and engage with the Taliban from a united perspective."

Two days before the fall of Kabul, that seems a bit clueless.

A request to guarantee the safe and orderly withdrawal of all foreigners and Afghans wishing to leave the country followed on Monday morning. It was signed by representatives from the EU and from parts of the international community. Chaotic scenes at Kabul airport, however, show that only military evacuation is still an option; civilian air traffic has been halted. A special EU foreign ministers' meeting was called for Tuesday afternoon.

Complaints, warnings from the European Parliament


The president of the European Parliament is urging a united EU response. "The country needs a lasting and inclusive political solution that protects the rights of women and allows Afghans to live in safety and with dignity. Asylum must be granted to those in danger of persecution," David Sassoli wrote on Twitter — a statement that also seems strangely belated.

Urging a united EU response: David Sassoli


The foreign policy spokespersons of the center-right European People's Party (EPP) in the European Parliament have urged that more people be brought to safety quickly. "In addition to the Afghan local forces of the German armed forces, for example, teachers, doctors, mayors and women's rights activists have also held the torch of peace, freedom, democracy and human rights high in Afghanistan," Daniel Caspary and David McAllister wrote in a statement, adding that the EU must step up humanitarian aid in the region to avoid a surge of refugees to Europe: "We must now do everything we can to ensure that those fleeing get protection close to home."

The Greens are demanding that, at the least, the EU must now rescue the approximately 600 local personnel who worked in the EUPOL police mission, for the EU delegation in Kabul and the ECHO humanitarian aid mission — including their families. "Europe must live up to its responsibility for the local staff of the EU missions. Instead of acting quickly, the EU Commission and national governments are arguing about responsibilities," said Sven Giegold, a Green Party spokesman and lawmaker. He urged setting up an airlift for EU personnel.

Dacian Ciolos, spokesman for the Liberals in the European Parliament, called for a special summit of EU governments and a meeting of the EU Parliament. Afghanistan's "descent into darkness" must be urgently discussed, he said, in order to find a unified humanitarian and diplomatic response. "The international community must come together to protect those fleeing persecution," he wrote on Twitter.



'Some people won't get back'

Security committee meetings were called in several European NATO countries on Monday, including the UK, Belgium and France. The military alliance's headquarters in Brussels, however, is silent.

On Monday, British Defense Secretary Ben Wallace announced a speeding up of procedures for civilian workers, saying, "Where the rules need to be changed, they will be changed." The plan, he said, is to evacuate 1,200 to 1,500 people per day until August 31 while Kabul airport is still under Western control.

“Some people won't get back," he said. "It's sad, the West has done what it's done, and we have to do our very best to get people out and stand by our obligations." He added that only Afghans who make it to Kabul have a chance to be flown out.



A German Foreign Ministry spokesman said it was unclear how long the evacuation of Kabul will be able to continue. In a Christian Democratic Union (CDU) party presidium meeting on Monday, German Chancellor Angela Merkel reportedly spoke of "bitter hours," saying the government identified some 2,500 local forces in Afghanistan, in addition to about 2,000 human rights activists and lawyers plus their families — a total of about 10,000 Afghans — who needed to be flown out, months ago.

GERMANY'S NATO MISSIONS
Germany's role in NATO
West Germany officially joined the trans-Atlantic alliance in 1955. However, it wasn't until after reunification in 1990 that the German government considered "out of area" missions led by NATO. From peacekeeping to deterrence, Germany's Bundeswehr has since been deployed in several countries across the globe in defense of its allies.

In cooperation with the United States, Germany is now evacuating people. "We could not perform such a mission without the help of the US," Merkel said. For women and the many Afghans "who chose progress and freedom," she said, what is happening now are "bitter events." The chancellor made it clear the German armed forces were dependent on the US concerning the rapid withdrawal from Afghanistan.

The plan is to continue evacuations for as long as possible, with special forces and paratroopers doing a dangerous job in Kabul, according to Defense Minister Annegret Kramp-Karrenbauer. Soldiers from previous Afghanistan missions were "shocked at what is happening," she said.

Speaking of the West's decades-long mission in Afghanistan, German government spokesman Steffen Seibert echoed Merkel's words Monday, calling recent developments "bitter." According to media reports, the Foreign Ministry paid no attention to situation reports from the embassy in Kabul urging speedy departures. CDU chancellor candidate Armin Laschet labeled developments in Afghanistan, "the biggest fiasco since the founding of NATO."


