Tuesday, July 15, 2025

UK

Technician-led eye clinics could lead to more timely NHS care



Innovative virtual eye clinics in shopping centers could significantly reduce waiting times for routine eye appointments, UCL-led research suggests in a first-of-its-kind study




University College London

Eye clinic 

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Technician-led eye clinic at Brent Cross shopping centre, north London.

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Credit: Moorfields Eye Hospital





Innovative virtual eye clinics in shopping centres could significantly reduce waiting times for routine eye appointments, UCL-led research suggests in a first-of-its-kind study.

The research, published in the journal BMJ Open, evaluates the impact of a community-based ‘pop-up’ eye clinic set up in Brent Cross shopping centre in north London in September 2021, at the height of the pandemic, on reducing the post-COVID-19 appointment backlog.

The researchers looked at data from 69,257 appointments attended by 39,357 patients with stable glaucoma and medical retinal conditions at sites across the Moorfields Eye Hospital network in London between June 2018 and April 2023.

During the pandemic, waits for NHS ophthalmology appointments rose sharply. By March 2023, 628,502 people in England were waiting for appointments, with 27,260 of those patients waiting for a year or more, according to the Association of Optometrists.¹

The researchers found that patients seen in the hospital network hosting the London virtual clinic bucked the national trend – for each week that passed, the delay they were expected to face fell by more than a week (eight days) for the first five months the clinic was operating.

For example, in November 2021 on average patients with stable chronic conditions across the Moorfields Eye Hospital network were being seen six months later than intended, and by April 2022, following the introduction of the clinic, appointments were happening only two months late.

Previous research has suggested so-called virtual clinics, where technicians perform routine scans during patients’ regular check-up appointments that are examined later on by a clinician, can reduce waits for outpatient appointments. In this innovative clinic, technicians without prior healthcare experience were trained on how to perform the scans, with ongoing support from senior clinicians, saving clinical specialists' face-to-face time for urgent and complex cases.²

But this is the first study to quantify how much delays for NHS outpatient ophthalmology appointments can be reduced by the impact of a COVID 19-era service innovation.

Lead author Siyabonga Ndwandwe (UCL Research Department of Primary Care and Population Health) said: “Our findings suggest that community-based, technician-led virtual review clinics could play a significant role in reducing wait times for patients with stable chronic eye conditions.

“This is especially relevant given current NHS challenges, including chronic workforce shortages – particularly among eye specialists – and limited hospital estate capacity.

“This is the first study to quantify the impact of a COVID 19-era service innovation on outpatient ophthalmology delays and the findings highlight a scalable model that could be adopted more widely to improve access and efficiency across the whole of the NHS.

“This is very much in line with the ambitious plans to reform the NHS announced by the Prime Minister and Health Secretary only weeks ago.”

The virtual clinic, led by technicians rather than specialists, was designed to monitor low-risk patients outside traditional NHS estates.

The research showed it led to a significant reduction in weekly average appointment delay days (delays reducing by an average of 8.1 days per week) following its launch.

This slowed to a reduction by 0.3 days per week after the initial backlog had been cleared at around five months after opening. Pre-pandemic appointment delays had been increasing on average by 0.9 days per week.  This rate increased sharply to 2.0 days per week due to service delivery interruptions associated with COVID-19 lockdowns. 

The researchers measured attendance delays by counting how many days passed between when a patient actually attended and the date they were supposed to attend, based on the appointment date set during their previous visit.

They excluded some patients from the analysis, such as patients with non-stable conditions which they defined as people who were required to be seen less than six months after their previous attendance. They also excluded those where the appointment could have been an emergency, indicated by it taking place more than four weeks earlier than required.

Joint first author Dr Dun Jack Fu (NIHR Moorfields Biomedical Research Centre) said:

“Our report draws on data from one the world’s largest specialist eye centres – Moorfields Eye Hospital NHS Foundation Trust - providing care at over 25 sites across London.”

“Our findings are highly relevant to the post-COVID era with millions of people facing long waits for routine NHS appointments.

