Friday, May 09, 2025

 

Researchers develop practical solution to reduce emissions and improve air quality from brick manufacturing in Bangladesh


A new study found that brick kiln owners were willing to implement energy-efficient operational changes after receiving training and support. The social benefits of reduced carbon emissions from these changes outweighed costs by a factor of 65 to 1


Boston University School of Public Health

Brick kilns 

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Pictured is an overhead view of brick kilns in Bangladesh. 

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Credit: Sushanta Kumar Paul



Brick manufacturing is a central component of the economy in South Asia, but also a major source of greenhouse gas emissions and air pollution, as the practice releases carbon dioxide (CO₂), fine particulate matter (PM2.5), and other contaminants into the environment. This coal-powered industry poses a serious threat to human health, agriculture, and the environment in low- and middle-income countries that lack the capacity to monitor and regulate these largely informal operations.

As scientists continue to sound the alarm on the increasing dangers of fossil fuels, a new study by researchers at Boston University School of Public Health (BUSPH), Stanford Universityicddr,bGreentech Knowledge Solutions, and the Bangladesh University of Engineering and Technology has introduced an evidence-based strategy proven to increase energy efficiency and reduce emissions in the brick manufacturing industry by encouraging operational changes that prioritize practicality and profit. 

Published in the journal Science, the study analyzes the results of a randomized controlled trial (RCT) that showed that brick kiln owners in Bangladesh are willing and able to implement cleaner and more efficient business practices within their operations—without legal enforcement—if they receive the proper training and support, and if those changes are aligned with their profit motives. The study is the first to rigorously demonstrate successful strategies to improve efficiency within the traditional brick kiln industry.

The RCT evaluated an intervention that provided educational resources, training, and technical support to kiln owners in Bangladesh during the 2022-2023 brick kiln season with 276 brick kilns. The intervention aimed to motivate the owners to make energy-efficient adjustments to their manufacturing process, such as streamlining brick stacking and using powered biomass fuel, both of which improve complete fuel combustion and reduce  heat loss in the kilns. 

The study found that 65 percent of the brick kiln owners adopted these changes, which led to a  23-percent reduction in energy use. The changes substantially improved air quality, contributing to 20-percent reductions in CO₂ and PM2.5 emissions. This intervention also brought substantial savings in coal expenditures and higher-quality bricks. Notably, the researchers estimated that the social benefits due CO2 reductions from the intervention outweighed costs by a factor of 65 to 1 and that the CO2 reductions were achieved at the low cost of $2.85/ton. When the team returned to participating brick kilns the next year, they found adoption of the improved practices had not only sustained but increased.

“Brick manufacturing is central to development, urbanization, and construction in Bangladesh and across South Asia, but the industry has not experienced much innovation, leaving open the possibility for win-win solutions that target low efficiency,” says study lead and corresponding author Dr. Nina Brooks, assistant professor of global health at BUSPH. “Our findings demonstrate that brick kiln owners are willing to embrace simple changes that protect human and environmental health when they have the knowledge and training, and those changes deliver tangible economic gain.”

These findings are promising, as previous efforts to regulate the brick kiln industry have been unsuccessful in Bangladesh, where workers produce 27 billion bricks annually in harsh working conditions. This industry accounts for 17 percent of CO₂ emissions and 11 percent of PM2.5  emissions each year. Existing regulations, such as fuel mandates that ban the use of firewood, or laws that require brick kilns to be distanced from schools, health facilities, and other establishments, are only minimally enforced; for example, the majority of brick kilns in Bangladesh are located illegally near schools

In a 2024 pilot study for this intervention, the researchers learned that zigzag brick kiln owners were unaware of proper zizgag kiln operation—which are already designed to be less polluting—or that these approaches could increase their profit. The owners were also skeptical to implement the intervention, for fear that the changes were too technologically advanced for their workers. Although the study included an experimental arm that explained the business case for incentivizing workers to adopt the new practices, these were not widely taken up. An important area for future research is identifying strategies to improve work conditions that are aligned with kiln owners’ profit motives and may be implemented within a weak regulatory state. 

“From what I’ve seen in brick kilns, the people working there really make all the difference," says study coauthor Mr. Debashish Biswas, assistant scientist at icddr,b in Dhaka, Bangladesh. "It’s not just about the technology or the strategies—if the workers aren’t taken care of, things just don’t run smoothly. I think there is a real opportunity to find ways where looking after workers actually helps the business, too, even if the rules aren’t always enforced. Owners and workers both stand to gain if we can figure that out.”

