Tuesday, June 10, 2025

 

Invoking civil rights may actually hurt public support for social causes, new study finds



University of British Columbia




Framing a cause as a “civil rights” issue may actually decrease public support—even among people who deeply value civil rights. That’s the key finding of a new study published in the American Sociological Review, which challenges long-held beliefs about how best to win public backing for social change.

Researchers found that Americans generally feel very positively about the idea of civil rights, in the abstract. However, in describing contemporary issues—like workplace discrimination, food insecurity or lack of healthcare—as civil rights problems, Americans are often less likely to support government action.

“We are interested in how to improve the life chances of vulnerable groups, like racial minorities, immigrants and low-wage workers,” said co-author Dr. Irene Bloemraad, professor and co-director of the Centre for Migration Studies at the University of British Columbia. “We wanted to test what kinds of claims resonate with ordinary Americans.”

In a large two-part study, the researchers surveyed more than 7,500 California voters in 2016 and 2019. Respondents were asked how they feel about civil rights and to describe what the term meant to them in their own words. Participants also read short stories about people experiencing challenges such as workplace discrimination, food insecurity or lack of healthcare, and were asked whether they supported government action to address the hardships.

“We found that respondents did indeed feel very positively about civil rights in the abstract and largely agreed about their meaning,” said lead author Dr. Fabiana Silva, an assistant professor at the Ford School of Public Policy. “But when hardships were framed as civil rights issues, it actually decreased public support for government action. Most surprising to us was how widespread this negative effect was.”

The team expected that civil rights language might work better for addressing problems of unequal treatment like workplace discrimination than problems of material deprivation like going hungry. But they found that using civil rights framing was counterproductive for both.

They also expected that the language of civil rights would work better to address hardships faced by African Americans, but instead they found it was counterproductive for all the beneficiary groups tested: African Americans, Mexican Americans, White Americans, and undocumented Mexican immigrants. Further, rather than being especially effective when targeted towards politically liberal survey respondents or non-Whites, the frame was counterproductive across respondent sub-groups.

“In fact, we found that civil rights framing even reduced Black respondents’ support for government action to address hardships faced by Black people,” Dr. Silva added. “At the same time, this is not what we would have expected from a racialized backlash account.”

The study also found that people tend to define civil rights narrowly—as the right to be treated equally regardless of race, gender or religion. Most respondents did not associate civil rights with economic struggles, like not having enough to eat or being unable to afford healthcare. As a result, using civil rights language to talk about poverty may feel like a stretch to many, weakening its impact.

According to the researchers, the problem may lie in how people remember the Civil Rights Movement of the 1960s. Because it is remembered as such a historic and heroic moment, today’s struggles might seem less urgent by comparison.

“When contemporary activists make civil rights claims, they unwittingly evoke an implicit comparison to the historic Civil Rights Movement,” said co-author Dr. Kim Voss, professor of sociology at the University of California, Berkeley. “We think that this might undermine the power of a civil rights claim, because contemporary hardships seem less significant and contemporary claims-making seems less heroic than that idealized collective memory.”

This pattern could have consequences for movements across the political spectrum. From racial justice and immigrant rights to gun rights and anti-abortion advocacy, many causes rely on civil rights language to gain support.

“This might be disheartening to activists,” said Dr. Voss. “But a better takeaway is that frames other than civil rights are likely to be more effective for building public support.”

A more promising alternative, the researchers suggest, is an “American values” frame. This frame can be used to foreground similar ideals as the civil rights frame—including ideals of fairness, equal opportunity and individual dignity—without triggering comparisons to past movements. Their findings suggest that this could be a more effective way to unite people around social change.

 

Revolutionary coating shields iron from rust with 99.6% efficiency



The Hebrew University of Jerusalem
Comparative Rusting: Coated vs. Uncoated Iron 

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Right: uncoated iron. Left: coated iron. Both shown after exposure to rust-promoting conditions.

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Credit: Linoy Amar





Researchers have developed a highly effective dual-layer coating that provides 99.6% protection against iron corrosion. The breakthrough combines a thin molecular primer with a durable polymer layer, creating a strong, long-lasting barrier against rust. This innovation could significantly reduce maintenance costs and extend the lifespan of iron-based materials used in construction, transportation, and manufacturing.

