Tuesday, July 13, 2021

 

More complex than we thought: The body's reaction to contact allergens

UNIVERSITY OF COPENHAGEN - THE FACULTY OF HEALTH AND MEDICAL SCIENCES

Research News

Hair dye, perfume, jewellery. Beautifying to most, but for some they are equivalent to rashes, irritation and reduced quality of life. Together with hay fever and food allergies, allergic contact dermatitis due to exposure to e.g. nickel and perfume ingredients represents the majority of allergic reactions seen among Danes.

Traditionally, researchers have distinguished between immediate and delayed allergic reactions, depending on which parts of the immune system that is responsible for the reaction. E.g., hay fever and food allergies are 'immediate' forms that cause immediate symptoms, whereas it can take days before the skin reacts to things like nickel and perfume. But now a new study conducted by the LEO Foundation Skin Immunology Research Center at the University of Copenhagen changes this understanding.

'Some patients develop allergic contact dermatitis at a much earlier stage than described by text books. The aim of the study was therefore to try to determine why some react to contact allergens much faster than prescribed. It turns out that when a part of the skin is exposed to the allergen for the first time, the cells within that specific skin area will develop local memory towards the contact allergen. And then when the same area is re-exposed to the allergen at a later point in time, the patient will develop a clear reaction within only 12 hours', explains PhD Student and first author of the study Anders Boutrup Funch.

It is the T cells in the body that are responsible for delayed allergic reactions - also known as type 4 allergic reactions. But in the new study conducted on mice the researchers have shown that the T cells are capable of building a sophisticated memory that enables them to respond much faster than previously assumed. This gives us a more complex picture of contact allergy.

'We point to a need for clarification of this disease. Type 4 reactions should be subcategorised, giving us both the classic delayed reaction - that is, where the patient reacts 24-72 hours after exposure - and an immediate reaction, where the patient develops symptoms much faster. Based on these results, we may have to change the text books on contact allergy. At any case, we will need to add a chapter', says the main author of the study, Professor Charlotte Menné Bonefeld.

The study also reveals that activation of the memory T cells following exposure to an allergen leads to massive recruitment of the most abundant type of white blood cells in the body - the so-called neutrophils - to the affected part of the skin. Normally, neutrophil recruitment is used to fight infections, as these cells are capable of effectively eliminating microorganisms. At the same time, they cause intense infection and local tissue damage, which is what the patients experience as a rash. Neutrophil recruitment is not seen in connection with delayed reactions to contact allergens. 

The next step in the research is to test the study results on humans. Once a person has developed contact allergy, they are likely to suffer from it for the rest of their lives. Therefore, the researchers behind the study hope the new knowledge may improve contact allergy patients' chances of getting treatment in the future.

'First and foremost, we need to tell the world that we have new knowledge which should change our understanding of the disease', Anders Boutrup Funch concludes.

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Resilience, not collapse: What the Easter Island myth gets wrong

BINGHAMTON UNIVERSITY

Research News

BINGHAMTON, N.Y. -- New research from Binghamton University, State University of New York suggests that the demographic collapse at the core of the Easter Island myth didn't really happen.

You probably know this story, or a version of it: On Easter Island, the people cut down every tree, perhaps to make fields for agriculture or to erect giant statues to honor their clans. This foolish decision led to a catastrophic collapse, with only a few thousand remaining to witness the first European boats landing on their remote shores in 1722.

But did the demographic collapse at the core of the Easter Island myth really happen? The answer, according to new research by Binghamton University anthropologists Robert DiNapoli and Carl Lipo, is no.

Their research, "Approximate Bayesian Computation of radiocarbon and paleoenvironmental record shows population resilience on Rapa Nui (Easter Island)," was recently published in the journal Nature Communications. Co-authors include Enrico Crema of the University of Cambridge, Timothy Rieth of the International Archaeological Research Institute and Terry Hunt of the University of Arizona.

Easter Island, or Rapa Nui in the native language, has long been a focus of scholarship into questions related to environmental collapse. But to resolve those questions, researchers first need to reconstruct the island's population levels to ascertain whether such a collapse occurred and, if so, the scale.

"For Rapa Nui, a big part of scholarly and popular discussion about the island has centered around this idea that there was a demographic collapse, and that it's correlated in time with climate changes and environmental changes," explained DiNapoli, a postdoctoral research associate in environmental studies and anthropology.

Sometime after it was settled between the 12th to 13th centuries AD, the once-forested island was denuded of trees; most often, scholars point to human-prompted clearing for agriculture and the introduction of invasive species such as rats. These environmental changes, the argument goes, reduced the island's carrying capacity and led to a demographic decline.

