Thursday, July 10, 2025

 

Like humans, monkeys are attracted to videos showing conflict



Long-tailed macaques share some of our interests, study finds



Ohio State University





COLUMBUS, Ohio – Have you ever wondered what kind of video content would most grab the attention of monkeys?

A new study of long-tailed macaques suggests the monkeys seem to like some of the same kind of content that humans do: videos featuring aggression and individuals they know.

“Humans and macaques are both social animals who have a fundamental need to belong,” said Brad Bushman, co-author of the study and professor of communication at The Ohio State University.

“It’s not surprising that they both would be most interested in the video content that may help them navigate relationships in their groups.”

The study was published online recently in the journal Animal Cognition. It was led by Elisabeth H.M. Sterck, professor of animal behaviour and cognition at Utrecht University in The Netherlands.

Researchers showed two-minute videos to 28 macaques that lived at a primate research center in The Netherlands. Each macaque saw multiple videos over time featuring monkeys in their group or strangers. Each individual video showed monkeys in one of four types of activities: conflict, grooming of each other, running, or sitting.

The researchers calculated how much time the monkeys spent looking directly at the screen and their reactions while watching.

Findings showed the macaques paid the most attention to videos featuring conflicts between monkeys. Running was the next most popular type of video. Grooming and sitting attracted the least attention.

It is notable that both macaques and humans seem to be attracted to videos featuring similar content, Bushman said.

“We have plenty of research showing the popularity of violent media with humans. Now we have some evidence that other primates might also be attracted to conflict and aggression in videos,” Bushman said.

“From an evolutionary perspective, this makes sense. Both humans and other animals may be hardwired to pay attention to aggression because that is an adaptive response that increases survival,” he added.

The other significant finding of the study was that the macaques watched videos featuring members of their own group more closely than those involving strangers.

“This indicates that gathering social information on group members is more important than getting information about strangers,” Sterck said.

And seeing familiar faces on the screen isn’t just something that’s attractive to monkeys.

“When we as humans watch movies, we like to see actors we know – we like to see the stars playing in big movies more than we do actors who are not familiar to us,” Bushman said.

Findings also showed that low-ranking and less aggressive macaques paid more attention than others to the videos.

“More dominant individuals can be more confident that aggression will not affect them – they don’t have to pay attention to others as much,” Sterck said.

“Lower-ranking individuals can become an aggression victim and that may be why they pay more attention to what others are doing in the videos.”

In addition, high-strung macaques that were more easily stressed paid less attention to group members than those who did not act as stressed.

“We found that the gathering of social information from the videos differed with dominance rank and behavioral tendencies, which may reflect personality,” Sterck said.

The research involved two separate groups of macaques that live at the Biomedical Primate Research Centre in Rijswijk, The Netherlands.

The “stranger” videos that the macaques viewed were those monkeys from a third out-of-view group.

In each enclosure, there is a corridor where the macaques are accustomed to participating in cognitive tests. There were four compartments where the monkeys could watch videos on a laptop.  The subjects entered the corridor on their own volition, and were isolated from other monkeys of their multi-generational group during the two-minute videos.

“The macaques are very visual animals. Their eyesight is similar to that of humans and they are very interested in watching videos,” Sterck said.

The researchers said the findings showed that humans share tendencies with our monkey relatives, including the attraction to videos with conflict.

“Even this brief exposure to aggressive media captured the attention of macaques in the study,” Bushman said. “When you see this in some of our closest primate relatives, it is easy to see why humans are so interested in violent media.”

Other co-authors of the study, all from Utrecht University, were Sophie Kamp, Ive Rouart, Lisette van den Berg, Dian Zijlmans and Tom Roth.

 

Addressing “spay-neuter syndrome" with testosterone restoration for neutered male dogs



New research published in BMC Veterinary Research provides foundational safety and dosing data for hormone replacement in spayed/neutered pets



Peer-Reviewed Publication

Parsemus Foundation

Hormone restoration increases testosterone in a dose dependent manner in neutered dogs. 

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Testosterone levels in neutered dogs in the study at Day 0 (baseline) and during three months of testosterone therapy at three dose levels (1X, 3X, and 5X the standard dose). Measurements were taken one week following dosing, reflecting the low point in the week.

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Credit: Parsemus Foundation





The Parsemus Foundation, a nonprofit dedicated to advancing pet health, today announced the publication of groundbreaking research on the safety and dosing of testosterone therapy for neutered male dogs. Published in BMC Veterinary Research, this pivotal study provides crucial data for veterinarians to treat "spay-neuter syndrome” - a collection of health and behavioral problems associated with hormone loss following sterilization. Results show that injectable testosterone can safely restore physiological hormone levels in neutered dogs, offering a promising avenue to counteract the adverse health effects of neutering.

