Monday, August 11, 2025

Greener steel arrives in Canada to a market in turmoil and future unclear

By The Canadian Press
 August 10, 2025

Steam rises as water is poured over hot steel at Algoma's Direct Strip Production Complex in Sault Ste. Marie, Ont., on Wednesday, March 14, 2018. 
THE CANADIAN PRESS/Justin Tang

Like some superhero channelling the power of lightning, Algoma Steel Inc. has started using the heat cast off by the arcs of powerful electric currents to make greener steel.

Electric arc furnaces are nothing new — the technology is more than a century old, and there’s already a few in Canada — but Algoma is calling the achievement of production from its first of the kind furnace last month a win as it faces an existential threat from U.S. tariffs.

“We have reached a truly pivotal milestone for Algoma and the Canadian steel industry,” said chief executive Michael Garcia on a recent earnings call.

“Despite the uncertainty that the trade war has unleashed, this achievement reinforces our confidence in our transformation strategy.”

Part of that strategy has been to dramatically reduce emissions in an attempt to differentiate its products; it even trademarked Volta as the name for its cleaner steel that it plans to produce from a mix of low-emission iron feed and scrap metal.


But experts say the project is coming online as the market for green steel, and the metal more generally, faces turmoil from tariffs and price pressures, making it unclear what financial advantages producers may get from the big upfront investments needed.

“The question is, will the demand be there? Is there going to be sufficient demand in North America for green steel?” said Chris Bataille, who researches the steel transition as an adjunct research fellow at Columbia University’s Center on Global Energy Policy.

“The U.S. was starting to move fairly quickly in terms of moving to electric vehicles and to cleaner steel and everything else under the last administration, but now we’ve got a complete U-turn.”

Steel emissions had been a priority in the U.S., and remains one in Canada, because using coal to produce steel is so emissions intensive. Globally, steel production makes up about eight per cent of carbon emissions, according to the International Energy Agency.

But while it makes sense from an emissions perspective, buyers willing to pay a premium for the more eco-friendly steel have mostly been limited to the auto sector, said Bataille.

European automakers have been paying a premium of as much as 40 per cent for the cleaner material, since they can use it for marketing while only adding a little to the end cost of a car, but the more important building sector has been more hesitant, he said.

There is still demand in Europe, a region Canada has looked to diversify its exports, but with tariffs causing disruption there too it’s not clear how much potential there is, said trade expert Tommaso Ferretti.

“There is a structural demand in Europe, but to what extent that structural demand will remain in place, it’s a big question mark,” said the assistant professor at the University of Ottawa’s Telfer School of Management.

Garcia himself has warned that Algoma doesn’t see much potential to sell to Europe, or anywhere else internationally.

“We can put our steel on an ocean-going ship here in Sault Ste. Marie, but getting it to an export customer in Europe or elsewhere, there just aren’t those opportunities right now. I don’t think that there’ll be a lot of those opportunities going forward, to be frank,” he said.

The challenges help explain why the other flagship green steel project in Canada, at ArcelorMittal’s Hamilton, Ont., operations, is stuck in neutral.


The company made a big show of announcing in 2022 that it was moving ahead with a $1.8-billion project to move to green steel — but the last updates show the project is still at the engineering stage, with a spokesperson confirming there are no new milestones to report.

Wider oversupply issues in the industry that have pushed down prices is part of the problem, as are doubts about policies like carbon pricing, said Bataille.

“There’s some uncertainty about how fast the transition will go. ... It’s just a difficult business to make a buck, to be honest.”

ArcelorMittal said in its latest sustainability report in April that it doesn’t expect green steel projects to be economical until the 2030s, and that policies will be needed to address the high capital and operational costs.

Federal and provincial governments in Canada have already stepped in to help out with capital costs. Algoma received $420 million to help cover the more than $880 million cost of its project, while ArcelorMittal was offered $900 million to help ease its overall costs.

But unlike Algoma, ArcelorMittal’s plans also include building a plant in Hamilton to remove oxygen from iron ore using hydrogen, rather than coal — a process that remains expensive, leading to several recent project cancellations.

ArcelorMittal itself just cancelled two green steel projects in Germany in June, citing high electricity prices, while last year it noted the future of several other of its European steel projects is unclear because “there is limited willingness among customers to pay premiums for low-carbon emissions steel.”

Cleveland-Cliffs, which bought Hamilton-based Stelco Holdings Inc. last year, recently shelved plans for green steel conversion at a U.S. plant that already had US$500 million in government funding secured.

Lourenco Goncalves, chief executive of Cleveland-Cliffs, cited the lack of clear hydrogen supply as part of the reason for cancelling the project. He said on a July earnings call that plans to revamp the operation using existing resources, including “beautiful coal,” generates a very good conversation with the current U.S. Department of Energy.