Additionally, around the year 1500, there was a climactic shift in the Southern Oscillation index; that shift led to a dryer climate on Rapa Nui.

"One argument is that changes in the environment had a negative impact. People see that there was a drought and said, 'Well, the drought caused these changes,'" said Lipo, a professor of anthropology and environmental studies and associate dean of Harpur College. "There are changes. Their population changes and their environment changes; over time, the palm trees were lost and at the end, the climate got drier. But do those changes really explain what we're seeing in the population data through the radiocarbon dating?"

Reconstructing population changes

Archaeologists have different ways to reconstruct population sizes using proxy measures, such as looking at the different ages of individuals at burial sites or counting ancient house sites. That latter measure can be problematic because it makes assumptions as to the number of people who live in each house, and whether the houses were occupied at the same time, DiNapoli said.

The most common technique, however, uses radiocarbon dating to track the extent of human activity during a moment in time, and extrapolating population changes from that data. But radiocarbon dates can be uncertain, DiNapoli acknowledged.

For the first time, DiNapoli and Lipo have presented a method that is able to both resolve these uncertainties and show how changes in population sizes relate to environmental variables over time.

Standard statistical methods don't work when it comes to linking the radiocarbon data to environmental and climate changes, and the population shifts connected with them. To do so would involve estimating a "likelihood function," which is currently difficult to compute. Approximate Bayesian Computation, however, is a form of statistical modeling that doesn't require a likelihood function, and thus gives researchers a workaround, DiNapoli explained.

Using this technique, the researchers determined that the island experienced steady population growth from its initial settlement until European contact in 1722. After that date, two models show a possible population plateau, while another two models show possible decline.

In short, there is no evidence that the islanders used the now-vanished palm trees for food, a key point of many collapse myths. Current research shows that deforestation was prolonged and didn't result in catastrophic erosion; the trees were ultimately replaced by gardens mulched with stone that increased agricultural productivity. During times of drought, the people may have relied on freshwater coastal seeps.

Construction of the moai statues, considered by some to be a contributing factor of collapse, actually continued even after European arrival.

In short, the island never had more than a few thousand people prior to European contact, and their numbers were increasing rather than dwindling, their research shows.

"Those resilience strategies were very successful, despite the fact that the climate got drier," Lipo said. "They are a really good case for resiliency and sustainability."

Burying the myth

Why, then, does the popular narrative of Easter Island's collapse persist? It likely has less to do with the ancient Rapa Nui people than ourselves, Lipo explained.

The concept that changes in the environment affect human populations began to take off in the 1960s, Lipo said. Over time, that focus became more intense, as researchers began to consider changes in the environment as a primary driver of cultural shifts and transformations.

But this correlation may derive more from modern concerns with industrialization-driven pollution and climate change, rather than archaeological evidence. Environmental changes, Lipo points out, occur on different time scales and in different magnitudes. How human communities respond to these changes varies.

Take a classic example of the overexploitation of resources: the collapse of the cod fisheries in the American Northeast. While the economies of individual communities may have collapsed, larger harvesting efforts simply switched to the other side of the world.

On an isolated island, however, sustainability is a matter of the community's very survival and resources tend to be managed conservatively. A misstep in resource management could lead to tangible, catastrophic consequences, such as starvation.

"The consequences of your actions are immediately obvious to you, and everyone else around you," Lipo said.

Lipo acknowledged that proponents of the Easter Island collapse story tend to see him as a climate-change denier; that's emphatically not the case. But he cautioned that the ways ancient peoples dealt with climate and environmental changes aren't necessarily reflective of current global crises and their impact in the modern world. In fact, they may have a good deal to teach us about resilience and sustainability.

"There's a natural tendency to think that people in the past aren't as smart as we are and that they somehow made all these mistakes, but it's really the opposite," Lipo said. "They produced offspring, and the success that created the present. Even though their technologies might be more simple than ours, there is so much to be learned about the context in which they were able to survive."

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USC study shows dire impacts downstream of Nile River dam

The research forecasts water supply and economic risks as tensions mount over Grand Ethiopian Renaissance Dam

UNIVERSITY OF SOUTHERN CALIFORNIA

Research News

IMAGE

IMAGE: PHOTO CAPTION: NASA'S TERRA SPACECRAFT SHOWS FILLING OF THE GRAND ETHIOPIAN RENAISSANCE DAM ALONG THE BLUE NILE RIVER IS WELL UNDER WAY NEAR THE ETHIOPIA-SUDAN BORDER. view more 

CREDIT: (PHOTO/NASA-JPL)

Rapid filling of a giant dam at the headwaters of the Nile River -- the world's biggest waterway that supports millions of people -- could reduce water supplies to downstream Egypt by more than one-third, new USC research shows.

