Wednesday, June 18, 2025

 

The genomic organization of ant superorganisms





Center for Evolutionary & Organismal Biology at Zhejiang University
Similarity between cell differentiation in multicellular organisms and caste differentiation in ants 

image: 

Similarity between cell differentiation in multicellular organisms and caste differentiation in ants. (Credit: Yuanhui Cai and Guo Ding)

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Credit: Yuanhui Cai and Guo Ding





Aristotle praised the political organization of ant colonies while ancient Chinese Daoists appreciated ants as illustrative symbols showing how ephemeral human ambitions and power are. Throughout historical and pre-historic times, ant-workers are likely to be the first insects that toddlers relate to when they crawl around on all four.

Similar to so much else in biology, the first scientific understanding of ants goes back to Darwin, who spent many pages of the Origin of Species (1859) on these conspicuous social insects. Their very existence seemed to fly in the face of his theory of naturally selected adaptation -- how could ant workers have become so different from ant queens and ant males, he wondered, when workers are sterile and ‘cannot propagate their kind’?

Darwin hypothetically solved the enigma by assuming that natural selection had produced ant workers by increasing the reproductive success of their lifetime committed monogamous parents. Reproductive division of labor then becomes a logical corollary: ant males only provide sperm, the queens store that sperm for life allowing them to fertilize eggs for as long as two decades, and ant workers forage, nurse and defend brood, and die early.

Since the 1960s, we know that Darwin’s hypothesis is correct as it follows directly from the kin-selection idea that brothers and sisters are as effective in passing on gene copies to future generations as offspring are. A higher ergonomic efficiency of rearing siblings could thus gradually modify ant genomes to encode queen and workers castes in parallel, similar to how the genomes in a fertilized egg encode the differentiated cell-lineages of a multicellular body.

But how such complete rewiring of genomes into parallel developmental trajectories for reproductives and workers could happen was anybody’s guess. A new study, initiated 9 years ago at the Section for Ecology and Evolution in the Copenhagen Department of Biology, now provides an entire array of answers to this fundamental question – published in the journal Cell – biology’s most influential international journal in terms of impact factor.

Comparing more than 130 high-quality genomes from ants around the world shows that very little of ant genomic organization makes sense except to illuminate the origin and secondary elaboration of queen and worker castes. After the ants originated in the late Jurassic, the international consortium identified many signatures of natural selection affecting ant genomes while connecting them to increases in colony size, queen-worker size difference and further differentiation of the worker caste itself, including the emergence of sterile soldiers.

Once the ancestral ant genome had become evolutionary stable in the early Cretaceous, their genes were reshuffled to a degree not known from any other animals. As it turned out, the extent to which this happened predicted a good part of how many species the various ant subfamilies managed to evolve. At the same time, smaller clusters of linked genes that mediate reproductive division of labor between queens and workers tended to stay together for more than 100 million years, explaining many details of how the ants diversified.

The new Cell paper saw the light by an unusually fruitful collaboration between Professors Guojie Zhang and Jacobus (Koos) Boomsma, colleagues at the Copenhagen Section for Ecology and Evolution for almost a decade until Guojie Zhang returned to China to start the Center for Evolutionary & Organismal Biology at Zhejiang University in Hangzhou. Both were among the global pioneers of ant genome sequencing in 2010-11, using technology that was cutting edge then, but allowed little more than obtaining fragmented genomes of single ant species at the time.

To realize fundamental innovation of social insect genomics, Professors Zhang and Boomsma started GAGA - the Global Ant Genomics Alliance https://db.cngb.org/antbase/project, in 2016 to use long-read sequencing technology and new generations of bioinformatic analysis while asking global collaborators to collect ant samples, which ultimately produced this new milestone publication.

