Monday, August 29, 2022

Costlier Medicare Advantage plans do not always offer better quality

Better metrics needed to help consumers make quality-focused choices

Peer-Reviewed Publication

RAND CORPORATION

Enrolling in a highercost Medicare Advantage plan may not always get seniors better quality health care, according to a new RAND Corporation study.

Examining 15 different measures of quality among large representative samples of people enrolled in Medicare Advantage plans during 2016 and 2017, researchers found that plans that charged a higher monthly premium provided on average only slightly better care as compared to plans with no monthly premium.

Quality varied substantially within each premium cost tier studied, with high-quality care being observed among a number of plans in each of the cost tiers. More than 700 Medicare Advantage plans were part of the analysis.

The findings are published in the latest edition of JAMA Health Forum.

“Paying higher premiums is not necessary to receive high quality care from a Medicare Advantage plan,” said study lead author Amelia M. Haviland, a professor of statistics and public policy at Carnegie Mellon University and an adjunct statistician at RAND, a nonprofit research organization. “Seniors should look at metrics other than premium costs alone when looking for a Medicare Advantage plan that offers a high-quality of care, including direct measures of quality, such as Star Ratings.”

Health care costs are a concern for both consumers and policymakers. People enrolled in Medicare Advantage plans report that price measures such as premium costs and co-pays are their primary consideration when selecting a plan.

To examine the link between premium cost and quality, RAND researchers analyzed information about the care delivered to people enrolled in Medicare Advantage plans. About 40% of the enrollees were in plans with no monthly premium, while 6% were in plans with a monthly premium of more than $120.

Medicare Advantage plans provide coverage for hospital and physician services like traditional Medicare fee-for-service, but typically also offer additional services such as coverage for dental care and eyeglasses. In exchange for additional services and lower co-pays, members are restricted to in-network providers. More than one-third of Medicare enrollees choose Medicare Advantage plans.

The information used to measure the quality of care from Medicare Advantage plans included clinical quality measures based on administrative information such as medical charts involving more than 2 million enrollees. Those quality measures included items such as whether patients received recommended cancer screenings, whether high blood pressure was controlled and whether diabetes was treated adequately.

The analysis also examined surveys of more than 168,000 randomly sampled plan participants who were asked about their experiences with health care, prescription drug coverage and their plan. Those measures included the ability to get care, the ability to get care quickly and getting needed drugs.

Across most measures, people enrolled in the two higher-premium plan tiers reported similar or slightly better experiences on average than enrollees in the lower-premium categories. For example, people enrolled in the highest premium tiers were more likely to receive annual flu shots.  

However, on one measure, lower-cost plans offered better care. People enrolled in lower-tiered plans received better care on average for osteoporosis than their peers enrolled in higher-premium plans.

Given that many high- and low-quality plans were found in each of the premium tiers we studied, the premium cost is a poor proxy for assessing the quality of a Medicare Advantage plan,” Haviland said. “Making plan quality information more accessible and salient to consumers is a key to reducing consumers’ costs while improving quality.”

Support for the study was provided by the federal Centers for Medicare & Medicaid Services.  Other authors of the study are Sai Ma of Humana, and David J. Klein, Nathan Orr and Marc N. Elliott, all of RAND.

RAND Health Care promotes healthier societies by improving health care systems in the United States and other countries. 

 

Prosthetics design integrating 3D printing takes third place in international challenge

RIT student’s flexible limb socket design is recognized for improved performance and cost effectiveness

Grant and Award Announcement

ROCHESTER INSTITUTE OF TECHNOLOGY

Jade Myers Holding Prosthetic Limb 

IMAGE: JADE MYERS, AN ENGINEERING DOCTORAL CANDIDATE AND MEMBER OF RIT’S LIVEABILITY LAB, RECENTLY PLACED THIRD IN THE INTERNATIONAL NTOPOLOGY-EOS RESPONSIBLE PART CHALLENGE. SHE WAS RECOGNIZED FOR HER IMPROVED PROSTHETIC DEVICE DESIGNED WITH LATTICE STRUCTURES. view more 

CREDIT: A. SUE WEISLER/RIT

Jade Myers’ experience in Haiti several years ago helping refugees after a devastating earthquake left an impression that is inspiring her work today as a researcher in prosthetics and accessibility.

Myers, who uses 3D print technology to develop upper and lower limb prostheses for amputees, was a top three winner of the nTopology-EOS 2022 Responsible Part Challenge, an international design competition. Her project, improving prosthetic sockets with density-graded lattice, was recognized for its innovation and potential impact the new design could have.

