Friday, September 05, 2025

Will France’s ‘block everything’ movement jump from social media to the streets?

As 10 September nears, the emerging movement Bloquons Tout – “Let’s Block Everything” – is calling to bring France to a standstill in protest at economic policies. RFI asked political communications specialist Elliot Lepers and sociologist Quentin Ravelli whether online anger will be galvanised into real action.


Issued on: 05/09/2025 - RFI

Posts on social media have called for a general strike in France on 10 September 2025, in protest at planned budget cuts. 
AFP - BERTRAND GUAY

Born online, the movement Bloquons Tout – “Let's Block Everything” – is aiming to bring France to a standstill on 10 September.

The movement is a protest against Prime Minister François Bayrou’s 2026 budget, unveiled in mid-July, as well as the proposed scrapping of two public holidays – 8 May and Easter Monday – and the planned pension freeze, as well as wider cuts to public services.

It has also voiced demands for fairer taxation, calling for an economic reset that better supports ordinary workers and middle-class households.

With its origins elusive and its activity so far mostly limited to the online sphere, questions have been raised over whether Bloquons Tout will emerge as a genuine protest movement.

RFI put this question to Elliot Lepers, a political communications adviser who has been following the movement, and Quentin Ravelli, a sociologist at the French National Centre for Scientific Research.


Why does France want to scrap two of its public holidays?

RFI: How would you describe this call to action on 10 September? Is it possible to define the movement at this stage?

Quentin Ravelli: It’s difficult to define a movement that doesn’t yet exist. There is a call, but it hasn’t fully taken shape. For now, it’s ambivalent, shifting – with economic demands and an effort to build consensus beyond political divides. But movements evolve constantly as events unfold. We’ll have to see how, and if, it takes off.

Elliot Lepers: It’s a very “nebulous” movement – no clear hierarchy or organisation is visible. It’s also extremely diverse, with participants coming from varied cultural and political backgrounds. That diversity is something they actively defend. In the Telegram groups, after parties such as France Unbowed expressed support, there were reminders of the need to maintain neutrality – to keep 10 September a non-partisan space, not to be exploited by parties, unions or ideologies.

Yet the movement is said to have started with accounts close to the far right, before being supported by left-wing parties. How do you view this?

EL: It’s true that the first online relays came from so-called “patriot” circles – far-right conservative forums – and some Russian interference has been documented too. But those remain marginal. What’s more significant are the large, spontaneous surges of people self-organising around genuine anger. It’s a space of politicisation, where thousands are trying to turn shared experiences into political action. Yes, there are attempts at manipulation, but they coexist with sincere mobilisation.

Movement calls for September shutdown across France to protest budget cuts

Can a movement really channel anger without aligning with a political side?

QR: Since the 2008 crisis, we’ve seen economic grievances turn into political ones – think of the Indignados [an anti-austerity movement in Spain] or Occupy Wall Street. Many movements avoid being labelled left or right. This isn’t just strategic: participants often feel that consensus around economic demands matters more than political allegiance. Urgent issues like public services, wages or inflation are seen as priorities.

Do you see continuity with the Yellow Vests movement?

EL: The Yellow Vests are often mentioned as both inspiration and something to be distinguished from. They’re part of the political culture, but I don’t see the 10 September groups as direct heirs. For instance, organisers debate whether to use the tricolour flag in visuals, or whether yellow should feature – knowing it evokes the Yellow Vests.

QR: Many former Yellow Vests aren’t mobilising, although some are. Continuity is hard to gauge. The Yellow Vests had clear demands at the start, centred on fuel, and concrete tactics like roundabout occupations. In contrast, “Let's Block Everything” or opposing a budget is much more vague. The 10 September call is strategically blurry, echoing Yellow Vest sentiment in part, while aiming to broaden the scope of the protest.

Is the movement becoming more structured beyond the online sphere?

EL: Yes. Once you join a Telegram group, you find local offshoots by region, department or city, which then organise assemblies. These have multiplied as 10 September approaches. Early on, the focus was symbolic actions – withdrawing money, boycotting consumption. Now the tone has shifted to tangible blockades: road closures, street actions. But the movement is highly diverse, so expressions will vary from city to city.

