Wednesday, June 25, 2025

 

Study links air pollutant to year-round respiratory health in Jackson


UM researchers study impact of air pollutants on Mississippi residents



University of Mississippi

Jackson Black Carbon 

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Black carbon – commonly known as soot – may be contributing to a rise in hospital visits for respiratory issues among older adults in Jackson, according to an Ole Miss study.

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Credit: Graphic by John McCustion/University Marketing and Communications





University of Mississippi researchers have linked exposure to high levels of black carbon in the air to an increase in respiratory-related hospital admissions in Mississippi’s capital city, according to a study published in Environmental Pollution.  

Courtney Roper, assistant professor of environmental toxicology, found in a 2023 study that Jackson’s air contains the state’s highest concentration of black carbon, commonly referred to as soot. In a new study published this summer, her team found that this pollutant may be contributing to a rise in hospital visits for respiratory issues among older adults. 

“We can see that there is a connection between respiratory issues – particularly for women – and these exposures,” she said. “The thing that we, as Mississippians, can take right now from this research is that our environment impacts our health.” 

Black carbon is a component of PM 2.5 air pollution – pollutants whose particles are 2.5 microns or smaller, which is approximately 30 times smaller than the diameter of a human hair. PM 2.5 pollutants have been linked to increased risk of cancer, heart attacks, strokes and lung disease.  

Some 4 million deaths worldwide are attributed to long-term exposure to PM 2.5 air pollution.  

“There are many studies that show black carbon is associated with health problems,” said Hang Nguyen, postdoctoral research associate in the School of Pharmacy. “It is very small in size, so it can go deep into your lungs and actually pass into your bloodstream.”  

Black carbon pollution is created while producing energy for homes and commercial areas through coal, wood or fossil fuel burning, and by transportation and industrial emissions, according to the Climate and Clean Air Coalition

By combining air quality data with emergency department visits and hospitalization rates for respiratory-related issues from Medicare between 2014 and 2015, the researchers were able to show a positive correlation between exposure to black carbon and the likelihood of a hospital visit.  

“When we saw black carbon increases, we also saw an increasing rate of hospitalizations,” Nguyen said. “At 1.42 micrograms per cubic meter of black carbon in the air, there was a 1.3% increase in the rate of respiratory admissions.”  

This was particularly true for women, who experienced higher rates of respiratory hospital visits associated with increases in black carbon levels, the research found.  

“A higher percentage of women were going to the hospital because of this,” Roper said. “When we layer in that pollutant data, we can see that effect. It’s more likely that a woman is at risk following exposure to a pollutant.” 

While biology can explain some of this difference – particularly, because women’s airways and organs tend to be smaller than men’s – the reason black carbon disproportionately affected women remains unclear.  

The season and temperature can also play a role in how air pollutants affect hospitalizations, the researchers found. Unlike black carbon, PM 2.5 was not linked to increased hospitalizations year-round, though springtime spikes did coincide with higher asthma-related hospital admissions. 

“That could be related to pollen, traffic emissions or a combination of airborne irritants,” Roper said. “We were also surprised to find that colder temperatures led to increased hospital visits — not immediately, but 10 to 25 days later.  

“That could be tied to winter illnesses or people spending more time indoors with poor ventilation.” 

The team's next step will be to look at similar black carbon and PM 2.5 exposure data paired with cardiovascular hospitalizations or admissions, Roper said. The new study also will focus on Jackson.  

“When I came to the University of Mississippi, I was surprised by how little air quality research was being done here, especially given our health disparities,” she said. “So, it’s been an intentional choice to focus on this state and this population. 

“We do work with other states as well, but a lot of our focus has been here because it’s our air, too. We want to understand the air we're breathing.”  

 

U.S. neonatal mortality from perinatal causes




JAMA Pediatrics




About The Study: 

U.S. neonatal mortality has generally decreased, likely due to medical advancements, improved prenatal care, and neonatal intensive care interventions. However, mortality from slow fetal growth and malnutrition has increased by nearly 2% annually, possibly reflecting impaired prenatal nutrition. 