Researchers at the Hebrew University of Jerusalem have developed a highly effective new coating that can protect iron from rust with 99.6% efficiency. Led by Prof. Elad Gross from the NanoCenter and Institute of Chemistry at Hebrew University, the study introduces an innovative two-layer coating system that significantly improves upon existing methods for preventing corrosion.

Iron is widely used in industries such as construction, transportation, and manufacturing, but it is highly prone to rust when exposed to air and moisture. Rust weakens the metal, leading to structural damage and costly repairs. While protective coatings exist, many tend to degrade over time, offering limited long-term protection.

The new research presents a solution by combining two protective layers that work together to create a strong and long-lasting barrier. The first layer is an ultra-thin coating made of N-Heterocyclic Carbene (NHC) molecules, which form a tight bond with the iron surface. This primer layer ensures that the second layer—a polymer-based coating—sticks firmly, creating a highly stable and durable protective shield. Thanks to this improved adhesion, the coating remains intact even in harsh conditions, such as prolonged exposure to saltwater.

Experiments showed that this dual-layer system dramatically reduced the amount of corrosion, with tests conducted in a highly corrosive saltwater environment confirming its exceptional efficiency. By forming a strong chemical connection between the iron and the protective layers, this method offers far greater durability than conventional coatings, which often wear down or peel off over time.

"This discovery offers a major leap forward in protecting iron from corrosion," said Prof. Elad Gross. "By using a specially designed primer, we created a coating that is not only highly effective but also long-lasting. This could reduce maintenance costs, extend the lifespan of iron-based materials, and provide industries with a much more reliable solution."

This breakthrough has broad implications for industries that rely on iron and steel, from construction and transportation to infrastructure and manufacturing. By reducing the need for frequent repairs and replacements, this coating could also contribute to more sustainable and cost-effective material use. 
 

 

Mount Sinai receives $3.8 million grant to study new synthetic drugs and opioid overdoses in emergency departments to prevent deaths





The Mount Sinai Hospital / Mount Sinai School of Medicine

Alex Manini, MD, MS, Professor of Emergency Medicine at the Icahn School of Medicine at Mount Sinai, and Director of Mount Sinai’s Center for Research on Emerging Substances, Poisoning, Overdose, and New Discoveries will lead study on overdose cases 

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Mount Sinai has been awarded a $3.8 million grant from the National Institute on Drug Abuse, a division of the National Institutes of Health, to study drug overdose cases linked to novel synthetic opioids

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Credit: Mount Sinai Health System





The Icahn School of Medicine at Mount Sinai has been awarded a $3.8 million grant from the National Institute on Drug Abuse, a division of the National Institutes of Health, to study drug overdose cases linked to novel synthetic opioids. This work will help Emergency Department physicians better identify what substances people have taken, the severity of the overdose, and the best treatments to use in cases involving previously unknown or emergent drugs. This grant will be disbursed over five years.

“Front-line doctors urgently need better tools and information to manage overdose cases, especially involving synthetic drugs. Our study will give them real-time data and insights from across the country, so they can deliver faster, more accurate care,” says Principal Investigator Alex Manini, MD, MS, Professor of Emergency Medicine at the Icahn School of Medicine at Mount Sinai, and Director of Mount Sinai’s Center for Research on Emerging Substances, Poisoning, Overdose, and New Discoveries. “This work will help emergency providers identify what substances people have taken, how serious the situation is, and what treatments are most likely to save lives, especially in overdose cases involving unknown or newly emerging drugs.”

The country’s opioid epidemic is expanding, with drug overdose deaths doubling from 2015 to 2023. For the first time ever, drug overdose deaths surpassed 108,000 in the United States in 2023, and more than 70 percent of these cases involved an opioid. The opioid epidemic costs the United States more than $1 trillion every year and accounts for nearly 3 million Emergency Department visits annually.