“They are in the spirit of the government’s 2024 Change NHS campaign, which emphasises three key shifts for a future-ready health service: moving care from hospitals into communities, harnessing technology (the virtual review part), and focusing on prevention over treatment (preventing eyesight loss by timely monitoring). 

“We believe that pop-up virtual eye clinics in locations such as shopping centres could be a game-changer.”

The study was part of the Healthcare Exemplar for Recovery from COVID 19 Using Linear Examination Systems (HERCULES) project.³

Study limitations

The study has some limitations, including that no external control group was available, limiting comparison to national or regional trends.

Also, the study focused on glaucoma and medical retina patients but in 2022 the new clinic expanded the scope of its activities to include cataract patients and newly referred patients, so this analysis might underestimate the overall contribution to reducing ophthalmic appointment delays across the network.

Notes to Editors

For more information or to speak to the researchers involved, please contact Nick Hodgson, UCL Media Relations. T: 07769 240209, E: nick.hodgson@ucl.ac.uk

The pop-eye clinic was designed by a team of UCL architects and scientists led by Professor Paul Foster, based at UCL Institute of Ophthalmology and a consultant at Moorfields. More information about its launch and design can be found here: https://www.ucl.ac.uk/news/2021/dec/eye-care-clinic-future-launched-ucl-and-moorfields and here https://www.ucl.ac.uk/bartlett/ideas/bartlett-review/bartlett-review-2021/shopping-centre-pop-shows-way-forward-nhs

¹ Association of Optometrists. NHS patient backlogs are leading to life changing sight loss FOI request reveals, https://www.aop.org.uk/our-voice/media-centre/press-releases/2023/03/21/nhs-patient-backlogs-are-leading-to-life-changing-sight-loss-foi-request-reveals (2023, accessed 19 December 2023).

² All the Moorfield Eye Hospital network patients with chronic conditions were monitored regularly and had scans. In traditional NHS ophthalmology clinics, these scans are done by nurses and optometrists and the patient can see a consultant clinician after having all the scans if that turns out to be necessary as the scans are all looked at while the patient is there sitting in the waiting room. There were two key differences with the shopping centre clinic: the scans were performed by trained technicians who were not clinically trained (rather than clinical staff); and they were looked at ‘virtually’ by a clinical specialist using the hospital's electronic system, rather than on-site, and generally not straightaway. This meant patients didn’t have to wait for the scans to be examined, freed up senior clinical time and meant more appointments could be made available.

³ The HERCULES project is a collaboration between UCL and Moorfields Eye Hospital. It was made possible as a consequence of some visionary decisions around funding by the Moorfields Eye Hospital NHS Foundation Trust (via the NIHR Moorfields Biomedical Research Centre), Moorfields Eye Charity, The UCL Bartlett Faculty of the Built Environment, and Ubisense, with support in kind from Optos (now part of Nikon Medical Imaging). UCL departments involved in it include UCL Institute of Ophthalmology, the Research Department of Primary Care and Population Health and the UCL Research Department of Behavioural Science and Health. More information about the project can be found here: https://www.ucl.ac.uk/population-health-sciences/epidemiology-health-care/research/behavioural-science-and-health/research/health-care-organisation-and-management-group/hercules

Ndwandwe, Siyabonga; Fu, Dun Jack; Adesanya, Joy; Bazo-Alvarez, Juan Carlos; Ramsay, Angus I. G.; Fulop, Naomi, J.; Magnusson, Josefine; Napier, Steve; Cammack, Jocelyn; Baker, Helen; Kumpunen, Stephanie; Alarcón Garavito, Germán; Elphinstone, Holly; Mills, Grant; Scully, Peter; Symons, Anne; Webster, Paul; Wilson, Jonathan; Khaw, Peng Tee.; Sivaprasad, Sobha; Jayaram, Hari; Foster, Paul J.; Clarke, Caroline S., ‘Impact of a Community-Based Asynchronous-Review Clinic on Appointment Attendance Delays Across an Eye Hospital Network in London, UK: An Interrupted Time Series Analysis’ will be published in BMJ Open on Wednesday 16th July 2025, 00:01 UK time.