QR: I have mixed feelings. It does reach different social groups – former Yellow Vests, health workers opposed to cuts, people angry about lost public holidays. But the tactics are unclear. The 2018-2019 roundabout blockades provided structure. Today’s calls for strikes are more vague, and how they’ll translate locally remains uncertain.

Bayrou lays out his budget strategy, one week ahead of no-confidence vote

Does the confidence vote for François Bayrou on 8 September change things?

EL: When that announcement came, I observed a spike in online interaction – people asking about consequences, not about the movement’s legitimacy. If anything, it was seen as validation of the protest mood and rejection of current policies. The challenge now is how the movement adapts – what slogans, what targets – especially if there’s a resignation.

QR: People aren’t just mobilising against Bayrou. He’s just one factor in much wider anger. This goes beyond a showdown between a prime minister and a few activists – the conditions are there for a broader confrontation.

Could 10 September be a turning point?

EL: Like all spontaneous, digital-born movements, there are phases. First comes a vague recruitment drive, then the test in the real world. That’s when ideals meet reality, creating clarification. It’s a trial by fire – either the movement crystallises into something real, or it fragments.

QR: I feel something strong could emerge – but it will all be decided in the coming two weeks, on 8 September and especially on 10 September. The day could either lead to a quick sense of victory and exhaustion, or spark the real take-off of the movement.

(This interview has been adapted from the original French version and edited for clarity)



How did 'Block everything' go from Telegram to viral movement in France?

Issued on: 05/09/2025 -

“Bloquons tout” ("Block everything") began in a pro-sovereignty #Telegram group – now it’s a viral slogan on #TikTok, #X and #Facebook. With trending hashtags and left-wing voices amplifying it, the call is to shut #France down on September 10. FRANCE 24's Katrine Lyngsø explains.#Bloquonstout #10septembre #macron #french #protest #strike

Video by: FRANCE 24





French interior minister vows 'utmost firmness' against protesters' planned shutdown

French Interior Minister Bruno Retailleau said Friday he does not expect large-scale protests next week but ordered police to respond firmly to a viral online campaign calling for a protest movement to "block everything". The campaign’s organisers have suggested a range of actions from blocking train stations to picketing oil refineries.


Issued on: 05/09/2025 
By: FRANCE 24

France's Minister of the Interior Bruno Retailleau leaves after a weekly cabinet meeting at the Elysee Palace in Paris on September 3, 2025. © Ludovic Marin, AFP

France's hardline interior minister said Friday he did not anticipate a "large-scale" response to calls for protests next week, but ordered police to "show the utmost firmness" in case of any disorder.

A viral campaign has for weeks urged French people to stage a nationwide "shutdown" next Wednesday, two days after the government of Prime Minister François Bayrou faces a confidence vote in parliament over an austerity budget standoff.

"I don't believe there will be any large-scale movements," Interior Minister Bruno Retailleau said, adding that hard-left forces and some unions have backed the anti-government campaign dubbed "Let's block everything".

"It is very clear that the movement has shifted to the left," Retailleau said. "Given the nature of these movements and their radicalism, there may be some spectacular actions."

Read more
‘Block everything’: What we know about the movement to shut down France on September 10

Organisers of the campaign have floated tactics ranging from protests to civil disobedience action such as blocking train stations and picketing oil refineries.

Intelligence officials have warned the movement's decentralised nature makes its scale and impact difficult to predict, with law enforcement preparing for any eventuality.

"I have sent a telegram to the prefects (top local officials) asking them to show the utmost firmness," Retailleau said. "Blocking everything is worse than anything else. The country doesn't need to be blocked."

In the telegram, dated Thursday, Retailleau ordered police to fully mobilise to "manage this crisis".

"No damage to public buildings in general, and landmark buildings in particular, will be tolerated," he said, adding schools and universities must also be protected.

Signs have multiplied that many French people are growing exasperated with political deadlock as well as issues including the cost of living and crime.