Why the loss of a dog’s hormones matters

"Spaying and neutering remove critical hormones, not just fertility,” said Dr. Karen Becker, a leading integrative veterinarian and advocate for pet health. “The resulting deficiencies contribute to numerous degenerative diseases over time. Research-based HRT protocols are essential for veterinarians to restore hormonal balance and safeguard long-term canine health."

Neutering is commonly practiced globally, yet the removal of reproductive organs also eliminates essential hormones like testosterone and estrogen, which play important roles beyond preventing reproduction. This can result in what is increasingly recognized as "spay-neuter syndrome" (a term coined by Dr. Ruth Roberts, Integrative veterinarian, and Holistic Pet Health Coach Educator). Many spayed and neutered dogs develop conditions such as cancer, urinary incontinence, obesity, hypothyroidism, orthopedic problems, and behavioral changes like increased aggression, fearfulness, anxiety, or reactivity. Though hormone-sparing sterilization is gaining attention, research on hormone restoration for already-neutered dogs has been critically lacking.

Funded by the Parsemus Foundation, this is the first study to provide essential safety and dosing data for injectable testosterone in castrated male dogs. The goal is to give veterinarians clear guidance on safe dosages and monitoring parameters so they can better address hormonal imbalances that contribute to chronic health problems and diminished quality of life.

The first study to evaluate the safety of testosterone therapy for neutered dogs

The 90-day target animal safety study enrolled twelve neutered male dogs divided into four groups, each receiving a different weekly dose of injectable testosterone cypionate: 0x, 1x, 3x, or 5x the standard 0.5 mg/kg dose. Researchers monitored bloodwork, hormone levels, prostate health, behavior, and body condition.

Key findings include:

  • Safety: Testosterone therapy over a three-month period was safe at all tested doses, including up to five times the standard. Most health parameters remained stable, and adverse events were rare and generally unrelated to treatment.
  • Hormone Restoration: Testosterone levels measured one week after injection rose in proportion to the dosage, with significantly higher levels in the 3x and 5x groups.
  • LH Reduction: Luteinizing hormone (LH), which rises in neutered dogs due to a lack of negative feedback from gonadal hormones, decreased after 90 days of treatment, especially in the 5x group. This is notable because high LH levels have been associated with health risks including cancer.
  • Minimal Impacts: Behavioral measures, prostate health scores, body condition scores, clinical evaluations, and routine bloodwork showed only minor variations across groups or over time, indicating overall stability during treatment.

"This study marks a significant step forward in understanding how to restore hormone balance in neutered dogs safely," said Linda Brent, PhD, Executive Director of the Parsemus Foundation and lead author. "Our findings provide a critical foundation for veterinarians and pet owners considering testosterone therapy to alleviate the long-term health and behavioral challenges associated with spay-neuter syndrome."

The paper also discusses risks, offers LH-reduction strategies, and recommends further research to understand testosterone metabolism and long-term outcomes. While the initial results are encouraging, follow-up studies will be essential to confirm ongoing safety and efficacy.

“The latest research by Dr. Linda Brent and colleagues published in BMC Veterinary Research shows that data-driven testosterone dosing can safely restore testosterone in neutered dogs and dramatically improve their physical health and emotional well-being,” Dr. Peter Dobias, a conventional and integrative veterinarian, remarked. “As we continue to learn more, I believe that ongoing data collection and open communication with veterinarians are the keys to further refining these protocols and empowering dog lovers to make the best decisions for their pets.”

Advancing improvements in pet care

"The Parsemus Foundation is proud to support innovative solutions for under-researched pet health issues,” added Elaine A. Lissner, Founder and Trustee of the foundation. “We are drawn to simple, inexpensive solutions overlooked by the pharmaceutical industry. This study on testosterone restoration in neutered dogs offers more options for pet owners making informed decisions about their animals' health.”

The foundation’s website provides information on hormone-sparing sterilization methods such as vasectomy and hysterectomy, hormone restoration, and nonsurgical options for pet care, along with a veterinary directory for finding clinics that offer these services.

The full research paper, "Safety and dosing of testosterone for hormone restoration in neutered dogs," is available in BMC Veterinary Research.

About the Parsemus Foundation

The Parsemus Foundation is a non-profit private operating foundation dedicated to advancing innovative and neglected medical research that can improve human and animal health. The Foundation focuses on low-cost, high-impact solutions that pharmaceutical companies and other funding sources overlook. Through its work, the Parsemus Foundation aims to bring new, accessible medical options to those who need them most.

Pax, the neutered service dog of Dr. Peter Dobias, benefited from testosterone therapy, regaining his mobility, coat quality, and joyful personality.