When assessing the economic burden of the intervention, the researchers found that the social benefits outweighed the costs 65 to 1 by using the social cost of carbon of $185 per metric ton to value the CO2 reductions. If all zigzag kiln owners in Bangladesh adopted these changes, the team estimated that CO₂ levels could plummet by 2.4 metric tons in just one brick firing season, which would result in a two-percent reduction of the country’s annual CO₂ emissions.

“Brick kilns and other informal industries need not always look outside for finding solutions to improve their environmental performance," says study coauthor Dr. Sameer Maithel, an advisor at Greentech Knowledge Solutions in New Delhi, India. "The energy-efficient operating practices introduced in this study were identified working in close partnership with progressive brickmakers in South Asia. There are several such innovations being practiced in the field.”

There is an urgent need to put in place a system to identify these innovations and scale them, Dr. Maithel says. The researchers’ energy-efficient intervention may be scalable across South Asia, such as in India and Nepal, where brick manufacturing practices are similar—and possibly across other industries. Future research will consider how to best scale the intervention, as well as develop the next generation of efficiency improvements for the brick industry. 

"The remarkable success of the intervention demonstrates the benefit of deep engagement with local stakeholders," says co-senior author Dr. Stephen Luby, Lucy Becker Professor of Medicine and senior fellow at the Stanford Woods Institute for the Environment.

Hear more from Dr. Brooks and Dr. Luby in this Q&A, in which they further discuss what these findings reveal about how to make environmental progress in settings with little regulation or weak governance.

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About Boston University School of Public Health 

Founded in 1976, Boston University School of Public Health is one of the top ten ranked schools of public health in the world. It offers master's- and doctoral-level education in public health. The faculty in six departments conduct policy-changing public health research around the world, with the mission of improving the health of populations—especially the disadvantaged, underserved, and vulnerable—locally and globally.

'FOREVER CHEMICALS'

PFAS influence cellular immune response to coronavirus



UFZ study also reveals sex-specific differences as to how the immune system reacts to the virus


Helmholtz Centre for Environmental Research - UFZ





PFAS are found in multiple everyday products, such as cosmetics, outdoor clothing and coated pans. This is because of their special properties. They are heat-resistant, repel water and grease and are extremely resistant. There are thousands of different PFAS compounds and they are found in the soil, water and in the air where they accumulate for long periods. PFAS enter the human body via food, drinking water or the air we breathe and can then accumulate and affect our health. "PFAS are not acutely toxic. But since we encounter them almost everywhere in our surroundings and can hardly escape them, we are essentially subjected to chronic exposure to them. And this is especially problematic for vulnerable groups such as pregnant women, young children or the chronically ill," says Prof Ana Zenclussen, Head of the Department of Environmental Immunology at the UFZ.

Various studies have linked exposure to PFAS to conditions such as obesity, hormonal disorders and cancer. These forever chemicals can also influence the immune system. It is known from epidemiological studies that PFAS exposure has a negative effect on the development of antibodies following vaccination for SARS-CoV-2. In their current study, the researchers aimed to evaluate whether and how PFAS affect the second arm of the immune system, the so-called cellular immune response. This is especially important in the case of an infection with SARS-CoV-2 in order to protect against severe illness outcomes. "And unlike the case for other viruses, a high antibody titer against SARS-CoV-2 is not necessarily indicative of whether the development of the cellular immune response will be adequate upon encountering the virus," explains Ana Zenclussen. "We are therefore closing an important gap with our study."

For the study, the research team used blood samples from women and men who had been vaccinated against SARS-CoV-2 several times and had already been infected with the virus. The scientists cultured the immune cells contained in the blood samples in the laboratory and exposed them to PFAS for 24 hours. "We used a special mixture that realistically reflects the PFAS exposure of the European population," explains Ana Zenclussen. The PFAS mixture was developed by the Norwegian cooperation partners based on a large cohort study. In addition to a realistic PFAS concentration, the researchers also exposed the immune cells to higher concentrations of the PFAS mixture in further experiments - up to a concentration a thousand times higher, which corresponds to the exposure of people who work in the production of PFAS.

Dr Oddvar Myhre from the Norwegian Institute of Public Health in Oslo stresses: “The research emphasizes the importance of using a human-relevant PFAS mixture to understand its complex interactions with the immune system, particularly in the context of vaccination responses. This approach reflects real-world exposure scenarios more closely and helps shed light on the potential health risks associated with PFAS contamination."