Bayrou's government is expected to lose Monday's confidence vote, in a new blow to President Emmanuel Macron, now on his sixth prime minister since taking office in 2017.
French PM Bayrou set to lose no-confidence vote as talks end without breakthrough

Several French people who planned to take part in next week's protests said they were frustrated with government policies, including Bayrou's proposal to cut two public holidays, and said they wanted to have a greater say in political matters.

"Taxes on the rich are never voted in, while we are asked to tighten our belts," said 35-year-old Chloe Souske from the village of Monterfil in northwestern France.

"A gap has opened up with the political elite who work for billionaires," added Benjamin Ball, a 41-year-old from the northwestern Paris suburb of Argenteuil.

Separately, trade unions have called for protests on September 18 over France's "horror show" draft budget.

(FRANCE 24 with AFP)
Oil giants accused of dodging Niger Delta
clean-up as UN panel intervenes


Oil giants stand accused of walking away from decades of pollution in Nigeria’s Niger Delta without cleaning up the damage. A UN-appointed panel of experts wrote to Shell, Eni, ExxonMobil and TotalEnergies, warning the companies cannot sell off their assets and dodge their responsibilities to local communities.

Issued on: 05/09/2025 - RFI

The letters, sent on Sunday and published on a UN website, said the companies must provide remedies for people harmed by their operations under the UN Guiding Principles on Business and Human Rights.

The panel also said firms are obliged to use their influence to prevent abuses in their dealings with others.

Governments, the experts added, have a duty under international law to make sure companies meet these responsibilities – known as the “duty to regulate”.

People walk amid an oil spill in the Niger Delta in village of Ogboinbiri, Nigeria, 11 December 2024. AP - Sunday Alamba

Support for indigenous communities

For campaigners in the Niger Delta, the UN’s intervention is a major boost.

“It gives me so much joy that an organisation like the UN has added their voice to this campaign. I’m glad,” said Celestine AkpoBari, an Ogoni-born activist who coordinates the Ogoni Solidarity Forum and leads the Miideekor Environmental Development Initiative-MEDI.

He told RFI: “The statement is out there, that is what is important. I’m excited that they have come out to support the plights of community people and organisations that are crying for justice like the Ogoni and the Niger Delta people.”


A soil sampling exercise in an oil-contaminated site in Ogoniland, as conducted by the UN Environment Programme in Port Harcourt, Nigeria, in January 2019, taken to conduct an Institutional Capacity Assessment of the Hydrocarbon Pollution Remediation Project (HYPREP). © UN Environment Programme (UNEP)


Campaign groups say the letters may strengthen ongoing lawsuits against the oil firms.

According to the Polluter Pays project, the letters are important for both legal and moral reasons, especially as they could support existing cases against international oil companies.

“Human rights obligations may be used to interpret duties of negligence and nuisance in cases currently before the English High Court,” said Sophie Marjanac, environmental lawyer and director of legal strategy at Polluter Pays.

She pointed to cases involving the Billie and Ogale communities Nigeria and the Bodo community in India.

“The United Nations Working Group on Business and Human Rights is probably the only international body that really has the mechanism to provide some accountability to companies under their guiding principles,” Marjanac told RFI.


Decades of pollution and abuse

Shell, Eni, ExxonMobil and TotalEnergies have operated in Nigeria since the 1950s, reaping huge profits from crude oil exports. But oil spills in the Niger Delta have caused billions of dollars in environmental and human damage.

Most of the pollution has never been cleaned up, despite lawsuits and repeated demands. In recent years, the companies have sold many of their Nigerian holdings, mostly to local buyers who lack the means to repair the damage.

Reports say the impact is especially severe in Ogoniland, where residents have received no compensation or state support.

“If you look at UNEP's report on Ogoni, I call it a death sentence,” AkpoBari said.

“The report says that the water we drink is 1000 times worse than the level recommended by the World Health Organization. It says there is benzene, a carcinogen, in the water we drink.