The DOI of this paper will be: http://dx.doi.org/10.1136/bmjopen-2025-098820

About UCL – London’s Global University

UCL is a diverse global community of world-class academics, students, industry links, external partners, and alumni. Our powerful collective of individuals and institutions work together to explore new possibilities.

Since 1826, we have championed independent thought by attracting and nurturing the world's best minds. Our community of more than 50,000 students from 150 countries and over 16,000 staff pursues academic excellence, breaks boundaries and makes a positive impact on real world problems.

The Times and Sunday Times University of the Year 2024, we are consistently ranked among the top 10 universities in the world and are one of only a handful of institutions rated as having the strongest academic reputation and the broadest research impact.

We have a progressive and integrated approach to our teaching and research – championing innovation, creativity and cross-disciplinary working. We teach our students how to think, not what to think, and see them as partners, collaborators and contributors.  

For almost 200 years, we are proud to have opened higher education to students from a wide range of backgrounds and to change the way we create and share knowledge.

We were the first in England to welcome women to university education and that courageous attitude and disruptive spirit is still alive today. We are UCL.

www.ucl.ac.uk | Read news at www.ucl.ac.uk/news/ | Listen to UCL podcasts on SoundCloud | View images on Flickr | Find out what’s on at UCL Minds

 

About NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology

NIHR Moorfields BRC is an internationally renowned partnership between Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, ranked number one in the world for ophthalmology research. The BRC was first established in April 2007 and is now in the fourth five-year term to support research designed to take advances in basic medical research from the laboratory to the clinic. The centre’s broad spectrum of research into eye disease enables patients to benefit more quickly from world-class scientific breakthroughs, treatments and diagnostics, and has demonstrated a wider reach into other health conditions through digital technology and advanced therapies. For further information, please visit www.moorfieldsbrc.nihr.ac.uk/  

About the NIHR

The mission of the National Institute for Health and Care Research (NIHR) is to improve the health and wealth of the nation through research. We do this by:

  • Funding high quality, timely research that benefits the NHS, public health and social care;
  • Investing in world-class expertise, facilities and a skilled delivery workforce to translate discoveries into improved treatments and services;
  • Partnering with patients, service users, carers and communities, improving the relevance, quality and impact of our research;
  • Attracting, training and supporting the best researchers to tackle complex health and social care challenges;
  • Collaborating with other public funders, charities and industry to help shape a cohesive and globally competitive research system;
  • Funding applied global health research and training to meet the needs of the poorest people in low and middle income countries.

 

NIHR is funded by the Department of Health and Social Care. Its work in low and middle income countries is principally funded through UK international development funding from the UK government.


 

University of Birmingham and CBMM partner to drive disruptive innovation in carbon recycling





University of Birmingham






The University of Birmingham, UK, and Brazilian-based CBMM, have partnered on a project to ensure the future supply of Niobium, a non-critical but rare and important metal and an essential component for a carbon recycling technology that could radically reduce emissions from energy- and carbon-intensive foundation industries. 

CBMM, a global leader in the production of Niobium products, will work with Birmingham researchers led by Professor Yulong Ding to improve the efficiency of production, and reduce the cost of Niobium compounds for use in the closed-carbon-loop technology for foundation industries such as steel-making. 

The project is related to a technology that uses Niobium-based perovskites, which turn the CO₂ emitted from industrial processes into carbon monoxide (CO), which is then fed back into the process, creating a closed carbon loop.   

The Niobium-based perovskite has a 100% selectivity for CO production, meaning that CO₂ passing through the material is transformed only into CO, and this type of perovskite was used when Birmingham researchers modelled a novel adaptation for existing blast furnaces that could reduce steelmaking emissions by up to 90%. 

