Friday, May 16, 2025

 

Rice engineers tackle sunlight intermittency in solar desalination



Scalable, low-maintenance design recycles heat for a steady supply of drinking water off grid



Rice University

William Schmid 

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William Schmid

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Credit: Photo by Jorge Vidal/Rice University




HOUSTON – (May 14, 2025) – Fresh drinking water is a vital yet limited resource that will only grow scarcer over the next few years, according to the World Resources Institute. Desalination, the process of removing salt from water, is an established method used to increase the fresh water supply, especially in coastal regions. However, current desalination systems are dependent on large-scale centralized infrastructure and filtration membranes prone to fouling and degradation.

A team of Rice University engineers has developed a system that could transform desalination practices, making the process more adaptable, resilient and cheaper. The new system, described in a study published in Nature Water, is designed to be powered by sunlight and uses a creative approach to heat recovery for extended water production ⎯ with and without sunshine. In contrast to conventional systems, the setup is made from nondegradable materials and can handle high-salinity brines.

“Access to clean fresh water is a particularly challenging problem in off-grid communities,” said William Schmid, a doctoral student in electrical and computer engineering at Rice and National Science Foundation Fellow researching methods to increase the efficiency of light-driven desalination. “We wanted to focus on decentralized, modular desalination systems.”

Thermal desalination entails cycles of evaporation and condensation: As water evaporates, solids such as salts and other impurities are left behind; meanwhile, water vapor cools and condenses into fresh water. Evaporation uses up energy to overcome the intermolecular forces that characterize water in the liquid phase, and condensation releases the energy as vapor turns back into liquid. For thermal desalination systems to be efficient, the energy generated in the transition between liquid and vapor must be recovered and reused.

The new technology, called Solar Thermal Resonant Energy Exchange Desalination or STREED, leverages water flow and airflow using insights from the physics of resonant systems such as pendulums and electrical circuits. In resonant systems, energy naturally oscillates between different forms in a repeating cycle, doing so most efficiently at specific “resonant” frequencies.

Instead of energy alternating between potential and kinetic as in a pendulum or bouncing back and forth between a magnetic and an electric field as in a tuned electrical circuit, STREED is all about conserving the energy exchanged between two counter-flowing fluids: a stream of heated saline water and a flow of air. When tuned correctly, heat oscillates between these two streams in a resonant pattern, efficiently storing and transferring thermal energy even as the sun retreats behind clouds or the horizon. Because of this self-contained “resonant energy transfer,” STREED does not require external energy storage technologies, which add to the cost and maintenance burden of the overall system.

“Our key innovation is using insights from electrical engineering and the physics of oscillators to inform the adjustment of the system’s internal flow rates to match the sun’s shifting power throughout the day,” Schmid said. “This light-dependent flow control hasn’t been done before.”

Aleida Machorro-Ortiz, a graduate student in the Applied Physics Graduate Program at Rice and a first author on the study alongside Schmid, said the system operates “robustly and with minimal maintenance around the clock.”

The system was tested in San Marcos, Texas, producing up to 0.75 liters of drinking water per hour in its prototype form. The team also performed a range of simulations using solar intensity profiles from different locations across the U.S. ⎯ from cloudy Portland, Oregon, to sunny Albuquerque, New Mexico. Overall, STREED water-recovery efficiency outperformed systems using static flow rates by 77% for a representative week.

“This supports the idea that while the system benefits from sunny locations in terms of total freshwater output, achieving high energy-to-water efficiency is not dependent on high solar intensity,” Machorro-Ortiz said.

Most desalination plants use reverse osmosis (RO) technology, which cannot treat high-salinity water effectively due to membrane-based limitations. RO fresh water recovery rates from seawater are 35-50% with the rest typically discarded as hypersaline water. Meanwhile, STREED is able to handle high salinities without a significant decrease in water production or quality.

