Wednesday, October 29, 2025

 

Secret to a long life? In bowhead whales, a protein repairs damaged DNA




University of Rochester Medical Center





Bowhead whales—the only warm-blooded mammal that outlives humans—can survive for 200 years and seldom get age-related diseases like cancer. University of Rochester researchers discovered a new clue to the whales’ longevity: an abundant protein called CIRBP that helps repair DNA.

Acquiring cancer is a complex process that involves biology, inherited genes, and environmental exposures. Along the way, if breaks in DNA occur and the genetic damage is not repaired, cancer is more likely. The team found that in bowhead whales, the DNA-repair protein CIRBP, was present at 100-fold higher levels compared to other mammals.

Wilmot Cancer Institute members Vera Gorbunova, PhD, and Andrei Seluanov, PhD, led the collaborative research project with other institutions, and reported their findings in the journal, Nature.

The renowned scientists also investigate other long-lived species and the factors that allow for a healthy, extended life. Earlier this year, they reported that four common species of bats possess biological superpowers that deter cancer.

“This research shows it is possible to live longer than the typical human lifespan,” Gorbunova said.

While working with scientists in Alaska on the bowhead whale project, the Rochester team also discovered that lower temperatures seem to enhance the CIRBP protein.  

How might this translate to humans?

It’s too early to say, but Gorbunova suggested that it would be worth exploring how to boost the human body’s CIRBP activity. Hypothetically, lifestyle changes such as cold showers or cold-temperature exposure could work.

“There are different ways to improve genome maintenance and here we learn there is one unique way that evolved in bowhead whales where they dramatically increase the levels of this protein,” Gorbunova says. “Now we have to see if we can develop strategies to upregulate the same pathway in humans.”

For the full story: https://www.rochester.edu/newscenter/cirbp-protein-mammalian-longevity-bowhead-whales-674682/

Gorbunova and Seluanov are part of Wilmot’s Genetics, Epigenetics, and Metabolism basic science research program.

 

 

MIT study: Identifying kids who need help learning to read isn’t as easy as A, B, C



While most states mandate screenings to guide early interventions for children struggling with reading, many teachers feel underprepared to administer and interpret them.




Massachusetts Institute of Technology





CAMBRIDGE, MA -- In most states, schools are required to screen students as they enter kindergarten — a process that is meant to identify students who may need extra help learning to read. However, a new study by MIT researchers suggests that these screenings may not be working as intended in all schools.

The researchers’ survey of about 250 teachers found that many felt they did not receive adequate training to perform the tests, and about half reported that they were not confident that children who need extra instruction in reading end up receiving it.

When performed successfully, these screens can be essential tools to make sure children get the extra help they need to learn to read. However, the new findings suggest that many school districts may need to tweak how they implement the screenings and analyze the results, the researchers say.

“This result demonstrates the need to have a systematic approach for how the basic science on how children learn to read is translated into educational opportunity,” says John Gabrieli, the Grover Hermann Professor of Health Sciences and Technology, a professor of brain and cognitive sciences, and a member of MIT’s McGovern Institute for Brain Research.

Gabrieli is the senior author of the new open-access study, which appears today in Annals of Dyslexia. Ola Ozernov-Palchik, an MIT research scientist who is also a research assistant professor at Boston University Wheelock College of Education and Human Development, is the lead author of the study.

Boosting literacy

Over the past 20 years, national reading proficiency scores in the United States have trended up, but only slightly. In 2022, 33 percent of fourth-graders achieved reading proficiency, compared to 29 percent in 1992, according to the National Assessment of Educational Progress reading report card. (The highest level achieved in the past 20 years was 37 percent, in 2017.) 

In hopes of boosting those rates, most states have passed laws requiring students to be screened for potential reading struggles early in elementary school. In most cases, the screenings are required two or three times per year, in kindergarten, first grade, and second grade.

These tests are designed to identify students who have difficulty with skills such as identifying letters and the sounds they make, blending sounds to make words, and recognizing words that rhyme. Students with low scores in these measures can then be offered extra interventions designed to help them catch up.

“The indicators of future reading disability or dyslexia are present as early as within the first few months of kindergarten,” Ozernov-Palchik says. “And there’s also an overwhelming body of evidence showing that interventions are most effective in the earliest grades.”