Contact:

China : Prof. Guojie Zhang at Zhejiang University guojiezhang@zju.edu.cn, Associate Professor Weiwei Liu at Kunming Institute of Zoology, liuweiwei@mail.kiz.ac.cn

Denmark : Prof. Jacobus (Koos) J. Boomsma at University of Copenhagen  jjboomsma@bio.ku.dk

German: Associate Professor Lukas Schrader at University of Münster lukas.schrader@uni-muenster.de

CARNIVORE STUDIES

Feeding smarter: mannanase improves broiler growth even with less soy and energy



Maximum Academic Press



Researchers tested the enzyme’s effectiveness in a 3×2 factorial experiment, combining different SBM concentrations and mannanase doses under low-energy conditions. The findings show that mannanase improved feed conversion ratios, reduced gut inflammation, and enhanced microbial balance, especially in diets containing 17.83% or more SBM.

Soybean meal (SBM) is a primary protein source in poultry diets, but it contains anti-nutritional factors—particularly mannans—that hinder digestion and stimulate immune responses, leading to energy loss. Mannanase, an enzyme that breaks down β-1,4-mannosidic bonds in mannans, can reduce intestinal viscosity and enhance nutrient absorption. While mannanase has shown individual benefits, its interaction with varying SBM levels had not been thoroughly studied. Given that reducing metabolizable energy by just 50 kcal/kg can impair broiler growth and gut integrity, this study sought to determine whether mannanase could mitigate those negative effects—especially in diets with partial or minimal SBM content.

A study (DOI: 10.48130/animadv-0025-0009) published in Animal Advances on 07 May 2025 by Yuming Guo’s team, China Agricultural University, points to a promising nutritional strategy for poultry producers facing cost pressures or feed ingredient limitations.

To evaluate the impact of mannanase supplementation under varying soybean meal (SBM) levels in energy-restricted broiler diets, researchers conducted a controlled 3×2 factorial experiment using Arbor Acres broilers. Diets were formulated with three SBM inclusion rates (35.66%, 17.83%, and 8.92%) and two mannanase levels (0 or 100 mg/kg), all under a metabolizable energy deficit of 50 kcal/kg. Growth performance, nutrient digestibility, energy metabolism, intestinal health, gene expression, and microbiota composition were comprehensively assessed.

The results revealed a significant interaction between mannanase and SBM content. Mannanase supplementation improved growth performance metrics such as body weight and feed conversion ratio (FCR), particularly in the 35.66% and 17.83% SBM groups. Respiratory metabolism assessments showed reduced oxygen consumption and carbon dioxide output, increased nitrogen retention, and decreased nitrogen excretion with mannanase addition. Energy metabolism was enhanced as evidenced by higher retained energy (RE), net energy (NE) values, and improved protein energy utilization, especially when SBM was maintained at 35.66%. Nutrient digestibility also benefited from mannanase, with increased apparent total tract digestibility (ATTD) of crude protein and key amino acids. Intestinal health improvements included reduced jejunal chyme viscosity, enhanced villus height and tight junction gene expression (e.g., Claudin-1, Occludin), and decreased serum markers of barrier dysfunction (D-LA, DAO, ET).  Mannanase also suppressed inflammatory gene expression (IL-1β, IL-6, NF-κB) and improved anti-inflammatory profiles in the ileum. Microbial analysis showed a reduction in Escherichia coli and pathogenic genera, along with functional shifts in microbial metabolism, such as increased 2-oxocarboxylic acid pathways. These benefits, however, diminished when SBM content fell to 8.92%, suggesting a threshold for mannanase efficacy dependent on substrate availability.

These findings have important implications for poultry production systems seeking to reduce costs or soybean dependence without sacrificing performance. Mannanase supplementation enables better nutrient utilization, compensates for lower energy inputs, and supports gut health—key factors for efficient broiler growth. Feed formulators may strategically include mannanase in diets with moderate soybean meal levels (≥17.83%) to maintain performance metrics while managing ingredient variability or cost pressures. This enzyme-based strategy could reduce reliance on high-energy inputs and improve environmental sustainability by enhancing feed conversion efficiency.