Myers was one of the students from 28 colleges and universities across 16 countries who participated in the annual event featuring designs in light-weighting, thermal management, sustainable energy, architected materials, and industrial design categories.

The technology gets Myers one step closer to a distinctive type of prosthesis that is more functional than traditional designs. She created a variable-density lattice structure to improve the connection where the body meets the prosthetic device.

“Light-weighting is super important for people with limited muscle and bone structure, and this is one of the areas where 3D printing, in our experience, has been very positive. The devices are much lighter than those traditionally manufactured,” said Myers, a Ph.D. candidate in RIT’s Kate Gleason College of Engineering. She also teaches courses in the engineering college and participates in interdisciplinary projects taking place at the LiveAbility Lab, an initiative based in the university’s Partnership for Effective Access Technology Research and Development.

There are several types of prosthetic sockets designed to interface with residual limbs. A more recent style developed is called a compression-release-stabilized (CRS) socket. Compression on either side of the humerus bone, for example, helps stabilize the prosthesis, and release areas ensure the soft tissue has a place to emerge.

“That is where this lattice structure comes in,” she said. “There are better ways to precisely control compression by changing the density of the lattice structure.”

Picking up items with a prosthesis means weight is added causing uneven pressure, or weight-load, concentrated on the far end of the bone. Adjusting pressure along the length of the bone and device can increase utility and range of motion, plus ease pain on the compressed tissue.

Inspiration for her new socket design came from running shoes.

“I knew they were using lattice structures at Adidas for running shoes to adjust pressure in different areas of the foot based on sensor readings,” she said. “Where individuals were putting the most pressure on their feet, that is where they put the dense lattice to make it firmer. I thought, why can’t we do that with prosthetic sockets?”

Myers re-worked the idea to form a padded socket with varied areas of density in RIT’s AMPrint Center, a campus laboratory and research facility focusing on additive manufacturing and 3D print advances. After compression, pressure, fatigue, and new materials testing, she will begin prototyping 3D printed models.

“We want it to have both form and function,” she said.

When Myers first began work in prosthetics, she was part of a nonprofit health organization associated with RIT and was instrumental in helping clinicians in Haiti understand how 3D-printed prostheses could be added to their practice.

While there, she met Danie, a young woman who lost her arm during the earthquake in 2010. Myers was touched by her plight, but also saw her as someone with a will to live despite hardships and socio-cultural stigma encountered in her community because of her amputation.

“Danie inspired me. In Haiti it is very hard for a person to not only afford a prosthesis, but to get to a clinic. Some people are spending the night outside of the clinic waiting for them to create this device that takes several days for them to make,” said Myers. “Being able to manufacture the devices faster is one of the things we want to do. We want to be able to provide things people can afford, and that work well for them. The faster it happens, the sooner people like Danie can have the opportunity to wear these. It not only impacts them—it can have a ripple effect on families and their opportunities, too. It gives me greater drive, practically a desperation to do better faster because I have had the opportunity to see with my own eyes what a real difference it has potential to make for people. I can never imagine doing anything else with my life.”

Myers and Danie have remained in contact since meeting, now co-designing devices together. The two have become good friends, and Myers has visited Haiti on several occasions seeing her friend re-building her life. Myers expects to graduate with her doctoral degree in 2023.

Awareness, not mandatory GMO labels, shifts consumer preference

Peer-Reviewed Publication

CORNELL UNIVERSITY

ITHACA, N.Y. – Six years ago, the state of Vermont passed what turned out to be a short-lived law mandating disclosure of genetically modified organisms, or GMOs, on all food products. That law’s effect? A collective shrug of the shoulders.

That doesn’t mean people don’t care about whether GMO ingredients are in their food, according to new Cornell research. Although the mandatory labeling law didn’t change consumer purchasing patterns, the researchers found that the increased consumer awareness caused by the legislation, coupled with existing non-GMO labeling, actually did shift preferences.

“For the consumers who care about this non-GMO attribute, they already have a relevant information signal available in the form of the non-GMO label,” said Jura Liaukonyte, the Dake Family Associate Professor in the Charles H. Dyson School of Applied Economics and Management.

“That’s when the switching happens,” Liaukonyte said, “and this switching is triggered by a heightened awareness through these legislative conversations.”

GMO and non-GMO Labeling Effects: Evidence From a Quasi-Natural Experiment,” published Aug. 29 in Marketing Science. Liaukonyte’s co-authors were Aaron Adalja, assistant professor of food and beverage management in the Cornell Peter and Stephanie Nolan School of Hotel Administration; Emily Wang of the University of Massachusetts, Amherst; and Xinrong Zhu, of Imperial College Business School. Both Dyson and the Nolan School are in the Cornell SC Johnson College of Business.

The group’s key finding: An increase in consumer awareness around GMO-related topics – even in states that didn’t ultimately pass GMO labeling laws – is linked to an increase in demand for non-GMO products. And that difference can be quantified: They found that 36% of new non-GMO product adoption can be explained by differences in consumer awareness tied to legislative activity.

“What’s really interesting is the way legislative activity essentially generates consumer awareness,” Adalja said. “In the paper, we differentiate between this ‘indirect awareness effect’ and the direct effect of labeling, and we show that indirect awareness – in this case, the labeling legislation being discussed in the media – is really the primary mechanism by which we find consumer preferences are shifting.”

Over the last three decades, GMO labeling has become an increasingly important topic of public and political debate. The paper cites a 2016 National Academy of Sciences report finding no scientific evidence that GMO foods are less healthy or safe than non-GMO products; however, on Jan. 1, 2022, the United States mandated disclosure labels on all foods that contain GMOs.

The controversy over GMOs sparked several state-level labeling initiatives over the years, but Vermont was the only state to successfully pass and implement a labeling law. The law took effect July 1, 2016, but was quickly preempted by the National Bioengineered Food Disclosure Standard, signed into law by President Barack Obama on July 29, 2016.

For their study, the researchers analyzed GMO labeling in three steps. They first examined the relationship between the adoption rate of newly introduced non-GMO products and consumer awareness at the time of introduction. These products are identified by the “Non-GMO Project Verified” label, a certification from the third-party nonprofit Non-GMO Project, which has been used since 2010.

Then they analyzed the natural experiment condition created in the run-up to Vermont adopting its GMO labeling law in 2016, to gauge the relationship between product demand and the information available via on-the-ground efforts related to the legislation. The increase in demand tied to increased awareness was significant, the authors found.

And finally, the authors looked into whether actual adoption of the Vermont law – GMO labels appearing on store shelves – resulted in any additional demand for non-GMO or GMO products. It did not.

Previous studies, conducted via questionnaires or in laboratory settings, indicated that GMO labeling would result in big swings in consumer preference, but the Cornell researchers’ study in the field found a more subtle change.

“It’s difficult to approximate in the lab the complexity of the actual marketplace with its many co-existing information signals,” Liaukonyte said.

Adalja said the role of legislative discussion around GMO labeling – even in states that didn’t ultimately adopt labeling laws – was compelling.

“That has some important implications,” he said. “It’s another mechanism lawmakers need to consider when designing and debating policies that aim to change preferences of consumers.”

They also suggest that voluntary non-GMO labels – increasingly common over the last dozen years – may have provided a sufficient disclosure mechanism even without mandatory GMO labeling.

For additional information, see this Cornell Chronicle story.

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POLYMORPHOSLY PERVERSE POLYANDRY

Dolphins form largest alliance network outside humans, study finds

Peer-Reviewed Publication

UNIVERSITY OF BRISTOL

Image 1 

IMAGE: FOUR MALE ALLIES AND A FEMALE view more 

CREDIT: SIMON ALLEN

Male bottlenose dolphins form the largest known multi-level alliance network outside humans, an international team led by researchers at the University of Bristol have shown. These cooperative relationships between groups increase male access to a contested resource.

The scientists, with colleagues from the University of Zurich and University of Massachusetts, analysed association and consortship data to model the structure of alliances between 121 adult male Indo-Pacific bottlenose dolphins at Shark Bay in Western Australia. Their findings have been published today in The Proceedings of the National Academy of Sciences (PNAS).

Male dolphins in Shark Bay form first-order alliances of two-three males to cooperatively pursue consortships with individual females. Second-order alliances of four-14 unrelated males compete with other alliances over access to female dolphins and third-order alliances occur between cooperating second-order alliances.

Co-lead author Dr Stephanie King, Associate Professor from Bristol’s School of Biological Sciences explained: “Cooperation between allies is widespread in human societies and one of the hallmarks of our success. Our capacity to build strategic, cooperative relationships at multiple social levels, such as trade or military alliances both nationally and internationally, was once thought unique to our species.

“Not only have we shown that male bottlenose dolphins form the largest known multilevel alliance network outside humans, but that cooperative relationships between groups, rather than simply alliance size, allows males to spend more time with females, thereby increasing their reproductive success.”

Dr Simon Allen, Senior Lecturer at Bristol’s School of Biological Sciences, who contributed to the study, said “We show that the duration over which these teams of male dolphins consort females is dependent upon being well-connected with third-order allies, that is, social ties between alliances leads to long-term benefits for these males.”

Intergroup cooperation in humans was thought to be unique and dependent upon two other features that distinguish humans from our common ancestor with chimpanzees, the evolution of pair bonds and parental care by males. “However, our results show that intergroup alliances can emerge without these features, from a social and mating system that is more chimpanzee like” noted Richard Connor, Professor Emeritus at the University of Massachusetts and now affiliated with Florida International University, who co-led the study with Dr King.

The publication of the importance of third level or intergroup alliances in dolphins in 2022 holds special significance as the team celebrate the 40th anniversary of the start of Shark Bay dolphin research in 1982 and the 30th anniversary of the publication in 1992 of their discovery of two levels of male alliance formation, also published in The Proceedings of the National Academy of Sciences.

Professor Dr. Michael Krützen, an author on the study and Head of the Anthropology Institute at the University of Zurich, added; “It is rare for non-primate research to be conducted from an anthropology department, but our study shows that important insights about the evolution of characteristics previously thought to be uniquely human can be gained by examining other highly social, large-brained taxa”.

Dr King concluded: “Our work highlights that dolphin societies, as well as those of nonhuman primates, are valuable model systems for understanding human social and cognitive evolution.”

Paper

‘Strategic intergroup alliances increase access to a contested resource in male bottlenose dolphins’ Stephanie L. King, Richard C. Connor, Michael Krützen, Simon J. Allen and William B. Sherwin in The Proceedings of the National Academy of Sciences.

Image 2 

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Six allied males and female consort

CREDIT

Simon Allen


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Male trio with female

CREDIT

Simon Allen

Contact

Stephanie King stephanie.king@bristol.ac.uk

Simon Allen simon.allen@bristol.ac.uk

Richard Connor rconnor@umassd.edu

Inside the head of one of Australia’s smallest fossil crocs

Peer-Reviewed Publication

UNIVERSITY OF QUEENSLAND

Size comparison 

IMAGE: CREDIT: JORGO RISTEVSKI view more 

CREDIT: JORGO RISTEVSKI

Approximately 13.5 million years ago, north-west Queensland was home to an unusual and particularly tiny species of crocodile and now scientists are unlocking its secrets.

University of Queensland researchers have used state-of-the-art technology to reveal previously unknown details about the prehistoric Trilophosuchus rackhami’s anatomy.

Faculty of Science PhD candidate, Jorgo Ristevski said it is the most detailed examination ever undertaken of the skull anatomy of an extinct croc from Australia.

“By micro-CT scanning the beautifully preserved skull, we were able to digitally separate each bone,” Mr Ristevski said.

“We estimated that at adulthood, Trilophosuchus rackhami would have been between 70 and 90 centimetres long and weigh one to two kilograms, which was very small compared to most present-day crocs.

“This was a truly unique looking croc, with a short snout and three distinct ridges on the top of its skull.”

Trilophosuchus rackhami means Rackham’s three-crested croc, which was named in 1993 in honour of Alan Rackham, who now manages the Riversleigh Fossil Discovery Centre at Mt Isa.

Mr Ristevski said palaeoneurology, a field that studies the brain and nervous system of fossil species, can provide crucial insights into the animal’s evolution, morphology and even behaviour.

“For one of the studies, I digitally reconstructed the brain cavity of Trilophosuchus rackhami and found that it resembles that of some distantly related and potentially terrestrial extinct crocs from Africa and South America,” Mr Ristevski said.

“We were quite surprised to find this because evolutionarily speaking, Trilophosuchus rackhami is more closely related to today’s crocs.

“This may indicate that Trilophosuchus rackhami spent more time on land than most living crocs.”

Mr Ristevski said the findings would be useful in interpreting the evolutionary relationships of extinct crocs, something that will be researched in the future.

Associate Professor Steve Salisbury said up until very recently, Australia had an amazing diversity of prehistoric crocs.

Trilophosuchus rackhami was certainly one of the cutest,” he said.

“If we could travel back in time to north Queensland 13 million years ago, not only would you need to watch out for crocodiles at the water’s edge, but you’d also have to make sure you didn’t step on them in the forest.”

The research was published in The Anatomical Record and The Journal of Anatomy.

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Part fossil of Trilophosuchus rackhami skull.

CREDIT

Jorgo Ristevski

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Digital reconstruction using the part fossil sample of the Trilophosuchus rackhami skull.