A water deficit of that magnitude, if unmitigated, could potentially destabilize a politically volatile part of the world by reducing arable land in Egypt by up to 72%. The study projects that economic losses to agriculture would reach $51 billion. The gross domestic product loss would push unemployment to 24%, displacing lots of people and disrupting economies.

"Our study forecasts dire water supply impacts downstream, causing what would be the largest water stress dispute in modern human history," said Essam Heggy, a research scientist at the USC Viterbi School of Engineering and lead author of the study. "Averaging losses from all of the announced filling scenarios, these water shortages could nearly double Egypt's present water supply deficit and will have dire consequences for Egypt's economy, employment, migration and food supply."

The study was published July 1 in Environmental Research Letters.

Despite the risks, the study offers policy solutions for sustainability that could potentially minimize the downstream impacts and reduce tensions in the Nile River region. For example, the impacts could be partially offset by adjusting operations at the Aswan Dam downstream in southern Egypt, pumping more groundwater, cultivating different kinds of crops and improving irrigation systems.

So far, despite international negotiations, there's been little progress in the decade-long dispute.

The crux of the controversy is Ethiopia's $5 billion Grand Ethiopian Renaissance Dam nearing completion at the Nile headwaters. Now in the second phase of filling, it will be the largest hydropower project in Africa and would create a reservoir containing 74 billion cubic meters of water -- more than twice the operational capacity of Lake Mead on the Colorado River.

It's so vast that it will take years to fill, and depending on how long it takes, the water diversions could have devastating impacts downstream. Egypt and Sudan have water rights to the Nile, while Ethiopia was not allocated a quantifiable share. But as water and energy demand grows in the Nile River basin, Ethiopia is asserting its needs for hydropower and irrigated agriculture to promote development.

Some 280 million people in 11 countries in the basin depend on the waterway -- a primary source of irrigation for more than 5,000 years. Egypt relies on the Nile for more than 90% of its water. The region's population could increase by 25% in 30 years, increasing demand at a time when Egypt would expect less water from the Nile. Water rights along the Nile have been in dispute since 1959; today, the conflict threatens to escalate into a war.

The USC study examined various dam filling scenarios and water shortage impacts for Egypt. Based on the short-term filling strategies of 3 to 5 years, presently favored by Ethiopia, the water deficit downstream in Egypt could almost double; 83% of the additional water loss would be due to dam restraining flow and evaporation and 17% lost due to seepage into rocks and sand.

The study helps fill a gap in the dispute by reducing ambiguities about how dam filling scenarios would impact the water budget deficit in Egypt, as well as offering a feasibility index to the different potential solutions. As global warming and aridification accelerates, it underscores the need for more water research in arid lands, which is the core mission of the Arid Climates and Water Research Center at the USC Viterbi School of Engineering.

"There is a real need for sound science to resolve the ambiguity surrounding this controversy," Heggy said. "Our analysis doesn't point fingers, yet it shows a dire water situation that will result downstream, which is forecasted as the largest water stress dispute in human history. It can be avoided if proper support is made to the water, energy and environment research in the Nile basin."

The study comes amidst a 10-year dispute between Egypt and Ethiopia over water supply on the Nile River. The parties seek an international solution, yet talks led by the U.S. State Department -- and joined by the European Union and the United Nations -- have resulted in little agreement after four years.

Meanwhile, tensions run high as negotiators try to avert armed conflict. Egypt has vowed not to allow the dam to impede its water supply, and it held joint military maneuvers with Sudan in May. Sudan has since petitioned the United Nations Security Council to hold an emergency session as soon as possible.

The dispute is emblematic of wider disputes over water scarcity as climate change affects developing countries experiencing rapid growth. Disputes along the Mekong, Zambezi and Euphrates-Tigris rivers, among others, show the potential for political instability and conflict.

Heggy said it's possible a win-win solution may yet be found for the Nile River, based on policy options the study identifies. Progress has been impeded, though, due to a lack of credible information about downstream water supply and economic impacts. Getting an agreement will likely require better data and forecasts on impacts to human society as well as ecological effects along the Nile River.

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In addition to Heggy, co-authors of the study are Abotalib Z. Abotalib at USC and Zane Sharkawy at Cornell University.

The research was funded by the James H. Zumberge Research and Innovation Fund allocation to the Arid Climates and Water Research Center at the Viterbi School of Engineering.