German Chancellor Angela Merkel spoke of "bitter hours"

Emergency meeting in Paris

Many European countries, including Sweden, the Czech Republic, the Netherlands and Italy, have flown out their diplomatic staff and some relief workers. The French National Defense Council held an emergency meeting earlier Monday; President Emmanuel Macron plans to deliver a televised address in the evening. Human rights activists, journalists and artists with ties to France are to be flown out, along with embassy staff and Afghan personnel, in an airlift to Abu Dhabi.

The French government is not alone in fearing a new refugee crisis if millions of Afghans were to make their way to Europe. Greek Migration Minister Notis Mitarachi has already declared that his country will not be a "gateway for a new refugee wave."


Afghanistan's female footballers make tearful calls for help

LONDON (AP) — In frantic phone calls and voice messages, Khalida Popal can hear the distress and tearful pleas for help.

The football players in the Afghanistan women’s national team that Popal helped establish now fear for their lives after the Taliban swept to regain control of the country after two decades.

When they call, all Popal can do is advise them to flee their homes, escape from neighbors who know them as pioneering players, and try to erase their history — particularly activism against the Taliban who are now re-establishing the Islamic Emirate of Afghanistan.

“I have been encouraging to take down social media channels, take down photos, escape and hide themselves,” Popal told The Associated Press in a telephone interview from Denmark. “That breaks my heart because of all these years we have worked to raise the visibility of women and now I’m telling my women in Afghanistan to shut up and disappear. Their lives are in danger.”

The 34-year-old Popal can barely comprehend the speed of the collapse of the Afghan government and the sense of being abandoned by Western nations who helped to topple the Taliban in 2001. Having fled with her family after the Taliban captured Kabul in 1996, Popal returned to Afghanistan two decades ago as a teenager who had been living in a refugee camp in Pakistan. With the protection of the international community, Popal felt optimistic that women’s rights would be promoted.

“My generation had the hope of building the country, developing the situation for the next generation of women and men in the country,” she said. “So I started with other young women using football as a tool to empower women and girls."

By 2007, there were enough players for Popal to be part of Afghanistan's first women’s national team.

“We felt so proud of wearing the jersey,” Popal said. “It was the most beautiful, best feeling ever.”

Popal encouraged her teammates to use their platforms to speak out as escalating attacks were seeing the Taliban retake territory.

“I received so many death threats and challenges because I was quoted on the national TV," she said. “I was calling Taliban our enemy.”

Popal stopped playing in 2011 to focus on coordinating the team as a director at the Afghanistan Football Association. But the threats continued and she was eventually forced to flee Afghanistan to seek asylum in Denmark in 2016.

“My life was in great danger,” she said.

But she never abandoned the female footballers, helping to expose physical and sexual abuse, death threats and rape that implicated the Afghanistan federation leadership. The corruption in the sport was reflective of the shaky foundations of a country that has deteriorated rapidly after the withdrawal of troops from the U.S.-led mission.

“The women of Afghanistan believed in their promise but they left because there’s no more national interest. Why did you promise?” Popal asked. “This is what my girls crying and sending voice messages are saying. Why not say you would leave like this? At least we could protect ourselves.”

An exasperated Popal sighs.

“We would not have created enemies,” Popal said. “They are crying. They are just crying … they are sad. They are just like desperate. They have so many questions. What is happening to them isn’t fair.

“They are hiding away. Most of them left their houses to go to relatives and hide because their neighbors know they are players. They are sitting, they are afraid. The Taliban is all over. They are going around creating fear.”

Popal is a world away but connected by the messages pinging into her phone of the Taliban.

“They keep taking video and photos from the window showing they are just outside the home and that is very sad,” she said.

It's hard to even imagine Afghanistan, ranked 152nd by FIFA out of 167 women's teams, playing again.

“It’s been very painful to witness when yesterday the government surrendered,” Popal said. “Women lost hope.”