Corresponding Author: To contact the corresponding author, Muzamil Khan, MD, email muzamilkhan1411@gmail.com.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamapediatrics.2025.1710)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Embed this link to provide your readers free access to the full-text article 

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PREDICTABLE

Teen depression? Study finds clues in screen use and sleep quality



University of Pittsburgh





PITTSBURGH, June 23, 2025 – In this digital era, both kids and adults are often glued to smartphone screens. Digital technology keeps users entertained, connected to friends, and in tune with important news. But some reports suggest that, particularly for adolescents, excessive time on these screens can be linked to mental health problems and even depression.

New research from the University of Pittsburgh School of Medicine published today in JAMA Pediatrics suggests that that association is driven by shorter sleep and worse organization of the brain white matter during this crucial adolescent phase of brain development.

“Brain white matter connections are just like highways that connect cities,” said lead author Dr. João Paulo Lima Santos, M.D., research instructor in psychiatry at Pitt. “If these highways are not well-maintained, traveling from one city to another can be slow and inefficient, or even disrupted.”

In the study, researchers analyzed over 1,000 surveys where teens were asked to estimate how much time they spend per day looking at screens and how long they sleep each night, on average.

Participants’ brain scans revealed something intriguing: white matter connections between regions of the brain that control emotion regulation, memory and attention were weaker and more disorganized in teens who spent more time on their phone or tablet and did not get sufficient sleep – more like meandering paths through a forest than an eight-lane speedway. Those teens also had higher depression scores, suggesting that the intersection of screen time and sleep quality might hold the key to better brain function and mental health.

“Our study considered digital screen time as a broad definition but it’s really important to look at the nuances,” Lima Santos said. “Time of day when you are using your smartphone and what content you engage with matters.”

In his future research, Lima Santos is planning to further disentangle the relationship between brain organization, sleep and screen use habits. By collecting screen use data directly from phones, he hopes to get more answers about whether specific time of day when teens look at screens matters. He suspects the hour before sleep might hold the answer – but more research is needed to back it up.

“Taking away all digital media is not the answer,” Lima Santos cautions. “Digital media can be good – but in some situations, particularly when sleep is affected, we should be more careful and pay attention.”

Other authors of this research are Adriane Soehner, Ph.D., Candice Biernesser, Ph.D., Cecile Ladouceur, Ph.D., and Amelia Versace, M.D., all of Pitt.

 

Owls’ silent flight inspires new noise reduction technology




American Chemical Society

Owls’ silent flight inspires new noise reduction technology 

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A new soundproofing material (fluffy white disk, right image) that mimics the structure of owl skin and feathers reduced the rumble of a car engine more than a traditional felt fiber soundproofing material (fluffy white disk, left image).

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Credit: Adapted from ACS Applied Materials & Interfaces 2025, DOI: 10.1021/acsami.5c04691






If you’ve seen an owl fly, you probably didn’t hear a thing. That’s because their skin and feathers dampen sound by absorbing high- and low-frequency flight noise. Inspired by this natural soundproofing, researchers publishing in ACS Applied Materials & Interfaces developed a two-layer aerogel that mimics the structures inside owl feathers and skin to mitigate sound pollution. This new material could be used in cars and manufacturing facilities to reduce traffic and industrial noise.

Noise pollution is more than a nuisance; excessive noise can cause hearing loss and can worsen health conditions such as cardiovascular disease and type 2 diabetes. When eliminating the source of noise pollution isn’t feasible, soundproofing materials help dampen it. However, traditional materials absorb either high-frequency sounds, like squealing breaks, or low-frequency sounds, like the deep rumbling from a car engine. This means engineers often layer multiple types of soundproofing materials to achieve full-spectrum noise control, which adds weight and bulk. To overcome this, Dingding Zong and colleagues turned to an unlikely acoustic expert: the owl. The owl uses its soft feathers and porous skin to remain whisper-quiet during flight. The researchers’ goal was to engineer a similarly versatile broadband sound absorber.