"There is hydrocarbon in the air. The water we drink is coated with 20 centimetres of crude oil. The pollution has gone deeper up to the water tables. So, the land is dead, the air is dead, the river is dead.”



Staff from the UN Environment Programme visiting Port Harcourt in January 2019 to conduct an Institutional Capacity Assessment of the Hydrocarbon Pollution Remediation Project (HYPREP). © UN Environment Programme


He said fishing and farming – the backbone of family incomes – are no longer possible. He added that daily life has been disrupted, with students dropping out of school and crime rising as hunger and poverty deepen.

Communities in the Niger Delta and beyond now hope UN pressure will force both the oil companies and the Nigerian government to take responsibility.

Shell was ordered in 2021 to compensate Nigerian farmers for contaminated land and water after an appeals court in The Hague found its Nigerian subsidiary, SPDC, liable for multiple pipeline leaks.

On Tuesday, however, TotalEnergies signed a new deal with South Atlantic Petroleum in Nigeria – the first foreign oil contract in years – aimed at reviving the industry and attracting investment.

Court cases are expected to continue until at least 2027, with one major trial due in London in November 2025.
'Recognition brings obligation’: How declaring genocide could reshape war in Gaza

The International Association of Genocide Scholars has issued a landmark resolution defining Israel’s actions in Gaza as a genocide. RFI spoke to the organisation's Tim Williams about the evidence behind the move and its global implications.


Issued on: 05/09/2025 - RFI

Ahmed Al-Hajj carries the body of his daughter, Dana Al-Hajj, 13, who was killed in an Israeli airstrike in the Gaza Strip, 19 August, 2025. AP - Abdel Kareem Hana

By: David Coffey

The International Association of Genocide Scholars (IAGS) – the world’s leading professional body dedicated to the study of genocide – this week passed a resolution declaring that Israel’s actions against the Palestinians in Gaza meet the legal definition of genocide.

Backed by 86 percent of the members who voted, the resolution details acts that the Association says fall squarely within the UN Convention on the Prevention and Punishment of Genocide: the killing of tens of thousands of civilians, the deliberate targeting of children, the destruction of agricultural land and homes, and the systematic dismantling of health, education and cultural institutions.

It also points to explicit statements by Israeli leaders suggesting an intent to destroy the Palestinian nation in Gaza. Genocide scholars say that this amounts to the destruction of a people’s future and their ability to regenerate.

RFI spoke to Tim Williams, second vice president of the IAGS and Professor of Insecurity and Social Order at the Bundeswehr University in Munich. 

He outlines how the resolution was drafted, why it highlights children as proof of genocidal intent and how the recognition of a Palestinian state by countries – including France – could reshape the global perception of Israel’s actions.

'Nowhere in Gaza is safe' says RFI correspondent amid call for global media access

Recognition of genocide 'brings obligations'

One of the striking issues is why so many governments and institutions are reluctant to use the word genocide, despite mounting evidence. Williams is clear: hesitation is often a political stance.

“I wouldn’t say that international courts hesitate to use the term,” he told RFI. “They do when it is applicable in cases. States, on the other hand, do hesitate because in the UN Convention, there is an obligation under international law on states to prevent and punish genocide.

"So by recognising genocide, it obliges states to engage in prevention efforts, which would mean that if a state recognises it, they have to exert pressure on Israel. They would have to cease all arms delivery to Israel, and ultimately intervene in the situation to try and prevent the genocide from occurring.”

Naming genocide is more than a moral gesture – it carries heavy legal and political implications. Williams describes the paradox at the heart of the Genocide Convention: to declare it compels action, but that obligation can also delay acknowledgement until long after atrocities have unfolded.

Five key findings of the IAGS resolution

1. Genocide in Gaza
Israel’s actions meet the legal definition of genocide under the UN Convention, including mass killings, deliberate infliction of conditions that make survival impossible and explicit statements of intent by senior leaders.

2. Children as an indicator
More than 50,000 children have been killed or injured. The resolution stresses that targeting children is a clear sign of genocidal intent, as it destroys the group’s ability to regenerate.