Initially, most illicit opioid overdoses were linked to heroin, but the changing face of global drug commerce introduced synthetic opioid fentanyl analogues into the drug supply. Now, these drugs have far surpassed heroin as the primary cause of overdose deaths. These highly potent novel synthetic opioids, along with psychoactive adulterants, are now commonly detected in the illicit opioid supply within the United States, creating a toxic drug supply with new drugs that most clinicians have never heard of. As a result, when patients overdose on these novel drugs, it is challenging for physicians to identify them in their system or to find the most effective treatment. Naloxone, which rapidly reverses the effects of opioid overdose, is typically used in emergency rooms in these cases, but doctors have concerns that it may take more naloxone to reverse the effects of these new opioids, and new adulterants may not respond to naloxone.

This new study aims to answer questions involving synthetic opioids. Mount Sinai will lead the research, which involves 10 high-volume hospital systems across the United States that are part of the national Toxicology Investigators Consortium, a division of the American College of Medical Toxicology created to detect new and emerging drugs of abuse, adverse effects of new medications in the post-marketing phase, and emerging toxicological threats.

During the study, patients who arrive at emergency departments with opioid overdose will be studied in terms of their course of illness, confirmation of ingested substances, clinical risk factors, and treatment needs. Toxicologists will use state-of-the-art technology to conduct molecular identification to confirm if novel fentanyl analogs, adulterants, and nitazenes - opioids that are more potent than fentanyl, and increasingly identified in the U.S. illicit opioid supply and undetectable by conventional fentanyl testing strips - are in their system. Researchers will also disseminate information regarding overdose outbreaks and trends to the public by partnering with the Centers for Disease Control and Prevention (CDC). They will update study results onto the CDC’s suspected opioid overdose dashboard.

“We aim to predict the effects of emerging synthetic opioids and get ahead of regional outbreaks, delivering timely alerts to doctors, public health agencies, and the public,” adds Dr. Manini. “When this study is complete, the field of drug abuse will be significantly advanced to allow prediction of medical consequences for thousands of victims of the U.S. opioid epidemic.” 

About the Mount Sinai Health System

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with 48,000 employees working across seven hospitals, more than 400 outpatient practices, more than 600 research and clinical labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time—discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.

Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 9,000 primary and specialty care physicians and 11 free-standing joint-venture centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida. Hospitals within the System are consistently ranked by Newsweek’s® “The World’s Best Smart Hospitals, Best in State Hospitals, World Best Hospitals and Best Specialty Hospitals” and by U.S. News & World Report's® “Best Hospitals” and “Best Children’s Hospitals.” The Mount Sinai Hospital is on the U.S. News & World Report® “Best Hospitals” Honor Roll for 2024-2025.

For more information, visit https://www.mountsinai.org or find Mount Sinai on FacebookInstagramLinkedInX, and YouTube.

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Sea cucumbers could hold key to stopping cancer spread

UM-led study explores how sea cucumber sugars could be used in cancer therapy




University of Mississippi
Sea Cucumbers to Fight Cancer 

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A sugar compound found in sea cucumbers could hold the key to stopping the spread of cancer, according to a recent UM-led study published in Glycobiology. 

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Credit: Graphic by Stefanie Goodwiller/University Marketing and Communications





OXFORD, Miss. – Sea cucumbers are the ocean’s janitors, cleaning the seabed and recycling nutrients back into the water. But this humble marine invertebrate could also hold the key to stopping the spread of cancer.  

A sugar compound found in sea cucumbers can effectively block Sulf-2, an enzyme that plays a major role in cancer growth, according to a University of Mississippi-led study published in Glycobiology

“Marine life produces compounds with unique structures that are often rare or not found in terrestrial vertebrates,” said Marwa Farrag, a fourth-year doctoral candidate in the UM Department of BioMolecular Sciences.  

“And so, the sugar compounds in sea cucumbers are unique. They aren’t commonly seen in other organisms. That’s why they’re worth studying.” 

Farrag, a native of Assiut, Egypt, and the study's lead author, worked with a team of researchers from Ole Miss and Georgetown University on the project. 

Human cells, and those of most mammals, are covered in tiny, hairlike structures called glycans that help with cell communication, immune responses and the recognition of threats such as pathogens. Cancer cells alter the expression of certain enzymes, including Sulf-2, which in turn modifies the structure of glycans. This modification helps cancer spread.   

