Monday, June 02, 2025

 

Rise in expectant mothers in UK with autoimmune diseases since millennium



MuM-PreDiCT project found that some conditions are on rise in pregnant women, requiring a better understanding of managing these diseases during maternity



University of Birmingham





Thousands more UK women who are having children have been diagnosed with an autoimmune condition now compared to the beginning of the millennium.

In a paper published in Lancet Rheumatology today, researchers involved in the MuM-PreDiCT project run by the University of Birmingham and funded by the Medical Research Council have found that there has been increase by 4.7% in expectant mothers beginning pregnancy with autoimmune conditions.

Analysis of electronic healthcare records (CPRD) taken from 2000-2021 found that there was a rise in conditions diagnosed pre-pregnancy in women aged 15-49 including psoriasis, coeliac disease and type 1 diabetes mellitus as well as rarer conditions such as Grave’s disease and Hashimoto thyroiditis.

Dr Megha Singh from the University of Birmingham and lead author of the study said:

“This is the first time that this kind of study has been done, showing that there is a rise in autoimmune conditions in women that are becoming pregnant. We looked at a wide range of autoimmune conditions, unlike any study previously carried out, and we know that these conditions by and large affect women and previous studies have shown that there is an increase overall in autoimmune conditions. As a result, these findings are not surprising, but are crucial for public health.

“Our project is all about understanding how to support women during pregnancy who are managing medical conditions, often co-morbidly, and this data gives us a much better idea about the scale of autoimmune conditions for expectant mums.”

Further analysis of the data for factors of deprivation, ethnicity and other factors shows that the least deprived areas saw a 10% rise in pre-pregnancy autoimmune condition diagnosis, and ethnic minority groups of women had lower incidence rates compared to white women. However, some conditions such as psoriasis were more prevalent among deprived areas and among some ethnic minority groups.

Dr Francesca Crowe, senior author, from the University of Birmingham of the paper said:

“There are likely to be a combination of factors driving the increase in autoimmune condition diagnoses before pregnancy, including different factors among groups of people. An awareness of conditions and differential access to healthcare may be involved, and it is very likely therefore that the numbers we are seeing under reports the real scale of women’s health in pregnancy.”

Prof Krish Nirantharakumar, corresponding and co-author from King’s College London said: “This important study will aid clinicians and policy makers to redefine existing care- pathways and plan future health services for pregnant women with autoimmune conditions to achieve better outcomes for mums and their babies”

 

Majority of riders and drivers in UK 'gig economy' suffer anxiety over ratings and pay, study suggests




University of Cambridge





Some two-thirds of riders and drivers for food delivery and ride-hailing apps in the UK may work in fear of “unfair feedback” and experience anxiety over sudden changes to working hours, a new survey study led by the University of Cambridge suggests.*

Three-quarters of riders and drivers in the study report anxiety over potential for income to drop, with over half (51%) saying they risk health and safety while working. Some 42% of delivery and driver gig workers say they suffer physical pain resulting from work.

Riders and drivers also report spending an average of ten hours a week waiting for jobs to come through on the app – so logged on and working but not making any money.

The findings come from the first study to provide statistical data on job quality in the UK gig economy by surveying over 500 casual workers, and are published today in the journal Work, Employment and Society.

Gig economy delivery riders and ride-hailing drivers operate as self-employed contractors who sign up for work via digital platforms that algorithmically match them with customers and pay a base rate per job, with higher rates at peak times or “surges”.  

With plenty of flexibility, but no guaranteed income or sick pay and limited rights, some argue such work is exploitative. Companies do not publish data on employees or workloads, and the casual nature of app-based employment makes research difficult.

“All manner of gig work has exploded in recent years, from delivering food to building websites. Many of us now summon people and labour at the tap of a smartphone screen without much thought, rarely considering the process or the people behind it,” said lead author Dr Alex Wood from Cambridge’s Department of Sociology. 

“Rating systems can lead to deactivation for workers. If your job is at the mercy of a quick click on a stranger’s phone, it is likely to fuel a constant hum of uncertainty and anxiety, along with feelings of being judged, monitored and replaceable.”

The researchers set out to compare gig economy experiences of “local” workers – those tied to locations e.g. food delivery riders – with those whose labour is digital, such as data entry or coding, and so can “remote” work from anywhere.   

Data was collected in 2022, when just under half a million people in the UK worked in the gig economy. Researchers listed a survey on remote work platform Upwork with a £10 fee for completion, with 253 participants.

Local workers – the riders and drivers – are harder to reach, so researchers deployed paid advertising on Facebook and Instagram to target users listing gig economy companies such as Deliveroo and Uber as their employer.