3. Systematic destruction of life
Beyond civilian deaths, Israel has demolished 90 percent of Gaza’s housing, crippled healthcare, destroyed farmland, bakeries and desalination plants and restricted humanitarian aid — creating conditions unfit for survival.

4. Ethnic cleansing and forced displacement
Nearly all of Gaza’s 2.3 million residents have been displaced multiple times, with political plans openly discussed to permanently remove Palestinians from Gaza.

5. International obligations
The resolution calls on states to comply with the Genocide Convention, the International Criminal Court and ICJ rulings, including halting arms sales and ensuring accountability for war crimes and crimes against humanity.

Why children matter in proving intent

The IAGS resolution gives particular weight to the killing and maiming of children, a focus Williams sees as critical. He argues that targeting children is one of the clearest signals of genocidal intent under international law.

“Children are seen as a protected part of a group, and they are particularly important because they are also the future of the group,” he said. “By destroying the children of a nation, you’re precluding any possibility to regenerate the group and strengthen it. So it’s a particularly keen indicator of intent.”

He adds that children offer an unmistakable measure of civilian harm in conflicts often clouded by disputes over combatant status. “With children, it’s particularly clear that they are not combatants. And this is even more indicative of civilian status ... it doesn’t mean that all adults are combatants, but with children, it’s particularly clear.”

By highlighting the plight of children, the resolution not only underscores the human tragedy in Gaza but also strengthens the legal case for genocide.

Beyond the death toll

While media coverage often focuses on casualty figures – with more than 63,000 Palestinians killed in the conflict, according to Gaza’s Health Ministry – Williams stresses that genocide is not just about killings. It is also about creating conditions of life that make a group’s survival impossible.

“The core of genocide is, when we talk about it in public discourse, very much focused on the killing part,” he explained. “But really it’s about the destruction of the group in and of itself. And so the forced displacement of people and the removal of the conditions of life necessary are part and parcel of that destruction of a nation.”

The resolution cites the destruction of farmland, desalination plants and bakeries, along with the near-total destruction of Gaza’s housing and healthcare systems, as evidence that Israel has deliberately created unliveable conditions.

Williams warns that political plans to relocate Gazans permanently outside Gaza – once a fringe idea, now openly endorsed by Israeli leaders – could be read as further evidence of genocidal intent.

Defining famine: the complex process behind Gaza's hunger crisis

Recognition of Palestine

The political landscape is also changing. In recent months, France, Canada and Belgium have joined a growing number of states in recognising Palestinian statehood. For Williams, these moves matter both symbolically and practically speaking.

“I think these are very important moves that have been happening in the last weeks and months,” he said. “On the one hand, a strengthening of the legitimacy of the Palestinian nation and an attempt to push forward with, possibly, a two-state solution. But also, I think it’s important symbolically, because it departs from Israel’s interests, and it’s a sign that Western countries are increasingly withdrawing their support from Israel.”

Williams argues that recognition of Palestine forms part of a larger “mosaic” of pressure that could eventually compel change.

He cautions, however, that symbolic steps must be matched with legal obligations: halting arms transfers that could be used in war crimes and enforcing rulings by international courts.

Ultimately, the IAGS has no powers of enforcement, but Williams hopes the resolution will add weight to the global debate.

“We’re a large organisation of genocide scholars, but we have no political clout,” he said. “What I do hope this resolution means is that we can say that the International Association of Genocide Scholars recognises this as a genocide, and I hope that gives political credibility also to those in the political arena who are claiming that it’s genocide and would like to exert more pressure.”

For Williams, this is also about more than Gaza: it is a test of whether the world is willing to confront genocide while it is happening, rather than decades later.

Full Interview: How declaring genocide could reshape war in Gaza - Dr. Tim Williams

 

Researchers quantify rate of essential evolutionary process in the ocean




Bigelow Laboratory for Ocean Sciences

SCGC Facility 

image: 

Bigelow Laboratory researchers work to sequence microbial cells from seawater samples within the Single Cell Genomics Center.