###

References

DOI

10.48130/animadv-0025-0009

Original Source URL

https://doi.org/10.48130/animadv-0025-0009

Funding information

This work was supported by Shenyang Governmental Science and Technology Program (Project No. 22-316-2-02) and China Agriculture Research System Program (Project No. CARS-41-G04).

About Animal Advances

Animal Advances is an open-access journal which published by Maximum Academic Press in partnership with Nanjing Agricultural University. The journal is dedicated to delivering cutting-edge discoveries and progress in animal sciences to a diverse audience, encompassing scholars, academicians, and practitioners in the industry.

 

Sports arenas — the importance of politics, fan response and public money




The Boston Bruins’ failed move to New Hampshire in the early 1980s may hold lessons for other cities




Penn State





UNIVERSITY PARK, Pa. — Since World War II, professional baseball, football, basketball and hockey teams in the United States have commonly used public money to help build new venues or to facilitate teams moving to a new city. Onlookers sometimes speculate about why tax dollars are being used to build a stadium for a team that is privately owned, often by billionaires. Questions about the appropriateness of public funding have swirled in public discourse for decades.

Politicians and residents who support tax funding for sports-venue projects often point to the culturally unifying nature of sports teams and the revenue generated for surrounding businesses by events at these venues. Sports teams possess a lot of leverage in negotiating deals for stadiums because there are often more cities that want teams than there are teams. Still, history demonstrates that residents and politicians hold significant power and can fundamentally alter these deals — even without contributing public funds, according to Aaron Bonsu, doctoral candidate in kinesiology at Penn State.

Bonsu, who studies the history of stadium projects and their impact on cities and states, published an article in The International Journal of the History of Sport detailing a failed plan for the Boston Bruins to build a new arena in Salem, New Hampshire, an area considered an outer suburb of Boston.

In 1981, the owners of the Boston Bruins planned to move the National Hockey League (NHL) team from its home at the Boston Garden in Boston, Massachusetts, to a new facility in Salem, New Hampshire, where the team was going to receive a $5 million annual tax break to build a new arena. A coalition of national, state and local politicians along with concerned citizens in Massachusetts and New Hampshire were able to prevent the move, and the Bruins remain in downtown Boston to this day.

In this Q&A, Bonsu spoke about how this move was prevented and what this example can mean for other cities in the United States.

Q: Why should people care about a failed arena project from more than 40 years ago?

Bonsu: Questions of where sports venues go and who pays for them have been consistently relevant for decades in America’s big four sports — the NHL, Major League Baseball (MLB), the National Basketball Association (NBA) and the National Football League (NFL).

Stadium deals are always complicated. They are influenced by national, state and local politics, as well as by each city’s sense of how professional sports reflect its status as a nationally influential city. On top of that, the way that different groups — as examples, local and state governments or politicians and local residents — support or undermine one another can also have significant bearing on how these deals are negotiated.

My doctoral adviser Michelle Sikes, associate professor of kinesiology and of African studies at Penn State, was very supportive when I wanted to investigate the history of sports arenas in Boston because this story illustrates how communities can influence sports-venue projects.

Q: How does the Bruins story illustrate the potential for a city to influence a stadium deal?

Bonsu: In the early 1980s, many local Bostonians were upset about the prospect of the team moving to the suburbs. The most important factor in Boston’s retention of the Bruins downtown without spending public money was the formation of coalitions that all pushed back against the proposed relocation. United States Senator Paul Tsongas led a group of Massachusetts-affiliated leaders to challenge the Bruins’ potential move. Meanwhile, community groups and local politicians in both New Hampshire and Boston who opposed the move, wrote opinion pieces for local newspapers and otherwise kept up pressure to keep the Bruins in Boston.

When the Bruins did eventually build a new arena in the 1990s, it was constructed next to the former site and paid for by team owners without any taxpayer funding. The actions and circumstances in Boston exemplify the nuances of local loyalties and investments that drive the outcome of stadium deals across the nation.