In the new study, the researchers wanted to evaluate how effectively these screenings are being implemented in schools. With help from the National Center for Improving Literacy, they posted on social media sites seeking classroom teachers and reading specialists who are responsible for administering literacy screening tests.

The survey respondents came from 39 states and represented public and private schools, located in urban, suburban, and rural areas. The researchers asked those teachers dozens of questions about their experience with the literacy screenings, including questions about their training, the testing process itself, and the results of the screenings.

One of the significant challenges reported by the respondents was a lack of training. About 75 percent reported that they received fewer than three hours of training on how to perform the screens, and 44 percent received no training at all or less than an hour of training.

“Under ideal conditions, there is an expert who trains the educators, they provide practice opportunities, they provide feedback, and they observe the educators administer the assessment,” Ozernov-Palchik says. “None of this was done in many of the cases.”

Instead, many educators reported that they spent their own time figuring out how to give the evaluations, sometimes working with colleagues. And, new hires who arrived at a school after the initial training was given were often left on their own to figure it out.

Another major challenge was suboptimal conditions for administering the tests. About 80 percent of teachers reported interruptions during the screenings, and 40 percent had to do the screens in noisy locations such as a school hallway. More than half of the teachers also reported technical difficulties in administering the tests, and that rate was higher among teachers who worked at schools with a higher percentage of students from low socioeconomic (SES) backgrounds.

Teachers also reported difficulties when it came to evaluating students categorized as English language learners (ELL). Many teachers relayed that they hadn’t been trained on how to distinguish students who were having trouble reading from those who struggled on the tests because they didn’t speak English well.

“The study reveals that there’s a lot of difficulty understanding how to handle English language learners in the context of screening,” Ozernov-Palchik says. “Overall, those kids tend to be either over-identified or under-identified as needing help, but they’re not getting the support that they need.”

Unrealized potential

Most concerning, the researchers say, is that in many schools, the results of the screening tests are not being used to get students the extra help that they need. Only 44 percent of the teachers surveyed said that their schools had a formal process for creating intervention plans for students after the screening was performed.

“Even though most educators said they believe that screening is important to do, they’re not feeling that it has the potential to drive change the way that it’s currently implemented,” Ozernov-Palchik says.

In the study, the researchers recommended several steps that state legislatures or individual school districts can take to make the screening process run more smoothly and successfully.

“Implementation is the key here,” Ozernov-Palchik says. “Teachers need more support and professional development. There needs to be systematic support as they administer the screening. They need to have designated spaces for screening, and explicit instruction in how to handle children who are English language learners.”

The researchers also recommend that school districts train an individual to take charge of interpreting the screening results and analyzing the data, to make sure that the screenings are leading to improved success in reading.

In addition to advocating for those changes, the researchers are also working on a technology platform that uses artificial intelligence to provide more individualized instruction in reading, which could help students receive help in the areas where they struggle the most.

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The research was funded by Schmidt Futures, the Chan Zuckerberg Initiative for the Reach Every Reader project, and the Halis Family Foundation.

 

 

Biosensor identifies protein linked to depression and schizophrenia in saliva



Low-cost device quickly detects BDNF concentrations. Scientist at the University of São Paulo says the next step is to obtain a patent.




Fundação de Amparo à Pesquisa do Estado de São Paulo

Biosensor identifies protein linked to depression and schizophrenia in saliva 

image: 

The biosensor that can quickly identify a protein whose altered levels are associated with psychiatric disorders costs US$2.19 per unit.

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Credit: illustration: Amanda H. Imamura/Sci Illustrations




Brazilian researchers have developed a low-cost, portable biosensor that can quickly identify a protein whose altered levels are associated with psychiatric disorders, such as depression, schizophrenia, and bipolar disorder. When it becomes commercially available in the future, it may contribute to early detection, which is essential for treating and monitoring patients' clinical conditions.

The biosensor is the result of a partnership between researchers at the University of São Paulo (USP) and Embrapa Instrumentação, a decentralized unit of the Brazilian Agricultural Research Corporation (Embrapa). It consists of a flexible strip with electrodes that, when integrated with a portable analyzer, evaluates drops of human saliva. In less than three minutes, the biosensor provides the concentration of BDNF (brain-derived neurotrophic factor), a protein crucial for the growth and maintenance of neurons and the development of brain functions, including learning and memory.