“The cells in our body are essentially covered in ‘forests’ of glycans,” said Vitor Pomin, associate professor of pharmacognosy. “And enzymes change the function of this forest – essentially prunes the leaves of that forest.  

"If we can inhibit that enzyme, theoretically, we are fighting against the spread of cancer.”  

Using both computer modeling and laboratory testing, the research team found that the sugar – fucosylated chondroitin sulfate – from the sea cucumber Holothuria floridana can effectively inhibit Sulf-2.  

“We were able to compare what we generated experimentally with what the simulation predicted, and they were consistent,” said Robert Doerksen, professor of medicinal chemistry. “That gives us more confidence in the results.”  

Unlike other Sulf-2 regulating medications, the sea cucumber compound does not interfere with blood clotting, said Joshua Sharp, UM associate professor of pharmacology. 

“As you can imagine, if you are treating a patient with a molecule that inhibits blood coagulation, then one of the adverse effects that can be pretty devastating is uncontrolled bleeding,” he said. “So, it’s very promising that this particular molecule that we’re working with doesn’t have that effect.” 

As a marine-based cancer therapy, the sea cucumber compound may be easier to create and safer to use.  

“Some of these drugs we have been using for 100 years, but we’re still isolating them from pigs because chemically synthesizing it would be very, very difficult and very expensive,” Sharp said. “That’s why a natural source is really a preferred way to get at these carbohydrate-based drugs.”  

Unlike extracting carbohydrate-based drugs from pigs or other land mammals, extracting the compound from sea cucumbers does not carry a risk of transferring viruses and other harmful agents, Pomin said.  

“It’s a more beneficial and cleaner resource,” he said. “The marine environment has many advantages compared to more traditional sources.”  

But sea cucumbers – some variants of which are a culinary delicacy in the Pacific Rim – aren’t so readily abundant that scientists could go out and harvest enough to create a line of medication. The next step in the research is to find a way to synthesize the sugar compound for future testing. 

“One of the problems in developing this as a drug would be the low yield, because you can’t get tons and tons of sea cucumbers,” Pomin said.  “So, we have to have a chemical route, and when we’ve developed that, we can begin applying this to animal models.”  

The interdisciplinary nature of the scientific study, which featured researchers from chemistry, pharmacognosy and computational biology, underscored the importance of cross-disciplinary collaboration in tackling complex diseases like cancer, Pomin said. 

“This research took multiple expertise – mass spectrometry, biochemistry, enzyme inhibition, computation,” Pomin said. “It’s the effort of the whole team.”  

This work is based on material supported by the National Institutes of Health grant nos. 1P20GM130460-01A1-7936, R01CA238455, P30CA51008 and S10OD028623.  

 

Baby talk is real: Adults speak differently to babies in at least 10 different languages




International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo



Hypothetical vowel space triangles for /a/, /i/, and /u/ in speech directed to adults (ADS, orange) and speech directed to infants (IDS, blue). 

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The x-axis represents the average value of each vowel on the first formant (F1, relates to how high or low the tongue is during the vowel production), the y-axis the same on the second formant (F2, relates to how forward or backward the tongue is in the mouth during vowel production). The larger vowel space triangle in IDS represents the exaggeration of vowels.

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Credit: Irena Lovčević, International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo



Tokyo, Japan - There are many factors that contribute to infant language development, not least of which is baby talk—the modified speech mothers and other adults often use when speaking to infants.

 

Baby talk is more formally referred to as infant-directed speech (IDS) and often differs from adult-directed speech (ADS) in both pitch and vocabulary. One component of IDS that remains controversial, however, is the exaggeration or hyperarticulation of vowel sounds. Some experts contend that vowel exaggeration produces clearer speech sounds that are easier for infants to process, but studies conflict on whether or not vowel hyperarticulation is actually present in IDS.

 

A group of scientists from International Research Center for Neurointelligence (WPI-IRCN) at The University of Tokyo, the University of Amsterdam, PSL University and Aarhus University analyzed the existing research on vowel hyperarticulation in IDS to determine whether or not this specific type of speech exaggeration occurres in IDS.

 

The team published their research on 02-06-2025 in the journal Psychological Bulletin.