In other places, different factions compete rather than cooperate. For example, a suburban community often competes with their metropolitan area to house a team’s arena. If there is one takeaway lesson from Boston, it is that everyone needs to work towards a common goal if a city wants to maintain leverage in its negotiations with a team over a new arena.

Q: Sports teams want tax funding for venue projects to save money. Why do politicians and taxpayers frequently support these projects?

Bonsu: Since the 1960s, many politicians have echoed the rhetoric of sports teams, saying things like, “Without this new stadium, our city will become a second-tier city on the national stage.” And the presence of a major sports franchise does affect the national perception of a city.

Sports teams are an important component of people’s bond and identification with a location. Sports teams are often referred to as their city. If someone said, “Pittsburgh is playing Baltimore this Sunday” in the fall, many people would understand the reference to an NFL game between the Steelers and Ravens. By serving as proxies for their cities, the sports teams advertise the city where they reside.

So, teams can affect the national profile of a city, as well as build a local sense of identity for resident sports fans. For these reasons and others, many politicians believe that their constituents will vote them out if they do not work to retain a local franchise.

Q: When is a new stadium a bad deal for taxpayers?

Bonsu: Research has shown that new stadiums provide minimal gains and can even harm the local economy if public money is pumped into the project without careful consideration of return on investment.

New stadiums can cost billions of dollars. Any time sports teams want a new venue, they provide estimates of revenue generation for local businesses. Understandably, these projections typically suggest that the stadium will be an economic boon, but the truth is often more nuanced. Researchers highlight that patrons may spend less elsewhere in town in order to buy tickets for a game at a new stadium. A new sports venue often comes with financial trade-offs for communities.

The accuracy of these economic analyses matters because cost overruns are common on stadium projects. Taxpayers are sometimes left holding the unexpected bill when a stadium project has public funding.

Taxpayers can even end up paying money for stadiums that already exist. The city of St. Petersburg, Florida, for example, is expected to pay $22.5 million to repair hurricane damage to Tropicana Field, where MLB’s Tampa Bay Rays play.

When costs spiral beyond initial estimates or when revenue projections are not met, taxpayers do not receive the promised return on their investment.

Boston is seen as something of an aspirational model because little to no public money was used in the construction of the venues for the Patriots, the Red Sox, the Bruins or the Celtics. Any city that can keep a sports team in town — with all the cultural and economic benefits a team contributes to a city — without spending taxpayer money is getting a very good deal for its residents.

Q: What typically triggers the relocation of sports teams?

Bonsu: Team moves are often tied to larger economic and demographic trends along with aspirations for a new venue.

Recently, the MLB’s Athletics and NFL’s Raiders announced their departures from Oakland, California, for Las Vegas, Nevada, which grew from 1.4 million residents in 2000 to over 2 million in 2022. In Oakland, both franchises shared a metropolitan area, and therefore attention, with other teams, MLB’s Giants and NFL’s 49ers. In Las Vegas, the Raiders and Athletics solely control major league football and baseball in the city. Both franchises also expressed a desire for a new stadium in Oakland.

The team owners' decisions to relocate were a reflection of trends and circumstances, not the cause of those circumstances.  

Q: What can cities do to protect themselves against the potential loss of a team? 

Bonsu: Historically, there are two prominent options: A city can move aggressively to retain a team if that is realistic, or it can work to build a strong identity beyond sports.  

Boston fought hard against the proposed Bruins move. When the Bruins move was proposed, the team owners asked the New Hampshire legislature to pass a law forfeiting $5 million in tax revenues from the proposed arena. The legislature considered this because arena supporters thought the venue would generate more tax revenue and additional business for the community.

In an effort to thwart the move, politicians in Massachusetts proposed the construction of an arena in downtown Boston that was not slated to host either the Bruins or Celtics. Instead, it was proposed to host concerts and other events — the kind of events that keep sports venues occupied and make them profitable to operate even when sports are not in season.

The threat of the downtown Boston arena made the $5 million tax break look like it would not pay off for New Hampshire, and their legislature rejected the venue plan, effectively dooming the proposed move. Once the move to New Hampshire was abandoned, the proposed arena in Boston was also abandoned. Eventually, the team owners funded a new arena in Boston.

Los Angeles, on the other hand, relies on other aspects of its identity beyond sports. Over the last few decades, Los Angeles has gone from having two NFL teams to having no NFL teams to having two again. But the identity of that city rests on many other facets of life there — its automotive culture, Hollywood, Disneyland and more.

In a way, stadium deals are similar to business negotiations — leverage matters. If a sports team is the entire identity of a city, the owners will know that they can force a favorable deal on local politicians. But if a city’s leaders and residents show strength or see the city as more than a home for professional teams, then they have the ability to influence the negotiation process. This worked in Boston, and it can help cities elsewhere as well.

 

Paper-based devices diagnose malaria in asymptomatic people




During field test in Ghana, devices outperform existing methods



Ohio State University




COLUMBUS, Ohio – Devices made with cheap strips of paper have outperformed two other testing methods in detecting malaria infection in asymptomatic people in Ghana – a diagnostic advance that could accelerate efforts to eliminate the disease, researchers say.

Deceptively simple in appearance, the devices facilitate chemical reactions between a drop of blood and molecules embedded into paper layers and rely on sophisticated, but portable, instrumentation to make the diagnosis: a mass spectrometry measurement of the final product – in positive cases, a malaria-specific antigen that triggers the immune system.

“Typically you would take the sample to the lab, but now we are taking the lab to the sample – I’m taking it to Africa, one of the remotest parts of the world, and doing the analysis right there,” said Abraham Badu-Tawiah, lead author of the field study report and professor of chemistry and biochemistry at The Ohio State University.

“The question was, can we have a sensitive tool that can be delivered to people no matter where they are. Statistical analysis showed that our method is 90% accurate, comparable to a PCR test. It’s very good and we can deliver these results to people who need it the most.”

The research was published recently in Analytical Chemistry.

Malaria is caused by the bite of mosquitoes that spread infectious parasites. The World Health Organization estimates that in 2022, 249 million people globally had malaria, and about 608,000 died of the disease. A preventive vaccine is now available to children in Ghana, where over a quarter of the population was infected in 2011 compared to 8.6% by 2022.

Badu-Tawiah first reported on this invention in 2016, describing a device for at-home or remote-location testing using lightweight structures that could keep biological samples stable for months at a time.

Though the technology is already being refined for the detection of other diseases, malaria has been Badu-Tawiah’s chief concern – especially as increased uptake of the vaccine lowers natural immunity among the population, creating the need for widespread surveillance for potential infections in sub-Saharan Africa.

Since 2016, Badu-Tawiah’s lab has created a 3D automation process of storing antibodies and ions in the device and added a multipronged molecule to amplify the compound signal for detection by mass spectrometry, but the device fabrication process is still manual. Sheets of paper composing the device’s layers – coated with waxy sections that keep blood from seeping through – are printed individually and pressed together with double-sided tape. Twenty-five devices fit onto the 8x12-inch sheets.

Once applied, the blood is separated into four chambers – two acting as positive and negative controls – and induces chemical reactions as it passes through the layers. The chemists designed ionic probes to tag antibodies that extract the antigen from the blood and place it permanently onto the paper within about 10 minutes. Following a buffer wash, the strips are peeled apart and waved in front of a handheld mass spectrometer.

“The spectrometer measures the mass of the compound of interest. The molecular weight tells us if we see a specific mass, that means the malaria antigen is in your blood. That’s a yes. If it’s not there, that’s a no,” Badu-Tawiah said.

Results are available in about 30 minutes, but used devices can also be stored indefinitely without refrigeration for later analysis. The high stability means that after the washing phase, the devices can be transferred in ordinary envelops – a capability connecting people with asymptomatic infection in the remotest regions of Africa to resource-rich centers anywhere else in the world, without traditional cold-chain restrictions.

Over five weeks in 2022 in Ghana, Badu-Tawiah tested the device’s effectiveness in 266 asymptomatic volunteers and compared its results to three other common testing methods in current use for malaria diagnosis: microscopic examination of blood cells, commercially available rapid diagnostic tests and PCR (polymerase chain reaction).

A key factor in testing people without symptoms, Badu-Tawiah noted, is that if they are infected, the density of parasites in their blood is likely low – meaning a highly sensitive test is needed to detect their presence.

The comparison showed that microscopy, the gold standard in African hospitals, had the least accurate results, indicating only 24 positive cases, and rapid diagnostic tests identified 63 infections. PCR identified 142 positive cases, and the paper-based devices identified 184 positives.

“Microscopy works well when the person is sick and in the hospital. Here, we were in communities, where only 24 were shown as positive with microscopy – this test is telling us the majority are negative. That’s a big problem,” Badu-Tawiah said. “But when using a more sophisticated method like PCR, almost 50% of the people are sick, and yet microscopy can’t tell us that. And in people with very low parasite density, rapid diagnostic tests failed miserably – they can only detect higher parasite density.”

Calculation of each method’s sensitivity – the number of true positives divided by true positives plus false negatives – showed that the paper-based devices reached 96.5% sensitivity, compared to 17% for microscopy and 43% for rapid diagnostic tests.

Forty-seven out of 266 samples gave a false-positive result – and all were confirmed by microscopy to be negative. PCR, which is considered to be the most accurate test, also diagnosed these people as negative.

Badu-Tawiah said the false positives could have been caused by differing viscosity of the blood samples, leading to redistribution of blood channels during the washing phase. The team modified the device to account for that possibility.

Badu-Tawiah has begun conversations with the Ghana government about implementation of a testing program.

“We told people this was possible in 2016, and we’ve actually gone to the field and tested it. It’s very promising,” he said. “Technology will go hand-in-hand with vaccination, and you need a sensitive tool that is deliverable.”

He is also partnering with clinicians at Ohio State on adapting the devices to detect risks for, among other conditions, colorectal cancer and acute pancreatitis.

“I have the hammer now and I could hit different nails,” he said. “All we have to do is change the antibody to make it applicable to other diseases.”

This work was supported by the National Institute of Allergy and Infectious Diseases. Co-authors include Ayesha Seth, Suji Lee, Girish Muralikrishnan, Edgar Garcia and James Odei of Ohio State, and Abdul-Hakim Mutala and Kingsley Badu of Kwame Nkrumah University of Science and Technology in Ghana.

 

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New research examines the impact protected areas have on preserving biodiversity



Do designated safe spaces really protect our wildlife for the future?




Swansea University





Just how effective protected areas are at safeguarding habitats and the species that live within them is the focus of a new Swansea University study.

Establishing protected areas has become a conservation priority to mitigate the extinction crisis. The strategy has improved distinct aspects of biodiversity including species richness and abundance across ecosystems. However, researchers from the Department of Biosciences wanted gain a better understanding of how these areas are helping with the conservation of entire food webs: the networks of ecological interactions that focus on predator-prey relationships

Their study analysed hundreds of thousands of observational citizen science records from online databases such as eBird of 509 bird species distributed across 45 networks of European PAs located from Spain to Finland. They combined these observational data with information on predator-prey relationships between these species.

The team compared food webs in protected versus non-protected environments, relating any differences to environmental, geographical, and conservation status conditions of the protected areas. These included factors such as remoteness, habitat diversity, percentage cover of forests, agriculture, human pressure, or the specific designation of the protected areas.

Their findings have just been published by prestigious journal Proceedings B of the Royal Society.

The scientists discovered that whereas for some food web properties the effects of protection were positive, in general these effects were mixed across European bioregions, with no consistent trends in whether food webs were better off inside rather than outside protected areas.

