Saturday, January 10, 2026

For U.S. nuclear energy future, fuel supply cannot be overlooked

An industry-wide meeting organized by Stanford examined the reliability of the fuel supply chain for existing U.S. nuclear power plants and the affordability of fuel for next-generation reactors.

Stanford University

Chuck Fleischmann 

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U.S. Rep. Chuck Fleischmann, chair of the House Energy & Water Development Appropriations Subcommittee, opened the Stanford-led Nuclear Fuel Cycle Roundtable with a keynote address.

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Credit: Courtesy Precourt Institute for Energy, Stanford




The vision of a U.S. nuclear power renaissance has a blind spot – uranium fuel – in the near term and long, according to a Stanford University-led industry meeting.

AI data centers, reshoring of manufacturing, and the electrification of transportation, buildings and other sectors have heightened demand for affordable, reliable power around the clock. Nuclear energy could check those boxes, its proponents say, but supplies of enriched uranium for existing power plants are tight, vulnerable to geopolitics, and getting more expensive. New fuel forms for advanced reactors, meanwhile, offer promise, but scaling them affordably and in parallel with conventional fuel systems could squeeze conventional fuel markets even more.

Over 100 leaders across the nuclear fuel sector, utility executives, government regulators, and reactor designers and developers gathered in July in Arlington, Virginia, to examine these barriers and identify possible ways to overcome them. The Nuclear Fuel Cycle Roundtable was organized by STEER, an initiative of Stanford University’s Precourt Institute for Energy and SLAC National Accelerator LaboratoryCongressman Chuck Fleischmann (R-Tenn.), chair of the House Energy & Water Development Appropriations Subcommittee, opened the discussion with a keynote address.

On Dec. 29, Nature Energy published a summary of the insights that emerged from the meeting. The Trump administration has been moving to strengthen the U.S. nuclear fuel supply chain. On Jan. 5, the U.S. Department of Energy announced $2.7 billion in contracts to three domestic fuel enrichment companies for conventional reactors and next-generation reactors now in development.

 “As in any hard-tech sector, investment enthusiasm can often be driven by exuberance,” said the founder and team lead of STEER, Adrian Yao, who spearheaded the roundtable. “We sought to focus on the fuel supply chain while much of recent private investment activity has been focused on current- and next-generation reactors amid this new nuclear groundswell. Specifically, our objective is to identify ‘what must be true’ for the fuel supply chain to support the growing demand.”

STEER, which is funded in part by the U.S. Department of Energy, analyzes emerging energy technologies from supply chains to deployment roadmaps in order to inform what to build, where to innovate, and how to invest. The Precourt Institute is part of the Stanford Doerr School of Sustainability.

Conventional nuclear fuel

Immediate growth in nuclear power production – like last year’s announcement of restarting a Three Mile Island Nuclear Generation Station reactor – depends on the deeply international supply chain for nuclear fuel. That chain has four links:

  1. mining the uranium;
  2. converting it to a gas form;
  3. enriching it to increase the fissile U-235;
  4. and fabricating uranium pellets and fuel rods for shipment to nuclear power plants.

The industry discussion stressed that several links in this chain are at risk. Four countries dominate mining: Kazakhstan, Namibia, Australia, and Canada. The United States mines very little uranium, due to lower-grade ore and higher costs. While most meeting participants did not express strong concerns about mining due to friendly partners, some stressed the importance of rebuilding U.S. domestic mining, highlighting uranium as a critical mineral.  Also, the largest producer – Kazakhstan – continues to seek strategic autonomy from its interdependence on Russia and, increasingly, China. This may be viewed as an opportunity for the United States.

Only five facilities worldwide convert mined uranium on a large scale into the gas needed for enrichment. This step may pose one of the most critical pinch-points in the supply chain. Markets for these services have been turbulent in recent years, with price dips and spikes forcing western plants into shutdown and restart cycles. Stockpiles of converted uranium gas are shrinking. Without big, long-term contracts, conversion company executives at the July roundtable expressed hesitation to expand capacity.