As many gig workers are recent migrants to the UK, Wood used a variety of languages, including Polish, Spanish and Bengali. A further 257 riders and drivers completed the survey.

“Attempts to investigate working conditions in the UK gig economy have been hampered by the difficulty of identifying and accessing people doing the work,” said Prof Brendan Burchell, study co-author and Cambridge sociologist. “Classifying someone as self-employed doesn’t change the fact they can be economically dependent and exploited.”

Both local and remote workers said they have tight deadlines three-quarters of the time, and scored similarly on anxieties over losing the ability to make a living on their main platform (44% of local and 38% of remote workers). While a higher proportion of riders and drivers feared unfair feedback, remote workers were not far behind.

More local workers reported anxiety over the potential for pay to fall (75% compared to 59% of remote workers), and hourly pay was 20% lower on average for riders and drivers (£8) than remote gig workers (£10). This put average pay for local gig working below the UK minimum wage in 2022.

Riders and drivers also said they spend a significant amount of unpaid time on the app waiting for work to come in – around ten hours a week on average, compared to four for remote workers.

The flexibility prized by some gig workers came through in the findings. Remote workers reported high levels of autonomy, with 86% saying they could step away during work hours for a personal issue, and 92% reporting the ability to choose their own tasks. By comparison, around two-thirds of riders and drivers said the same on both counts.

Local workers also benefit from less isolation: with under half (45%) saying they rarely or never interact with other riders or drivers, compared to 75% of remote workers.

However, job insecurity and health issues were much higher among local workers. Some 65% of riders and drivers reported anxiety over unexpected changes to working hours (compared to 40% of remote workers), and 74% reported anxiety over potential changes that reduce their say in how they do their job (also 40% for remote workers).

Health differences were even more stark. Just over half of riders and drivers said they risked physical health or safety, nearly five times higher than remote workers (51% vs 11%), and close to half of drivers reported pain from work, more than three times higher than remote workers (42% vs 13%).

“Delivery and ride-hailing platforms combine manual work with tight algorithmic management and digital surveillance, while workers have little in the way of rights or bargaining power,” added Wood.

“Platform companies call themselves tech firms, but in practice they govern, control and profit from labour they claim not to own, without bearing employer responsibility.”

Notes:
*68% of local platform workers reported fearing unfair feedback, and 65% of local platform workers reported anxiety over unexpected changes to working hours.

Case studies: ‘I can’t do this work for a long time’

In separate yet-to-be-published research, Cambridge University PhD candidate Jon White is conducting interviews with delivery drivers in Cambridge city centre to gauge ‘time squeeze’: how the gig economy’s algorithms can change perceptions of time.

The responses White is recording reflect some of Wood’s latest findings, particularly the tension between pushing to earn enough to the detriment of drivers’ health, with some working on multiple apps at the same time.

One driver spoke of the need for a solid minimum pay rate: “…when it's busy on a rainy day, at that time they pay a really good fare. But sometimes when it's not busy, so that time fare is not enough for us because we go two miles, three miles and get a really low fare. So I think if they pay minimum every day, it will be really helpful for us.”

Another driver described the pain in their body: “…especially in my thighs, all the time, ever since I started, I've never had a good sleep. Every day, I get home, just have to take a shower quickly after my body gets cold… and eat something then go to sleep because I can’t do this work for a long time.”

They say the long hours are down to low pay: “Because I have to do my... a minimum every day so, I can at least pay my bills, right? Just to survive. I still have to pay rent, food, so... If I don't do this amount, this minimum in a day, I can't go home"

Several drivers told White, from Cambridge’s Department of Geography, that the work takes a physical toll after a few days: “…when I get my rest on a Sunday, usually on Monday, it is ok to work. But when it comes to Wednesday, I already feel you know, the body got really tired, a lot of pain…”

Measles-Mumps-Rubella (MMR)

New data shows MMR vaccination rate decline across US

Vaccinations fell in most counties over last five years



Johns Hopkins University

County-level MMR vaccination rates pre-pandemic 

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County-level MMR vaccination rates pre-pandemic.

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Credit: Johns Hopkins University




A new county-level dataset from Johns Hopkins University researchers reveals a national decline in the measles-mumps-rubella (MMR) vaccination rate among U.S. children since the start of the COVID-19 pandemic.

Out of 2,066 studied counties, 1,614 counties, 78%, reported drops in vaccinations and the average county-level vaccination rate fell 93.92% pre-pandemic to 91.26% post-pandemic—an average decline of 2.67%, moving further away from the 95% herd immunity threshold to predict or limit the spread of measles.

Only four of the 33 states in studied—California, Connecticut, Maine, and New York—reported an increase in the median county-level vaccination rate.

The data is published today in JAMA.

