Wednesday, March 13, 2024

Staying in the loop: how superconductors are helping computers “remember”

Superconducting loops may enable computers to retain and retrieve information more efficiently



UNIVERSITY OF CALIFORNIA - SAN DIEGO





Computers work in digits — 0s and 1s to be exact. Their calculations are digital; their processes are digital; even their memories are digital. All of which requires extraordinary power resources. As we look to the next evolution of computing and developing neuromorphic or “brain like” computing, those power requirements are unfeasible.

To advance neuromorphic computing, some researchers are looking at analog improvements. In other words, not just advancing software, but advancing hardware too. Research from the University of California San Diego and UC Riverside shows a promising new way to store and transmit information using disordered superconducting loops.

The team’s research, which appears in the Proceedings of the National Academy of Sciences, offers the ability of superconducting loops to demonstrate associative memory, which, in humans, allows the brain to remember the relationship between two unrelated items.

“I hope what we're designing, simulating and building will be able to do that kind of associative processing really fast,” stated UC San Diego Professor of Physics Robert C. Dynes, who is one of the paper’s co-authors.

Creating lasting memories

Picture it: you’re at a party and run into someone you haven’t seen in a while. You know their name but can’t quite recall it. Your brain starts to root around for the information: where did I meet this person? How were we introduced? If you’re lucky, your brain finds the pathway to retrieve what was missing. Sometimes, of course, you’re unlucky.

Dynes believes that short-term memory moves into long-term memory with repetition. In the case of a name, the more you see the person and use the name, the more deeply it is written into memory. This is why we still remember a song from when we were ten years old but can't remember what we had for lunch yesterday.

“Our brains have this remarkable gift of associative memory, which we don't really understand,” stated Dynes, who is also president emeritus of the University of California and former UC San Diego chancellor. “It can work through the probability of answers because it's so highly interconnected. This computer brain we built and modeled is also highly interactive. If you input a signal, the whole computer brain knows you did it.”

Staying in the loop

How do disordered superconducting loops work? You need a superconducting material — in this case, the team used yttrium barium copper oxide (YBCO). Known as a high-temperature superconductor, YBCO becomes superconducting around 90 Kelvin (-297 F), which in the world of physics, is not that cold. This made it relatively easy to modify. The YBCO thin films (about 10 microns wide) were manipulated with a combination of magnetic fields and currents to create a single flux quantum on the loop. When the current was removed, the flux quantum stayed in the loop. Think of this as a piece of information or memory.

This is one loop, but associative memory and processing require at least two pieces of information. For this, Dynes used disordered loops, meaning the loops are different sizes and follow different patterns — essentially random.

A Josephson juncture, or “weak link,” as it is sometimes known, in each loop acted as a gate through which the flux quanta could pass. This is how information is transferred and the associations are built.

Although traditional computing architecture has continuous high-energy requirements, not just for processing but also for memory storage, these superconducting loops show significant power savings — on the scale of a million times less. This is because the loops only require power when performing logic tasks. Memories are stored in the physical superconducting material and can remain there permanently, as long as the loop remains superconducting.

The number of memory locations available increases exponentially with more loops: one loop has three locations, but three loops have 27. For this research, the team built four loops with 81 locations. Next, Dynes would like to expand the number of loops and the number memory locations.

“We know these loops can store memories. We know the associative memory works. We just don’t know how stable it is with a higher number of loops,” he said.

This work is not only noteworthy to physicists and computer engineers; it may also be important to neuroscientists. Dynes talked to another University of California president emeritus, Richard Atkinson, a world-renowned cognitive scientist who helped create a seminal model of human memory called the Atkinson-Shiffrin model.

Atkinson, who is also former UC San Diego chancellor and professor emeritus in the School of Social Sciences, was excited about the possibilities he saw: “Bob and I have had some great discussions trying to determine if his physics-based neural network could be used to model the Atkinson-Shiffrin theory of memory. His system is quite different from other proposed physics-based neural networks, and is rich enough that it could be used to explain the workings of the brain’s memory system in terms of the underlying physical process. It’s a very exciting prospect.”