Ferretti worries that the pressures the industry is facing will also mean less investment in research and development to try and bring costs down.

He said there needs to be even greater collaboration between the public and private sector for the critical industry to chart a path forward.

“The real question in fact is to see … the collaboration between the companies, the steel manufacturers, Canadian government, and their ability to reinvent themselves.”

For Bataille, that path could include using Canada’s vast renewable energy and iron ore deposits to build a direct reduction plant for processing closer to the source, and then shipping the already oxygen-reduced iron around the world.

“You could triple the value of those exports,” said Bataille.

“So on the one hand we face headwinds and the Chinese overcapacity continues, but on the other hand, I think there’s new possibilities open in shipping green iron places that, you know, we hadn’t considered before.”

This report by The Canadian Press was first published Aug 10, 2025.

Ian Bickis, The Canadian Press
Ford hits the pedal on EV production with US$2 billion overhaul of Kentucky plant


By The Associated Press
August 11, 2025 

Ford CEO Jim Farley speaks at the Louisville Assembly Plant, Monday, Aug. 11, 2025, in Louisville, Ky. (AP Photo/Darron Cummings)

LOUISVILLE, Ky. — Ford Motor Co. will invest nearly US$2 billion retooling a Kentucky factory to produce electric vehicles that it says will be more affordable, more profitable to build and will outcompete rival models.

The automaker’s top executive unveiled the new EV strategy at Ford’s Louisville Assembly Plant which, after producing gas-powered vehicles for 70 years, will be converted to manufacture electric vehicles.

“In our careers, as automobile people we’re lucky if we get to work on one, maybe two, projects that really change the face of our industry,” CEO Jim Farley told plant workers in Kentucky on Monday. “And I believe today is going to light the match as one of those projects for all of us here.”

The Big Detroit automakers have continued to transition from internal combustion engines to EV technology even as President Donald Trump’s administration unwinds incentives for automakers to go electric. Trump’s massive tax and spending law targets EV incentives, including the imminent removal of a credit that saves buyers up to $7,500 on a new electric car.

Yet Farley and other top executives in the auto industry say that electric vehicles are the future and there is no going back.

The first EV to be produced by the revamped Louisville production process will be a midsize, four-door electric pickup truck in 2027 for domestic and international markets, the company said Monday.

The new electric trucks will feature plenty of interior space to fit five adults and pack enough power to have a targeted 0-60 time as fast as a Mustang EcoBoost but with more downforce, Ford said

The electric trucks will be powered by lower-cost batteries made at a Ford factory in Michigan. The Detroit automaker previously announced a $3 billion investment to build the battery factory.

The automaker sees this as a “Model T moment” for its EV business - a reference to revolutionary changes on the production line led by the company’s founder, Henry Ford, when it began churning out vehicles from a factory more than a century ago. Farley said the changes will upend how electric vehicles are made in the U.S.

“It represents the most radical change on how we design and how we build vehicles at Ford since the Model T,” Farley said.

The company said it will use a universal platform and production system for its EVs, essentially the underpinning of a vehicle that can be applied across a wide range of models.

The Louisville factory - one of two Ford assembly plants in Kentucky’s largest city - will be revamped to cut production costs and make assembly time faster as it’s prepared to churn out electric vehicles.

The result will be “an affordable electric vehicle that we expect to be profitable,” Farley said in an interview with The Associated Press ahead of the announcement. “This is an example of us rejuvenating our U.S. plants with the most modern manufacturing techniques.”

The new platform enables a lineup of affordable vehicles to be produced at scale, Ford said. It will reduce parts by 20 per cent versus a typical vehicle, with 25 per cent fewer fasteners, 40 per cent fewer workstations dock-to-dock in the plant and a 15 per cent faster assembly time, Ford said.

The traditional assembly line will be transformed into an “assembly tree” at the Louisville plant, the company said. Instead of one long conveyor, three subassembly lines will operate simultaneously and then join together, it said.

Other specifications for the midsize electric truck -- including its reveal date, starting price, EPA-estimated battery range, battery sizes and charge times -- will be announced later, the company said. Farley revealed that the truck will have a targeted starting price of about $30,000.


Ford said its investment in the Louisville plant will secure 2,200 hourly jobs.

Kentucky Gov. Andy Beshear said Monday that the automaker’s plans for the Louisville plant will strengthen a more than century-old partnership between Ford and the Bluegrass State.

“This announcement not only represents one of the largest investments on record in our state, it also boosts Kentucky’s position at the center of EV-related innovation and solidifies Louisville Assembly Plant as an important part of Ford’s future,” Beshear said.

Ford said its combined investment of about $5 billion at the Kentucky assembly plant and Michigan battery plant is expected to create or secure nearly 4,000 direct jobs between the two plants while strengthening the domestic supply chain with dozens of new U.S.-based suppliers.

