Friday, June 13, 2025

 

Rutgers health researchers challenge FDA warning on common epilepsy drug



A study offers evidence supporting the cardiac safety of a popular antiseizure medication




Rutgers University





Rutgers Health researchers found that lamotrigine, a widely prescribed antiseizure medication, to be safe in older adults with epilepsy, contrary to a safety warning by the Food and Drug Administration (FDA).

 

According to the Centers for Disease Control and Prevention, about 2.9 million adults throughout the United States are living with the neurological disorder.

 

Lamotrigine, sold under the brand name Lamictal, represents about 10% of all antiseizure medication use. In 2020, the FDA placed a safety warning label on lamotrigine based on reports the drug could increase the risk of heart conditions. As such, patients with epilepsy who may be good candidates for the drug but had a history of heart issues may be precluded from being prescribed this effective treatment modality.

 

The FDA safety warning, however, came with the caveat that it was based on limited evidence. That prompted Rutgers Health researchers to further analyze the health risks associated with the drug in epilepsy patients.

 

“The FDA’s safety warning of lamotrigine may have limited the use of this effective drug in patients with epilepsy,” said Chintan Dave, a senior author of the study, a core member of Rutgers Institute for Health, Health Care Policy and Aging Research (IFH), and an assistant professor of pharmacy and epidemiology at the Ernest Mario School of Pharmacy. “It’s important for the public to know that our research found that lamotrigine is safe in older adults with epilepsy, including those with underlying heart disease.”

 

Their study, published online on June 11 in Neurology, the medical journal of the American Academy of Neurology, examined data from more than 158,000 adults with epilepsy to compare outcomes of two common antiseizure drugs in use, making it the largest study to date analyzing the effects of lamotrigine on cardiac risks in epilepsy patients.

 

Researchers found no increased risk for heart rhythm problems or sudden cardiac arrest among older adults taking lamotrigine compared to those using the other commonly prescribed antiseizure drug, levetiracetam. Study findings were consistent across a range of subgroups, including age, gender, race and those with histories of heart conditions.

 

“Our results do not support the FDA safety warning about the use of lamotrigine in patients with heart issues,” said Gloria Ho, a visiting scholar at the Center for Pharmacoepidemiology and Treatment Science (PETS) at IFH and a corresponding author of the study.

 

Study coauthors include Tobias Gerhard of PETS, IFH and the Ernest Mario School of Pharmacy; Daniel Horton of PETS, IFH and Rutgers Robert Wood Johnson Medical School; and Parin Patel of Ascension St. Vincent Heart Center in Indiana.

 

Doctors raise concern over rise in recreational ketamine use



More individuals are seeking treatment for ketamine addiction; Greater awareness, research, and treatments are needed




BMJ Group






The rise in non-prescribed ketamine use across the UK in recent years is a cause for concern, say doctors in The BMJ today.

Irene Guerrini at South London & Maudsley NHS Foundation Trust and colleagues warn that its low cost has made it popular among young people, and the number of people starting treatment for ketamine addiction in 2023-2024 reached 3609, more than eight times higher than in 2014-2015.

They say public awareness of the risks and long term harms associated with ketamine remains insufficient, and they call for better diagnostic criteria, a national registry, and screening tools to support earlier identification, guide treatment, and help evaluate emerging therapies.

Ketamine is routinely used as a general anaesthetic and lower doses are prescribed for chronic pain, treatment resistant depression and suicidality, they explain. Intranasal esketamine is also licensed for the treatment of depression.

But ketamine is also increasingly used recreationally at doses much higher than those prescribed for depression, which can cause serious health problems, such as irreversible damage to the bladder and kidneys and psychiatric conditions, they warn.

And as ketamine use increases, more individuals are seeking treatment for addiction. The number of people starting treatment for ketamine addiction in 2023-24 was 3609, more than eight times higher than the 426 reported in 2014-15.

However, the authors point out that ketamine use disorders remain inadequately defined in psychiatric guidelines, and there is a lack of evidence around potential drugs for treatment and prevention.

Individuals who use ketamine also report that health services often lack an understanding of ketamine addiction and offer minimal treatment options specific to the drug, meaning treatment is often partially effective. 

Balancing ketamine’s medical value with rising non-prescribed use presents a complex challenge, write the authors.

“The Home Office is considering reclassifying ketamine as class A, but opinions remain divided. A proportionate response should go beyond legislation to include clear governance of therapeutic use, investment in treatment and prevention, and balanced public messaging.”

[Ends]

 

New index ranks 917 European cities on urban design for health and well-being



Smaller cities tend to show better environmental quality and a higher overall score, while large metropolitan cities perform better on urban design and sustainable transport indicators




Barcelona Institute for Global Health (ISGlobal)





The Barcelona Institute for Global Health (ISGlobal), a centre supported by the ’la Caixa’ Foundation, has unveiled a new tool: the Healthy Urban Design Index (HUDI). The HUDI is a composite index that evaluates 917 European cities based on 13 indicators connected  to peoples’ health and well-being and divided into four domains: urban design, sustainable transport, environmental quality and green space accessibility. The HUDI is the result of scientific work published in The Lancet Planetary Health. The data for all cities is publicly available on https://isglobalranking.org/hudi/.