The researchers froze droplets of hexane into a layer of soft material, using a technique called emulsion-templated freeze-reconstruction. Removing the frozen hexane revealed a honeycomb-like pattern in the material. They added a second layer with silicon nanofibers instead of hexane droplets to create a fibrous pattern. The resulting light, porous two-layer aerogel mimics the structures in owl skin and feathers: The bottom porous layer resembles the bird’s skin with microscopic cavities that cancel out low-frequency noise; and the top feather-inspired layer, made of fluffy nanofibers, dampens high-frequency sounds.

Notably, the researchers found that their owl-inspired aerogels can:

  • Absorb 58% of soundwaves that strike it, surpassing the threshold for effective noise control materials.
  • Reduce 87.5 decibels of automobile engine noise to a safe level of 78.6 decibels, which is a better reduction than existing high-end noise absorbers.
  • Maintain structural integrity through 100 compression cycles, with only 5% deformation.

The researchers believe this study paves the way for high-performance, lightweight and durable sound-absorbing materials that can significantly alleviate noise pollution from industrial equipment and traffic.

The authors acknowledge funding from the Natural Science Foundation of Tianjin and the Open Project Program of the Ministry of Education Key Laboratory for Advanced Textile Composite Materials, Tiangong University.

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The American Chemical Society (ACS) is a nonprofit organization founded in 1876 and chartered by the U.S. Congress. ACS is committed to improving all lives through the transforming power of chemistry. Its mission is to advance scientific knowledge, empower a global community and champion scientific integrity, and its vision is a world built on science. The Society is a global leader in promoting excellence in science education and providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, e-books and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research. As a leader in scientific information solutions, its CAS division partners with global innovators to accelerate breakthroughs by curating, connecting and analyzing the world’s scientific knowledge. ACS’ main offices are in Washington, D.C., and Columbus, Ohio. 

Registered journalists can subscribe to the ACS journalist news portal on EurekAlert! to access embargoed and public science press releases. For media inquiries, contact newsroom@acs.org

Note: ACS does not conduct research but publishes and publicizes peer-reviewed scientific studies. 

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Research alert: CBD might help children with autism, but more research needed


In the first controlled clinical trial of CBD in boys with autism, two-thirds of participants showed behavioral improvements with treatment, but there was also a significant placebo effect.




University of California - San Diego





Researchers at the Center for Medicinal Cannabis Research at University of California San Diego School of Medicine have found that cannabidiol (CBD), a non-intoxicating compound found in cannabis, could help reduce problematic behaviors in autistic boys. The results provide valuable insights into the potential benefits and limitations of CBD as a therapeutic intervention for autism.

Autism spectrum disorder is a complex neurodevelopmental condition characterized by social communication difficulties, repetitive behaviors and restricted interests. In more severe cases, these behaviors can also include self-injury or aggression. While existing treatments can help manage these symptoms, there is a pressing need for effective and safe interventions to address the diverse needs of autistic individuals.

Some prior studies have suggested that CBD could help reduce problematic behaviors in children with autism. However, no controlled clinical trials have addressed safety, tolerability and efficacy of this treatment approach until now.

In the trial, autistic boys with severe behavior problems aged 7–14 years were split into two groups. One received eight weeks of daily CBD then eight weeks of placebo, separated by a four-week “washout” period in which no treatment was given. The other group received placebo first, then CBD. Behavioral assessments were completed before and after each treatment phase. A total of 30 participants completed the trial.

The researchers found:

  • CBD was safe and well-tolerated in boys with severe autism and behavioral problems – participants were able to take the drug without difficulty and there were no serious adverse events.
  • While no significant differences were found between CBD and placebo on broad measures of behavior, clinician impressions suggested that approximately two-thirds of participants showed evidence of clinical improvement with CBD.
  • Reductions in aggressive behaviors and hyperactivity were observed most frequently by clinicians, with improvements in communication seen in almost 30% of participants.
  • While both groups showed improvements during the study, demonstrating a strong placebo effect, the CBD group generally showed greater improvement than the placebo group.