Ford previously forecast weaker earnings growth for this year and further losses in its electric vehicles business as it works to control costs. Model e, Ford’s electric vehicle business, posted a full-year loss of $5.08 billion for 2024 as revenue fell 35 per cent to $3.9 billion.

Ford’s new EV strategy comes as Chinese automakers are quickly expanding across the globe, offering relatively affordable electric vehicles.

“We’re not in a race to build the most electric cars,” Farley told the AP when asked about competition from China. “We’re in a race to have a sustainable electric business that’s profitable, that customers love.

“And this new vehicle built in Louisville, Kentucky, is going to be a much better solution to anything that anyone can buy from China,” he added.

Ford could have opted to launch its EV project overseas to reap lower-cost labor and currency advantages but instead is “taking the fight to our competition” from the plant in Kentucky, Farley said at Monday’s event. But the Ford CEO cautioned that “there are no guarantees” with project.

“We’re doing so many new things I can’t tell you with 100 per cent certainty that this will all go just right,” he said. “It is a bet. There is risk. The automotive industry has a graveyard littered with affordable vehicles that were launched in our country with all good intentions. And they fizzled out with idle plants, laid off workers and red ink. And at Ford ... we set out to break that cycle.”

Bruce Schreiner, The Associated Press
Pot stocks jump as Trump signals possible reclassification

By Reuters
 August 11, 2025 

A cannabis plant approaching maturity is photographed at the CannTrust Niagara Greenhouse Facility during the grand opening event in Fenwick, Ont., on Tuesday, June 26, 2018. THE CANADIAN PRESS/ Tijana Martin (Tijana Martin/THE CANADIAN PRESS)

Shares of pot companies jumped on Monday after U.S. President Donald Trump said his administration is looking at reclassifying marijuana as a less dangerous drug, potentially easing criminal penalties and reshaping the industry’s federal standing.

Tilray Brands’ shares gained nearly 24 per cent, while the U.S.-listed shares of SNDL and Cronos Group were up 15.5 per cent and 13.2 per cent, respectively.

Toronto-listed shares of Canopy Growth and Trulieve Cannabis jumped 30 per cent and 27 per cent, respectively.

ETF AdvisorShares Pure US Cannabis was up 18.5 per cent.

Even mere speculation of federal-level reclassification can catalyze outsized moves in cannabis stocks, as shifting marijuana from its current Schedule I classification could unlock banking access, attract institutional investors and spur mergers and acquisitions.

Reclassification would also remove the tax burden under Section 280E, which denies standard business deductions to cannabis companies. Resolution of this tax barrier could pave the way for cannabis companies to list on U.S. stock exchanges, further unlocking capital–market access.

Under the Controlled Substances Act, marijuana is listed as a Schedule I substance, meaning it has a high potential for abuse and no current accepted medical use.

The Biden administration had directed the U.S. Department of Health and Human Services to review marijuana’s status, leading the agency to recommend moving it to Schedule III, a category for drugs with moderate to low potential for dependence.

That review is now in the hands of the Drug Enforcement Administration, which will determine if rescheduling happens.

(Reporting by Mrinalika Roy in Bengaluru; Editing by Alan Barona)
Hudson’s Bay lease sale may negatively impact pension fund: OMERS’ real estate arm

Oxford is the real estate division of Ontario Municipal Employees Retirement System



By The Canadian Press
Updated: August 11, 2025 


Ruby Liu is shown leaving court in Toronto on Monday June 23, 2025. THE CANADIAN PRESS/Nathan Denette

TORONTO — The real estate investment arm of one of the country’s largest pension funds is worried about the value of its assets if a B.C. billionaire is able to buy Hudson’s Bay leases at its properties.

In documents filed with the Ontario Superior Court over the weekend, Oxford Properties Group argues transferring leases to “an unvetted and unproven” entrepreneur like Ruby Liu “poses a serious and unacceptable risk” to the company.

“A diminution in the value or stability of Oxford’s real estate portfolio would negatively impact the performance of OMERS’ investments, and by extension, adversely affect the long-term interests of millions of current and future pension plan beneficiaries,” Nadia Corrado, a vice-president with Oxford, said in affidavit entered into the court record Saturday.

Oxford is the real estate division of Ontario Municipal Employees Retirement System, which administers the pensions of more than 600,000 plan members. Oxford has more than $79 billion in assets under management and hundreds of properties on four continents.

Liu, who owns three B.C. malls and a golf course, is looking to take over about two dozen Bay leases.

Three of those leases are in Oxford properties — Southcentre Mall in Calgary, Hillcrest Shopping Centre in Richmond Hill, Ont., and Upper Canada Mall in Newmarket, Ont.