Full list of authors: Uday S. Goteti and Robert C. Dynes (both UC San Diego); Shane A. Cybart (UC Riverside).

This work was primarily supported as part of the Quantum Materials for Energy Efficient Neuromorphic Computing (Q-MEEN-C) (Department of Energy DE-SC0019273). Other support was provided by the Department of Energy National Nuclear Security Agency (DE-NA0004106) and the Air Force Office of Scientific Research (FA9550-20-1-0144).

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New research at Georgia Aquarium helps conserve endangered beluga whales in Alaska


Metabolic and caloric measurements show belugas have big caloric needs to maintain their cold-water lifestyle



GEORGIA AQUARIUM




ATLANTA – New data provided by studying the beluga whales at Georgia Aquarium helps close a key information gap about how much food these whales need to thrive. The information will inform important management decisions for their counterparts in Alaska’s Cook Inlet, which are protected under the U.S. Endangered Species Act (ESA).

A new study released in the Journal of Experimental Biology, led by Terrie M. Williams, Director of the Integrative Carnivore EcoPhysiology Lab, with her graduate student Jason John at the University of California-Santa Cruz in partnership with Georgia Aquarium, reveals that the whales’ unique metabolism and elevated caloric needs may limit their ability to escape from potential human disturbances.

The Cook Inlet beluga population was listed as endangered in 2008 due to a decline from over-harvesting by Alaska’s native hunters. But despite a cessation in whaling and other efforts to help the population recover, their numbers have not increased, and it is unknown why.

Difficulty collecting this type of data on belugas in the wild has made it hard for scientists to identify why they have failed to recover from excessive harvest. This study, which started in 2018, was a collaboration between U.C. Santa Cruz and Georgia Aquarium with the Alaska Region of NOAA Fisheries, which has management authority for Cook Inlet belugas. Scientists collected data about energy output from the aquarium’s one adult male and two adult female belugas while resting in metabolic domes, during submerged swimming, and when diving for food. 

“We are losing large wild species all over the world,” said Williams. “One way that we might be able to prevent wholesale extinctions is to do the basic science that allows us to predict what these animals need to live in this crazy, changing world.” 

“This study is one element we can do here to create a better understanding of how these animals take in and use energy,” said Dennis Christen, Georgia Aquarium’s Senior Director, Mammals and Birds. “That’s a measurement that’s nearly impossible to get in the wild. By understanding their metabolism, we can get an understanding of what they have to feed on in the wild and whether it is enough.”  

“Taking these baseline measurements – which are the gold standard for conservation modeling – helps us to understand how these whales are built,” Williams explained. “There aren’t many facilities like Georgia Aquarium that have the capabilities and research mindset to conduct this type of research.”  

Georgia Aquarium scientists prepared the belugas for the study over a six-month period, using positive reinforcement and operant conditioning techniques to measure their resting and active metabolic rates in different states. Open flow respirometry was used to measure oxygen consumption using a plexiglass dome for the animals to breathe in, and accelerometers were used to measure movement and swim stroke rates in the water. 

Data gleaned from this research will help create predictive energy models to evaluate the potential impact of human activities on beluga whales, and a close relative, Arctic narwhals.

The metabolic study conducted by this collaboration is helping to inform measures to ensure Cook Inlet belugas have adequate resources to fuel their caloric needs. Under the ESA, any action that is funded or permitted by the federal government that has the potential to impact a threatened or endangered species must be reviewed. This includes activities like oil and gas exploration and development, marine construction, and commercial fishing. This review includes mitigations to reduce impacts on ESA species. Obtaining a baseline on the calorie needs of Cook Inlet belugas will help inform these mitigations to reduce the effects of these activities on Cook Inlet belugas.

“Wild belugas typically use the calories from ingesting fish to fuel growth, activity, maintaining their health and reproducing,” said Williams. “With increased human disturbance, calories will have to be diverted to respond to perceived threats. Such energy imbalance cannot be sustained for long periods without negative consequences.”  

“The whales at Georgia Aquarium are ambassadors for their species. Getting the opportunity to participate in a research study like this one means a lot,” said Katie Flammer, associate curator, Mammals and Birds. “These animals, and our training team, are helping beluga whales globally.” 

To learn more about Georgia Aquarium’s conservation work, click here.  


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ABOUT THE JOSEPH M. LONG MARINE LABORATORY/UC-SANTA CRUZ  

The Joseph M. Long Marine Laboratory (LML) provides a state-of-the-art home for interdisciplinary research and teaching on marine life, coastal conservation, climate change impacts and other marine and coastal science issues. LML is world-renowned for innovative research in coastal ecology, marine vertebrates and invertebrates, and marine mammal studies in the lab and field, including physiology, sensory reception, behavior and bioacoustics. 

 

ABOUT GEORGIA AQUARIUM 
Georgia Aquarium is a leading 501(c)(3) non-profit organization located in Atlanta, Ga. that is Humane Certified by American Humane and accredited by the Alliance of Marine Mammal Parks and Aquariums and the Association of Zoos and Aquariums. Georgia Aquarium is committed to working on behalf of all marine life through education, preservation, exceptional animal care, and research across the globe. Georgia Aquarium continues its mission each day to inspire, educate, and entertain its millions of guests about the aquatic biodiversity throughout the world through its engaging exhibits and tens of thousands of animals across its eight major galleries. 

Media Contact:

Paige Hale / Georgia Aquarium / Phale@georgiaaquarium.org

Federal housing programs protect residents from lead exposure

HOUSING FOR PEOPLE NOT PROFIT

COLUMBIA UNIVERSITY'S MAILMAN SCHOOL OF PUBLIC HEALTH




Americans already living in housing supported by federal housing assistance programs have significantly lower blood lead levels than counterparts who would later join these programs, according to new research led by environmental health scientists at Columbia University Mailman School of Public Health and Tufts Medical Center. The findings appear in the peer-reviewed journal Environmental Health Perspectives.

“Living in federally-supported housing—especially public housing—limited opportunities for residents’ exposure to lead,” says first author MyDzung Chu, Ph.D., assistant professor in the Institute for Clinical Research and Health Policy Studies at Tufts Medical Center. “This likely relates to stricter compliance and enforcement of federal residential lead paint laws in HUD housing compared to non-assisted housing in the private market.”

“Federal housing assistance is an important social-structural safety net for very low-income households to access both affordable and safe, healthy housing,” adds senior author Ami Zota, PhD, associate professor of environmental health sciences at Columbia University Mailman School of Public Health. “Lead is a major health risk at any level of exposure.”

The new study is the first to examine blood lead levels (BLLs) by federal housing assistance status in a nationally representative sample of HUD-eligible adolescents and adults. Researchers used the 1999-2018 National Health and Nutrition Examination Survey (NHANES) linked with housing records from the U.S. Department of Housing and Urban Development (HUD) to compare BLLs of NHANES participants on housing assistance (a total of 3,071) at the time of the survey and those who would receive assistance within two years after the survey (i.e., pseudo-waitlist recipients, a total of 1,235).

Participants living with HUD housing assistance had 11.4 percent lower BLLs than those in the pseudo-waitlist group. They also had 40 percent lower odds of having a BLL greater than or equal to 3.5 µg/dL—a level used to identify children with BLLs higher than those of most U.S. children, determine appropriate follow-up actions, and prevent further exposure. These numbers were adjusted to account for demographic and socioeconomic confounders. 

Additional findings:

  • Comparing three main HUD housing assistance programs, public housing was the most protective against lead exposure followed by multifamily income-restricted housing. No protective effect was seen for tenant-based housing choice vouchers (HCVs). HUD enforces more stringent lead control strategies in public housing units, which provide more long-term/permanent solutions to reduce lead exposure, such as requiring lead-based paint inspections and lead abatement for affected units. In contrast, tenant-based rental assistance programs like HCVs only require that HCV-eligible units undergo a visual assessment and lead paint stabilization if lead is found, which are considered short-term/interim controls and thus less effective.
  • The link between HUD housing assistance and BLLs was weaker for non-Hispanic Black and Mexican American participants than for non-Hispanic Whites. This discrepancy could be due to Black and Mexican American individuals’ exposure to other lead sources, such as lead-contaminated drinking water and proximity to industrial pollution, though authors could not directly assess these sources in the NHANES or HUD data. Moreover, Black households face barriers to high quality housing due to legacies of racist housing policies and urban planning practices. Black families receiving vouchers tend to live in more disadvantaged, racially segregated, and overcrowded neighborhoods compared to White families receiving vouchers. The researchers say more attention is needed to ensure quality housing and racial equity across HUD’s housing assistance programs.

Key Background

BLLs in adults are linked with elevated blood pressure and risk of cardiovascular disease, renal insufficiency, and cognitive impairments. Elevated BLLs among children have been associated with neurocognitive and intellectual impairments, poor school performance, behavioral problems, and criminality later in life, even at low levels of exposure.

HUD provides affordable housing assistance to nearly 5 million families, including about 3 million children through three major programs administered by local public housing agencies: public housing (0.84 million households), tenant-based housing choice vouchers (HCVs) (2.3 million households), and multifamily income-restricted housing (1.4 million households).

Additional study co-authors include Andrew Fenelon, University of Minnesota; and Gary Adamkiewicz, Harvard T.H. Chan School of Public Health.

The study was funded by a grant from the U.S. Department of Housing and Urban Development.

The authors declare no conflicts of interest.

 

Air quality in Europe shows significant improvements over the last two decades, study finds


Despite air quality improvements, 98.10%, 80.15% and 86.34% of the European population lives in areas exceeding the WHO recommended levels for PM2.5, PM10 and NO2, respectively


Peer-Reviewed Publication

BARCELONA INSTITUTE FOR GLOBAL HEALTH (ISGLOBAL)





A study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, and the Barcelona Supercomputing Center - Centro Nacional de Supercomputación (BSC-CNS), has consistently estimated daily ambient concentrations of PM2.5, PM10, NO2 and O3 across a large ensemble of European regions between 2003 and 2019 based on machine learning techniques. The aim was to assess the occurrence of days exceeding the 2021 guidelines of the World Health Organization (WHO) for one or multiple pollutants, referred to as “unclean air days”.

The research team analysed pollution levels in more than 1,400 regions in 35 European countries, representing 543 million people. The results, published in Nature Communications, show that overall suspended particulate matter (PM2.5 and PM10) and nitrogen dioxide (NO2) levels have decreased in most parts of Europe. In particular, PM10 levels decreased the most over the study period, followed by NO2 and PM2.5, with annual decreases of 2.72%, 2.45% and 1.72% respectively. In contrast, O3 levels increased annually by 0.58% in southern Europe, leading to a nearly fourfold rise in unclean air days.

The study also looked at the number of days on which the limits for two or more pollutants were exceeded simultaneously, a confluence known as a “compound unclean air day”. Despite the overall improvements, 86.3% of the European population still experienced at least one compound unclean day per year during the study period, with PM2.5-NO2 and PM2.5-O3 emerging as the most common compound combinations.

The results highlight the significant improvements in air quality in Europe followed by the decline of PM10 and NO2, while PM2.5 and O3 levels continue to exceed WHO guidelines in many regions, resulting in a higher number of people exposed to unclean air levels. "Targeted efforts are needed to address PM2.5 and O3 levels and associated compound unclean days, especially in the context of rapidly increasing threats from climate change in Europe," says Zhao-Yue Chen, ISGlobal researcher and lead author of the study.

"Our consistent estimation of population exposure to compound air pollution events provides a solid basis for future research and policy development to address air quality management and public health concerns across Europe," points out Carlos Pérez García-Pando, ICREA and AXA Research Professor at the BSC-CNS.

Heterogeneous geographical distribution

The research team has developed machine learning models to estimate high-resolution daily concentrations of major air pollutants like PM2.5, PM10, NO2 and O3. This data-driven approach creates a comprehensive daily air quality picture for the European continent, going beyond sparsely distributed monitoring stations. The models gather data from multiple sources, including satellite-based aerosol estimates, existing atmospheric and climate data, and land use information. By analysing these air pollution estimates, the team calculated the annual average number of days in which the WHO daily limit for one or more air pollutants is exceeded.

Despite air quality improvements, 98.10%, 80.15% and 86.34% of the European population lives in areas exceeding the WHO recommended annual levels for PM2.5, PM10 and NO2, respectively. These results closely match the European Environment Agency (EEA)'s estimates for 27 EU countries using data from urban stations only. Additionally, no country met the ozone (O3) annual standard during the peak season from 2003 to 2019. Looking at short-term exposure, over 90.16% and 82.55% of the European population lived in areas with at least 4 days exceeding WHO daily guidelines for PM2.5 and O3 in 2019, while the numbers for NO2 and PM10 were 55.05% and 26.25%.

During the study period, PM2.5 and PM10 levels were highest in northern Italy and eastern Europe, while PM10 levels were highest in southern Europe. High NO2 levels were mainly observed in northern Italy and in some areas of western Europe, such as in the south of the United Kingdom, Belgium and the Netherlands. Similarly, O3 increased by 0.58% in southern Europe, while it decreased or showed a non-significant trend in the rest of the continent. On the other hand, the most significant reductions in PM2.5 and PM10 were observed in central Europe, while for NO2 they were found in mostly urban areas of western Europe.

The complex management of ozone

The average exposure time and population exposed to unclean air concentrations of PM2.5 and Ois much higher than for the other two pollutants. According to the research team, this highlights the urgency of greater control for these pollutants and the importance of addressing the increasing trend and impact of O3 exposure.

Ground-level or tropospheric Ois found in the lower layers of the atmosphere and is considered a secondary pollutant because it is not emitted directly into the atmosphere, but is formed from certain precursors - such as volatile organic compounds (VOCs), carbon monoxide (CO) and nitrogen oxides (NOx) - that are produced in combustion processes, mainly in transport and industry. In high concentrations, ozone can damage human health, vegetation and ecosystems.

"Ozone management presents a complex challenge due to its secondary formation pathway. Conventional air pollution control strategies, which focus on reducing primary pollutant emissions, may not be sufficient to effectively mitigate Oexceedances and associated compound unclean days," says Joan Ballester Claramunt, ISGlobal researcher and senior author of the study. However, addressing climate change, which influences ozone formation through increased sunlight and rising temperatures, is crucial for long-term ozone management and protection of public health," he adds.

The challenge of compound episodes

Despite improvements in air pollution, the research team reported that over 86% of Europeans experienced at least one day with compound air pollution events each year between 2012 and 2019, where multiple pollutants exceeded WHO limits simultaneously. Among those compound days, the contribution of PM2.5-O3 compound days increased from 4.43% in 2004 to 35.23% in 2019, becoming the second most common type in Europe, indicating a worrying trend. They mainly occur in lower latitudes during warm seasons and are likely linked to climate change and the complex interplay between PM2.5 and O3.

Warmer temperatures and stronger sunlight in summer boost O3 formation through chemical reactions. Subsequently, higher levels of O3 will accelerate the oxidation of organic compounds in the air. This oxidation process leads to the condensation of certain oxidized compounds, forming new PM2.5 particles. Additionally, climate change increases the likelihood of wildfires, which further elevate both O3 and PM2.5 levels. “This complex interplay creates a harmful loop, highlighting the urgent need to address climate change and air pollution simultaneously,” explains Ballester Claramunt.