The research, published in ACS Polymers Au, shows that the device can reliably measure extremely low concentrations of the protein in a wide range of saliva (from 10⁻²⁰ to 10⁻¹⁰ grams per milliliter), down to minimal amounts that are still detectable (1.0 × 10⁻²⁰ grams per milliliter).

The biosensor has an estimated cost of US$2.19 per unit — less than R$12.00 at the current exchange rate — and long-term storage capacity. According to the scientists, the next step is to obtain the patent.

"There are few sensors that perform this type of analysis, and ours was the one that performed best. It detected a wide range of concentrations, which is a very good result from a clinical point of view. When protein levels are very low, it can serve as a warning sign for diseases and psychiatric disorders. On the other hand, by being able to signal an increase in BDNF, it contributes as a tool to monitor the patient's progress according to the treatment," explains Paulo Augusto Raymundo Pereira, a researcher at the São Carlos Institute of Physics (IFSC-USP) and corresponding author of the article, in an interview with Agência FAPESP.

Pereira, who has experience in chemistry and biotechnology, has been working with flexible sensors and electrochemical biosensors. Last year, he was one of the authors of an article in the Chemical Engineering Journal that presented the results of a portable sensor for urine self-testing aimed at detecting markers of diseases such as gout and Parkinson's (read more at https://agencia.fapesp.br/51727).

Link to disorders

Scientific literature shows that low levels of BDNF are one of the factors involved in some neurological and psychiatric disorders associated with cognitive decline. Depression is one such disorder. The effect of the protein is restored by antidepressants. Healthy individuals have BDNF levels above 20 nanograms per milliliter (ng/mL), whereas people with major depressive disorder (MDD) have levels below 10 or 12 ng/mL.

According to data from the World Health Organization (WHO), more than 1 billion people live with mental disorders, with anxiety and depression being the most prevalent conditions. According to the organization's reports, including the Mental Health Atlas 2024, these disorders have increased in prevalence in all countries, affecting people of all ages and income levels.

Between 2022 and 2024, worker absences due to mental health issues in Brazil increased by 134%. According to the Occupational Safety and Health Observatory, these absences rose from 201,000 to 472,000 and were caused by episodes of depression, anxiety, and recurrent depression.

Pereira adds, "The increase in cases of mental disorders and the consequent rise in the use of medication, especially after the COVID-19 pandemic, motivated us to work on this issue and seek alternatives." Pereira has the support of FAPESP through scholarships (16/01919-623/09685-8, and 22/02164-0).

The device

The researchers developed a flexible strip screen-printed on a polyester film substrate with three electrodes: one functionalized working electrode, one pure carbon auxiliary electrode, and one silver reference electrode.

The working electrode was modified with carbon nanospheres. It received a layer of two chemical compounds – polyethyleneimine and glutaraldehyde – to increase sensitivity and act as a matrix to immobilize the BDNF-specific capture antibody (anti-BDNF). To prevent other types of interaction, a reactive layer of ethanolamine was added.

BDNF detection is based on the formation of antibody-antigen immunocomplexes, which increase resistance to electron transfer on the sensor surface. This growth is captured by electrochemical impedance spectroscopy, a technique used to study processes that occur at the interface between an electrode and a solution.

The results can be displayed in real time on a mobile device (smartphone) via wireless communication (Bluetooth).

The current techniques used to analyze BDNF levels include the enzyme-linked immunosorbent assay (ELISA), electrochemiluminescence, fluorescence, and high-performance liquid chromatography (HPLC). These techniques require time, large sample volumes, and specialized laboratories.

"We're moving toward personalized medicine, in which treatments will be increasingly tailored to each individual. In the case of the biosensor, it can be optimized to suit different profiles," says the researcher.

FAPESP also supported the study through the Thematic Project "Towards the Convergence of Technologies: From Sensors and Biosensors to Information Visualization and Machine Learning for Data Analysis in Clinical Diagnosis", as well as two other projects (23/07686-7 and 20/09587-8).

The team includes the following researchers: Nathalia GomesMarcelo Luiz Calegaro, Luiz Henrique Capparelli MattosoSergio Antonio Spinola Machado, and Osvaldo de Oliveira Junior.


The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe.