Friday, June 13, 2025

 

How the brain solves complicated problems



Study shows humans flexibly deploy different reasoning strategies to tackle challenging mental tasks — offering insights for building machines that think more like us



Massachusetts Institute of Technology




CAMBRIDGE, MA -- The human brain is very good at solving complicated problems. One reason for that is that humans can break problems apart into manageable subtasks that are easy to solve one at a time.

This allows us to complete a daily task like going out for coffee by breaking it into steps: getting out of our office building, navigating to the coffee shop, and once there, obtaining the coffee. This strategy helps us to handle obstacles easily. For example, if the elevator is broken, we can revise how we get out of the building without changing the other steps.

While there is a great deal of behavioral evidence demonstrating humans’ skill at these complicated tasks, it has been difficult to devise experimental scenarios that allow precise characterization of the computational strategies we use to solve problems.

In a new study, MIT researchers have successfully modeled how people deploy different decision-making strategies to solve a complicated task — in this case, predicting how a ball will travel through a maze when the ball is hidden from view. The human brain cannot perform this task perfectly because it is impossible to track all of the possible trajectories in parallel, but the researchers found that people can perform reasonably well by flexibly adopting two strategies known as hierarchical reasoning and counterfactual reasoning.

The researchers were also able to determine the circumstances under which people choose each of those strategies.

“What humans are capable of doing is to break down the maze into subsections, and then solve each step using relatively simple algorithms. Effectively, when we don’t have the means to solve a complex problem, we manage by using simpler heuristics that get the job done,” says Mehrdad Jazayeri, a professor of brain and cognitive sciences, a member of MIT’s McGovern Institute for Brain Research, an investigator at the Howard Hughes Medical Institute, and the senior author of the study.

Mahdi Ramadan PhD ’24 and graduate student Cheng Tang are the lead authors of the paper, which appears today in Nature Human Behavior. Nicholas Watters PhD ’25 is also a co-author.

Rational strategies

When humans perform simple tasks that have a clear correct answer, such as categorizing objects, they perform extremely well. When tasks become more complex, such as planning a trip to your favorite cafe, there may no longer be one clearly superior answer. And, at each step, there are many things that could go wrong. In these cases, humans are very good at working out a solution that will get the task done, even though it may not be the optimal solution.

Those solutions often involve problem-solving shortcuts, or heuristics. Two prominent heuristics humans commonly rely on are hierarchical and counterfactual reasoning. Hierarchical reasoning is the process of breaking down a problem into layers, starting from the general and proceeding toward specifics. Counterfactual reasoning involves imagining what would have happened if you had made a different choice. While these strategies are well-known, scientists don’t know much about how the brain decides which one to use in a given situation.

“This is really a big question in cognitive science: How do we problem-solve in a suboptimal way, by coming up with clever heuristics that we chain together in a way that ends up getting us closer and closer until we solve the problem?” Jazayeri says.

To overcome this, Jazayeri and his colleagues devised a task that is just complex enough to require these strategies, yet simple enough that the outcomes and the calculations that go into them can be measured.

The task requires participants to predict the path of a ball as it moves through four possible trajectories in a maze. Once the ball enters the maze, people cannot see which path it travels. At two junctions in the maze, they hear an auditory cue when the ball reaches that point. Predicting the ball’s path is a task that is impossible for humans to solve with perfect accuracy.

“It requires four parallel simulations in your mind, and no human can do that. It’s analogous to having four conversations at a time,” Jazayeri says. “The task allows us to tap into this set of algorithms that the humans use, because you just can’t solve it optimally.”

The researchers recruited about 150 human volunteers to participate in the study. Before each subject began the ball-tracking task, the researchers evaluated how accurately they could estimate timespans of several hundred milliseconds, about the length of time it takes the ball to travel along one arm of the maze.

For each participant, the researchers created computational models that could predict the patterns of errors that would be seen for that participant (based on their timing skill) if they were running parallel simulations, using hierarchical reasoning alone, counterfactual reasoning alone, or combinations of the two reasoning strategies.

The researchers compared the subjects’ performance with the models’ predictions and found that for every subject, their performance was most closely associated with a model that used hierarchical reasoning but sometimes switched to counterfactual reasoning.

That suggests that instead of tracking all the possible paths that the ball could take, people broke up the task. First, they picked the direction (left or right), in which they thought the ball turned at the first junction, and continued to track the ball as it headed for the next turn. If the timing of the next sound they heard wasn’t compatible with the path they had chosen, they would go back and revise their first prediction — but only some of the time.

Switching back to the other side, which represents a shift to counterfactual reasoning, requires people to review their memory of the tones that they heard. However, it turns out that these memories are not always reliable, and the researchers found that people decided whether to go back or not based on how good they believed their memory to be.

“People rely on counterfactuals to the degree that it’s helpful,” Jazayeri says. “People who take a big performance loss when they do counterfactuals avoid doing them. But if you are someone who’s really good at retrieving information from the recent past, you may go back to the other side.”

Human limitations

To further validate their results, the researchers created a machine-learning neural network and trained it to complete the task. A machine-learning model trained on this task will track the ball’s path accurately and make the correct prediction every time, unless the researchers impose limitations on its performance.

When the researchers added cognitive limitations similar to those faced by humans, they found that the model altered its strategies. When they eliminated the model’s ability to follow all possible trajectories, it began to employ hierarchical and counterfactual strategies like humans do. If the researchers reduced the model’s memory recall ability, it began to switch to hierarchical only if it thought its recall would be good enough to get the right answer — just as humans do.

“What we found is that networks mimic human behavior when we impose on them those computational constraints that we found in human behavior,” Jazayeri says. “This is really saying that humans are acting rationally under the constraints that they have to function under.”

By slightly varying the amount of memory impairment programmed into the models, the researchers also saw hints that the switching of strategies appears to happen gradually, rather than at a distinct cut-off point. They are now performing further studies to try to determine what is happening in the brain as these shifts in strategy occur.

###

The research was funded by a Lisa K. Yang ICoN Fellowship, a Friends of the McGovern Institute Student Fellowship, a National Science Foundation Graduate Research Fellowship, the Simons Foundation, the Howard Hughes Medical Institute, and the McGovern Institute.

From plastic waste to clean hydrogen: A scalable solar-powered solution



Korean researchers develop eco-friendly technology to turn plastic into hydrogen using sunlight




Institute for Basic Science

Figure 1. Turning Plastic Waste into Clean Hydrogen with Sunlight 

image: 

This illustration shows how a newly developed floatable nanocomposite system produces hydrogen gas by using sunlight to break down everyday plastic waste. The sponge-like material floats on water and absorbs sunlight while converting discarded PET bottles and PLA cups into useful byproducts like ethylene glycol, terephthalic acid, and lactic acid. At the same time, it releases clean hydrogen gas into the air. This simple yet powerful process demonstrates a sustainable and scalable way to upcycle plastic waste into renewable energy using only natural sunlight and water.

view more 

Credit: Institute for Basic Science






A team of Korean scientists has developed an innovative green technology that transforms plastic waste into clean hydrogen fuel using only sunlight and water.

Researchers at the Institute for Basic Science (IBS) Center for Nanoparticle Research, led by Professor KIM Dae-Hyeong and Professor HYEON Taeghwan of Seoul National University, announced the successful development of a photocatalytic system that produces hydrogen from PET bottles. The key innovation lies in wrapping the photocatalyst in a hydrogel polymer, which helps it float on water and stay active even under harsh environmental conditions.

Hydrogen is gaining attention as a next generation clean energy source. However, the most common method for producing it—methane steam reforming—consumes large amounts of energy and releases significant greenhouse gas emissions. Photocatalytic hydrogen production, which relies on sunlight, is a cleaner alternative but faces challenges in maintaining stability under strong light and chemical stress.

To overcome these limitations, the IBS research team introduced a strategy that stabilizes the catalyst within a polymer network while placing the reaction site at the interface between air and water. This setup allows the system to avoid common problems such as catalyst loss, poor gas separation, and reverse reactions. The system breaks down plastics like PET into useful byproducts such as ethylene glycol and terephthalic acid, while releasing clean hydrogen into the air.

“The key was engineering a structure that works not only in theory but also under practical outdoor conditions,” explained Dr. LEE Wanghee, a postdoctoral researcher at MIT and co-first author of the study. “Every detail — from material design to the water-air interface — had to be optimized for real-life usability.”

The researchers demonstrated that their system remained stable for over two months, even in highly alkaline conditions. The floatable catalyst system also works in diverse real-world water environments, including seawater and tap water.

In tests using a one-square-meter device placed outdoors under natural sunlight, the system successfully produced hydrogen from dissolved PET bottle waste. Additional economic and scale-up simulations showed that the technology can be expanded to 10 or even 100 square meters, offering a pathway toward cost-effective, carbon-free hydrogen production.

“This research opens a new path where plastic waste becomes a valuable energy source,” said Professor KIM Dae-Hyeong. “It’s a meaningful step that tackles both environmental pollution and clean energy demand.”

Professor HYEON Taeghwan added, “This work is a rare example of a photocatalytic system that functions reliably in the real world — not just the lab. It could become a key stepping stone toward a hydrogen-powered, carbon-neutral society.”

 

KAIST succeeds in real-time carbon dioxide monitoring without batteries or external power​




The Korea Advanced Institute of Science and Technology (KAIST)
Photo 1 

image: 

Photo 1. (From left) Master's Student Gyurim Jang, Professor Kyeongha Kwon

view more 

Credit: The Kwon Research Group





KAIST (President Kwang Hyung Lee) announced on June 9th that a research team led by Professor Kyeongha Kwon from the School of Electrical Engineering, in a joint study with Professor Hanjun Ryu's team at Chung-Ang University, has developed a self-powered wireless carbon dioxide (CO2) monitoring system. This innovative system harvests fine vibrational energy from its surroundings to periodically measure CO2 concentrations.

 

This breakthrough addresses a critical need in environmental monitoring: accurately understanding "how much" CO2 is being emitted to combat climate change and global warming. While CO2 monitoring technology is key to this, existing systems largely rely on batteries or wired power system, imposing limitations on installation and maintenance. The KAIST team tackled this by creating a self-powered wireless system that operates without external power.

 

The core of this new system is an "Inertia-driven Triboelectric Nanogenerator (TENG)" that converts vibrations (with amplitudes ranging from 20-4000 ㎛ and frequencies from 0-300 Hz) generated by industrial equipment or pipelines into electricity. This enables periodic CO2 concentration measurements and wireless transmission without the need for batteries.

 

 

< Figure 1. Concept and configuration of self-powered wireless CO2 monitoring system using fine vibration harvesting (a) System block diagram (b) Photo of fabricated system prototype >

 

The research team successfully amplified fine vibrations and induced resonance by combining spring-attached 4-stack TENGs. They achieved stable power production of 0.5 mW under conditions of 13 Hz and 0.56 g acceleration. The generated power was then used to operate a CO2 sensor and a Bluetooth Low Energy (BLE) system-on-a-chip (SoC).

 

Professor Kyeongha Kwon emphasized, "For efficient environmental monitoring, a system that can operate continuously without power limitations is essential." She explained, "In this research, we implemented a self-powered system that can periodically measure and wirelessly transmit CO2 concentrations based on the energy generated from an inertia-driven TENG." She added, "This technology can serve as a foundational technology for future self-powered environmental monitoring platforms integrating various sensors."

 

 

< Figure 2. TENG energy harvesting-based wireless CO2 sensing system operation results (c) Experimental setup (d) Measured CO2 concentration results powered by TENG and conventional DC power source >

 

This research was published on June 1st in the internationally renowned academic journal `Nano Energy (IF 16.8)`. Gyurim Jang, a master's student at KAIST, and Daniel Manaye Tiruneh, a master's student at Chung-Ang University, are the co-first authors of the paper.
*Paper Title: Highly compact inertia-driven triboelectric nanogenerator for self-powered wireless CO2 monitoring via fine-vibration harvesting
*DOI: 10.1016/j.nanoen.2025.110872

This research was supported by the Saudi Aramco-KAIST CO2 Management Center.


  

Figure 1. Concept and configuration of self-powered wireless CO2 monitoring system using fine vibration harvesting (a) System block diagram (b) Photo of fabricated system prototype

Figure 2. TENG energy harvesting-based wireless CO2 sensing system operation results (c) Experimental setup (d) Measured CO2 concentration results powered by TENG and conventional DC power source

Credit

Authors: Daniel Manaye Tiruneh et al.

 

Norms lead young people to consent to sex despite uncertainty 




University of Gothenburg





In theory, young people describe sexual consent as something obvious, based on trust, respect, and mutual understanding. But when they share their own experiences, a more complex picture emerges. They admit sometimes having sex even when they do not truly want to. 

“It can be about not wanting to disappoint someone, wanting to be kind, or living up to expectations. Saying yes sometimes feels easier than saying no,” says Kristin Blom, PhD student in Social Work at the University of Gothenburg. 

Consent Shaped by Gender Norms 
The thesis explores how young people are influenced by societal norms around gender and sexuality. Young men describe pressure to be respectful and egalitarian, while also feeling the need to impress peers with sexual experiences. 

Young women, on the other hand, often feel compelled to be attractive and accommodating, making it harder to say no for fear of being perceived as boring or difficult. 

“This affects the choices young people make in sexual situations. Consent is sometimes given to fit into a role, not because they truly want to. Norms can make it difficult to navigate these situations and give consent on one’s own terms, especially when young and inexperienced,” says Kristin Blom. 

A Gap Between Ideals and Practice 
While young people hold a clear ideal of how consent should work, safe, mutual, and ongoing, real-life communication is often more subtle and context-dependent. Consent may be expressed verbally, non-verbally, or even silently. 

“It’s not always clear what you or the other person wants. In theory, consent should be given and received before and during every sexual act, with the freedom to change your mind. But in practice, it’s not always a clear verbal question and answer,”  Kristin Blom explains. 

A Societal Issue That Requires Dialogue 
The research began in the wake of the #MeToo movement and the introduction of Sweden’s consent law. Blom emphasizes the importance of open conversations about sex and consent, especially in schools, youth clinics, and among adults. 

“Sex education in schools and the work of youth clinics are especially important in helping young people reflect on and articulate their experiences,” she says. 

Both the thesis and a recent report from the Swedish Schools Inspectorate show that young people themselves want more education and dialogue about sex, consent, and relationships. 

“It’s important to talk about how consent isn’t always simple. That makes it easier to understand your own desires—and to challenge narrow ideals,” says Kristin Blom. 

More information:

  • The thesis is based on 31 qualitative interviews with 19 young people, from different parts of Sweden, aged 16–21, conducted between 2020 and 2022. The study focuses on how young people talk about and understand sexual consent in relation to gender, power, and societal norms. 
  • The thesis is written in Swedish, but has an abstract in English: https://hdl.handle.net/2077/85401

 

Mental health interventions proved most effective at workplace health promotion, but more information on their long-term effects is needed





University of Eastern Finland





Workplaces implement various interventions aimed at promoting employee health, including those targeting dietary habits, physical activity, education, stress management, mindfulness and environmental modifications to promote movement. Published in The Lancet Public Health, a recent review concludes that in workplace health promotion, the most consistent impacts are achieved through mental health and stress management interventions, such as group-based mindfulness training.

E-health interventions conducted via the internet or over the mobile phone can be used to reduce mental health symptoms and stress; however, in weight management, multicomponent interventions yielded the best impacts. For instance, movement-promoting modifications of the work environment were somewhat effective at reducing sedentary behaviour during the workday.

“However, based on the studies included in this review, it should be noted that on average, the effects were minor, and there is little information on how long they persisted in participants' daily lives after the intervention. Only the effectiveness of mindfulness interventions appeared to be strong on average,” Professor Marianna Virtanen of the University of Eastern Finland notes.


Longer follow-up times could provide information on long-term effects

The review analysed the results of a total of 88 meta-analyses published in 2011–2024, reporting a total of 339 interventions. Of these interventions, 36 percent were targeted at mental health promotion and stress reduction, 25 percent addressed weight management or cardiovascular health, 22 percent addressed health-related behaviours, and 17 percent were targeted at musculoskeletal disorders.