The study's findings suggest that while CBD may have some benefits in reducing problematic behaviors in autistic children, its effectiveness is not universally established, and more research is needed to fully understand its therapeutic potential. The study's results also underscore the importance of rigorous, controlled trials in evaluating the efficacy of novel treatments for autism.

The study, published in the Journal of Autism and Developmental Disorders, was led by UC San Diego School of Medicine distinguished professors Doris Trauner, M.D., in the Departments of Neurosciences and Pediatrics, and Igor Grant, M.D., in the Department of Psychiatry.

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THIRD WORLD U$A

Food insecurity linked to elevated mortality risk among cancer survivors 



Researchers urge that cancer survivors with food insecurity get better access to food assistance programs 



University of Pennsylvania School of Medicine






Philadelphia, PA — Lack of access to healthy food is a threat to the lives of cancer survivors—a significant and often overlooked factor affecting their long-term health outcomes. A new study shows that those experiencing food insecurity had a 28 percent relative increase in risk of death as compared to those who were food secure.   

In the study, published recently in JAMA Health Forum, researchers from the University of Pennsylvania Perelman School of Medicine analyzed data from more than 5,000 respondents who shared their cancer diagnoses as part of a nationwide, government-sponsored health survey.  

“Food matters in cancer care and outcomes,” said study senior author Jaya Aysola MD, MPH, Associate Professor of Medicine and executive director of the Centers for Health Equity Advancement at Penn Medicine. “The results show that simple, integrated solutions can help prolong the lives of cancer survivors by helping put healthy food on their table.” 

Addressing root causes 

Food insecurity, estimated to affect about 40 million people in the US alone, is the condition in which good nutrition is of limited or uncertain availability. It is considered a significant socioeconomic factor in overall health and has been linked to higher risks of chronic diseases including heart disease, diabetes, some mental health disorders, hypertension, kidney disease, and colorectal cancer. 

The investigators made use of data from the US Centers for Disease Control and Prevention’s 2011 and 2012 National Health Interview Surveys (NHIS), as well as the U.S. National Death Index through 2019. Their analysis covered a total of 5,603 adults 40 and older who reported having had a cancer diagnosis on the NHIS and answered its questions relating to food security. 

A total of 579 (10.3%) of the respondents reported food insecurity. This group had higher all-cause mortality—overall risk of death—through 2019, compared to cancer survivors who did not report food insecurity. After adjustment for potentially relevant differences between respondents, such as sex, age, smoking status, and the presence of other illnesses, there remained a significant mortality gap between the groups—the food-insecure group having an estimated 28 percent increased risk of all-cause mortality. 

Analyses of subsets of the respondents also showed that respondents reporting food insecurity and non-participation in government food assistance programs had about 42 percent increased risk of all-cause mortality—and 42 percent of increased risk of cancer mortality.  

This is the first study to review and find a connection between food insecurity and mortality in people with cancer. “Screening for food-insecurity in clinical practice, expanding food assistance program eligibility, and guiding people to resources may help reduce this apparent connection,” according to John Lin, a medical student and HEAL (Health Equity Advancement Lab) fellow at the Centers for Health Equity Advancement, and the study’s first author. 

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The Perelman School of Medicine is consistently among the nation's top recipients of funding from the National Institutes of Health, with $580 million awarded in the 2023 fiscal year. Home to a proud history of “firsts” in medicine, Penn Medicine teams have pioneered discoveries and innovations that have shaped modern medicine, including recent breakthroughs such as CAR T cell therapy for cancer and the mRNA technology used in COVID-19 vaccines. 

The University of Pennsylvania Health System’s patient care facilities stretch from the Susquehanna River in Pennsylvania to the New Jersey shore. These include the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Chester County Hospital, Doylestown Health, Lancaster General Health, Penn Medicine Princeton Health, and Pennsylvania Hospital—the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others. 

Penn Medicine is an $11.9 billion enterprise powered by more than 48,000 talented faculty and staff.