Following PFAS exposure, the immune cells were exposed to proteins of the SARS-CoV-2 coronavirus. Can the immune cells previously treated with PFAS still react sufficiently to the virus and fight it? Is the immune response worse or significantly different? The research team led by Ana Zenclussen conducted a detailed immune analysis to answer these questions. They employed spectral flow cytometry, a modern method that enables identification, quantification and analysis of multiple immune cell types in a single measurement step. The functionality of the respective cell types can also be determined by measuring the messenger substances released.

In comparison with the unexposed samples, two immune cell types released more inflammatory mediators in response to SARS-CoV-2 proteins in the samples that had previously been exposed to elevated PFAS concentrations. "This suggests an excessive immune response," explains Ana Zenclussen. "It is interesting that this effect was especially pronounced in the immune cells of the male study participants." The situation was different for the female study participants. In this case, proportionally fewer B cells were present following increased PFAS exposure. B cells are immune cells that are crucial for the development of antibodies and long-term immunity. "The fact that high PFAS exposure affects the immune system differently depending on the biological sex is an important result that should be investigated more thoroughly in further studies," says Zenclussen.

The production of immune soluble mediators that play a key role in attracting further immune cells or in wound healing, was negatively affected in both sexes. "Our results show that exposure to high PFAS concentrations clearly alters the immune response to SARS-CoV-2 and may reduce its effectiveness," says Ana Zenclussen. "This could mean that people who are highly exposed to PFAS have a higher risk of poor disease progression or may respond less well to vaccinations. This is important information to adapt and individualise vaccination strategies."

 

Nature visits can improve well-being disparities among urban dwellers




Kobe University

250508-Uchiyama-Relatedness-Image 

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Access to nature, especially during childhood, has been shown to have a positive correlation to overall well-being, but disparities based on socioeconomic status and location continue to grow. Improving existing natural spaces and providing opportunities for residents to access nature should prove effective in reducing inequality in overall well-being.

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Credit: UCHIYAMA Yuta




How relatedness to nature is linked to well-being is determined by district-level socioeconomic status. The Kobe University analysis is based on survey results from two major Japanese metropolitan areas.

Hiking. Camping. Even just walking in the park. Be it a current hobby or a childhood pastime, many urban residents have engaged in activities that have nurtured in them a positive relationship with nature. But in our modern society, disparities in access to nature have only grown larger between residential areas. And while this especially affects those that face social and economic challenges, research that explores the relationship between district-level socioeconomic status, nature and well-being remains limited.

Kobe University human environmental scientist UCHIYAMA Yuta specializes in studying how differences in urban and rural lifestyles affect quality of life. He and his team surveyed 3,500 residents in two major metropolitan areas of Japan (Tokyo-Yokohama and Osaka-Kobe) in order to determine their relationship with nature both objectively (based on proximity and access to natural spaces) and subjectively (based on perceived relatedness to nature). The responses were then categorized based on socioeconomic status by area and the degree of urban development of their residential area to serve as a third dimension in clarifying the relationship between well-being and nature.

The results of this study, published in Landscape and Urban Planning, show that the more related to nature people feel, the better their overall well-being is, and that this relationship is particularly pronounced in urbanized areas with poorer socioeconomic conditions.

But why is this the case? Related studies have suggested that nature visits are important for maintaining and improving health for those under substantial stress, and that this is especially true for residents of areas with poorer socioeconomic conditions. Conversely, residents of areas with better socioeconomic conditions have access to additional resources for enhancing their health and overall well-being, making the effects of nature visits relatively less pronounced. 

Uchiyama explains what this means for policies aimed at reducing inequality in well-being, saying: “We anticipate that conserving and enhancing existing natural spaces and organizing community events will have a positive effect on well-being in areas of relatively poor socioeconomic status. Interestingly, of the factors we surveyed, childhood experience with nature in particular was a significant predictor of adult well-being.” This finding further emphasizes that early-life exposure and equitable access to nature are essential to public health.

Moving forward, further analysis of the relationships between independent variables as well as key factors that vary over time (e.g., moving between regions of differing socioeconomic level) should prove useful in obtaining a clearer picture of the relationship between nature relatedness, socioeconomic level and well-being. Uchiyama says, “As these findings are consistent with similar studies conducted in other regions, interventions for both subjective and objective factors should be applicable to other regions with similar socioeconomic contexts, such as other cities in Monsoon Asia. Currently, as part of an international collaborative project (link), we are analyzing how knowledge and perceptions influence well-being, resilience, and preparedness of citizens and decision-makers in major cities in Asia including Bangkok and Manila.”

This research was funded by the Japan Society for the Promotion of Science (grants JP23K25067, JP23K25106, JP23K28298, and JP23K28295), the Environment Research and Technology Development Fund (grant 1FS-2201), and Asia-Pacific Network for Global Change Research (CRRP2023-10MY-Uchiyama). It was conducted in collaboration with researchers from the University of the Ryukyus, the University of Tokyo and Nanzan University.