Credit

Dr. Peter Dobias

 

More rural, minoritized people get amputations – AI gets closer to why



Researchers hope the model will help avoid preventable amputations from vascular disease



University of Maryland

Dr Paula Strassle 

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Dr. Paula Strassle, Assistant Professor of Epidemiology at the University of Maryland School of Public Health. 

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Credit: UMD





Why do rural adults and racial and ethnic minorities with vascular disease get major leg amputations more often? A new study out today in Epidemiology uses AI to solve the mystery, finding an unaccounted-for factor that researchers think points to implicit bias in the clinical decision-making process.

“The AI model allowed us to distinguish among the many reasons behind these much higher rates of amputation among certain groups of people with vascular disease,” said Paula Strassle, lead author and assistant professor of epidemiology at UMD’s School of Public Health. “We found that, after accounting for everything else, people’s unconscious biases are likely behind why some groups receive amputation instead of alternative treatment that preserves their limb.” 

“We hope our results will be a catalyst to create evidence-based guidelines that help vascular surgeons and other providers who make this life-changing decision do so objectively.” 

More than 12 million adults in the US live with a vascular disease called Peripheral Artery Disease (PAD), a chronic circulation condition that restricts blood flow to the limbs. It results in leg pain, numbness and in severe cases, limb loss. About 10% of people with PAD develop Chronic Limb-Threatening Ischemia (CLTI) at which point either they receive a procedure to restore blood flow to their lower leg or their limb must be amputated. Revascularization is a surgical procedure that can save the limb, but it also requires intensive follow-up and is a relatively expensive surgical procedure. Vascular surgeons are also in short supply

After accounting for known differences in clinical presentation, the study found higher rates of amputation among Black, Hispanic, Native American, and white people in rural areas as well as among Black and Native American people in urban areas. After further accounting for differences in hospital and neighborhood resources, higher amputation rates persisted among Black, Hispanic, and Native American people in rural areas, and Black and Native American people in urban areas.

“We found a substantial unexplained portion that would suggest an implicit bias in clinical decision-making occurring at the physician and hospital level,” Strassle said. 

The study examined hospitalizations between 2017 and 2019 of people under 40 with PAD or CLTI, across five states (Florida, Georgia, Maryland, Mississippi and New York) using State Inpatient Databases from the Healthcare Cost and Utilization Project. 

Researchers programmed an AI model to consider a huge number of variables (70+) that contribute to known reasons for differences in leg amputations of people with PAD. Variables included clinical factors such as age and other health conditions, healthcare system capacity to perform revascularization and limb amputations, legal and regulatory climate, and the physical environment such as a person’s distance to the nearest emergency room and ZIP code median income. 

“This AI model will allow us to easily assess intersectionality across race, sex, income and rurality, and offers us the ability to indirectly study hard-to-measure causes of disparities, like implicit bias and stereotyping,” said Strassle. 

Limb-threatening conditions are often the result of decades of difficult-to-control diseases like diabetes, high cholesterol and nicotine dependence. For surgeons, who know these conditions lead to worse surgical outcomes, this can make the decision to pursue a complex limb-saving surgery even trickier. 

“As vascular surgeons we have surgical guidelines, but we don’t have detailed guidelines to help us make the decision between amputating someone’s leg and limb-saving surgery in patients who are not medically ready. Given the number and complexity of variables involved, we need more information describing the optimal treatment for each person in different conditions. We need to know we can perform a successful vascular operation, and also not increase the risk of dying,” said Katharine McGinigle, a vascular surgeon, associate professor of surgery at the University of North Carolina and senior author of the paper. 

“There are so many medical, surgical, and social factors that contribute to disease progression, limb-loss and even death. Surgeons and others making treatment recommendations deserve evidence-based guidance that will help us avoid unconscious biases and make the right decision at the right time for each person based on their unique clinical and social needs. AI methods, similar to the one used in this research, can help us achieve that goal,” said McGinigle.

Strassle and McGinigle hope that their findings will inform comprehensive guidelines and health policies that help clinicians avoid unconscious bias and other unjustified differences in the quality of care provided, to safely save limbs of people living with advanced vascular disease. 

To request an interview with Dr. Strassle, please contact sph-comm@umd.edu

***
Funding for this project was provided by the Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the National Institutes of Health, the Department of Health and Human Services, or the United States government.

 

Sage inspires over 200 attendees to speak out against censorship at the American Library Association  ALA Annual Conference


More than 200 attendees visited the Sage-sponsored “Banned Books from the Big Chair” at the ALA Annual Conference




SAGE





At the 2025 American Library Association (ALA) Annual Conference, more than 200 attendees visited the Sage-sponsored “Banned Books from the Big Chair” booth to denounce book challenges, share advice for combatting censorship locally, and read aloud from banned titles. The exhibit highlighted the number of books challenged and the 10 most-challenged titles in the US in 2024.   