Liu has said she plans to use the spaces to build a new department store she will name after herself. It will have three tiers of stores — flagship, platinum and standard — filled with entertainment, dining and recreation spaces.

She has said she and a team of 1,800 staff she will hire can get the bulk of the stores open within 180 days of signing leases. She has allocated $325 million to accomplishing the feat, which will involve repairing stores, forging relationships with suppliers and marketing her entirely new brand.

Liu, who did not comment for this story, has said she is confident she can win property owners over if the court allows her purchase of the leases to go through.

However, landlords, including Oxford, are fighting Liu, saying her plans are underfunded, have unrealistic timelines and are bound to fail.

A court hearing is scheduled in the case for later this month.

Oxford’s doubts about Liu emerged as soon as its executives met with her on June 2.

“That meeting was unproductive and revealed a troubling absence of financial transparency, commercial sophistication and basic preparedness,” Corrado recalled in her affidavit. “No financial statements, proof of funding or evidence of capital readiness were provided.”

She alleged Liu, who made her fortune in Chinese real estate, told Oxford she had a business plan but wouldn’t provide it unless Oxford pledged its support for her taking over the lease.

When Oxford asked about whether she had suppliers willing to sell her merchandise to fill stores, Corrado alleges Liu told the company to “relax, lay back and do not worry.”

Oxford had a hard time taking that advice. At stake were leases with terms ranging from 49 to 65 years and covering some of the company’s most desirable shopping spaces.


The size and orientation of the Bay space at Hillcrest Mall alone “means that any misstep will materially affect the overall customer experience, tenant retention, and, in turn, diminish the value of Oxford’s asset,” Corrado said.

Based on her experience, she said it takes years for companies to curate a concept for a new retailer, even for one taking over very small units. She said in the court documents that she found it hard to believe Liu thought such work could be done in a matter of months for even a single leased location of more than 150,000 square feet and thought the timeline spoke to Liu’s inexperience.

“The introduction of an unproven anchor tenant lacking established retail credibility poses a significant risk in that it can degrade the customer experience, diminish the overall quality of the shopping centre, and generate a negative ‘halo effect’ that impacts entire wings of the mall,” Corrado said.

“Given that anchor leases can endure for decades, the long-term presence of a poor anchor can permanently undermine and potentially destroy the commercial viability of substantial portions, or even the entirety of a shopping centre.”

In their own filings made Saturday, many other landlords agreed with Oxford’s concerns.

Morguard Investments Ltd. called information Liu supplied about her plans “surprisingly deficient and superficial and frankly, puerile.”

It said it was willing to wait to find a better long-term tenant and, in the meantime, wants to enter into temporary leases terminable by the landlord with 90 days’ notice with clothing company Urban Behavior and accessories retailer Ardene.

Primaris Real Estate Investment Trust said it left four hours’ worth of meetings with Liu and her team with “absolutely no confidence that she had the relevant experience or understanding of the enormity of what she is seeking to undertake by opening a multi-store business concept in several provinces from the ground up.”

Cadillac Fairview felt her plan “defies commercial common sense” but hired Ernst & Young to evaluate it anyway.

A report filed with the court showed the consultancy firm thought the estimated costs and timelines in Liu’s business plan are not feasible and would be significantly higher given the large number of repairs the properties require and the complex relationships she must forge with suppliers and other vendors.

Liu and the Bay have until Tuesday to file a response to the landlords in court. At the end of the week, they will begin cross-examinations before a judge hears their case at the end of the month.

This report by The Canadian Press was first published Aug. 11, 2025.

This is a corrected story. Due to an editing error, a previous version said Oxford has $79 million in assets under management.

Tara Deschamps, The Canadian Press
Air Canada flight attendants picketing at 4 major airports on national day of action


By The Canadian Press
 August 11, 2025 


Air Canada says they don’t expect their flights to be impacted as flight attendants are set to demonstrate at 4 major airports today.


TORONTO — Air Canada flight attendants gathered for simultaneous demonstrations outside airports in some major Canadian cities Monday as the clock ticked down toward a possible strike that could begin as soon as this weekend.

In what their union called a national day of action, members of the Air Canada component of the Canadian Union of Public Employees planned pickets at Montreal’s Pierre Elliott Trudeau International Airport, Toronto Pearson International Airport, Vancouver International Airport and Calgary International Airport.

In Toronto, hundreds of flight attendants in uniform began piling out of yellow school buses shortly before 1 p.m. ET, as they lined up in front of the departure gate entrances at Terminal 1 of Pearson airport.

They stood in silence looking straight ahead, with some carrying signs reading “unpaid work won’t fly” and “unfAir Canada.”

Some drivers in Vancouver honked in support as flight attendants stood silently for more than 30 minutes curbside outside the departures level.