___

Rob Harris, The Associated Press



 

The Lancet Infectious Diseases: Benefits of COVID-19 vaccines far outweigh very rare risk of Bell’s palsy, study confirms


Peer-Reviewed Publication

THE LANCET

  • Study is the first large-scale population analysis of the risk of Bell’s palsy following vaccination with CoronaVac (Sinovac Biotech vaccine, an inactivated vaccine) or BNT162b2 (Fosun-BioNTech, equivalent to Pfizer-BioNTech vaccine, an mRNA vaccine).
  • Bell’s palsy is the one-sided facial paralysis, and in most cases the condition is temporary and resolves itself.
  • Study finds a small increased risk of Bell’s palsy associated with CoronaVac vaccination (for every 100,000 people vaccinated, an additional 4.8 may develop the condition), but non-significant increased risk associated with vaccination with BNT162b2.
  • Beneficial and protective effects of the vaccines far outweigh the risk of this rare adverse event.

The first large-scale population-based study on the association between the SARS-CoV-2 vaccines and Bell’s palsy confirms that the beneficial and protective effects of the vaccines far outweigh the risk of this rare adverse event. The study, published in The Lancet Infectious Diseases journal, finds that for every 100,000 people vaccinated with inactivated vaccine, CoronaVac, an additional 4.8 people may develop the condition.

Bell’s palsy is the sudden onset of one-sided facial paralysis. In the majority of cases (70%), the condition resolves itself within six months without treatment and the chance of recovery is even higher (90%) if patients receive early treatment with corticosteroids.

A small number of cases of Bell’s palsy have been reported in clinical trials of mRNA COVID-19 vaccines, but so far, analyses of the association have come to conflicting conclusions. In the USA, the Federal Drug Administration (FDA) did not consider there to be a clear causal association for the two mRNA vaccines BNT162b2 (Pfizer-BioNTech) and the mRNA-1273 (Moderna) vaccines but recommends ongoing surveillance. Acute partial facial paralysis is reported as a rare side effect of both vaccines by the European Medicines Agency. Current prescribing information for CoronaVac (an inactivated vaccine) does not list Bell’s palsy as a rare adverse event, but based on the findings from the study, approval has been obtained to include information on the potential association.

Ongoing safety surveillance for any new treatment or vaccines is always recommended to understand the prevalence of rare adverse events. This is only possible with very large population studies after the initial randomised controlled trials.

In this study, researchers analysed cases of Bell’s palsy related to the two approved vaccines in Hong Kong – CoronaVac and BNT162b2. The study uses data from the Hong Kong drug regulatory authority pharmacovigilance system, which includes reports of adverse events logged by health professionals throughout the territory. Cases of Bell’s palsy were included in the analysis if they occurred within 42 days of the first or second vaccine dose, within the timeframe of the study. They also conducted a nested case-control study using territory wide electronic health record database including 298 Bell’s palsy cases and 1181 matched controls.

Between February 23rd, 2021 and May 4th, 2021, 28 clinically confirmed cases of Bell’s palsy were identified among the 451,939 individuals who received at least a first dose of CoronaVac (equivalent to 3.61 cases per 100,000 doses administered) and 16 cases were identified among the 537,205 individuals who received at least a first dose of BNT162b2 (equivalent to 2.04 cases per 100,000 doses administered).

By analysing data from 2010-2020, the researchers estimated the background risk of Bell’s palsy in Hong Kong – around 27 cases per 100,000 people, per year. Global estimates range from 15-30 cases per 100,000 people, per year. The nested case-control study found that receiving CoronaVac was associated with 2.4 times increased risk of Bell’s palsy (odds ratio (OR): 2.4; 95% CI 1.4 to 4.0) whereas receiving BNT162b2 was not associated with a significantly increased risk (OR: 1.8; 95% CI: 0.9 to 3.5).

They conclude that for every 100,000 people vaccinated with CoronaVac, an additional 4.8 people may develop Bell’s palsy. For BNT162b2, the increased risk was equivalent to an additional 2 cases per 100,000 people vaccinated – this finding may be attributed to underpower in the current study. Further studies with a sufficient sample size are needed to evaluate the association between Bell’s palsy and BNT162b2.