STREED also replaces the delicate membranes found in many desalination systems with something far simpler: air. In place of a more traditional two-liquid channel design separated by a membrane, the team uses a single heated channel of polluted or salty water and an adjacent channel of air that carries away water vapor. The vapor then condenses in a water-air heat exchanger, leaving contaminants behind.

“The system is more robust because we don’t have any membranes to foul or break,” said Alessandro Alabastri, assistant professor of electrical and computer engineering at Rice and a corresponding author on the study. “We were intentional in using durable, low-maintenance materials to make the system easily scalable and accessible.”

Naomi Halas, University Professor and the Stanley C. Moore Professor of Electrical and Computer Engineering, is also corresponding author on the study alongside Alabastri. Additional authors are Qian Ye, a Rice graduate student; Pratiksha Dongare, former Rice faculty and senior physicist at SLB; and Peter Nordlander, Rice’s Wiess Chair in Physics and Astronomy and professor of electrical and computer engineering and materials science and nanoengineering.

The research was supported by the National Science Foundation (1842494), Mexico’s National Council of Science and Technology (2021-000014-01EXTF-00140), the Robert A. Welch Foundation (C-1220 and C-1222) and the Department of Energy’s Solar Desalination Prize. The content herein is solely the responsibility of the authors and does not necessarily represent the official views of the funding organizations and institutions.

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Rice engineers tackle sunlight intermittency in solar desalination [VIDEO] | 

A team of Rice University engineers has developed a system that could transform desalination practices, making the process more adaptable, resilient and cheaper. The new system, described in a study published in Nature Water, is designed to be powered by sunlight and uses a creative approach to heat recovery for extended water production ⎯ with and without sunshine. In contrast to conventional systems, the setup is made from nondegradable materials and can handle high-salinity brines.

Credit

Video by Jorge Vidal/Rice University


Aleida Machorro-Ortiz

Credit

Photo by Jorge Vidal/Rice University


This news release can be found online at news.rice.edu.

Follow Rice News and Media Relations via Twitter @RiceUNews.

Peer-reviewed paper:

Resonant energy transfer for membrane-free, off-grid solar thermal humidification-dehumidification desalination | Nature Water | DOI: 10.1038/s44221-025-00438-3

Authors: William Schmid, Aleida Machorro-Ortiz, Qian Ye, Peter Nordlander, Pratiksha Dongare, Naomi Halas and Alessandro Alabastri

https://www.nature.com/articles/s44221-025-00438-3


Video is available at:
https://www.youtube.com/watch?v=TXjb-f5atVA


About Rice:

Located on a 300-acre forested campus in Houston, Texas, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of architecture, business, continuing studies, engineering and computing, humanities, music, natural sciences and social sciences and is home to the Baker Institute for Public Policy. Internationally, the university maintains the Rice Global Paris Center, a hub for innovative collaboration, research and inspired teaching located in the heart of Paris. With 4,776 undergraduates and 4,104 graduate students, Rice’s undergraduate student-to-faculty ratio is just under 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for lots of race/class interaction and No. 7 for best-run colleges by the Princeton Review. Rice is also rated as a best value among private universities by the Wall Street Journal and is included on Forbes’ exclusive list of “New Ivies.”

 

Low-cost formulation reduces dose and increases efficacy of drug against worms



Praziquantel, usually administered in large tablets, is the only anthelmintic available on the market. New form of presentation uses nanotechnology and facilitates use by children and pets.




Fundação de Amparo à Pesquisa do Estado de São Paulo

Low-cost formulation reduces dose and increases efficacy of drug against worms 

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Ana Mengarda conducts a test at the Research Center for Neglected Diseases (NPDN) at Guarulhos University: a low-cost solution increases the efficiency of the drug against worms 

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Credit: Mário Salvador/UnG




A group of researchers supported by FAPESP has developed a new formulation for the only drug available on the market to treat helminths, as worms such as schistosomes and tapeworms are known. According to the World Health Organization (WHO), 400 million people worldwide suffer from these worms.

Praziquantel is sold in large tablets that are difficult to swallow, especially for children and pets such as cats and dogs, which are also colonized by helminths and require preventive treatment. The drug also tastes bitter, which also makes it difficult to administer.