The union said it is looking to raise awareness about what it calls “poverty wages” and unpaid labour when planes aren’t in the air.

In a statement, Air Canada spokesman Peter Fitzpatrick said flights would not be affected by Monday’s demonstrations and that customers should expect their travel to run as usual.

“Demonstrations of this nature are common during negotiations,” he said in an emailed statement.

“We respect our flight attendants’ right to express themselves and note the union has said they will not affect Air Canada’s operations.”

Toronto Pearson airport said on social media that staff would be on site Monday to assist passengers and help maintain the flow of traffic during the demonstration.

“To help avoid any potential delays, we recommend travellers give themselves extra time if they are flying out,” it added.

Vancouver International Airport also said it did not expect the demonstration to affect travellers but advised them to check the status of their flight before coming to the airport.

Bargaining talks with the airline resumed last Friday after the union’s members voted 99.7 per cent in favour of a strike mandate.

The vote, which wrapped last Tuesday, means flight attendants are in a strike position as of this Saturday at 12:01 a.m. ET, with at least 72 hours’ notice provided for any work action.

The two sides have been in contract talks since the beginning of the year. The strike mandate came after the airline and union concluded a conciliation process without reaching a deal.

Fitzpatrick said Air Canada “remains at the bargaining table and is focused on achieving a negotiated settlement with CUPE.”


He said the airline hopes to reach a deal that “recognizes the contributions of its flight attendants by making them the best paid in the country, and that also supports the competitiveness and long-term growth of the company.”

“Our goal is to achieve this without any disruption to travel,” said Fitzpatrick, adding Air Canada would not comment further on the substance of negotiations.

“For customers, there has been no impact and we continue to operate as normally and they can travel as planned.”

Air Canada has said it believes there’s enough time to get a deal done and avoid interrupting the plans of thousands of travellers.

Should this change, however, the airline said it plans to notify customers via email and text message in advance of their travel.

For passengers whose itineraries potentially change mid-journey, Air Canada said it will “actively explore all options to keep you travelling, including rebooking with other airlines on your behalf.”

The negotiations concern flight attendants working for Air Canada’s main operations, as well as for Air Canada Rouge.

This report by The Canadian Press was first published Aug. 11, 2025.

 

Rice’s dean of engineering and computing building new software infrastructure for evolutionary biology



Rice University
Luay Nakhleh 

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Luay Nakhleh, dean of the George R. Brown School of Engineering and Computing at Rice University. 

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Credit: Jeff Fitlow/Rice University.





Rice University computer scientist Luay Nakhleh, who also serves as the dean of the George R. Brown School of Engineering and Computing, has received a $1.9 million grant from the National Science Foundation to build a powerful new software infrastructure that could significantly expand how scientists study evolution. The project, titled PhyNetPy, aims to bring the next generation of evolutionary modeling tools into the hands of researchers around the world by enabling the widespread use of phylogenetic networks — complex, nontreelike models of evolutionary history.

“For decades, biology has relied on phylogenetic trees to study evolutionary relationships, but those models fall short in many real-world scenarios,” Nakhleh said. “Processes like hybridization, gene flow and horizontal gene transfer don’t fit neatly on a tree. Phylogenetic networks are essential for capturing the full picture.”

While thousands of tools and libraries exist for phylogenetic tree analysis, comparable resources for phylogenetic networks are scarce and fragmented. PhyNetPy aims to be the first open-source, general-purpose Python library designed specifically for network-based evolutionary modeling.

“Our goal is to create the kind of software ecosystem for networks that already exists for trees,” Nakhleh said. “That means not just inference tools but also robust data structures, simulation engines, visualization capabilities and a user-friendly interface. We want to lower the barrier to entry, so more biologists — and computer scientists — can use and build on these models.”

The project is designed with broad compatibility in mind, enabling interoperability with tools like DendroPy, ETE Toolkit and Biopython. It also promises seamless cloud deployment, so users can access powerful analytical tools without needing to install or configure complicated software.

Traditional tree models assume evolution is strictly branching with species splitting and never merging again. But in reality, evolutionary history is often tangled. Hybridization in plants, gene flow in animals and horizontal gene transfer in bacteria all create reticulate patterns that look more like webs than trees.

“More than 25% of plant species are of hybrid origin,” Nakhleh said. “In agriculture, this has huge implications. For example, hybrid crops can outperform their parents, a phenomenon known as hybrid vigor. Understanding how that happens at the genomic level requires network models.”

Even in animals, hybridization occurs.

“Studies suggest that at least 10% of animal species have experienced hybridization,” Nakhleh said. “Without networks, we’re missing critical insights into how evolution works.”