Kobe University is a national university with roots dating back to the Kobe Higher Commercial School founded in 1902. It is now one of Japan’s leading comprehensive research universities with nearly 16,000 students and nearly 1,700 faculty in 11 faculties and schools and 15 graduate schools. Combining the social and natural sciences to cultivate leaders with an interdisciplinary perspective, Kobe University creates knowledge and fosters innovation to address society’s challenges.

 

Eating ultra-processed foods may harm your health




Study finds each additional 100 grams/day consumption of ultra-processed foods increased risk of hypertension, cardiovascular events, cancer and more



American College of Cardiology



Consumption of ultra-processed foods, such as sugar-sweetened beverages, potato chips and packaged cookies, may be associated with adverse health outcomes, according to research being presented at the ACC Asia 2025 Together with SCS 36th Annual Scientific Meeting taking place May 9-11 in Singapore. This risk for hypertension, other cardiovascular events, cancer, digestive diseases, mortality and more, increased with every 100 grams of ultra-processed foods consumed each day.

“Ultra-processed foods are characterized by high sugar, high salt, and other non-nutritive components, exhibiting low nutritional density yet high caloric content,” said Xiao Liu, MD, with the department of cardiology at Sun Yat-sen Memorial Hospital of Sun Yat-sen University in Guangzhou, China. “These products may contribute to adverse health outcomes through multiple mechanisms, including but not limited to dysregulation of blood lipid profiles, alterations in gut microbiota composition, promotion of obesity, induction of systemic inflammation, exacerbation of oxidative stress and impairment of insulin sensitivity.”

The systematic review included 41 prospective cohort studies spanning the Americas, Europe, Asia and Oceania assessing the association between ultra-processed foods and health outcomes prior to April 2024. Taken together, the studies involved a total of 8,286,940 adult patients aged 18 years or older from the general population (30.8% male, 69.2% female).

All included studies used the Nova food classification system to define ultra-processed foods as industrially manufactured food products derived from natural foods or other organic constituents. These products undergo extensive multi-stage processing and typically contain significant quantities of food additives, including preservatives, colorants and flavor enhancers. According to the researchers, common examples of ultra-processed foods include commercially produced breads, sugar-sweetened beverages, potato chips, chocolate confectionery, candy, packaged cookies, etc.

The study found ultra-processed food consumption was associated with hypertension, cardiovascular events, cancer, digestive diseases and all-cause mortality. Each additional 100 g/day of ultra-processed food consumption was associated with a 14.5% higher risk of hypertension, 5.9% increased risk of cardiovascular events, 1.2% increased risk of cancer, 19.5% higher risk of digestive diseases and 2.6% higher risk of all-cause mortality. Researchers also observed increased risk of obesity/overweight, metabolic syndromes/diabetes and depression/anxiety.

The researchers used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence included in the analysis. GRADE assessment indicated high to moderate certainty for most outcomes, except low certainty for metabolic syndrome/diabetes.

“Clinicians should clearly explain that ultra-processed foods are typically high in added sugars, sodium, and unhealthy fats, while being low in fiber, essential vitamins, and other protective nutrients. This nutritional imbalance contributes to a wide range of adverse health outcomes,” Liu said. “Emerging evidence suggests a dose-response relationship between ultra-processed food consumption and negative health outcomes—meaning the more ultra-processed foods consumed, the greater the health risk. Therefore, reducing ultra-processed foods intake, even modestly, may offer measurable health benefits.”

According to the researchers, governments may consider implementing measures to reduce the consumption of ultra-processed foods and mitigate the associated health impacts. Some suggested measures include establishing stringent food labeling regulations, requiring manufacturers to provide explicit and comprehensive ingredient disclosures—particularly detailing all additives present in ultra-processed foods, Liu said. Clinicians should also encourage patients to gradually lower their ultra-processed food intake, replacing them with more nutritious, minimally processed foods.

While the study was limited in generalizability and comparability by different definitions of ultra-processed foods, Liu said the findings are not just about what to avoid, but also about what to embrace. Emerging evidence has linked health benefits to whole foods, simple ingredients, and culturally appropriate healthy eating patterns such as the Mediterranean or DASH diet, he said. High quality studies about this topic are further needed.