The new, nanotechnology-based formulation is water-soluble and more efficiently absorbed, requiring half the usual dose to achieve the same effect as a tablet. A patent application has been filed for this innovation.

The results were published in ACS Applied Nano Materials, a journal of the American Chemical Association.

“Neglected tropical diseases, such as worms, are lacking in treatment innovations, mainly due to the industry’s lack of interest in investing in drugs for poor populations, who are the most affected by these ailments,” says Josué de Moraes, who heads the Research Center for Neglected Diseases (NPDN) at Guarulhos University (UnG) in the state of São Paulo, Brazil.

“Even though praziquantel was created more than 40 years ago, it is 75% to 95% effective. As creating a new drug takes a lot of time and investment, we thought of this low-cost, incremental innovation, which improves absorption by the body and acceptance by children and pets,” adds the researcher.

The study is part of the project “Selection of drugs with anthelmintic activity, nanoencapsulation and pre-clinical evaluation in an experimental model of schistosomiasis”, supported by FAPESP.

The first author of the article is Ana Carolina Araujo Mengarda, who has a PhD scholarship at the Biomedical Sciences Institute of the University of São Paulo (ICB-USP).

After developing the product in collaboration with researchers from the University of Brasilia (UnB), the UnG researchers conducted a series of tests, both directly on the parasites and on animal models and mammalian cells.

The tests showed low toxicity of the formulation in cells other than those of the parasites. Also in these preliminary analyses, the new formulation showed greater efficacy in eliminating schistosomes than the active ingredient alone.

“In addition, it remained in the blood plasma for longer. This is the likely explanation for the formulation needing half the dose to achieve the same effect,” says Mengarda, who is currently a post-doctoral fellow at ICB-USP on a scholarship from FAPESP.

Tailor-made innovation

The limited arsenal of drugs and formulations for neglected tropical diseases motivated the WHO to publish a roadmap in 2021 to accelerate control and elimination of these diseases by 2030.

One need identified in the document was for a pediatric formulation of praziquantel. Currently, a pediatric orodispersible tablet (which dissolves in the mouth) is in clinical trials, the result of research by an international consortium that includes pharmaceutical companies, governments, NGOs, universities and the Institute of Drug Technology (Farmanguinhos), of the Oswaldo Cruz Foundation (FIOCRUZ, an agency affiliated with the Brazilian Ministry of Health).

One of the consortium’s key innovations was to separate the part of the original praziquantel formulation that makes the drug bitter. This, according to the researchers of the study now published, requires chemical processes that increase the cost of the final product.

The Brazilian formulation is low cost, masks the bitter taste and requires a very small dose. It can also be mixed with excipients (inactive substances that complement the formulation) to make it more palatable.

Another special feature of the new formulation is that it has two phases, one of which is an oily phase based on castor oil, which allows it to be absorbed through human cell membranes. The other phase occurs when the formulation reaches the stomach and finishes emulsification.

“This is essential for more efficient absorption by the body, which allows only half the usual dose to be used,” stresses Mengarda.

In addition to its stability, which allows it to be stored at room temperature for more than a year, another advantage of the formulation is that it can be combined with other active ingredients for other worms in a single medicine.

The strategy is widely used in the veterinary pharmaceutical industry. At the request of companies in this sector, the researchers are now testing combinations for the veterinary market.

“The regulation of veterinary medicines, carried out by the Ministry of Agriculture and Livestock [MAPA], is less burdensome and bureaucratic than that for human health, carried out by the National Health Surveillance Agency [ANVISA], which is giving our formulation good prospects,” says Moraes.

At the same time, disease control in animals is desirable in a One Health context, as some cat and dog parasites can infect humans.

Therefore, although it will require clinical trials to one day become a human medicine, the innovation could indirectly benefit worm control by improving the care of pets.

The researchers are open to partnerships with public or private institutions interested in conducting clinical trials and bringing a new product to the market. The study also showed the feasibility of semi-industrial production, which will facilitate large-scale production in the future.