One of PhyNetPy’s most ambitious goals is to unite the phylogenetics and population genetics communities, which have traditionally used different languages and models to study similar phenomena. Phylogeneticists typically speak of “networks,” while population geneticists often talk of “graphs,” including ancestral recombination graphs or admixture graphs. Despite their different names, these structures can be mathematically equivalent.

“By providing a unified framework, we hope to bridge the gap between these two communities,” Nakhleh said. “If we can get more researchers using shared tools and terminology, it will accelerate discovery across the board.”

The five-year NSF-funded project is structured around five technical thrusts, including data structures, inference algorithms, simulation tools, network characterization methods and visualization capabilities. Nakhleh and his team will also reimplement and expand many of the successful methods from his earlier project, PhyloNet, to make them more scalable, user-friendly and ready for the cloud. The project will also include education and outreach efforts with undergraduate and graduate students contributing to PhyNetPy’s development and its use integrated into courses at Rice. As with Nakhleh’s previous tools, the entire PhyNetPy platform will be open-source and freely available to the scientific community.

“This isn’t just about building software; it’s also about building a community,” he said. “We want PhyNetPy to be a platform where researchers can contribute new methods, share ideas and collaborate to push the boundaries of evolutionary science.”

 

Researchers discover all-new antifungal drug candidate in McMaster’s greenhouse



McMaster University






A research team at McMaster University has discovered a new drug class that could someday lead to breakthrough treatments for dangerous fungal infections.

The new molecules, dubbed coniotins, were isolated from a plant-dwelling fungus called Coniochaeta hoffmannii — the samples of which were collected from the McMaster greenhouse, located on the university’s campus.

Detailed recently in the journal Nature Communications, the discovery responds to a critical need for new antifungal medicines.  

 “There is a huge, growing clinical need for new drugs that target fungal infections,” says Gerry Wright, a professor of biochemistry and biomedical sciences at McMaster and principal investigator on the new study. “Unlike antibiotics, of which there are dozens of different classes approved for use in clinics, there are really only three classes of antifungals on the market right now.”

The reason for such a limited arsenal, Wright says, is two-fold.

First, although disease-causing fungi are microscopic like bacteria and viruses, they’re actually more closely related to humans than they are to other microbes — “so things that kill fungi tend to kill us too,” he says. This makes finding antifungals that are safe for human consumption a real challenge.

And then there’s the historical lack of urgency. Wright says that most fungi cannot withstand our internal body temperature, and usually die off before they can cause serious infection. It’s why fungal infections typically occur on us instead of in us — think athlete’s foot, for example. Because our bodies can generally handle these pathogens naturally, Wright says there’s been little incentive for pharmaceutical companies to invest in antifungal R&D — until recently.

“Discovery remains a challenge today, but the level of urgency has changed dramatically over the past 15 years or so,” he says. “In 2009, a novel fungal pathogen called Candida auris emerged all over the world, and this fungus thrives at higher temperatures — and it can be extremely drug-resistant, too.”

C. auris is particularly problematic for individuals with compromised immune systems, like cancer patients undergoing chemotherapy. It can infect the lungs, the bloodstream, and the nervous system, and can be fatal. For these reasons, C. auris sits atop the World Health Organization’s list of priority fungal pathogens.

It’s a good thing then that the Wright Lab’s new molecule exhibits potent activity against C. auris.

Indeed, the research team showed that coniotins not only attack C. auris and several other fungal pathogens, but do so without harming human cells.

The new molecules function unlike any other antifungal on the market. Where most target proteins and membranes, coniotins instead bind to the fungal cell wall.

Wright, a member of the Michael G. DeGroote Institute for Infectious Disease Research at McMaster, likens the cell wall to the candy coating on an M&M — a protective shell that provides structural integrity for what’s inside. Disturbing this structure, as coniotins do, fundamentally changes how well the organism can survive.

Xufei Chen, a postdoctoral fellow in Wright’s lab and first-author on the new paper, identified the new drug class through a process called prefractionation, which allows scientists to tease specific molecules out from complex chemical mixtures.  

“Since the golden age of antibiotic discovery, progress has slowed, due primarily to the frequent rediscovery of known compounds,” she says. “To address this, we implemented a prefractionation screening approach to target overlooked or masked metabolites. By integrating mass spectrometry, metabolomics, and computational analysis, I was able to discover this previously hidden molecule.”

Using this same process, Wright’s lab recently discovered a new class of antibiotics. They have also used prefractionation to identify several other new drug candidates, which remain under study.

“What’s really amazing is that we’ve only screened about five percent of the chemical library that we’ve built here at McMaster,” Wright says. “We have an immense, largely unexplored chemical space at our fingertips, and a cost-effective way to reduce the rediscovery of known compounds. Who knows what else is in there?”