 

Emotions and culture are most important for acceptance of carnivore management strategies

LEIBNIZ INSTITUTE FOR ZOO AND WILDLIFE RESEARCH (IZW)

Research News

IMAGE

IMAGE: SPOTTED HYENA WITH MAASAI PASTORALIST AND CATTLE IN NGORONGORO CRATER view more 

CREDIT: PHOTO: OLIVER HĂ–NER/LEIBNIZ-IZW

Emotions towards and cultural importance of large carnivores are better predictors of the acceptance of management strategies by local communities than the extent of livestock depredation. This is the result of a new interdisciplinary investigation led by scientists from the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW). They conducted 100 questionnaires with Maasai pastoralists in Ngorongoro Conservation Area, Tanzania, focusing on three large carnivore species (spotted hyenas, lions and leopards) and three management strategies (no action, relocation and lethal control). An emphasis on socio-cultural variables is key to understanding human-carnivore relationships and challenges the traditional focus on livestock depredation in human-carnivore conflict research, the scientists conclude. The findings are published in the open access scientific journal "Frontiers in Conservation Science".

Support from local communities is required to implement successful wildlife management strategies. A key challenge is that the relationship between local communities with large carnivores are complex: on the one hand, the animals are often considered charismatic, culturally important and emotionally evocative. Positive emotions such as joy have been suggested to predict the success of conservation-oriented management strategies. This is also true for the cultural importance of large carnivores. On the other hand, negative emotions such as fear and disgust as well as negative experiences such as livestock depredation - the traditional focus of human-carnivore conflict research - have been suggested to predict the acceptance of invasive measures such as relocation and lethal control. Past research looked at these factors separately, but did not compare them at the same time to see which is the best predictor - and which should therefore be prioritised by wildlife managers.

"We assessed for the first time several factors simultaneously for several carnivores to determine which factor best predicted the acceptance of commonly applied management strategies", explains first author Arjun Dheer (Leibniz-IZW). The investigation was conducted in the Ngorongoro Conservation Area (NCA) in Tanzania. "The NCA is a protected area which includes both wildlife conservation and human livelihoods in its management plan", adds Dheer. The investigation focused on three species: spotted hyena (Crocuta crocuta), lion (Panthera leo) and leopard (Panthera pardus). "The species we chose are the main predators of livestock in the region and past research in other areas showed that people view them in different ways", explains Dr Oliver Höner (Leibniz-IZW), co-senior author of the paper. The investigation focused on the acceptance of no action (continued protection of the carnivores), relocation and lethal control. Respondents rated the emotions of joy, disgust and fear and the cultural importance of each carnivore species. They were also asked to report on how many cattle, goats, sheep and donkeys they lost to the carnivores over the past three years.

The main result is that emotions and cultural importance were stronger predictors for the acceptance of specific management strategies than the extent of livestock depredation. "Amongst the emotions, joy was the strongest predictor; it was linked to a preference for no action and a negative assessment of relocation and lethal control. Cultural importance showed a trend similar to joy", explains Dheer. Overall, respondents favoured no action towards the carnivores and rejected relocation and lethal control. "It goes to show how scientists might be barking up the wrong tree by focusing on livestock depredation and negative emotions", explains co-senior author Dr Tanja Straka (Leibniz-IZW & TU Berlin).

"Our findings underpin the role of emotions and cognitions in human-wildlife relationships", concludes Dheer. The traditional emphasis on livestock depredation as the primary issue of concern when harnessing human tolerance of large carnivores is called into question, the authors summarise: it is apparent that emotions and cultural importance need to be considered, even across species that have different reputations. Multi-pronged approaches that combine emotions and cultural factors with the close involvement of local communities can help pave the way for continued human-carnivore coexistence.

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__ Publication

Dheer A, Davidian E, Jacobs MH, Ndorosa J, Straka TM†, Höner OP† (2021): Emotions and cultural importance predict the acceptance of large carnivore management strategies by Maasai pastoralists. Frontiers in Conservation Science. DOI: 10.3389/fcosc.2021.691975.
†co-senior authors

__ Contact

Leibniz Institute for Zoo and Wildlife Research (IZW) in the Forschungsverbund Berlin e.V.
Alfred-Kowalke-Str. 17, 10315 Berlin, Germany
http://www.izw-berlin.de, hyena-project.com


 

When a single tree makes a difference

Individual trees in urban areas provide cooling during evening, research shows

AMERICAN UNIVERSITY

Research News

A single tree along a city street or in a backyard can provide measurable cooling benefits, according to a new study from American University. The research shows that "distributed" trees, those that are stand-alone and scattered throughout urban neighborhoods, can help to reduce evening heat. The research suggests that planting individual trees can be a strategy to mitigate urban heat, particularly in areas where land for parks can be scarce.

"There are plenty of good reasons to plant trees, but our study shows we shouldn't underestimate the role that individual trees can play in mitigating heat in urban areas," said Michael Alonzo, assistant professor of environmental science and lead author of the new study. "City planners can take advantage of the small spaces that abound in urban areas to plant individual trees." The study is published in Environmental Research Letters.

While urban parks provide important mid-day cooling for residents and visitors, the key to cooling from individual trees happens in the evening. In the new study, which was conducted in Washington, D.C., cooling benefits from distributed trees were found to occur around 6 or 7 p.m. and after sunset. The study revealed lower temperatures in neighborhoods where at least half the area was covered by canopy from distributed trees. Temperatures were 1.4 degrees Celsius cooler in the evening compared with areas with few trees. Even in the predawn hour, areas with only modest distributed canopy cover (about 20 percent of the area) were cooler than those with no trees, showing that on average, afternoon and evening cooling effects last well into the night, Alonzo added.

To arrive at the findings, Alonzo and his colleagues examined air temperature readings. The data was collected over one hot summer day in 2018, across different areas in Washington, D.C. and at multiple times throughout the day, resulting in more than 70,000 air temperature readings. In their analysis, Alonzo and his colleagues examined tree canopy over paved surfaces, over unpaved surfaces, and both patches such as parks, and distributed trees, such as those one might plant in their back or front yards.

The new study confirms that planting individual trees should be considered as part of a strategy to combat rising temperatures in urban areas. In hot summer months many cities across the United States turn into "heat islands." Due to the urban heat island effect, urban areas, with fewer green spaces and higher amounts of impervious surface, get hotter compared to their rural surroundings.

In urban areas, people are more likely to live adjacent to distributed trees rather than parks. In D.C., there are many places to plant individual trees where canopy will shade paved or unpaved surfaces: on streets with single family homes, streets with rowhouses, backyard or small park plantings, Alonzo said. This opens up avenues for increasing the racial and socioeconomic equity of tree planting, but more effort is required to first reduce impervious surface cover in the most built-up residential and commercial districts, Alonzo added. The top five trees along D.C.'s streets include several species of maples, oaks and elms, all of which provide plentiful shade.

Climate studies show that urban temperatures are warming at all times of day including evenings. Yet studying the cooling benefits from individual trees, as well as their benefits during evening hours, has not been widely researched, Alonzo said, and this is an area scientists should continue to explore. More research will be needed in other locations in the United States and under different weather conditions. Alonzo also plans to conduct more research and has collected air temperature readings by bicycle around D.C. during the pandemic.

Though the study was conducted in D.C., Alonzo said the findings are likely applicable along the East Coast or in other cities with a similar climate.

"Evenings are not quite the respite from heat that we once had," Alonzo said. "These distributed trees do help the city cool off in the evening and that's important for human health."

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 GMO IS OMG BACKWARDS

Genome editing for food: how do people react?

Research team from the Universities of Göttingen and British Columbia investigates evaluations of breeding technology

UNIVERSITY OF GĂ–TTINGEN

Research News

A research team from the University of Göttingen and the University of British Columbia (Canada) has investigated how people in five different countries react to various usages of genome editing in agriculture. The researchers looked at which uses are accepted and how the risks and benefits of the new breeding technologies are rated by people. The results show only minor differences between the countries studied - Germany, Italy, Canada, Austria and the USA. In all countries, making changes to the genome is more likely to be deemed acceptable when used in crops rather than in livestock. The study was published in Agriculture and Human Values.

Relatively new breeding technologies, such as CRISPR gene editing, have enabled a range of new opportunities for plant and animal breeding. In the EU, the technology falls under genetic engineering legislation and is therefore subject to rigorous restrictions. However, the use of gene technologies remains controversial. Between June and November 2019, the research team collected views on this topic via online surveys from around 3,700 people from five countries. Five different applications of gene editing were evaluated: three relate to disease resistance in people, plants, or animals; and two relate to achieving either better quality of produce or a larger quantity of product from cattle.

"We were able to observe that the purpose of the gene modification plays a major role in how it is rated," says first author Dr Gesa Busch from the University of Göttingen. "If the technology is used to make animals resistant to disease, approval is greater than if the technology is used to increase the output from animals." Overall, however, the respondents reacted very differently to the uses of the new breeding methods. Four different groups can be identified: strong supporters, supporters, neutrals, and opponents of the technology. The opponents (24 per cent) identify high risks and calls for a ban of the technology, regardless of possible benefits. The strong supporters (21 per cent) see few risks and many advantages. The supporters (26 per cent) see many advantages but also risks. Whereas those who were neutral (29 per cent) show no strong opinion on the subject.

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This study was made possible through funding from the Free University of Bozen-Bolzano and Genome BC.

Original publication: Busch et al. (2021): Citizen views on genome editing: effects of species and purpose. In: Agriculture and Human Values (2021). https://link.springer.com/article/10.1007/s10460-021-10235-9

http://www.uni-goettingen.de/de/dr.+gesa+busch/613570.html

 STILL WAITING FOR THE 100% SAFE MALE CONTRACEPTIVE

BU researchers develop novel, woman controlled contraceptive product

Currently being tested in a Phase I Clinical Trial

BOSTON UNIVERSITY SCHOOL OF MEDICINE

Research News

(Boston)--Despite the availability of numerous effective birth control methods, more than 40 percent of pregnancies worldwide are unintended. In addition to contributing significantly to population growth, unintended pregnancies can have pronounced adverse effects on maternal physical, mental and economic wellbeing.

Researchers from Boston University School of Medicine (BUSM) and ZabBio (San Diego, CA) have developed an anti-sperm monoclonal antibody, the Human Contraception Antibody (HCA), which they found to be safe and possess potent sperm agglutination (clumping) and immobilization activity in laboratory tests.

"HCA appears to be suitable for contraceptive use and could be administered vaginally in a dissolvable film for a woman-controlled, on-demand method birth control method," explains senior author Deborah Anderson, PhD, Professor of Medicine at BUSM.

To evaluate its suitability as a topical contraceptive, the researchers tested HCA over a wide range of concentrations and under different physiologically relevant conditions in vitro. Specifically, HCA was mixed with sperm from normal, healthy volunteers and then tested. Within 15 seconds, sperm became immobilized and firmly stuck together. The researchers also found that HCA did not to cause vaginal inflammation in lab tissue culture tests.

Due to its effectiveness and safety profile, HCA may address current gaps in the contraception field. "HCA could be used by women who do not use currently available contraception methods and may have a significant impact on global health," said Anderson. To that end, HCA is currently being tested in a Phase I Clinical Trial.

The researchers also believe HCA could also be combined with other antibodies such as anti-HIV and anti-HSV antibodies for a multipurpose prevention technology, a product that would both serve as a contraceptive and prevent sexually transmitted infections.

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These findings appear online in the journal EBioMedicine: https://protect-us.mimecast.com/s/yb1zCQWmvEC812KEhMruGs?domain=authors.elsevier.com

Funding for this study was provided by grants R01 HD095630 and P50 HD096957 from the National Institutes of Health.

Editors note:

LZ, MB, MP and KJW are employed by ZabBio, Inc., a company developing contraceptive antibodies. The other authors (GBV, JGM, JAP, EM, JP, JD, EN, DJA) have no conflict of interest.

 

Neutron-clustering effect in nuclear reactors demonstrated for first time

Long-theorized phenomenon observed in a working reactor could improve reactor safety, according to a new study

DOE/LOS ALAMOS NATIONAL LABORATORY

Research News

IMAGE

IMAGE: REACTOR OPERATOR NICHOLAS THOMPSON OF LOS ALAMOS NATIONAL LABORATORY HELPS TO SET UP THE NEUTRON CLUSTERING MEASUREMENTS AT THE WALTHOUSEN REACTOR CRITICAL FACILITY AT RENSSELAER POLYTECHNIC INSTITUTE IN SCHENECTADY, NY. view more 

CREDIT: LOS ALAMOS NATIONAL LABORATORY

Los Alamos, N.M., July 12, 2021--For the first time, the long-theorized neutron-clustering effect in nuclear reactors has been demonstrated, which could improve reactor safety and create more accurate simulations, according to a new study recently published in the journal Nature Communications Physics.

"The neutron-clustering phenomenon had been theorized for years, but it had never been analyzed in a working reactor," said Nicholas Thompson, an engineer with the Los Alamos Advanced Nuclear Technology Group. "The findings indicate that, as neutrons fission and create more neutrons, some go on to form large lineages of clusters while others quickly die off, resulting in so-called 'power tilts,' or asymmetrical energy production."

Understanding these clustering fluctuations is especially important for safety and simulation accuracy, particularly as nuclear reactors first begin to power up. The study was a collaboration with the Institute for Radiological Protection and Nuclear Safety (IRSN) and the Atomic Energy Commission (CEA), both located in France.

"We were able to model the life of each neutron in the nuclear reactor, basically building a family tree for each," said Thompson. "What we saw is that even if the reactor is perfectly critical, so the number of fissions from one generation to the next is even, there can be bursts of clusters that form and others that quickly die off."

This clustering phenomenon became important to understand because of a statistical concept known as the gambler's ruin, believed to have been derived by Blaise Pascal. In a betting analogy, the concept says that even if the chances of a gambler winning or losing each individual bet are 50 percent, over the course of enough bets the statistical certainty that the gambler will go bankrupt is 100 percent.

In nuclear reactors, from generation to generation, each neutron can be said to have a similar 50 percent chance of dying or fissioning to create more neutrons. According to the gambler's ruin concept, the neutrons in a reactor might then have a statistical chance of dying off completely at some future generation, even though the system is at critical.

This concept had been studied widely in other scientific fields, such as biology and epidemiology, where this generational clustering phenomenon is also present. By drawing on this related statistical math, the research team was able to analyze whether the gambler's ruin concept would hold true for neutrons in nuclear reactors.

"You would expect this theory to hold true," says Jesson Hutchinson, who works with the Laboratory's Advanced Nuclear Technology Group. "You should have a critical system that, while the neutron population is varying between generations, runs some chance of becoming subcritical and losing all neutrons. But that's not what happens."

To understand why the gambler's ruin concept didn't hold true, researchers used a low-power nuclear reactor located at the Walthousen Reactor Critical Facility in New York. A low-power reactor was essential for tracking the lifespans of individual neutrons because large-scale reactors can have trillions of interactions at any moment. The team used three different neutron detectors, including the Los Alamos-developed Neutron Multiplicity 3He Array Detector (NoMAD), to trace every interaction inside the reactor.

The team found that while generations of neutrons would cluster in large family trees and others died out, a complete die-off was avoided in the small reactor because of spontaneous fission, or the non-induced nuclear splitting of radioactive material inside reactors, which creates more neutrons. That balance of fission and spontaneous fission prevented the neutron population from dying out completely, and it also tended to smooth out the energy bursts created by clustering neutrons.

"Commercial-sized nuclear reactors don't depend on the neutron population alone to reach criticality, because they have other interventions like temperature and control rod settings," Hutchinson said. "But this test was interested in answering fundamental questions about neutron behavior in reactors, and the results will have an impact on the math we use to simulate reactors and could even affect future design and safety procedures."

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Funding: This work was supported by the DOE Nuclear Criticality Safety Program, funded and managed by the National Nuclear Security Administration for the Department of Energy.

Paper: Dumonteil, E., Bahran, R., Cutler, T. et al. Patchy nuclear chain reactions. Nature Communications Physics. 01 July 2021

DOI: https://doi.org/10.1038/s42005-021-00654-9

About Los Alamos National Laboratory

Los Alamos National Laboratory, a multidisciplinary research institution engaged in strategic science on behalf of national security, is managed by Triad, a public service oriented, national security science organization equally owned by its three founding members: Battelle Memorial Institute (Battelle), the Texas A&M University System (TAMUS), and the Regents of the University of California (UC) for the Department of Energy's National Nuclear Security Administration.

Los Alamos enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health, and global security concerns.

 

Direct flights save lives! New airline routes can increase kidney sharing by more than 7%

INSTITUTE FOR OPERATIONS RESEARCH AND THE MANAGEMENT SCIENCES

Research News

INFORMS Journal Management Science Study Key Takeaways:

  • Lack of direct airline routes limit the flexibility of organ transplantation policies.
  • A new airline route can increase the number of kidneys shared between different regions by more than 7% while also decreasing the organ discard rate.
  • An increase in the quantity of kidneys does not come with a decrease in kidney quality.

CATONSVILLE, MD, July 12, 2021 - It's a supply and demand problem, it's a transportation problem, it's a donor problem - and that just scratches the surface. According to the Organ Procurement and Transplantation Network, every 9 minutes a new patient is added to the organ waiting list. Every day 17 people die waiting for a kidney transplant. New research in the INFORMS journal Management Science tackles the transportation part of this problem.

"Airline transportation limits the flexibility of organ transplantation, but new, more direct airline routes can increase the number of kidneys shared between regions connected by these routes by more than 7%," said Tinglong Dai of Johns Hopkins University. "Operations research and analytics is trying to save lives and allow kidneys to be more readily available to those who need them when they need them. Too often, viable kidneys are wasted because they can't reach a patient in time."

The study, "Does Transportation Mean Transplantation? Impact of New Airline Routes on Sharing of Cadaveric Kidneys," was conducted by Dai alongside Guihua Wang of the University of Texas at Dallas and Ronghuo Zheng of the University of Texas at Austin.

The research identifies how new airline routes can provide the necessary efficient airline transportation needed for the time-sensitive nature of kidney transplantation and reduce the number of viable kidneys being wasted because they didn't reach the patient in time.

The authors analyze U.S. airline transportation and kidney transplantation datasets. They use the data to track the evolution of airline routes connecting all U.S. airports. Then they look at kidney transplants between donors and recipients connected by these airports.

"Transportation plays a major role in providing patients with available donations, if new airline routes can increase the volume of shared kidneys by 7.3%, think of how many lives could be saved," continued Dai, a professor in the Carey Business School at Johns Hopkins. "We also find the post-transplant survival rate remains largely unchanged. It's a step forward in organ donations thanks to O.R. and analytics."