The work was also supported by FAPESP through a Scientific Initiation scholarship awarded to Vinicius de Castro Rodrigues, co-author of the study.

About FAPESP

The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the state of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration.

 

 

 

An ink that boosts coral reef settlement by 20 times




Cell Press

A slow-release carrier system to restore coral reefs 

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A slow-release carrier system to restore coral reefs

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Credit: Kundu et al., Trends in Biotechnology




With coral reefs in crisis due to climate change, scientists have engineered a bio-ink that could help promote coral larvae settlement and restore these underwater ecosystems before it’s too late. In a paper publishing May 14 in the Cell Press journal Trends in Biotechnology, researchers demonstrate that the ink could boost coral settlement by more than 20 times, which they hope could contribute to rebuilding coral reefs around the world. 

“When people think about a coral reef, they often think about how beautiful it is,” says author Daniel Wangpraseurt of the University of California San Diego. “What we sometimes forget is that coral reefs are one of the best structures in protecting our coasts. We are hoping to develop technologies to restore not just the ecosystem but the natural structures that will buffer shorelines against waves, storms, and floods.” 

In the past, researchers have tried to restore coral reefs—which have halved across the globe since the mid-20th century—mainly through planting nursery-grown corals. But Wangpraseurt says these lab-grown corals are genetically identical, meaning that they’re susceptible to the same threats.  

“If there’s a warming event or a disease outbreak, it can wipe out the whole population. Ideally, we want to recruit corals naturally, which can introduce genetic diversity to the population and enhance their resilience,” says Wangpraseurt. 

Biologists have recently discovered that certain rocky pink algae, called crustose coralline algae (CCA), play an important role in attracting coral larvae and encouraging them to settle on the reef. It appears that CCA emits metabolites into the surrounding water, and coral larvae follow these chemical signals. Inspired by this finding, Wangpraseurt and his team, including first author Samapti Kundu at the University of California San Diego, developed a transparent ink material infused with metabolites derived from CCA. Dubbed SNAP-X, the ink slowly releases these natural chemical cues into seawater over the course of a month. By applying SNAP-X to rocks or other surfaces, researchers can create an inviting microhabitat that helps coral larvae settle and grow. 

The team tested SNAP-X outdoors using natural seawater and continuous water flow to simulate the ocean environment. They found that the larvae of Montipora capitata, a primary reef-building coral in Hawaii, were 20 times more likely to settle on substrates sprayed with SNAP-X, and the settlements became denser when the team increased the concentration of the metabolites in SNAP-X. 

Given that some species of coral reproduce by releasing their eggs and sperm at the exact same time every year, the researchers recommend syncing SNAP-X deployment with the coral’s spawning cycle to support natural coral recruitment. Depending on the species of coral, scientists can also tweak the ingredients of SNAP-X to include different metabolites and chemical signals that support the development of coral reefs.  

The team is now working on methods to scale up the production of SNAP-X. Because the ink contains no living materials, they hope that it will soon be approved for application in the real world.  

“It’s really exciting to be able to learn from adjacent disciplines like materials science and bioengineering,” says Wangpraseurt. “I think a lot of the technologies for restoring and protecting our environment are already there, we just need to look outside the box into other fields of study.” 

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This research was supported by funding from the Defense Advanced Research Projects Agency and the UC San Diego Materials Research Science and Engineering Center.  

Trends in Biotechnology, Kundu et al., “Biomimetic chemical microhabitats enhance coral settlement.” https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(25)00126-X

Trends in Biotechnology (@TrendsinBiotech) is a multi-disciplinary Cell Press journal publishing original research and reviews on exciting developments in biotechnology, with the option to publish open access. This journal is a leading global platform for discussion of significant and transformative concepts across applied life sciences that examine bio-based solutions to real-world problems. Trends in Biotechnology provides cutting-edge research that breaks new ground and reviews that provide insights into the future direction of the field, giving the reader a novel point of view. Visit https://www.cell.com/trends/biotechnology. To receive Cell Press media alerts, contact press@cell.com.      