Uranium buyers, meanwhile, are reluctant to pen long-term agreements inflated by today’s high prices. Even when buyers are prepared to sign, the incremental demand is significantly less than the stepwise supply added by capacity expansions. To break this deadlock, several meeting participants suggested that U.S. federal and state governments could act as customers of last resort for new facilities.

“This could provide the payment certainty required for investment in new conversion capacity,” said Yao, PhD ’25.

Enrichment, the third stage of the nuclear fuel supply chain, remains heavily concentrated: Nearly half of global capacity is in Russia, with only two major commercial enrichers operating in the United States and western Europe. This poses a strategic challenge for the United States, which relies on Russia for nearly 30% of its enriched uranium supply. In response to Russia’s invasion of Ukraine, Congress passed legislation in 2024 to ban enriched uranium imports from Russia. Several European countries are also working to reduce their dependence on Russian fuel.

The United States is self-sufficient only in the final fourth step of the conventional fuel supply chain: making ceramic pellets from enriched uranium and producing fuel rod assemblies. Meeting attendees generally agreed, however, that for national and economic security the United States should develop capacity across the entire supply chain for conventional reactors.

The U.S. ban on enriched uranium from Russia sparked some interest in investment to do just this, but the investments stalled due to concerns about the ban’s effectiveness and durability. For example, waivers can be granted if alternatives to Russian supplies are insufficient, and Russia may be able to circumvent the ban via other countries.

“Many participants suggested that China could circumvent the ban by ‘flag swapping’ Russian uranium in U.S. markets,” said Bennett Johnson, MBA ’24/MS ’25, a co-author of the report and STEER’s strategic partnerships lead. “Other participants questioned how long the political support for the ban would last. Investors want some certainty that it would last at least 10 years.”

Next-generation reactors

The meeting turned its attention to next-generation fission reactors now mostly in development, generally known as “Gen IV.” Fuel for these new generators will need a much higher degree of enrichment. One ton of Gen IV nuclear fuel is estimated to require almost 40 tons of mined uranium, compared to less than 10 tons for conventional nuclear fuel. Those higher degrees of enrichment translate into fuel that generates electricity for a longer time, so the impact on mined uranium is less severe than four to one. Still, fuel suppliers at the roundtable said that without significant additional mining, conversion, and enrichment capacity, next-generation reactors could further stress uranium supplies for the existing nuclear fleet, already burdened with high fuel costs.

Reactor designers and fuel manufacturers working on next-generation advanced reactors noted that the complexity and limited commercial experience with new fuel forms could lead to low fabrication yields and high costs.

Access to test reactors, critical for validating fuel performance and refining manufacturing specifications, is limited, the designers and fuel manufacturers emphasized. Today the only operating Gen IV reactor is in China. Standardization of chemistries and fuel specifications, particularly through coordination between reactor designers and fuel fabricators, was proposed to accelerate the fuel manufacturing learning curve.

Broadly, the Nuclear Fuel Cycle Roundtable highlighted the need to reduce technological, economic, and policy uncertainty throughout the nuclear fuel supply chain to stimulate growth. Primary avenues for doing so potentially include strategic global partnerships and coordination of fuel standards; additional clarity on enforcement of geopolitical policy actions, like the ban on uranium from Russia; R&D to support efficient and low-cost manufacturing of nuclear fuels for advanced reactors; and independent and timely analysis.

“Combining Stanford’s convening power with our impartial investigation enables us to help answer ‘what to build, where to innovate, and how to invest’ while being grounded in the realities of deployment,” said William Chueh, director of the Precourt Institute, as well as the Kimmelman professor of materials science and energy science at Stanford, and of photon science at SLAC.

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Pharmacists are at elevated risk for suicide, study finds


Pharmacists are often the invisible backbone of our health care system; their mental health suffers for it.