In general, protected food webs had more species, with a larger fraction of those at intermediate levels of the food web. Importantly, the body size of both intermediate and top predator species was larger inside protected areas. However, for other relevant food web properties such as the mean length of food chains or the connectivity of the network, there were no clear trends.

In terms of drivers behind these patterns, the authors found that remoteness of the protected areas, their habitat diversity, human pressure and fraction of agricultural land were highly correlated with changes in food webs. Interestingly, the effects of protection were stronger in protected areas designated as part of the European Bird Directives initiative, highlighting the importance of having clear management goals in mind when setting up protected areas.

Co-author Dr Miguel Lurgi, lead of the Computational Ecology Lab said: "Studies like ours highlight the complexity of conservation action and the importance of  considering key aspects of biodiversity beyond species richness, such as ecological interactions and the tangled networks that they form, into biodiversity assessments.

“These networks not only structure communities and enable their persistence, but they also play important roles in the functions that ecosystems fulfil in nature."

 

Researchers examine the impact of mycoestrogen exposure on birth outcomes



Rutgers Health scientists call for greater awareness of the matter and the potential effects on maternal and fetal health




Rutgers University





Exposure to mycotoxins – a broad group of harmful substances produced by mold – during pregnancy may impact placental function, which could result in lower birthweight in humans, according to Rutgers Health researchers.

One such mycotoxin is zearalenone, a compound with estrogen-like activity. Zearalenone, more specifically classified as a mycoestrogen, contaminates food sources, as its synthetic form is given to livestock in the United States to promote metabolic growth. Because it mimics estrogen, a hormone critical to pregnancy and fetal development, zearalenone may interfere with crucial biological processes during gestation.

Zearalenone is an emerging and understudied environmental health concern that enters the body through food and diet – and it has been detected in humans around the world, the researchers said.

Their study, published in Environmental Health Perspectives, investigated the presence of these compounds in pregnant individuals and assessed whether genetic differences influence their impact on fetal development. The researchers said it is the first study to examine prenatal exposure to mycoestrogens in relation to placental and birth outcomes.

“Our findings emphasize the need for greater awareness of mycoestrogen exposure and its potential impact on maternal and fetal health,” said Zorimar Rivera-Núñez, an assistant professor at the Rutgers School of Public Health and lead author of the study. “This research underscores the importance of considering genetic factors when evaluating environmental exposures and their health effects.”

Researchers analyzed data from a cohort of pregnant participants and found widespread exposure to mycoestrogens. Notably, the study examined the role of a genetic variant, ABCG2 Q141K, that affects the body's ability to transport and eliminate certain compounds. Individuals carrying this variant showed altered birth outcomes, suggesting genetic predisposition may play a crucial role in the effects of mycoestrogen exposure during pregnancy.

The study’s results suggest a need for further research into dietary guidelines and public health policies aimed at reducing exposure to mycoestrogens, particularly among pregnant individuals who may be more vulnerable due to genetic variations.

“We know that ultra-processed foods are associated mycoestrogen content, so pregnant people can lower their exposure by avoiding those foods when possible,” said Rivera-Núñez, citing another study she was involved with. “Ultra-processed foods that may contain zearalenone are derived from grains and grain-based products, such as pasta, breakfast cereals, baked goods and breads.”

The study adds to an expanding body of evidence that environmental factors, coupled with genetic predisposition, can influence birth outcomes.

“We expect mycoestrogen exposure to increase worldwide due to climate change, as the presence of mycoestrogens in crops increases with warmer temperatures,” said Rivera-Núñez. “In fact, mycoestrogen exposure has been documented in many populations around the world, and in the past decade, the number of scientific studies characterizing exposure in humans has increased as a reflection of increasing concern about this emergent exposure.”

Future research will explore potential interventions that could mitigate these risks to protect pregnant women and their babies, including regulating the use of mycoestrogens and other endocrine-disrupting chemicals.

For more information on this study and other public health research at Rutgers, visit the School of Public Health website.

Explore more of the ways Rutgers research is shaping the future.