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Credit: Bigelow Laboratory for Ocean Sciences






The movement of genetic material between organisms that aren’t directly related is a significant driver of evolution, especially among single-celled organisms like bacteria and archaea. A team led by researchers at Bigelow Laboratory for Ocean Sciences have now estimated that an average cell line acquires and retains roughly 13 percent of its genes every million years via this process of lateral gene transfer. That equates to about 250 genes swapped per liter of seawater every day.

The new study, recently published in The ISME Journal, provides the first quantitative analysis of gene transfer rates across an entire microbiome. It calls into question the strict classification lines drawn between individual species. It also confirms that many transferred genes have direct ecological benefits, highlighting how this process enables microbes to adapt to new environments and furnishes them with valuable capacities, such as the ability to access essential nutrients.

“All the processes that microbes drive on our planet have evolved, and that evolution, to a large extent, is driven by lateral gene transfer, but the process is very difficult to study, and no one has been able to put numbers to the process,” said Bigelow Laboratory Senior Research Scientist Ramunas Stepanauskas, the study’s lead author. “We know in general how it works, but we had no idea if you take a drop of seawater, are genes being exchanged once a minute or once a year or once a million years? That was completely unknown — until now.”

Genes can be transferred laterally through multiple mechanisms, including the uptake of floating genetic material in the environment, direct transfer between cells, and the injection of foreign DNA into a host by a virus.

Scientists have struggled to quantify those processes, though, given the immense diversity of microbial life. Traditional “evolutionary tree” approaches can be used to study the transfer of specific, widespread genes — a handful at a time — but are impractical for studying an entire ecosystem. Likewise, the common method for studying microbial genomes, metagenomics, works by stitching together assemblies of related, “typical” genes, meaning it actively excludes transferred genes that are rare or come from unrelated organisms.

Advances in computational modeling and single-cell genomics, though, have allowed scientists to begin answering these questions.

The team used genomes of 12,000 randomly-sampled microbial cells from the tropical and subtropical surface ocean sequenced by Stepanauskas’s team at the Single Cell Genomics Center (SCGC). The unique dataset is one of the largest compilations of microbial genomes ever produced. They compared the distribution of shared genes in that real-world data with a computer model that assumed that genes can only be transferred vertically between parents and offspring, not laterally.

“This project was an exciting opportunity to think differently about how to measure an essential yet elusive evolutionary process that shapes the microbial component of ecosystems globally,” said Siavash Mirarab, a professor at UC San Diego and a co-author on the study whose team led the development of the model.

The approach confirmed that most genes are exchanged between closely related cells, but not all. Some genes with obvious ecological value can be successfully transferred between microbes that are as distantly related to each other as humans to kangaroos. For example, they found evidence of microbes acquiring novel genes that enable them to uptake new sources of phosphorus in the phosphorus-limited Sargasso Sea.

The findings also show evidence of the exchange of genes that encode ribosomal RNA, the cellular machinery responsible for protein synthesis. That, Stepanauskas said, was surprising given that those genes are often used as metrics for biological diversity exactly because scientists assumed they were not engaged in lateral transfer.

In the future, the team hopes to expand this approach into new environments and tease apart differences between lineages, transfer mechanisms, and ecosystems. That work could have significant biotechnology implications by revealing how nature effectively and rapidly engineers cells for different environments and processes. To that end, SCGC is continually improving and scaling up its analytical capabilities to enable the large-scale studies that work will require.

“Answering these questions may have become possible, but only if we can continue to improve our modeling toolkit,” Mirabab said.

“I see this as just the beginning,” Stepanauskas added. “We finally have sufficient data to start doing this kind of quantitative analysis, but we still need to go much further to say how frequently specific kinds of microbes do it, what processes are involved, and how we can use this knowledge in environmental stewardship and bioeconomy.”

Funding for this work was provided by the Simons Foundation, National Science Foundation, and the National Institutes of Health. The study also features researchers from Woods Hole Oceanographic Institution, University of Pretoria, Wellesley College, and Massachusetts Institute of Technology.

Caption

Bigelow Laboratory Senior Research Scientist and Single Cell Genomics Center Director Ramunas Stepanauskas analyzes microbial samples.