Wright’s team is eager to move coniotins along the development pathway. The next steps, he says, include producing it at scale through fermentation, and formulating the new drug class so that it may eventually be suitable intravenous (IV) delivery.

 

How organic matter traps water in soil — even in the driest conditions



Water molecules form bridges between mineral and carbohydrates to lock in moisture, study finds



Northwestern University

Moisture trapped in soil 

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Illustration of water trapped as molecular bridges at carbohydrate-clay interfaces.

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Credit: Aristilde Research Group/Northwestern University





From lifelong farmers to backyard gardeners, most plant-lovers know that adding organic matter to a field, vegetable plot or flowerpot increases the soil’s moisture.

Now, for the first time, Northwestern University scientists have uncovered the molecular mechanisms that enable organic matter to boost soil’s ability to retain water — even in desert-like conditions.

Carbohydrates — key components of plants and microbes — act like a molecular glue, using water to form sticky bridges between organic molecules and soil minerals, the team found. These bridges lock in moisture that otherwise might evaporate. The discovery sheds light onto how soils stay moist during drought and even how water might have survived for billions of years trapped in otherworldly rocks, including on Mars and in meteorites. 

The study was published on Saturday (Aug. 9) in the journal PNAS Nexus.

“The right amount of minerals and organic matter in soils leads to healthy soils with good moisture,” said Northwestern’s Ludmilla Aristilde, who led the study. “It’s something everyone has experienced, but we haven’t fully understood the physics and chemistry of how that works. By figuring this out, we could potentially engineer soil to have the right chemistry, turning it into long-term sponges that preserve moisture.”

An expert in the dynamics of organics in environmental processes, Aristilde is an associate professor of civil and environmental engineering at Northwestern’s McCormick School of Engineering and is a member of the Center for Synthetic BiologyInternational Institute for Nanotechnology and Paula M. Trienens Institute for Sustainability and Energy. Recent Ph.D. graduate Sabrina Kelch and postdoctoral researcher Benjamin Barrios-Cerda — both from Aristilde’s laboratory — are the paper’s first and second authors, respectively.

Water-trapping bridges

To conduct the study, Aristilde’s team mi

xed a common clay mineral (smectite) found in soils with three types of carbohydrates: glucose, amylose and amylopectin. While glucose is a simple carbohydrate or sugar, amylose and amylopectin are complex polymers in starch, made from linking glucose units together. Amylose is a long, linear chain of glucose; amylopectin also is a long chain but has tree-like branches.

“We decided to use carbohydrates as a type of organic matter because it exists everywhere,” Aristilde said. “Cellulose, which is the most abundant biopolymer on Earth, is made of glucose, and plants and microbes secrete different, simple to complex carbohydrates into soil. We also selected carbohydrates because they have simple chemistry to avoid complicating our results with certain side reactions.”

Using a combination of molecular dynamics simulations, quantum mechanics and laboratory experiments, Aristilde and her team examined the nanoscale interactions among clay minerals, water molecules and the three types of carbohydrates compounds. The scientists found that hydrogen bonds provided a key mechanism that enables clays and carbohydrates to hold onto water. 

A weak, attractive force, hydrogen bonds make water molecules “stick” together to form a droplet or flow through a faucet. Aristilde’s team discovered water also forms hydrogen bonds with the surface of clay minerals and carbohydrates at the same time, creating bridges of water between the two entities. These bridges lock in water more tightly, making it less likely to be lost through evaporation.

“When a water molecule is retained via a hydrogen bond with a carbohydrate and a hydrogen bond with the surface of a mineral, this water has a strong binding energy and is stuck between the two things it’s interacting with,” Aristilde said.

Complex sugar quintuples bond strengths 

Using molecular simulations, the researchers found that water molecules lodged between the clay mineral surface and the carbohydrates had stronger binding energy compared to water bound to clay alone. In fact, complex sugar polymers helped clay bind water up to five times more tightly than clay without an associated carbohydrate. Even in extremely dry conditions, water bound to clay and carbohydrates was far less likely to evaporate and more likely to remain trapped within the nanopores of the clay.

“We increased the temperature to measure water loss in both the presence and absence of carbohydrates,” Aristilde said. “Compared to the clay by itself, it required higher temperatures for water to leave the matrix with the presence of the clay and carbohydrates together. This means the water was retained more strongly in the presence of the carbohydrates.” 

The branched and long-chain carbohydrates also prevented the clay’s pores from completely collapsing in dry conditions. Typically, as clay dries out, its nanoscale pores shrink with increasing loss of water from the pores. But the complex carbohydrates can prevent full collapse of the clay nanopore. This may help preserve the retention of moisture associated with the trapped organics in the pores for long periods of time, including during droughts.

Not only will this new information help us understand soil on our own planet, it also could provide new insights about neighbors in our solar system and beyond.