University of California - San Diego





A new national study led by researchers from University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences  reveals that pharmacists and female pharmacy technicians face a significantly higher risk of suicide compared to their counterparts in the general population. The findings, published in the American Journal of Health-System Pharmacy, underscore the urgent need for improved workplace policies, mental health resources and stigma reduction in pharmacy settings. They also speak to the broader issue of burnout severity in health care workers. 

“Pharmacists are an invisible workforce that drive the engine of medication delivery in every health care setting,” said Kelly Lee, PharmD, professor of clinical pharmacy at Skaggs School of Pharmacy. “Every medication that reaches a patient has been touched by a pharmacist and/or a pharmacy technician. These health care workers are under unique strains, but it can be difficult to seek help. We need to make it easier.”

“Our study helps confirm that pharmacists and female pharmacy technicians are at high risk for suicide nationwide” added first author Hirsh Makhija, a medical student at the Kirk Kerkorian School of Medicine at the University of Nevada, Las Vegas. “While wellness promotion has slowly progressed for the pharmacy workforce, substantial gaps remain.” 

The study analyzed data from across the U.S., using the National Violent Death Reporting System (NVDRS) from 2011 to 2022. The study’s key findings were:

  • Pharmacists were about 21% more likely to die by suicide than people in the general population.

  • By sex, female pharmacists had a comparable risk to women in the general population, male pharmacists faced a 25% higher risk than other men.

  • Although pharmacy technicians overall had about a 14% lower risk of suicide, female pharmacy technicians had a 22% higher risk of suicide than women in the general population.

  • Males account for 76% of pharmacist suicides and 39% of pharmacy technician suicides, while females account for 24% and 61%, respectively

The researchers also looked into the factors driving suicide deaths among pharmacists and pharmacy technicians, finding that job-related stress and mental health could both be significant factors. Pharmacists were more likely to experience workplace problems prior to suicide, and pharmacy technicians were more likely to have a history of mental health challenges.

To Lee, these findings speak to the broader issues of managing mental health and burnout in highly demanding health care work settings.

“The field talks a lot about mental health, especially after COVID, but our overall work culture hasn’t changed,” she said. “Access to mental health resources is limited, and stigma continues to be a major barrier to seeking help.”

Lee also notes that pharmacists face unique workplace challenges that likely exacerbate these negative mental health trends. For example, the increasing clinical responsibilities for pharmacists — such as administering vaccinations and helping manage ongoing health conditions — have not been matched by recognition or reimbursement. Pharmacists also face frequent challenges with insurance approvals, prior authorizations, and payment for medications.

“Pharmacists are highly trained, but unlike other health care providers, we’re not necessarily paid for our clinical services,” she said. “The lack of payment and recognition adds to the strain facing these workers.” 

To help mitigate some of the challenges pharmacists and other health care workers face, Lee emphasizes that more resources and compassionate workplace policies are needed. For example, UC San Diego has piloted programs such as the HEAR initiative to provide immediate support for health care workers in crisis.

“Employers must create environments where taking time for mental health is normalized and supported. It shouldn’t be difficult for someone to seek help,” she said.

The research team is now focused on implementing and studying targeted interventions for at-risk health care workers, including pharmacy professionals.

“Our goal is to prevent even a single suicide,” said Lee. “That means immediate access to help, reducing stigma, and workplace policies that truly support mental health.” 

Link to full study: https://academic.oup.com/ajhp/advance-article/doi/10.1093/ajhp/zxag006/8416933.

Additional coauthors of the study include Judy E. Davidson, Sidney Zisook, and Nam Nguyen at UC San Diego School of Medicine; Arianna Barnes at Barnes Jewish Hospital and Amanda Choflet at Northeastern University.

The research was unfunded.

Disclosures: Kelly Lee reports consulting for LexiDrugs and honoraria from WebMD Health Corp. Sidney Zisook reports grants from Compass Pathways. The other authors report no competing interests.