Credit

Bigelow Laboratory for Ocean Sciences

 

Natural medicines target tumor vascular microenvironment to inhibit cancer growth




Compuscript Ltd
fig 1 

image: 

Image Caption:  TME and tumor blood vessels. 

Image linkhttps://ars.els-cdn.com/content/image/1-s2.0-S2352304225001126-gr1_lrg.jpg

 

 

 

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Credit: Genes & Diseases

 

Recent advances in cancer treatment highlight the potential of natural medicines to target the tumor vascular microenvironment, offering a novel strategy to inhibit tumor growth and metastasis. Unlike conventional therapies that directly target tumor cells, natural compounds focus on normalizing tumor vasculature and inhibiting pathological angiogenesis, crucial processes in cancer progression. This innovative approach holds promise in enhancing anti-cancer therapies while minimizing side effects.

 

The tumor vascular microenvironment plays a pivotal role in cancer development. Tumor blood vessels are often irregular, immature, and leaky, which leads to poor blood perfusion, increased interstitial pressure, and hypoxia within the tumor. These abnormal conditions create a conducive environment for tumor invasion and metastasis. As tumors grow, they actively recruit blood vessels by secreting angiogenic factors like VEGF and FGF, resulting in an unorganized vascular network that fails to deliver therapeutic agents efficiently.

 

Natural medicines have emerged as promising agents to normalize tumor vasculature. Certain phenolic compounds such as resveratrol and curcumin demonstrate anti-angiogenic properties by inhibiting VEGF signaling and reducing the production of matrix metalloproteinases (MMPs). Resveratrol, derived from plants, has shown potential in suppressing endothelial cell (EC) proliferation and reducing the formation of abnormal blood vessels. Similarly, curcumin, known for its anti-inflammatory properties, blocks VEGF and IL-8 signaling pathways, inhibiting tumor angiogenesis and preventing cancer cell migration.

 

Moreover, alkaloids like paclitaxel and colchicine inhibit tumor growth by disrupting microtubule dynamics in endothelial cells, effectively impairing blood vessel formation. Paclitaxel not only inhibits EC proliferation but also enhances apoptosis, thereby reducing vascular density within tumors. Colchicine, through its effect on microtubule stability, suppresses the formation of new blood vessels, limiting nutrient supply to the tumor.

 

Terpenoids such as ursolic acid and artesunate target signaling pathways linked to angiogenesis, including NF-κB and STAT3, reducing the proliferation of endothelial cells. By mitigating the expression of pro-angiogenic factors, these compounds contribute to vascular stabilization and improved tumor perfusion. Additionally, crustal oligosaccharides, derived from natural sources, show potential in enhancing vascular normalization by reducing endothelial permeability and promoting blood vessel integrity.

 

Incorporating natural medicines into cancer treatment strategies offers multiple advantages. These agents not only complement conventional therapies but also reduce toxicity by promoting vascular normalization. By stabilizing the tumor blood supply, they enhance the delivery of chemotherapeutic drugs, making treatments more effective. Furthermore, the use of natural compounds helps mitigate resistance mechanisms that often limit the efficacy of anti-angiogenic therapies.

 

As research progresses, the integration of natural medicines with existing oncological practices could significantly improve patient outcomes. By targeting the tumor vascular microenvironment, these therapies not only suppress tumor growth but also inhibit metastasis, offering a comprehensive approach to cancer management. The continued exploration of these compounds holds promise for developing more sustainable and less toxic cancer therapies.

 

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Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis is placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.

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Reference

Yirui Lu, Zhiliang Guo, Hong Li, Jiao Wen, Xiaoyun Zhang, Xiumei Guan, Xiaodong Cui, Min Cheng, Natural medicines target tumor vascular microenvironment to inhibit tumor, Genes & Diseases, Volume 12, Issue 6, 2025, 101623, https://doi.org/10.1016/j.gendis.2025.101623

 

Funding

Weifang Science and Technology Development Projects (Shandong, China) 2023YX092