The data is released as more than one thousand measles cases have been reported this year in the United States. With the exception of 2019, this is the most cases reported in the U.S. in a single year in over three decades, with the vast majority of cases occurring in unvaccinated children.

“This open, high resolution dataset provides a critical resource to explore and better understand the country’s vaccination landscape and its implications for the risk of measles spread,” said senior author Lauren Gardner, director of Johns Hopkins University’s Center for Systems Science and Engineering, an expert in using data and modeling to better understand the spread of disease. This work draws on her experience leading the data collection efforts behind the Johns Hopkins’ COVID-19 dashboard that was relied upon globally during the pandemic.

Gardner created Johns Hopkins’ COVID-19 dashboard that was relied upon globally to track cases during the pandemic.

The county-level vaccination data complements the state and national-level from the Centers for Disease Control and Prevention, confirming a widespread decline in MMR vaccination rates in the U.S. following the COVID-19 pandemic, while also revealing the significant heterogeneity of vaccination patterns within and across states.

The team collected county-level 2-dose MMR vaccination rates for kindergarteners from each state’s department of health website from 2017 to 2024, where available. The dataset includes at least one year of vaccination data for 2,237 counties across 38 states.

All data available for downloadhttps://github.com/CSSEGISandData/MMR_data

Authors include: Former adjunct assistant research scientist Ensheng Dong; graduate student Samee Saiyed; former research assistant Andreas Nearchou; and undergraduate student Yamato Okura, all of Johns Hopkins.

 

Synthetic compound shows promise against multidrug resistance



American Society for MicrobiologyWeChat



Highlights:

  • Infections by antimicrobial resistant (AMR) pathogens are a leading cause of death worldwide, with more than 1 million deaths annually, highlighting the need for new treatments.

  • Researchers have synthesized a new compound called infuzide that shows activity against resistant strains of pathogens.

  • Infuzide works against known, problematic gram-positive pathogens.

  • In lab and mouse tests, infuzide reduced bacterial populations, suggesting it might be useful as a new treatment for drug-resistant infections. 

Washington, D.C.—Antimicrobial resistance directly causes more than 1 million deaths every year and contributes to more than 35 million more, according to the World Health Organization. Staphylococcus aureus and Enterococcus sp., 2 gram-positive pathogens highly likely to develop resistance to known treatments, can cause dangerous hospital-acquired and community-acquired infections.

This week in Microbiology Spectrum, researchers describe a newly synthesized compound called infuzide that shows activity against antimicrobial resistant strains of S. aureus and Enterococcus in laboratory and mouse tests. In addition, the findings suggest that infuzide kills bacteria in ways that differ from other antimicrobials, which may help keep resistance at bay. 

Infuzide emerged from more than a decade of work by interdisciplinary researchers looking for ways to create compounds that could act against pathogens in ways similar to known pharmaceutical compounds. Those include hydrazones, inorganic synthesized compounds that previous studies have shown to demonstrate antibacterial activity, including against resistant strains. The researchers synthesized 17 new compounds that contained hydrazones, and among those infuzide showed activity against gram-positive S. aureus and Enterococcus.

“We started the project as a collaboration, looking for ways to synthesize compounds and connecting them with compounds that might have biological activities,” said medicinal chemist Michel Baltas, Ph.D., from the Laboratoire de Chimie de Coordination at the University of Toulouse in France. Baltas co-led the new work, along with Sidharth Chopra, Ph.D., from the CSIR-Central Drug Research Institute in Lucknow, India. 

The researchers found that infuzide specifically attacks bacterial cells. In lab tests, they compared the antimicrobial effects of infuzide against vancomycin, a powerful antibiotic representing the standard of care in treating resistant infections. They found that infuzide more quickly and effectively reduced the size of bacterial colonies than the standard drug. In tests of resistant S. aureus infections on the skin of mice, the compound effectively reduced the bacterial population. The reduction was even higher, the researchers reported, when infuzide was combined with linezolid, a synthetic antibiotic.

Infuzide did not show significant activity against gram-negative pathogens, though Baltas said the group is looking for small changes to infuzide that might expand its antimicrobial activity.

The researchers synthesized the compounds without the need of solvents, which can be expensive and environmentally hazardous. The simplicity of the chemical reactions, Baltas said, would make it easy to make large quantities to be used in new treatments. “I am sure the same reactions can scale up.” 

In addition, the group has been investigating the effects of synthesized compounds on other infectious diseases, including tuberculosis. “We have many other candidates to make antimicrobial compounds,” Baltas said.

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The American Society for Microbiology is one of the largest professional societies dedicated to the life sciences and is composed of over 37,000 scientists and health practitioners. ASM's mission is to promote and advance the microbial sciences. 