“Our study suggests a small increased risk of Bell’s palsy associated with CoronaVac vaccination. Nevertheless, Bell’s palsy remains a rare, mostly temporary, adverse event. All evidence to date, from multiple studies, shows that the beneficial and protective effects of the inactivated COVID-19 vaccine far outweigh any risks. Ongoing surveillance, through pharmacovigilance studies such as ours are important to calculate with increasing levels of confidence the risks of rare adverse events,” says lead author Professor Ian Chi Kei Wong, The University of Hong Kong. [1]

The authors note that they cannot conclude a causal relationship between Bell’s palsy and vaccination in any individual cases from this study, and that the mechanism by which vaccination can – in very rare instances – lead to Bell’s palsy remains unclear. Other studies have identified rare cases of Bell’s palsy after other inactivated vaccines, such as influenza. A previous study, using the WHO Pharmacovigilance Database reported no higher risk of facial paralysis following mRNA COVID-19 vaccination than with other viral vaccines, including influenza.

The authors note that the study is limited to patients with a new diagnosis of Bell’s palsy in Hong Kong, so further studies including patients with a history of Bell’s palsy and patients in other regions should be done to confirm their findings. Further analyses are also needed to understand whether the risk varies by sex or age.

In a linked Comment, Professor Nicola Cirillo, University of Melbourne, Australia and Dr Richard Doan, University of Toronto, Canada, (who were not involved in the study) write: “From a clinical, patient-oriented perspective, none of the studies published so far provide definitive evidence to inform the choice of a specific vaccine in individuals worldwide with a history of Bell’s palsy. However, the data published by Wan and colleagues do offer valuable information for a rational and informed choice of COVID-19 vaccines for patients in Hong Kong, and for those in countries where both BNT162b2 and CoronaVac are available. While waiting for conclusive evidence on vaccine-associated facial paralysis, one certainty remains: the benefit of getting vaccinated outweighs any possible risk.”

NOTES TO EDITORS

The study was funded by the Food and Health Bureau of The Government of the Hong Kong Special Administrative Region.

[1] Quote direct from author and cannot be found in the text of the Article.

The labels have been added to this press release as part of a project run by the Academy of Medical Sciences seeking to improve the communication of evidence. For more information, please see: http://www.sciencemediacentre.org/wp-content/uploads/2018/01/AMS-press-release-labelling-system-GUIDANCE.pdf if you have any questions or feedback, please contact The Lancet press office pressoffice@lancet.com  

For interviews with the Article authors, please contact Professor Ian Chi Kei Wong, The University of Hong Kong, directly E) wongick@hku.hk T) +852 3917 9441 [or via Ms Edith Tai E) edithtai@hku.hk T) +852 3971 9460] or Dr Celine Sze Ling Chui, The University of Hong Kong, E) cslchui@hku.hk T) +852 3917 6629

For interviews with the Comment author, Professor Nicola Cirillo, University of Melbourne, please contact: E) nicola.cirillo@unimelb.edu.au T) +44 745 3418908

NOTE: THE ABOVE LINK IS FOR JOURNALISTS ONLY; IF YOU WISH TO PROVIDE A LINK FOR YOUR READERS, PLEASE USE THE FOLLOWING, WHICH WILL GO LIVE AT THE TIME THE EMBARGO LIFTS: http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00451-5/fulltext 

Contact The Lancet press office:

LONDON 
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Tel: +44 (0) 7920 530997
emily.head@lancet.com

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Breaching tipping points would increase economic costs of climate change impacts


Researchers create new model for economic impacts

Peer-Reviewed Publication

GRANTHAM RESEARCH INSTITUTE ON CLIMATE CHANGE AND THE ENVIRONMENT

LONDON Exceeding tipping points in the climate system could lead to a measurable increase in the economic impacts of climate change, according to a new paper published today (16 August 2021) in the journal ‘Proceedings of the National Academy of Sciences’.

Researchers from the London School of Economics and Political Science, University of Delaware and New York University have created a new model to estimate the economic impacts of climate tipping points, such as disintegration of the Greenland Ice Sheet.

The paper on ‘Economic impacts of tipping points in the climate system’ was written by Simon Dietz (London School of Economics and Political Science), James Rising (University of Delaware), Thomas Stoerk (London School of Economics and Political Science), and Gernot Wagner (New York University).

In the authors’ main scenario, the risks of these tipping points occurring increases the economic cost of damages we can expect from climate change by about 25 per cent compared with previous projections.

However, the authors stress that the results for their main scenario could be conservative, and that tipping points could increase the risks of much greater damages. Their study finds that there is a 10 per cent chance of the tipping points at least doubling the costs of climate change impacts, and a 5 per cent chance of them tripling costs.