The American College of Cardiology (ACC) is a global leader dedicated to transforming cardiovascular care and improving heart health for all. For more than 75 years, the ACC has empowered a community of over 60,000 cardiovascular professionals across more than 140 countries with cutting-edge education and advocacy, rigorous professional credentials, and trusted clinical guidance. From its world-class JACC Journals and NCDR registries to its Accreditation Services, global network of Chapters and Sections, and CardioSmart patient initiatives, the College is committed to creating a world where science, knowledge and innovation optimize patient care and outcomes. Learn more at www.ACC.org or connect on social media at @ACCinTouch.

 

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Too fast to see


Eye movements predict speed limits in perception



Technische Universität Berlin – Science of Intelligence

Eye movements predict the speed limits of perception 

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Much like chipmunks dart around in rapid bursts, our eyes swiftly dart from one place to the next. These eye movements create high-speed motion that increases with the distance they cover. The new study shows that the speed of eye movements predicts the speed limit of perception.

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Credit: Adapted by Martin Rolfs by from https://commons.wikimedia.org/wiki/File:Eastern_Chipmunk,_Ontario,_Canada.jpg, CC BY-SA 3.0




If you quickly move a camera from object to object, the abrupt shift between the two points causes a motion smear that might give you nausea. Our eyes, however, do movements like these two or three times per second. These rapid movements are called saccades, and although the visual stimulus during a saccade shifts abruptly across the retina, our brain seems to keep it under the hood: we never perceive the shift. New research shows that the speed of our saccades predicts the speed limit in our vision when an object becomes too fast to see. According to a study published in Nature Communications by researchers from the Cluster of Excellence Science of Intelligence (TU Berlin), visual stimuli ––think a chipmunk darting around or a tennis ball hit with full force–– become invisible when they move at a speed, duration, and distance similar to those of one of our saccades. This suggests that the properties of the human visual system are best understood in the context of the movements of our eyes.

 

When does a moving stimulus become too fast to see? 

The limits of how fast an object can be before it becomes invisible to us is directly related to the speed of our own eye movements. Beyond a certain speed, a moving stimulus becomes too fast for us to see. As a result, the speed of our eye movements across a specific distance can be used to predict at what speed a moving stimulus becomes invisible to us. And since the speed of our eye movements changes from person to person, people who make particularly rapid eye movements can also see objects moving at higher speeds than people with slower eye movements. This might mean that the best baseball batters, action video game players, or wildlife photographers are the ones with quicker eye movements. 

Our movements shape our perception
This result is exciting as it provides first evidence of the idea that our body movements fundamentally shape the abilities of our perceptual system.  “What parts of the physical world we can sense depends fundamentally on how good our sensors are,” explains Martin Rolfs, the lead author of the study. “For example, we don't see infrared light because our eyes are not sensitive to it, and we fail to see flicker on our screens because they flicker at higher frequencies than our eyes can resolve. In this paper, however, we show that the limits of seeing are not just defined by these biophysical constraints but also by the actions and movements that impose changes on the sensory system. To show this, we used the body's fastest and most frequent motions, i.e. the saccadic eye movements that people make more than a hundred thousand times a day.” 

A motion we don’t perceive
Much like a camera movement causes motion in a movie, saccades create movement patterns on the retina. “But we never consciously perceive that motion,” says Rolfs. “We have shown that stimuli that follow the same (very specific) movement patterns as saccades (while people are holding their eyes still) also become invisible. So we are basically suggesting that the kinematics of our actions (here, saccades) fundamentally constrain a sensory system’s access to the physical world around us.” Rolfs explained that this is to be considered an intelligent trait of the visual system, because it remains sensitive to fast motion, but only up to speeds that result specifically from saccades, and these speeds are not seen consciously albeit available to the brain. “In simple terms,the properties of a sensory system such as the human visual system are best understood in the context of the kinematics of actions that drive its input(in this case, rapid eye movements),” said Rolfs. 

A finely tuned machine

“Our visual system and motor system are finely tuned to each other, but this has long been ignored,” says Martin Rolfs. “One of the issues is that the people who study motor control are not the same ones who study perception. They attend different conferences, they publish in different journals –– but they should be talking!”
This study suggests that our visual system can recognize when a stimulus moves in a way that is similar to our own eye movements, and then filters out the conscious perception of this movement. This also introduces a new mechanism to explain why we do not see visual motion smear on the retina during eye movements as we would if we were using a camera.

 

In brief: 

  • Objects moving at speeds, durations, and distances similar to those of our saccades can become invisible to us—even when our eyes are still.

  • People with faster saccadic eye movements can perceive faster-moving objects better than those with slower ones.

  • The ability to perceive motion is not just about sensory limits but also shaped by the movements that drive sensory input.

  • Our visual and motor systems are tightly coordinated, yet often studied separately—to understand perception, we need to understand action.