A major advantage of this closed-loop carbon-recycling approach lies in its applicability to retrofit existing industrial processes, in a way that reduces significantly the need for major infrastructural replacements. 

This facilitates large-scale adoption and minimizes the stranded assets. Additionally, the perovskite technology operates at a lower temperature compared to conventional alternatives, resulting in a reduced costs and energy efficiency gains.

The outcomes will help advance the commercialisation of the decarbonisation technology through PeroCycle, a spin-out backed by the University of Birmingham and Anglo American, with venture-building led by Cambridge Future Tech.

CBMM's involvement will ensure the necessary support for future scalability of Niobium based perovskite production. “This partnership represents an important step in the search for viable and sustainable solutions to the challenges facing global industry. We are looking at a promising solution for industrial decarbonisation, especially in the steel sector, due to its potential technical and economic feasibility. Furthermore, the use of Niobium across different markets reinforces our commitment to innovation and sustainability,” says Leonardo Silvestre, Executive Innovation Manager at CBMM.

The project will explore its use not only in steel-making but also in other industries. 

Professor Yulong Ding, Chamberlain Chair of Chemical Engineering, and founder of the University of Birmingham’s Centre for Energy Storage, said: “Foundation industries such as steel-making, which provides essential materials to a wide range of other industries, are major emitters of CO2 and amongst the hardest sectors to decarbonise.  We are pleased to work with CBMM on this project, which aims to deliver a decarbonisation solution that is not only technically and economically viable, but also environmentally sustainable.”


 

Only Amazon MTurk’s ‘master’ workers provide reliable research data quality




Bar-Ilan University




A new study led by Dr. Vadim Axelrod, of the Gonda (Goldschmied) Multidisciplinary Brain Research Center at Bar-Ilan University, has revealed serious concerns about the quality of data collected on Amazon Mechanical Turk’s (MTurk) — a platform widely used for behavioral and psychological research.

MTurk, an online crowdsourcing marketplace where individuals complete small tasks for payment, has served as a key resource for researchers for over 15 years. Despite previous concerns about participant quality, the platform remains popular within the academic community. Dr. Axelrod’s team set out to rigorously assess the current quality of data produced by MTurk participants.

The study, involving over 1,300 participants across main and replication experiments, employed a straightforward but powerful method: repeating identical questionnaire items to measure response consistency. “If a participant is reliable, their answers to repeated questions should be consistent," added Dr. Axelrod. In addition, the study included different types of “attentional catch” questions that should be easily answered by any attentive respondent.

The findings, just published by Royal Society Open Science, were stark: the majority of participants from MTurk’s general worker pool failed the attention checks and demonstrated highly inconsistent responses, even when the sample was limited to users with a 95% or higher approval rating.

“It’s hard to trust the data of someone who claims a runner isn’t tired after completing a marathon in extremely hot weather or that a cancer diagnosis would make someone glad,” Dr. Axelrod noted. “The participants did not lack the knowledge to answer such attentional catch questions — they just weren’t paying sufficient attention. The implication is that their responses to the main questionnaire may be equally random.”

By contrast, Amazon’s elite “Master” workers — selected by Amazon based on high performance across previous tasks — consistently produced high-quality data. The authors recommend using Master workers for future research, taking into consideration that these participants are much more experienced and far fewer in number.

“Reliable data is the foundation of any empirical science,” said Dr. Axelrod. “Researchers need to be fully informed about the reliability of their participant pool. Our findings suggest that caution is warranted when using MTurk’s general pool for behavioral research.”

 

 

Ancient fault line poses future earthquake hazard in Canada’s North



University of Victoria






New research led by the University of Victoria (UVic) has illuminated a significant and previously unrecognized source of seismic hazard for the Yukon Territory of northwestern Canada. 

The Tintina fault is a major geologic fault approximately 1,000 km long that trends northwestward across the entire territory. It has slipped laterally a total of 450 km in its lifetime but was previously believed to have been inactive for at least 40 million years. However, using new high-resolution topographic data collected from satellites, airplanes and drones, researchers have identified a 130-km-long segment of the fault near Dawson City where there is evidence of numerous large earthquakes in the much more recent geologic past (the Quaternary Period, 2.6 million years to present), indicating possible future earthquakes. 