 

Reference

Main study: Chen, Z.Y., Petetin, H., Turrubiates, R.F.M., Achebak, H., García-Pando, C.P. and Ballester, J., 2024. Population exposure to multiple air pollutants and its compound episodes in Europe, Nature CommunicationsDoi: 10.1038/s41467-024-46103-3

Related study: Chen, Z.Y., Turrubiates, R.F.M., Petetin, H., Lacima, A., García-Pando, C.P. and Ballester, J., 2024. Estimation of pan-European, daily total, fine-mode and coarse-mode Aerosol Optical Depth at 0.1° resolution to facilitate air quality assessments. Science of The Total Environment, p.170593. Doi: 10.1016/j.scitotenv.2024.170593

Curbing coal-burning emissions translates 

to health gains for children


COLUMBIA UNIVERSITY'S MAILMAN SCHOOL OF PUBLIC HEALTH



Residential heating by coal has for decades been the major contributor to the high levels of air pollution in Krakow, Poland. New research finds a nearly 40 percent decline in the annual average concentration of respirable particulate matter (PM2.5) in Kraków, Poland, between 2010 and 2019 following the implementation of policies targeting emissions from the burning of coal and other solid fuels. Researchers show the improvement in air quality translated to substantial benefits for children’s outcomes, including fewer cases of asthma and better birth outcomes.

The findings by researchers at Columbia University Mailman School of Public Health and Jagiellonian University Medical College in Krakow appear in the journal Environmental Research Letters.

The researchers modeled health gains that would have occurred in 2010 if PM2.5 had been at the lower level achieved in 2019 through policy changes The benefits included 505 fewer new cases of asthma in the 1-14 age group (a 35.7% decline), 81 fewer preterm births (16.8% decrease), and 52 fewer cases of low birth weight (12.3% decrease).

They also modeled gains based on a second hypothetical, which assumed that city had adhered to the WHO’s 2005 guidelines on PM2.5. They found this scenario of a 74% reduction in PM2.5 would have avoided 780 new asthma cases in the 1-14 age group (54.5% decrease), 138 preterm births (28.3% decrease), and 90 cases of low birth weight (21.2% decrease).

In 2021, Krakow was ranked 28th out of 858 European studies in air pollution related-mortality in the ISGlobal-Ranking of Cities survey. These high levels of pollution have been attributed largely to the use of coal-burning ovens in residential spaces, and to a lesser extent transportation and power plant emissions. Government interventions, including a co-financing program to replace coal-burning stoves in the 1990s, markedly improved the city’s air quality, positively impacting children’s health outcomes. However, according to researchers, levels of human-derived air pollution, such as emissions from motor vehicles, is still a concern.

“Fetuses, infants, and children are uniquely vulnerable to air pollution,” explains study senior author Frederica Perera, PhD, DrPH, professor of environmental health sciences and director of translational research at the Columbia Center for Children’s Environmental Health at Columbia Mailman, “Our results show very large benefits can be achieved for children’s health by curbing fossil fuel emissions.”

“This is one of the first studies describing the impact of pollution on the Polish pediatric population,” noted study first author Agnieszka Pac, MSc., PhD, chair of Epidemiology and Preventive Medicine at Jagiellonian University Medical College, Krakow, Poland. “New policies must take into account children’s health, especially given that children often engage in vigorous outdoor activities, making them vulnerable to higher doses of pollutants.”

In earlier studies, the researchers reported a significant improvement in air quality based on personal air monitoring in our Kraków cohort study of pregnant women and their children based on personal air monitoring. They also identified links between air pollution exposure and birth outcomes, growth trajectories, lung function, developmental delays, behavioral problems, and cancer risk.

Additional authors of the new study include Renata Majewska, Natalia Nidecka, and Elzbieta Sochacka-Tatara from Jagiellonian University Medical College. This study was supported by a grant from an anonymous foundation.