“Even though our goal was to understand how soil on Earth holds on to its moisture, the mechanisms we uncovered here may have implications in understanding phenomenon beyond our planet,” Aristilde said. “There is a lot of interest in how this relationship between organics and water might play out on other planets — especially those that are considered to have once harbored life.”

The study, “Mechanisms of water retention at carbohydrate-clay interfaces,” was supported by supported by the U.S. Department of Energy (DE-SC0021172) and Northwestern’s International Institute for Nanotechnology.

 

Victims of ‘enforced disappearances’ face unique mental health challenges, says Dr Anis Ahmed



Aston University



  • Dr Anis Ahmed has co-written an article for Medicine, Science and the Law on the challenges faced by victims and families of ‘enforced disappearances’

  • Enforced disappearances are defined as the arrest, detention, abduction, or any other form of deprivation of liberty by state agents

  • In his editorial, he examines the psychological trauma and highlights the need for culturally sensitive mental health responses.

Dr Anis Ahmed, clinical lead in psychiatry at Aston Medical School, has co-written an article looking at the mental health challenges for the victims of ‘enforced disappearances’.

This is defined by the UN as “the arrest, detention, abduction, or any other form of deprivation of liberty by state agents, or those acting with state approval.”

Together with his co-author, Professor Andrew Forrester, professor of forensic psychiatry at Cardiff University, Dr Ahmed says that the psychological trauma of victims and their families is under-researched. There is, therefore, no clear guidance for mental health professionals treating them. The authors say that there is a “dire need” to develop evidence-based treatments, and that addressing the “therapeutic void” is “not just a clinical necessity but a moral imperative.”

Enforced disappearances are a globally significant human rights violation, affecting thousands of people across the globe. Historical examples include the ‘Dirty War’ in Argentina (1976–1983), where 30,000 people went missing, while in Syria now, tens of thousands of people are missing due to state repression and conflict.

Families of those who have disappeared live in a state of what is known as “ambiguous loss”, with a prolonged state of uncertainty in which they are unable to grieve or move forward, often suffering chronic depression and anxiety and, in some cases, post-traumatic stress disorder (PTSD).

Traditional grief therapy assumes a confirmed death, and the social and cultural rituals that follow that, which allow for mourning and closure. However, in cases of enforced disappearance, these conditions are absent. Families are left in a painful limbo, trapped between hope and despair, with no closure. Conventional grief models fail to address the unique psychological suffering caused by prolonged uncertainty and ambiguous loss.

Victims who return also face unique challenges. As well as the psychological aftermath of prolonged captivity and torture, they struggle with trust, hypervigilance and shame. Reappearance can attract unwanted attention, suspicion and social stigma.

Dr Ahmed and Professor Forrester acknowledge the significant challenges in conducting research and developing the appropriate mental health guidelines. Fear acts as a powerful barrier, not only for victims, who may remain silent due to threats of reprisal or renewed targeting, but also for mental health professionals, who may hesitate to engage fully out of concern for their own safety. Even with assurances of medical confidentiality, many are only willing to speak openly after the fall of an oppressive regime, obstructing efforts to uncover the full extent of harm and delaying the development of effective, culturally appropriate treatments.

They say that the first step towards developing the necessary guidance is a study to map the prevalence and psychological impact across different regions. The second step should be developing and testing targeting treatments.

They write:

“Mental health professionals must advocate for policy changes that support victims’ families, including legal recognition of their status, access to mental health services, and the right to seek justice without persecution. International psychiatric associations, human rights organisations, and trauma researchers need to collaborate to fill this critical gap.”

Dr Ahmed said:

“Enforced disappearances remain a deeply neglected area in academic and clinical discourse, especially concerning mental health impacts. I’m currently working to establish an international, multidisciplinary research collaboration to address this gap – bringing together voices from psychiatry, anthropology, sociology, human rights, and legal studies. This is a complex issue that requires cross-sector engagement.”

To read the full paper, ‘Mental health challenges of enforced disappearances: A call for research and action’, in Medicine, Science and the Law, visit https://doi.org/10.1177/00258024251349373.

On 29 August 2025, Dr Ahmed will host an international conference in London entitled ‘Healing the Unseen Scars: Mental Health Responses to Enforced Disappearances’. Held in commemoration of World Enforced Disappearances Day on 30 August, the event will include contributions from UN representatives, forensic psychiatrists, human rights lawyers, and global researchers including from Latin America and south Asia. For more information, visit https://www.eventbrite.co.uk/e/healing-the-unseen-scars-mental-health-responses-to-enforced-disappearance-tickets-1390870283459.

In addition, Dr Ahmed is working with victims, families and mental health professionals in Bangladesh to develop recommendations for a peer-reviewed publication, aiming to set the foundation for future research and policy advocacy.