“Over the past couple of decades there have been a few small earthquakes of magnitude 3 to 4 detected along the Tintina fault, but nothing to suggest it is capable of large ruptures,” says Theron Finley, recent UVic PhD graduate and lead author of the recent article in Geophysical Research Letters. “The expanding availability of high-resolution data prompted us to re-examine the fault, looking for evidence of prehistoric earthquakes in the landscape.” 

Currently, the understanding of earthquake rates and seismic hazard in much of Canada is based on a catalogue of earthquakes from oral Indigenous accounts, written historical records and modern seismic monitoring networks. Collectively, these records only cover the last couple hundred years. However, for many active faults, thousands of years can elapse between large ruptures.  

When earthquakes are large and/or shallow, they often rupture the Earth’s surface and produce a linear feature in the landscape known as a fault scarp. These features, which can persist in the landscape for thousands of years, are typically tens to hundreds of kilometres long, but only a few metres wide and tall. They are difficult to detect in heavily forested regions like Canada, and require extremely high-resolution topographic data to identify. 

The team, consisting of researchers from UVic, the Geological Survey of Canada and University of Alberta, used high resolution topographic data from the ArcticDEM dataset from satellite images, as well as from light detection and ranging (lidar) surveys conducted with airplanes and drones. They identified a series of fault scarps passing within 20 km of Dawson City.  

Crucially, they observed that glacial landforms 2.6 million years in age are laterally offset across the fault scarp by 1000 m. Others, 132,000 years old, are laterally offset by 75 m. These findings confirm that the fault has slipped in multiple earthquakes throughout the Quaternary period, likely slipping several meters in each event. What’s more, landforms known to be 12,000 years old are not offset by the fault, indicating no large ruptures have occurred since that time. The fault continues to accumulate strain at an average rate of 0.2 to 0.8 millimetres per year, and therefore poses a future earthquake threat. 

"We determined that future earthquakes on the Tintina fault could exceed magnitude 7.5,” says Finley. “Based on the data, we think that the fault may be at a relatively late stage of a seismic cycle, having accrued a slip deficit, or build-up of strain, of six metres in the last 12,000 years. If this were to be released, it would cause a significant earthquake.”  

An earthquake of magnitude 7.5 or greater would cause severe shaking in Dawson City and could pose a threat to nearby highways and mining infrastructure. Compounding the hazard from seismic shaking, the region is prone to landslides, which could be seismically triggered. The Moosehide landslide immediately north of Dawson City and the newly discovered Sunnydale landslide directly across the Yukon River both show ongoing signs of instability.  

Canada’s National Seismic Hazard Model (NSHM) includes the potential for large earthquakes in central Yukon Territory, but the Tintina fault is not currently recognized as a discrete seismogenic fault source. The recent findings by this team will ultimately be integrated into the NSHM, which informs seismic building codes and other engineering standards that protect human lives and critical infrastructure. The findings will also be shared with local governments and emergency managers to improve earthquake readiness in their communities.

This research occurred on the territory of the Tr’ondëk Hwëch’in and Na-Cho Nyäk Dun First Nations 

 

Playing an instrument may protect against cognitive aging



Older musicians show youthful pattern of brain activity during speech perception



PLOS

Playing an instrument may protect against cognitive ageing 

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An older violinist stands in silhouette, while her younger self plays within, symbolizing how lifelong musical training preserves youth-like brain function. Just as melodies transcend time, playing music holds back age-related neural upregulation, supporting better speech perception in older musicians.

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Credit: Mohan Yuan (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/)






Long-term musical training may mitigate the age-related decline in speech perception by enhancing cognitive reserve, according to a study published July 15th in the open-access journal PLOS Biology by Claude Alain from the Baycrest Academy for Research and Education, Canada, and Yi Du from the Chinese Academy of Sciences.