 

Chinese researchers reveal lipid-based communication between body and gut microbes




Chinese Academy of Sciences Headquarters
The proposed model for the novel apolipoprotein APOL9 that enhances mucosal immunity by activating the IFN-γ-MHC-II pathway through induction of OMVs release in Bacteroidales 

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The proposed model for the novel apolipoprotein APOL9 that enhances mucosal immunity by activating the IFN-γ-MHC-II pathway through induction of OMVs release in Bacteroidales.

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Credit: Image by Prof. QIAN's group




The human gut is home to trillions of microbes that not only aid in digestion but also play a key role in shaping our immune system. These microbes communicate with the body by releasing a range of molecules that influence how immune cells grow and function. 

To maintain a healthy balance between host defense and microbial coexistence, the body deploys a variety of defense tools—such as mucus, antimicrobial proteins, antibodies, and complement proteins—to control microbial activity and fend off harmful invaders. But one mystery has lingered: Can our bodies selectively recognize and manage specific bacteria among this incredibly diverse microbial community?

In a study published in Nature on May 14, a team of researchers investigated this question and uncovered a surprising new way that the body interacts with gut microbes to help maintain intestinal health. This study was led by Prof. QIAN Youcun from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences (CAS), and Prof. SONG Xinyang from the Center for Excellence in Molecular Cell Science of CAS.

The researchers began by using advanced protein analysis techniques to compare gut lining samples from germ-free mice and conventional lab mice. This comparison led to the identification of a previously less characterized protein called APOL9, which was much more abundant in regular mice with gut microbes. Further experiments showed that this protein was mainly produced by cells in the intestinal lining.

Then the researchers developed a technique called "APOL9-seq"—a method that combines flow cytometry with genetic sequencing—to identify which bacteria APOL9 binds to. Surprisingly, they found that APOL9—and its human equivalent, APOL2—binds strongly and specifically to a group of bacteria called Bacteroidales, which are common in the gut.

Digging deeper, the researchers discovered that APOL9's ability to recognize these bacteria depends on a unique fat molecule called ceramide-1-phosphate (Cer1P), which is found on the bacterial surface. When this molecule was removed using gene editing, APOL9 could no longer bind to the bacteria. This study is the first to show that the host can selectively target specific microbes by recognizing their unique lipid signatures.

Interestingly, unlike typical antimicrobial proteins that kill bacteria, APOL9 does not harm the microbes it binds to. It causes them to release tiny bubbles called outer membrane vesicles (OMVs)—nanometer-sized sacs filled with bacterial molecules. These OMVs can be taken up by the host's immune system and used to boost immune readiness. The researchers found that OMVs enhance interferon-gamma (IFN-γ) signaling and increase the amount of MHC-II molecules on intestinal cells. These latter molecules are essential for training a unique group of T cells (CD4+CD8αα+) that help maintain immune balance in the gut.

To better understand APOL9's role in immune defense, the researchers used a widely accepted mouse model to study the effects of removing the gene. When exposed to Salmonella bacteria, mice lacking APOL9 showed a weaker immune response and more widespread bacterial infection. However, when treated with OMVs derived from the bacteria, these mice displayed stronger immune activity and fewer signs of infection.

"The specific interaction between APOL9 and Cer1P highlights a finely tuned molecular 'dialogue' forged through long-term coevolution between the host and its microbiota. In the future, we plan to explore the role of human APOL2 and investigate whether modulating this pathway can strengthen the intestinal immune barrier," said Prof. QIAN, leading researcher of the study.

This study is the first to show how a host protein can specifically recognize bacterial lipids, thus triggering beneficial immune responses. It also highlights a new way the body actively shapes the gut microbiome—not just by tolerating microbes, but by communicating with them to maintain balance. The findings reveal exciting possibilities for developing next-generation treatments that work by tuning interactions between the microbiota and the immune system.