The authors considered eight tipping points that have been described in the scientific literature:

  • Thawing of permafrost, leading to carbon feedback resulting in additional carbon dioxide and methane emissions, which flow back into the carbon dioxide and methane cycles.
  • Dissociation of ocean methane hydrates, resulting in additional methane emissions, which flow back into the methane cycle.
  • Arctic sea ice loss (also known as ‘the surface albedo feedback’), resulting in changes in radiative forcing, which directly affects warming.
  • Dieback of the Amazon rainforest, releasing carbon dioxide, which flows back into the carbon dioxide cycle.
  • Disintegration of the Greenland Ice Sheet, increasing sea-level rise.
  • Disintegration of the West Antarctic Ice Sheet, increasing sea-level rise.
  • Slowdown of the Atlantic Meridional Overturning Circulation, modulating the relationship between global mean surface temperature and national mean surface temperature.
  • Variability of the Indian summer monsoon, directly affecting GDP per capita in India.

The study found that economic losses associated with the tipping points would occur almost everywhere in the world. The dissociation of ocean methane hydrates and thawing permafrost would create the largest economic impacts.

The model includes national-level climate damages from rising temperatures and sea levels for 180 countries.

The authors emphasise that their estimate of the impacts are probably underestimates, but their model can be updated as more information about tipping points is discovered.

Professor Simon Dietz at the Department of Geography and Environment and the Grantham Research Institute on Climate Change and the Environment at the London School of Economics and Political Science, said: “Climate scientists have long emphasised the importance of climate tipping points like thawing permafrost, ice sheet disintegration, and changes in atmospheric circulation. Yet, save for a few fragmented studies, climate economics has either ignored them, or represented them in highly stylised ways. We provide unified estimates of the economic impacts of all eight climate tipping points covered in the economic literature so far.”

To obtain an embargoed copy of ‘Economic impacts of tipping points in the climate system’, or for interviews with the authors, please contact Bob Ward on +44 (0)7811 320346 or r.e.ward@lse.ac.uk

Notes to Editors:

The Grantham Research Institute on Climate Change and the Environment was established in 2008 at the London School of Economics and Political Science. The Institute brings together international expertise on economics, as well as finance, geography, the environment, international development and political economy to establish a world-leading centre for policy-relevant research, teaching and training in climate change and the environment. It is funded by the Grantham Foundation for the Protection of the Environment, which also funds the Grantham Institute – Climate Change and the Environment at Imperial College London. www.lse.ac.uk/grantham/

The College of Earth, Ocean and Environment at the University of Delaware has a mission to advance scientific knowledge of the ever-changing coupled natural and human systems for long-term sustainability by leading-edge research and effective teaching to ensure our science serves society by informing policy and engaging communities. www.udel.edu/academics/colleges/ceoe/

New York University, which was founded in 1831, is one of the world’s foremost research universities and is a member of the selective Association of American Universities. NYU has degree-granting university campuses in New York, Abu Dhabi, and Shanghai and has 11 other global academic sites, including London, Paris, Florence, Tel Aviv, Buenos Aires, and Accra. Through its numerous schools and colleges, NYU is a leader in conducting research and providing education in the arts and sciences, engineering, law, medicine, business, dentistry, education, nursing, the cinematic and performing arts, music and studio arts, public administration, social work, and professional studies, among other areas. www.nyu.edu

 

 

New study analyzes global environmental consequences of weakening US-China trade relationship


Peer-Reviewed Publication

UNIVERSITY OF MARYLAND CENTER FOR ENVIRONMENTAL SCIENCE


CAMBRIDGE, MD (August 16, 2021)—A new study has found that United States would face intensifying nitrogen and phosphorus pollution and increasing irrigation water usage in agricultural production as a result of persistent US-China trade tension, such as China’s retaliatory tariffs on US agriculture. In fact, the impacts do not stay within the two countries but spill over to other countries through international trade, adding additional pressure on those already stressed ecosystems, such as the Brazilian Amazon.

“Trade negotiations have often focused on direct economic and political impacts, but it also has profound impacts on the environment for the two trade partners and the world, which will, in turn, have influence on their economic and social well-being,” said the study’s lead author Dr. Guolin Yao.