 “We evaluated the quality of the intervention studies and found that only 21 percent could be considered of even moderate quality, whereas the rest of them were poorer than that. Our review results are based on these 21 percent. The research designs and implementation processes of interventions should be improved, and follow-up periods extended to obtain more accurate and reliable information on their effectiveness and long-term impact.”

Workplaces are essential for health promotion, as they offer a setting for reaching the working-age population. According to Virtanen, intervention studies provide robust evidence for effectiveness.

“Meta-analyses, in turn, bring together existing intervention research and therefore, they provide stronger and more reliable evidence.”

From a public health perspective, the lack of high-quality studies and long-term follow-up, as well as the fragmentation of existing evidence, currently prevent fully reliable conclusions about the significance and overall effectiveness of workplace health interventions.

POLYCRISIS

Global action urgently needed to tackle antimicrobial resistance, experts warn




King's College London





Researchers from King’s College London have called for urgent changes to the way new antibiotics are developed to address the growing problem of antimicrobial resistance (AMR).

In a new review published in npj Antimicrobials and Resistance, the authors outline the scientific, economic, and regulatory barriers that are slowing progress in the fight against highly resistant bacterial infections.

AMR is a growing global health crisis, already linked to nearly 5 million deaths each year. Without effective action, this number could rise to 10 million annually by 2050. Some of the most concerning threats come from Gram-negative bacteria. These include the bacteria Klebsiella pneumoniae, which can cause deadly bloodstream infections from simple medical procedures in hospitals, and Acinetobacter baumannii, which can lead to ventilator-associated pneumonia.

Despite this, very few new antibiotics have reached the market in the past two decades. The need is clear, but the development process remains extremely difficult.

One major challenge is economic. Antibiotics are usually used for short periods and are often used only when necessary to slow the development of resistance. This means they generate much less revenue than drugs for chronic diseases like cancer, which are used over longer timeframes and are more profitable. As a result, many of the world’s largest pharmaceutical companies, such as AstraZeneca, Johnson & Johnson and Pfizer, have withdrawn from antibiotic research.

The authors argue that new models are needed to make antibiotic development more attractive to industry. They highlight the importance of separating profits from the volume of antibiotics sold. A mix of incentives could help: push incentives like research grants and tax breaks to support early-stage research, and pull incentives like market entry rewards or subscription payments to support successful products.

The review highlights the UK’s Antimicrobial Product Subscription Model as a positive example. Launched in 2022, it pays companies a fixed annual fee for access to new antibiotics, regardless of how much is used. The proposed PASTEUR Act in the US follows a similar approach.

Regulatory hurdles are another key barrier. Clinical trials for antibiotics are often large, complex, and expensive, with difficulties in recruiting suitable patients. Different standards across countries also make the process more complicated. The authors call for better global coordination and clearer guidance on trial design and evaluation, to make approval processes more efficient and predictable.

There are several scientific challenges in developing new antibiotics for Gram-negative bacteria. These include overcoming their tough, protective outer membrane, which prevents many drugs from entering. Additionally, these bacteria have resistance mechanisms such as efflux pumps that expel antibiotics and enzymes that break them down. Another major challenge is identifying new drug targets and effective compounds capable of killing these highly resistant organisms.

The review emphasises the need to combine different areas of expertise to revitalise antibiotic discovery. New scientific approaches include using artificial intelligence to identify promising molecules, exploring under-studied environments such as the deep sea, and examining rare microbiomes. Non-traditional approaches such as phage therapy are also being explored, though they bring their own challenges.

Lead author, Miraz Rahman, Professor of Medicinal Chemistry and Antimicrobial Research Theme Group Lead at King’s College London, said:

“Reviving the antibiotic pipeline will require cooperation across academia, industry, policy, and global health systems. We need not only innovative science but also a supportive economic and regulatory environment to bring new antibiotics to patients.”

The review is a call to action to scientists, drug developers, governments, and all other stakeholders with influence over the antibiotic development pipeline. It describes the present challenging landscape and presents a practical path forward that urges stakeholders to work together to safeguard the future of modern medicine.