Normal aging is typically associated with declines in sensory and cognitive functions. These age-related changes in perception and cognition are often accompanied by increased neural activity and functional connectivity – the statistical dependence of activity between different brain regions – in widely distributed neural networks. The recruitment of neural activity and strengthening of functional connectivity are thought to reflect a compensatory strategy employed by older adults to maintain optimal cognitive performance.

Positive lifestyle choices, such as musical training, higher levels of education, and bilingualism, contribute to cognitive and brain reserve, which represents the accumulation of cognitive and neural resources before the onset of age-related brain changes. Cognitive Reserve Theory suggests that this reserve accrued through experience and training can help mitigate the impact of age-related brain decline, leading to better-than-expected cognitive performance. Yet how cumulative reserves influenced by positive lifestyle factors affect neural activity in older populations remains controversial.

To investigate this question, the researchers used functional magnetic resonance imaging (fMRI) to measure brain activity in 25 older musicians, 25 older non-musicians, and 24 young non-musicians who were asked to identify syllables masked by noise sounds. The researchers focused their analysis on neural responses within the auditory dorsal stream, which includes auditory, inferior parietal, dorsal frontal motor, and frontal motor areas, supporting sound-to-action mapping and sensorimotor integration during speech processing.

As predicted, the results revealed reduced age-related declines in speech-in-noise performance among older musicians compared to older non-musicians. During speech-in-noise perception, the older non-musicians showed the typical age-related compensatory increase in functional connectivity in auditory dorsal streams bilaterally (i.e., in both hemispheres of the brain). By contrast, older musicians exhibited a connectivity pattern in bilateral auditory dorsal streams that resembled young non-musicians, with connectivity strength in the right dorsal stream correlating with speech-in-noise perception. In addition, older musicians exhibited more youth-like spatial pattern of functional connectivity during the task, whereas older non-musicians consistently showed a spatial pattern that deviated from young non-musicians.

Taken together, these findings support the “Hold-Back Upregulation” hypothesis, which posits that cognitive reserve from musical training promotes a more youthful functional connectivity pattern, leading to superior behavioral outcomes. Beyond merely compensating for age-related declines, cognitive reserve may work by maintaining the integrity and functional architecture of neural networks, thereby mitigating the adverse effects of aging on cognitive performance. But due to the study design, it was not possible to determine cause-and-effect relationships between musical training and performance in the perception task.

According to the authors, future studies should further test the “Hold-Back Upregulation” hypothesis using different cognitive tasks, such as memory and attention tasks, and investigate other sources of reserve, such as physical exercise and bilingualism. Eventually, these findings may inform interventions aimed at preserving cognitive function and improving communication outcomes in aging populations.

Dr. Lei Zhang adds, “A positive lifestyle helps older adults cope better with cognitive ageing, and it is never too late to take up, and stick with, a rewarding hobby such as learning an instrument.”

Dr. Yi Du adds, “Just like a well-tuned instrument doesn’t need to be played louder to be heard, the brains of older musicians stay finely tuned thanks to years of training. Our study shows that this musical experience builds cognitive reserve, helping their brains avoid the usual age-related overexertion when trying to understand speech in noisy places.”


In your coverage, please use this URL to provide access to the freely available paper in PLOS Biologyhttp://plos.io/3FMpr6l  

Citation: Zhang L, Ross B, Du Y, Alain C (2025) Long-term musical training can protect against age-related upregulation of neural activity in speech-in-noise perception. PLoS Biol 23(7): e3003247. https://doi.org/10.1371/journal.pbio.3003247

Author countries: China, Canada

Funding: This work was supported by STI 2030—Major Project (2021ZD0201500, https://service.most.gov.cn/) to YD, the Natural Sciences and Engineering Research Council (RGPIN-2021-02721, https://www.nserc-crsng.gc.ca/index_eng.asp) to CA, and Canadian Institute for Health Research (PJT 183614, https://cihr-irsc.gc.ca/e/193.html) to CA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.