The study quantified and mapped several major environmental impacts, including nutrient pollution and irrigation water consumption. “The visualization of such impacts provides a basis for including the consideration of environmental consequences of trade and trade policies,” noted co-author, Xin Zhang, associate professor at the University of Maryland Center for Environmental Science. “These trade tensions have variable, sometime opposite and surprising impacts for different regions or for different environmental concerns.”

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“The increasing global environmental consequences of a weakening US–China crop trade relationship” by Guolin Yao, Xin Zhang and Eric Davidson from the University of Maryland Center for Environmental Science and Farzad Taheripour from Purdue University was published in Nature Food.

UNIVERSITY OF MARYLAND CENTER FOR ENVIRONMENTAL SCIENCE

The University of Maryland Center for Environmental Science leads the way toward better management of Maryland's natural resources and the protection and restoration of the Chesapeake Bay. From a network of laboratories located across the state, UMCES scientists provide sound evidence and advice to help state and national leaders manage the environment, and prepare future scientists to meet the global challenges of the 21st century.

 

New analysis of landmark scurvy study leads to update on vitamin C needs


Peer-Reviewed Publication

UNIVERSITY OF WASHINGTON

It was wartime and food was scarce. Leaders of England’s effort to wage war and help the public survive during World War II needed to know: Were the rations in lifeboats adequate for survival at sea? And, among several experiments important for public as well as military heath, how much vitamin C did a person need to avoid the deadly disease scurvy?

In one experiment at the Sorby Research Institute in Sheffield, called the “shipwreck” experiment, volunteers were fed only what the navy carried in lifeboats. The grueling experiment resulted in more water and less food being carried in lifeboats. 

One of the more robust experiments run on human subjects during this time in England, which has had long-lasting public health consequences, was a vitamin C depletion study started in 1944, also at Sorby. This medical experiment involved 20 subjects, most of whom were conscientious objectors living in the building where many experiments, including the shipwreck experiment, were conducted. They were overseen by a future Nobel Prize winner, and detailed data was kept on each participant in the study.

“The vitamin C experiment is a shocking study,” said Philippe Hujoel, lead author of a new study on the Sorby vitamin C experiment, a practicing dentist and professor of oral health sciences in the UW School of Dentistry. “They depleted people’s vitamin C levels long-term and created life-threatening emergencies. It would never fly now.”

Even though two trial participants developed life-threatening heart problems because of the vitamin C depletion, Hujoel added, none of the subjects were permanently harmed, and in later interviews several participants said they would volunteer again given the importance of the research. 

Because of the war and food shortages, there was not enough vitamin C available, and they wanted to be conservative with the supplies, explained Hujoel, who is also an adjunct professor of epidemiology. The goal of the Sorby investigators was not to determine the required vitamin C intake for optimal health; it was to find out the minimum vitamin C requirements for preventing scurvy.  

Vitamin C is an important element in your body’s ability to heal wounds because the creation of scar tissue depends on the collagen protein, and the production of collagen depends on vitamin C. In addition to knitting skin back together, collagen also maintains the integrity of blood vessel walls, thus protecting against stroke and heart disease.

In the Sorby trial, researchers assigned participants to zero, 10 or 70 milligrams a day for an average of nine months. The depleted subjects were then repleted and saturated with vitamin C. Experimental wounds were made during this depletion and repletion. The investigators used the scar strength of experimental wounds as a measure of adequate vitamin C levels since poor wound healing, in addition to such conditions as bleeding gums, are an indication of scurvy.  

In the end, the Sorby researchers said 10 milligrams a day was enough to ward off signs of scurvy. Partly based on these findings, the WHO recommends 45 milligrams a day. Hujoel said that the findings of the re-analyses of the Sorby data suggest that the WHO’s recommendation is too low to prevent weak scar strength.  

In a bit of scientific detective work, Hujoel said he tracked down and reviewed the study’s data, and with the aid of Margaux Hujoel, a scientist with Brigham and Women’s Hospital/Harvard Medical School, put the data through modern statistical techniques designed to handle small sample sizes, techniques not available to the original scientists. The results of their work were published Monday in the American Journal of Clinical Nutrition.

The Hujoels discovered that the data from this unique study — which has been a cornerstone used by WHO and other agencies for establishing healthy levels of vitamin C in humans — needed more than an “eyeball method” of data assessment. 

“It is concluded that the failure to reevaluate the data of a landmark trial with novel statistical methods as they became available may have led to a misleading narrative on the vitamin C needs for the prevention and treatment of collagen-related pathologies,” the researchers wrote. 

“Robust parametric analyses of the (Sorby) trial data reveal that an average daily vitamin C intake of 95 mg is required to prevent weak scar strength for 97.5% of the population. Such a vitamin C intake is more than double the daily 45 mg vitamin C intake recommended by the WHO but is consistent with the writing panels for the National Academy of Medicine and (other) countries,” they add. 

The Hujoels’ study also found that recovery from a vitamin C deficiency takes a long time and requires higher levels of vitamin C. Even an average daily dose of 90 milligrams a day of vitamin C for six months failed to restore normal scar strength for the depleted study participants. 

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For more information, contact Philippe Hujoel at hujoel@uw.edu

Related UW study: Bleeding gums may be a sign you need more vitamin C in your diet

 

Humble pond plant duckweed may help researchers to develop better crops


Rutgers-led study puts the spotlight back on the rapidly growing aquatic species

Peer-Reviewed Publication

RUTGERS UNIVERSITY

Rutgers duckweed study 

IMAGE: DUCKWEED, A TINY FRESHWATER FLOATING PLANT, IS AN EXCELLENT LABORATORY MODEL FOR SCIENTISTS TO DISCOVER NEW STRATEGIES FOR GROWING HARDIER AND MORE SUSTAINABLE CROPS IN AN AGE OF CLIMATE CHANGE AND GLOBAL POPULATION BOOM, A RUTGERS-LED STUDY FINDS. view more 

CREDIT: RUTGERS UNIVERSITY

New Brunswick, N.J. (Aug. 16, 2021) – Duckweed, a tiny freshwater floating plant, is an excellent laboratory model for scientists to discover new strategies for growing hardier and more sustainable crops in an age of climate change and global population boom, a Rutgers-led study finds.

“There is a need for new models to tackle complex molecular and ecological processes in plant biology using multidisciplinary approaches,” said the study’s senior author Eric Lam, a Distinguished Professor in the Department of Plant Biology at Rutgers University-New Brunswick. “Duckweeds are well suited to play an important role in these endeavors.”

The study appears in the journal The Plant Cell.

Duckweed (family Lemnaceae), the smallest flowering and fastest growing plant on Earth, has many benefits, including providing wildlife habitat and being a sustainable source of food, livestock feed and biofuel. But also can spread rapidly and deprive ponds of oxygen, thereby killing fish and beneficial algae when not managed properly.

Named for its global distribution (like ducks) and its rapid growth (like weeds), duckweed was commonly used in lab research from 1950 to 1990 before being largely replaced in the genomics era by thale cress or mouse-ear cress (Arabidopsis thaliana), a model plant in the mustard family that offers facile genetics and a small genome.

But advances in genomic technologies over the past decade and the growing need to find alternative and more sustainable crops have renewed interest in duckweed as a model to enable discoveries in diverse fields from plant biology and ecology to chronobiology.

Researchers from Rutgers, the Salk Institute and an international team of specialists reviewed the anatomy, growth, physiology and molecular characteristics of duckweed, which has unique characteristics compared to other model plants that make them excellent candidates as model plants to tackle complex biological questions. One example is that genome sequences from multiple species of duckweed showed that these aquatic plants have a smaller number of genes compared to other model plant species, which may make duckweed a simpler plant model to characterize each gene's function.

In addition, recent studies published by collaborating teams at Rutgers and the Salk Institute revealed that the smallest member of the duckweed family, Wolffia, may economize its energy for growth by minimizing the level of gene control over the daily day-night cycle.

“We thus suggest that the duckweed plant family is an excellent platform to discover novel strategies for improved plant growth as well as environmental responses to optimize plant resilience and productivity,” Lam said.

Although duckweed has adapted to an aquatic habitat, it has all the same types of genes and pathways as in well studied crop plants.

“As such, the novel strategies that we can learn from studying these small plants could potentially be used to re-engineer traditional crop plants to endow them with new traits,” Lam said. “Furthermore, as the commercialization of duckweed-based bioproducts gathers steam, we and our co-authors are optimistic that the basic research we are carrying out in the laboratory will help translate duckweed's prodigious productivity into new sustainable crops that can augment traditional agricultural products.”