 

Before the meta-analysis, one group of studies suggested that adults particularly exaggerate the vowels “a”, “i” and “u” when speaking to infants, making vowels easier to perceive and potentially facilitating word learning. In contrast, other studies had not detected the consistent exaggeration of vowels in IDS, suggesting that baby talk may instead be a by-product of smiling or some other positive effect.

 

“[W]e decided to conduct [a] meta-analysis on all studies done on this topic to understand if vowel exaggeration is a feature of speech directed to babies, and if so, which factors lead to it and to the observed differences in existing research,” said Irena Lovčević, postdoctoral researcher at the International Research Center for Neurointelligence  (WPI-IRCN) at The University of Tokyo and first author of the research paper.

 

The researchers performed meta-analyses on 20 IDS vowel hyperarticulation studies that used similar methodology and 35 studies that used any research method. Meta-analysis techniques combine the results of more than one similar research study to improve the statistical power of the results.

 

“Our meta-analysis confirms that mothers exaggerate vowels in speech directed to babies in at least 10 languages. However, our results also point to the diversity of methods used in the existing research. Hence, we want the readers, especially speech acquisition researchers, to carefully consider and document the methodological decisions in their research and avoid the generalization from one language to another or one method to another,” said Lovčević.

Overall, the team observed that IDS vowel hyperarticulation studies have lower sample sizes than would be expected for well-powered statistical analysis and recommend that study size be increased. The researchers also noted that differences in hyperarticulation across languages were difficult to detect due to smaller sample sizes for less represented languages and that more cross-linguistic and cross-cultural research is needed to be able to generalize language acquisition research findings. Additionally, the size of vowel hyperarticulation could also be influenced by the measurement scale (e.g., Hertz, Mel) used by the research team, illustrating how intimately methodology can influence experimental results and the ability to compare those results across studies.

 

After establishing the presence of vowel hyperarticulation in IDS, the research team has their sights set on learning more about other aspects of infant language development. “The next step is further examination of different factors influencing language development in babies, with special focus on modifiable factors from babies’ immediate environment, such as the amount of speech that babies are exposed to and the qualities of vocal caregiver-baby interactions. How babies learn to speak without so much effort is still a big puzzle, so my goal is to contribute to solving … this puzzle,” said Lovčević.

 

Titia Benders from the University of Amsterdam, Netherlands; Sho Tsuji from the International Research Center for Neurointelligence  (WPI-IRCN) at The University of Tokyo Institutes for Advanced Studies in Japan and the Laboratoire de Sciences Cognitives et de Psycholinguistique, Département d′Études Cognitives, ENS, EHESS, CNRS at PSL University in France; and Riccardo Fusaroli from Department of Linguistics in the Cognitive Science and Semiotics and the Interacting Minds Centre at Aarhus University in Denmark also contributed to this research.

 

This work was supported by a MEXT World Premier International Research Center Initiative startup grant, JSPS KAKENHI Grant Number 20H05617 and 20H05919, and Seed funding from the Interacting Minds Center.

 

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The article, “Acoustic Exaggeration of Vowels in Infant-Directed Speech: A Multi- Method Meta-Analytic Review”, was published in Psychological Bulletin at DOI: 10.1037/bul0000479

 

About the World Premier International Research Center Initiative (WPI)

 

The WPI program was launched in 2007 by Japan's Ministry of Education, Culture, Sports, Science and Technology (MEXT) to foster globally visible research centers boasting the highest standards and outstanding research environments. Operating at institutions throughout Japan, the 18 centers that have been adopted are given a high degree of autonomy, allowing them to engage in innovative modes of management and research. The program is administered by the Japan Society for the Promotion of Science (JSPS).

See the latest research news from the centers at the WPI News Portal: https://www.eurekalert.org/newsportal/WPI

Main WPI program site: www.jsps.go.jp/english/e-toplevel

 

International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo

 

The IRCN was established at the University of Tokyo in 2017, as a research center under the WPI program to tackle the ultimate question, “How does human intelligence arise?” The IRCN aims to (1) elucidate fundamental principles of neural circuit maturation, (2) understand the emergence of psychiatric disorders underlying impaired human intelligence, and (3) drive the development of next-generation artificial intelligence based on these principles and function of multimodal neuronal connections in the brain.

Find out more at: https://ircn.jp/en/