 

New biosensor technology could transform how viruses are detected



Biochar Editorial Office, Shenyang Agricultural University
Recent advances in aptamer-based biosensors for viral detection 

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Recent advances in aptamer-based biosensors for viral detection

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Credit: Furong Wang, Qihan Meng, Zhimei Huang, Yiming Ren, Zijie Zhang, Yangyang Chang, Rui Zhang, Yingfu Li, Jiuxing Li, & Meng Liu





Rapid and reliable virus detection is one of the most critical tools for controlling outbreaks, from seasonal influenza to global pandemics like COVID-19. A new review published in Biocontaminant highlights major advances in a promising class of diagnostic tools known as aptamer-based biosensors, which could help deliver faster, cheaper, and more portable virus testing in clinics, communities, and the field.

The review, led by researchers at Dalian University of Technology, examines how short strands of DNA or RNA called aptamers are being engineered and integrated into next-generation biosensors for viral detection. Aptamers can bind to viruses with high precision, similar to antibodies, but they are easier to manufacture, more stable at high temperatures, and simpler to modify for different sensing platforms.

“Reliable viral detection underpins nearly every public health response, from patient diagnosis to outbreak surveillance,” said corresponding author Jiuxing Li. “Our review shows that aptamer-based biosensors are rapidly closing the gap between laboratory accuracy and real-world usability.”

Traditional viral detection methods, such as cell culture, antigen tests, and PCR, have played essential roles in disease control but come with tradeoffs. Cell culture is slow and requires specialized facilities. Antigen tests can lack sensitivity. PCR is highly accurate but depends on expensive instruments and trained personnel. These limitations can delay detection, particularly in low-resource or high-demand settings.

Aptamer-based biosensors offer a different approach. Aptamers are selected in the laboratory through a process called SELEX, which identifies sequences that bind tightly and specifically to viral targets. Unlike antibodies, aptamers are fully synthetic, allowing precise control over their structure, performance, and cost.

The review outlines recent innovations in selecting aptamers against viral proteins or entire virus particles, including advanced SELEX techniques that improve speed, efficiency, and binding performance. These developments are enabling aptamers to keep pace with rapidly mutating viruses, an ongoing challenge for many diagnostic tools.

Once selected, aptamers can be incorporated into a wide range of biosensors that convert virus binding into a measurable signal. The authors describe electrochemical sensors that generate electrical signals, fluorescent and color-changing assays that can be read visually, and advanced optical platforms such as surface plasmon resonance and surface-enhanced Raman scattering for ultra-sensitive detection.

“These biosensors can be designed for rapid testing outside traditional laboratories,” said co-corresponding author Meng Liu. “Some platforms can deliver results in minutes, require minimal sample preparation, and operate with portable or handheld devices.”

Importantly, the review emphasizes that aptamer-based biosensors are not limited to clinical diagnostics. They also show strong potential for environmental monitoring, food safety, and early warning systems that detect viruses on surfaces, in water, or in the air before outbreaks escalate.

The authors also address remaining challenges, including large-scale validation, standardization, and integration into real-world testing workflows. They note that combining aptamer technology with microfluidics, nanomaterials, and data analysis tools could further enhance performance and reliability.

“Our goal is to provide a clear framework for researchers and developers,” Li said. “By understanding both the strengths and the remaining hurdles, we can accelerate the translation of these biosensors from the lab to practical use.”

As the world continues to prepare for future viral threats, aptamer-based biosensors may become a key part of the global diagnostic toolkit, offering a faster and more flexible way to detect viruses wherever and whenever they emerge.

 

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Journal reference: Wang F, Meng Q, Huang Z, Ren Y, Zhang Z, et al. 2025. Recent advances in aptamer-based biosensors for viral detection. Biocontaminant 1: e020  

https://www.maxapress.com/article/doi/10.48130/biocontam-0025-0018  

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About Biocontaminant:
Biocontaminant (e-ISSN: 3070-359X) is a multidisciplinary platform dedicated to advancing fundamental and applied research on biological contaminants across diverse environments and systems. The journal serves as an innovative, efficient, and professional forum for global researchers to disseminate findings in this rapidly evolving field.

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