CREDIT

Jorgo Ristevski

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Trilophosuchus rackhami skull.

CREDIT

Jorgo Ristevski

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Trilophosuchus rackhami croc.

CREDIT

Jorgo Ristevski



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Lead author on the research, Jorgo Ristevski.

CREDIT

Jorgo Ristevski

CRISPR CRITTER

CRISPR-based technology targets global crop pest

Designed to sterilize a fly species known to cause extensive crop damage, a new genetic technique replaces the need for harmful pesticides

Peer-Reviewed Publication

UNIVERSITY OF CALIFORNIA - SAN DIEGO

Fruit crop damage 

IMAGE: THE INVASIVE DROSOPHILA SUZUKII FRUIT FLY HAS CAUSED MILLIONS OF DOLLARS OF DAMAGE TO BERRY AND OTHER CROPS. view more 

CREDIT: MICHELLE BUI, UC SAN DIEGO

Applying new CRISPR-based technology to a broad agricultural need, researchers at the University of California San Diego have set their aims on a worldwide pest known to decimate valuable food crops.

Nikolay Kandul, Omar Akbari and their colleagues first demonstrated the precision-guided sterile insect technique, or pgSIT, in Drosophila melanogaster, the common fruit fly, in 2019. The technology, later adapted to mosquitoes, uses programmable CRISPR techniques to edit key genes that control sex determination and fertility. Under the new system, pgSIT-developed insect eggs are deployed into a targeted population and only sterile males hatch, resulting in a fertility dead end for that species.

Kandul, Akbari and their colleagues have now adapted the technology for use in Drosophila suzukii, an invasive fruit fly (also known as the spotted-wing drosophila) responsible for millions of dollars in crop damage. The advancement is described in the journal GEN Biotechnology.

“It’s a safe, evolutionary stable system,” said Akbari, a professor in the School of Biological Sciences’ Department of Cell and Developmental Biology. “Also, the system does not lead to uncontrolled spread nor does it persist in the environment—both important safety features that will help it gain approvals for use.”

D. suzukii flies have invaded many parts of the world and caused widespread agricultural and economic damage to several crops, including apples, cherries, raspberries, blueberries, strawberries, peaches, grapes, olives and tomatoes.

The flies are known to proliferate by depositing their eggs inside growing fruit. They are notoriously difficult to control since their larvae consume ripening fruit pulp, limiting the effectiveness of insecticide sprays. Some flies have been known to become resistant to insecticides and many chemicals used in insecticides are now banned because of threats to human health.

The concepts behind pgSIT date back to the 1930s, when farmers found ways to release sterile males into their crops to reduce damage from pests. By mid-century, United States farmers began using radiation to sterilize pests such as the New World screwworm fly.

With CRISPR, UC San Diego scientists avoided the need for harmful radiation and instead use CRISPR editing to specifically target genes essential for female D. suzukii viability and male fertility. As envisioned, pgSIT eggs could be produced at a factory and released at sites invaded by pests such as D. suzukii. Eggs could be deployed directly into areas where the flies are causing damage and only sterile males would hatch after about two weeks. Since only two genes are knocked out, the males emerge fit enough to compete with their wild counterparts and quickly seek females to mate with, resulting in inviable offspring.

“This technology would replace the need for insecticides and only suppress the target species population,” said Akbari. “In the last four years, we’ve developed pgSIT for several different species. Going forward we’re hoping to use it as a platform technology that can be ported to a whole range of pests to safely solve real-world problems.”

Agragene Inc., a private biotechnology company co-founded by Akbari, has licensed the pgSIT base technology from UC Riverside (where Akbari initially led the technology’s development) and is implementing U.S. Department of Agriculture-administered field trials of pgSIT in D. suzukii. The company hopes that the trials will demonstrate the safety and effectiveness of pgSIT and lead to regulatory approval of the technology for broad agricultural use.

The GEN Biotechnology paper was coauthored by: Nikolay Kandul, Junru Liu, Anna Buchman, Isaiah Shriner, Rodrigo Corder, Natalie Warsinger-Pepe, Ting Yang, Amarish Yadav, Maxwell Scott, John Marshall and Omar Akbari.

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Former UC San Diego graduate student Stephanie Gamez created this artistic depiction of genetics and the fruit crop pest Drosophila suzukii.

CREDIT

Stephanie Gamez



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Spotted-wing drosophila flies deposit their eggs inside strawberries and other ripening fruit.

CREDIT

Michelle Bui, UC San Diego