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About INFORMS and Management Science

Management Science is a premier peer-reviewed scholarly journal focused on research using quantitative approaches to study all aspects of management in companies and organizations. It is published by INFORMS, the leading international association for operations research and analytics professionals. More information is available at http://www.informs.org or @informs.

 

Shape-memory alloys might help airplanes land without a peep

S-shaped, shape-memory alloy filler in wings can reduce aircraft noise

TEXAS A&M UNIVERSITY

Research News

Having a home near a busy airport certainly has its perks. It is close to many establishments and alleviates the problem of wading through endless traffic to catch flights. But it does come at a cost -- tolerating the jarring sounds of commercial airplanes during landing and takeoff.

Researchers at Texas A&M University have conducted a computational study that validates using a shape-memory alloy to reduce the unpleasant plane noise produced during landing. They noted that these materials could be inserted as passive, seamless fillers within airplane wings that automatically deploy themselves into the perfect position during descent.

"When landing, aircraft engines are throttled way back, and so they are very quiet. Any other source of noise, like that from the wings, becomes quite noticeable to the people on the ground," said Dr. Darren Hartl, assistant professor in the Department of Aerospace Engineering. "We want to create structures that will not change anything about the flight characteristics of the plane and yet dramatically reduce the noise problem."

The researchers have described their findings in the Journal of Aircraft.

Aircraft noise has been an ongoing public health issue. Airplanes can generate up to 75-80 decibels during landing, which can be damaging to hearing over the long term. For example, studies have shown that people exposed to sustained aircraft noise can experience disturbed sleep and an increased risk of stroke and heart disease compared to those who do not live near airports.

The source of aircraft noise is different during ascent and descent. During takeoff, the engines are the primary source of noise. On the other hand, when airplanes slow down to land, the engines do not need to generate power and are mostly idling. At this time, the wings begin to reconfigure themselves to slow down the airplane and prepare for touchdown. Similar to the opening of Venetian blinds, the front edge of the wing separates from the main body. This change causes air to rush into the space created, circle around quite violently and produce noise.

"The idea is similar to how a sound is generated in a flute," said Hartl. "When a flute is played, air blown over a hole begins to swirl around the hole, and the size, the length and how I cover the holes, produces a resonant sound of a certain frequency. Similarly, the circulating air in the cove created between the front edge of the wing and the main wing resonates and creates a sharp, unpleasant noise."

Earlier work from Hartl's collaborators at NASA showed that fillers used as a membrane in the shape of an elongated "S" within this cove could circumvent the noise-causing air circulation and thereby lessen the jarring sound. However, a systematic analysis of candidate materials that can assume the desired S-shaped geometry during descent and then recess back into the front edge of the wing after landing was lacking.

To address this gap, the researchers performed comprehensive simulations to investigate if a membrane made of a shape-memory alloy could go back and forth, changing shape for every landing. Their analysis considered the geometry, the elastic properties of the shape-memory alloy and the aerodynamic flow of air around the material during descent. As a comparison, the researchers also modeled the motion of a membrane made of a carbon-fiber-reinforced polymer composite under the same airflow conditions.

Hartl said these types of simulations are computationally expensive since the flow of air around the conformal material has to be modeled while analyzing the air-induced motion of the material.

"Every time the air applies some pressure to the material, the material moves. And every time the material moves, the air moves differently around it," he said. "So, the behavior of the airflow changes the structure, and the motion of the structural changes the airflow."

Consequently, the team had to perform calculations hundreds to thousands of times before the motion of the materials was correctly simulated. When they analyzed the outcomes of their simulations, they found that both the shape-memory alloy and the composite could change their shape to reduce air circulation and thereby reduce noise. However, the researchers also found that the composite had a very narrow window of designs that would enable noise canceling.

As a next step, Hartl and his team plan to validate the results of their simulations with experiments. In these tests, the researchers will place scaled-down models of aircraft wings with the shape-memory alloy fillers into wind tunnels. The goal is to check if the fillers can deploy into the correct shape and reduce noise in near real-world situations.

"We would also like to do better," said Hartl. "We might be able to create smaller structures that can reduce noise and do not require the S-shape, which are actually quite large and potentially heavy."

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Other contributors to this research include Dr. Gaetano Arena, Dr. Rainer Groh and Dr. Alberto Pirrer from the University of Bristol, England; Dr. Travis Turner from the NASA Langley Research Center, Virginia; and William Scholten, now at ATA Engineering, Inc.

This research is funded by the Engineering and Physical Sciences Research Council, the Royal Academy of Engineering and the NASA Langley Research Center.