ASM advances the microbial sciences through conferences, publications, certifications, educational opportunities and advocacy efforts. It enhances laboratory capacity around the globe through training and resources. It provides a network for scientists in academia, industry and clinical settings. Additionally, ASM promotes a deeper understanding of the microbial sciences to all audiences.

 

Geological time capsule highlights Great Barrier Reef’s resilience



A combination of stressors, not sea levels alone, cause the demise of reefs




University of Sydney

Professor Jody Webster with a core extracted from beneath the Great Barrier Reef's shelf edge 

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Professor Jody Webster examines a fossil coral reef core from the Great Barrier Reef soon after it is brought on deck.  

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Credit: International Ocean Drilling Program




New research led by the University of Sydney adds to our understanding of how rapidly rising sea levels due to climate change foreshadow the end of the Great Barrier Reef as we know it.  

The findings suggest the reef can withstand rising sea levels in isolation but is vulnerable to associated environmental stressors arising from global climate change. 

Led by Professor Jody Webster from the School of Geosciences, the research was published today in Nature Communications. It draws from a geological time capsule of fossil reef cores, extracted from the seabed under the Great Barrier Reef.  

The findings suggest rapid sea level rise in isolation did not spell the end of the reef’s predecessor, Reef 4. Rather, associated environmental stressors like poor water quality and warming climates led, in combination, to its demise about 10,000 years ago (towards the end of the last ice age). 

The ensuing one to two thousand years saw Reef 4 transition. Its shallow reef ecosystem moved landward to reestablish itself as the Great Barrier Reef we know today.  

“This research shows us a healthy, active barrier reef can grow well in response to quite fast sea level rises,” said Professor Webster. “It’s the combination of additional environmental stressors, on top of rapid sea level rise, that lead to its demise. 

The findings lend weight to already grave concerns about the Great Barrier Reef. 

“The modern reef faces rising sea levels, more heat waves and extensive bleaching, along with increasing sediment and nutrient input. This combination, on top of rising sea levels, is of deep concern. If the current trajectory continues, we should be concerned about whether the Great Barrier Reef will survive the next 50 to 100 years in its current state. 

“It won’t die but its characteristics may change. We will see a different collection of coral species, perhaps simpler and not as structurally complex.” 

Learning from the ‘proto–Great Barrier Reef’  

The 15 to 20-metre cores underpinning this research comprise a mix of fossil coral, algae and sediments. They reveal how the reef’s previous incarnations responded to rapid sea level rise. The cores analysed for this research focus on how the reef ecosystem evolved between 13,000 to 10,000 years ago.   

Of particular interest to Professor Webster’s team was the period known as Meltwater pulse 1B, between 11,450 and 11,100 years ago, when sea levels rose very rapidly.   

“This 350-year period is crucial; it covers a time when global sea levels rose very rapidly,” Professor Webster said. “It’s a period when polar ice sheets are thought to have experienced accelerated melting due to warming temperatures. Based on records from Barbados, we previously thought sea levels were rising by about 40 millimetres a year at this time. 

“Our research shows the rise wasn’t so large and fast. It was more likely to have been in the order of three to five millimetres a year, comparable to what we’re experiencing today.” 

Extracted by a drilling ship from beneath the Great Barrier Reef’s shelf edge at a depth of 40 to 50 metres, the cores offered new insight into how Reef 4, also known as the proto-Great Barrier Reef, was impacted by rising sea levels.  

“Reef 4 is very exciting,” Professor Webster said. “It had a similar morphology and mix of coral reef communities to the modern Great Barrier Reef. The types of algae and corals, and their growth rates, are comparable. 

“Understanding the environmental changes that influenced it, and led to its ultimate demise, therefore offers clues on what might happen to the modern reef.” 

Professor Webster and colleagues used radiometric dating and reef habitat information to accurately pinpoint core samples pertaining to Meltwater pulse 1B.  

The cores underpinning this research were obtained under the International Ocean Discovery Program International Ocean Drilling Program (IODP), an international marine research collaboration involving 21 nations.  

Professor Webster said his latest research highlights the importance of IODP and shows the value of these records, obtained by drilling deep beneath the seabed. They provide paleoclimate and paleoenvironmental data, going far further back in time than instrumental records which go back only 50 to 100 years.  

“These data allow us to more precisely understand how reef and coastal ecosystems have responded to rapid environmental changes, like the rises in sea level and temperature we face today.” 

Professor Webster completed this research in collaboration with colleagues from the University of Tokyo, Australian National University, Nagoya University, the University of Granada and Aix-Marseille University. 

Computer simulation of the core being extracted from beneath the Great Barrier Reef's shelf edge (VIDEO)