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Study of structural variants in cacao genomes yields clues about plant diversity


Peer-Reviewed Publication

PENN STATE

cacao tree map 

IMAGE: IN THIS STUDY, THE RESEARCHERS ANALYZED AND COMPARED CHROMOSOME-SCALE GENOME ASSEMBLIES OF 31 NATURALLY OCCURRING POPULATIONS OF THEOBROMA CACAO, THE LONG-LIVED TREE SPECIES THAT IS THE SOURCE OF CHOCOLATE. THIS MAP SHOWS THEIR ORIGINS IN THE AMAZON BASIN IN SOUTH AMERICA. view more 

CREDIT: PENN STATE

Molecular geneticists have known for about a decade that genomic structural variants can play important roles in the adaptation and speciation of both plants and animals, but their overall influence on the fitness of plant populations is poorly understood. That’s partly because accurate population-level identification of structural variants requires analysis of multiple high-quality genome assemblies, which are not widely available.

In this study, the researchers investigated the fitness consequences of genomic structural variants in natural populations by analyzing and comparing chromosome-scale genome assemblies of 31 naturally occurring populations of Theobroma cacao, the long-lived tree species that is the source of chocolate. Among those 31 strains of cacao, they found more than 160,000 structural variants.

In findings published today (Aug. 16) in the Proceedings of the National Academy of Sciences, the researchers reported that most structural variants are deleterious and thus constrain adaptation of the cacao plant. These detrimental effects likely arise as a direct result of impaired gene function and as an indirect result of suppressed gene recombination over long periods of time, they noted.

However, despite the overall detrimental effects, the study also identified individual structural variants bearing signatures of local adaptation, several of which are associated with genes differentially expressed between populations. Genes involved in pathogen resistance are among these candidates, highlighting the contribution of structural variants to this important local adaptation trait.

An exhaustive and painstaking comparison of the genomes of multiple strains of the cacao tree by a team of researchers has provided insights into the role genomic structural variants play in the regulation of gene expression and chromosome evolution, giving rise to the differences within populations of the plant.

The research, which has implications for plant genetics in general, would not have been possible before powerful computers made the high-resolution sequencing of genomes possible, affordable and relatively fast, according to team member Mark Guiltinan, J. Franklin Styer Professor of Horticultural Botany and professor of plant molecular biology in Penn State’s College of Agricultural Sciences.

“The genomes of different populations of cacao trees are 99.9% identical, but it’s the structural variants in that one-tenth of 1% of their genomes that accounts for the plant’s diversity in different regions and its adaptation to climate and various diseases,” he said. “This study makes an association between structural variation and the ability of a plant to adapt to a local environment.”

Overall, their findings provide important insight into processes underlying the fitness effects of structural variants in natural populations, the researchers pointed out. They suggest that structural variants influence gene expression, which likely impairs gene function and contributes to their detrimental effects. They also provided empirical support for a theoretical prediction that structural variants result in the suppression of gene recombination, making it less likely the plants can adapt to stressors.


CAPTION

Genomic structural variants are associated with genes differentially expressed between populations, such as genes involved in resistance to pathogens like the one that causes black pod rot, shown here.

CREDIT

Andrew Fister/Penn State

Beyond revealing new empirical evidence for the evolutionary importance of structural variants in all plants, documenting the genomic differences and structural variants among the 31 strains of cacao provides a valuable resource for ongoing genetic and breeding studies for that valuable plant, Guiltinan noted.

“All cacao comes from the Amazon basin — plants were collected a long time ago from the wild by collectors and they were cloned, so we have a permanent collection,” he said. “Their genomes have been sequenced, and that represents a huge amount of work and data. As a result of this study, we know that structural variation is important to the survival of the plant, to the evolution of the plant and especially to the adaptation of the plant to local conditions.”

Also involved in the research at Penn State were Claude dePamphilis, director of the Center for Parasitic and Carnivorous Plants, Dorothy Foehr Huck and J. Lloyd Huck Distinguished Chair in Plant Biology and Evolutionary Genomics, and professor of biology; Eric Wafula, bioinformatics programmer, Eberly College of Science; and Paula Ralph, senior research technologist, Eberly College of Science. Other team members were Tuomas Hamala and Peter Tiffin, Department of Plant and Microbial Biology, University of Minnesota.

The National Science Foundation and the U.S. Department of Agriculture’s National Institute of Food and Agriculture supported this work.

 

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