Guests in the Big Chair included award-winning authors of frequently challenged books including Laurie Halse Anderson, A.S. King, Sarah and Ian Hoffman, Judah Freed, and more. Recordings of attendees and authors will be released during Banned Books Week, October 5-11, on the ALA Office for Intellectual Freedom Banned Books Week YouTube channel(opens in a new tab).   

Sage has proudly co-hosted this exhibit for more than a decade in partnership with ALA’s Office for Intellectual Freedom, Unite Against Book Bans, and the Banned Books Week Coalition, as part of its larger effort to champion academic freedom.   

Sage also co-sponsors the Robert B. Downs Intellectual Freedom Award(opens in a new tab) and celebrated the 2024 recipient, Dr Shannon M. Oltmann(opens in a new tab), at the conference. An associate professor at the University of Kentucky’s School of Information Science, Oltmann received the award for translating her research on censorship and intellectual freedom into practical guidance for library professionals.   

Sage’s independence means the company is free to advocate for intellectual freedom and a more equitable academic future. Sage publishes Index on Censorship(opens in a new tab), which promotes censored writers and artists, fosters debate, and monitors threats to freedom of speech. Find out more about Sage’s initiatives to combat censorship on the company’s Academic Freedom webpage. 

 

Global trends and cross-country inequalities of acute hepatitis E in the elderly, 1990–2021



Xia & He Publishing Inc.
Global Trends and Cross-country Inequalities of Acute Hepatitis E in the Elderly, 1990–2021: A Comprehensive Analysis 

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The burden of elderly AHE, as a major public health issue, remains substantial. While cross-country inequities have been alleviated over time, the pressure on lower socio-demographic index countries to control the disease remains high. AHE in elderly women requires further attention. This emphasizes the significant challenges faced in controlling and managing elderly AHE.

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Credit: Jun Chen, Deliang Huang





Background and Aims

Acute hepatitis E (AHE) in the elderly can lead to severe complications including liver failure and mortality, yet the epidemiological landscape remains poorly characterized. This study aimed to assess the burden, trends, and health inequalities of AHE among the elderly over the past three decades, and to further predict its changes by 2030.

Methods

Data on AHE in the elderly were obtained from the Global Burden of Disease 2021. The burden of AHE was analyzed by trends, decomposition, cross-country inequalities, and predictive analysis.

Results

In 2021, the global incidence and Disability-Adjusted Life Years (DALYs) for AHE among the elderly were recorded as 1,130,013.35 and 20,084.77, respectively. Although there were significant differences in the incidence and DALYs across countries, the number of incident cases increased from 1990 to 2021, with a slight rise in age-standardized rates, while the number and age-standardized rate of DALYs showed a declining trend. Decomposition analysis revealed that population growth and aging are the drivers of changes in incidence, while epidemiological changes somewhat offset the increases in DALYs driven by population growth. Low socio-demographic index countries bear a disproportionate burden of elderly AHE, although inequality gaps have narrowed over time. Notably, up to 2030, the number of incident cases and DALYs will continue increasing. The burden in elderly women was more pronounced than in men.

Conclusions

AHE remains a critical public health challenge for the elderly, with rising global incidence and persistent disparities. Population growth and aging are key drivers of this trend, necessitating enhanced prevention strategies to counterbalance their impact. Although SDI-related inequalities have diminished, lower-SDI countries continue to bear a disproportionate burden. Moving forward, tailored interventions that account for regional transmission dynamics, demographic shifts, and gender disparities are essential to reduce the AHE burden and safeguard elderly health worldwide. Policymakers must prioritize adaptable, context-specific measures to strengthen healthcare systems and ensure equitable resource distribution.

 

Full text

https://www.xiahepublishing.com/2310-8819/JCTH-2025-00101

 

The study was recently published in the Journal of Clinical and Translational Hepatology.

The Journal of Clinical and Translational Hepatology (JCTH) is owned by the Second Affiliated Hospital of Chongqing Medical University and published by XIA & HE Publishing Inc. JCTH publishes high quality, peer reviewed studies in the translational and clinical human health sciences of liver diseases. JCTH has established high standards for publication of original research, which are characterized by a study’s novelty, quality, and ethical conduct in the scientific process as well as in the communication of the research findings. Each issue includes articles by leading authorities on topics in hepatology that are germane to the most current challenges in the field. Special features include reports on the latest advances in drug development and technology that are relevant to liver diseases. Regular features of JCTH also include editorials, correspondences and invited commentaries on rapidly progressing areas in hepatology. All articles published by JCTH, both solicited and unsolicited, must pass our rigorous peer review process.

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