In order to make the cities comparable, they have been grouped into five categories according to the number of inhabitants: large metropolitan, metropolitan, medium and small-sized cities and small towns. The 13 indicators assessed include urban compactness, housing density, walking, cycling and public transport infrastructures, air pollution levels, capacity to mitigate and manage heat, and accessibility of green spaces. The index assigns a score between 0 and 10 for each of the indicators analysed and establishes a combined HUDI score. 

Small cities lead the HUDI

Generally, the category with the highest HUDI scores is small-sized cities, which includes all European cities with a population between 50,000 and 200,000 inhabitants. Pamplona (Spain), Geneva (Switzerland) and Harlow (UK), all small-sized cities, lead the HUDI scoring across all categories with scores of 6.8, 6.65 and 6.64, respectively. “The HUDI score differences are often only very small. However, the HUDI shows tendencies and none of the 917 cities achieves a score of 7 or higher out of 10, which gives us an idea of the room for improvement in promoting health and well-being through urban design in Europe," explains Federica Montana, researcher at ISGlobal and lead author of the study.

Large metropolitan cities generally scored better on indicators of urban design (housing density, compactness, mid-rise development and permeability) and sustainable transport (walking and cycling opportunities and number of public transport stops), particularly those in Northern Europe and some in Spain. In contrast, smaller cities show better environmental quality (air pollution, green space and lower urban heat island effects), with higher scores on better air quality and heat mitigation indicators, particularly in Northern Europe.

Differences between Western and Eastern Europe

“One of the trends we observed is that the lowest HUDI scores tended to be concentrated in Eastern European countries such as Romania, Bulgaria and Poland. Conversely, it is in Western European cities, with notable concentrations in the UK, Spain and Sweden that we find the highest scoring cities”, says Natalie Mueller, ISGlobal researcher and co-author of the study. 

Not a final ranking

“The HUDI is not intended to be a final ranking of cities, but rather a first approach using only open spatial data to see how European cities of all sizes perform and compare in terms of providing a healthy urban design to their residents”, says Mark Nieuwenhuijsen, director of ISGlobal's Climate, Air Pollution, Nature and Urban Health programme. “Cities of similar size often face similar challenges and opportunities and providing a high spatial resolution of the indicators and combined HUDI scores can help to pinpoint problems and develop targeted  intervention strategies. Our HUDI is a work in progress and we invite the research, urban planning and policy communities to develop this work further in the future and make other relevant indicators available”, Nieuwenhuijsen adds.  

Top cities by category

The cities with the best HUDI scoring in each category are Madrid (Spain), with a score of 6.04 in large metropolitan cities; Lisbon (Portugal), with a score of 6.09 in metropolitan cities; Bilbao (Spain), with a score of 6.35, in medium-sized cities; Pamplona (Spain), with a score of 6.8, in small-sized cities; and Campobasso (Italy), with a score of 6.02, in the small towns cluster.  

Large metropolitan areas (more than 1.5 million inhabitants)

Total rank

City

Country

Score

39

Madrid

Spain

6.04

148

Barcelona

Spain

5.67

407

Vienna

Austria

5.29

421

London

United Kingdom

5.01

560

Rome

Italy

5.08


Metropolitan areas (500,000 to 1.5 million inhabitants)

Total rank

City

Country

Score

27

Lisbon

Portugal

6.09

54

Stockholm

Sweden

5.96

88

Athens

Greece

5.86

111

Glasgow

United Kingdom

5.79

125

Seville

Spain

5.76


Medium-sized urban areas (200,000 to 500,000 inhabitants)

Total rank

City

Country

Score

10

Bilbao

Spain

6.35

21

A Coruña

Spain

6.14

24

Edinburgh

United Kingdom

6.10

25

Southampton

United Kingdom

6.10

30

Móstoles

Spain

6.08


Small urban areas (50,000 to 200,000 inhabitants)

Total rank

City

Country

Score

1

Pamplona

Spain

6.80

2

Geneva

Switzerland

6.65

3

Harlow

United Kingdom

6.64

4

San Sebastián

Spain

6.51

5

Stevenage

United Kingdom

6.46


Small towns (less than 50,000 inhabitants)

Total rank

City

Country

Score

45

Campobasso

Italy

6.02

272

Ibiza

Spain

5.47

372

Przemysl

Poland

5.35

385

Santurtzi

Spain

5.32

482

Igualada

Spain

5.18


Methodology

The Healthy Urban Design Index assesses 917 cities from 26 European countries, including the United Kingdom, and it has been developed using open data sources, including remote sensing data, OpenStreetMap and EU and government open datasets. 

The team defined 13 indicators that scientific evidence links to physical and/or mental health and grouped them into four key domains: urban design, sustainable transport, environmental quality and accessibility to green space. For each of the indicators, a reference value was defined based on previous studies or recommendations from experts or international organisations. For example, for the air pollution indicators, the recommendations of the annual average values of particulate matter PM2.5 and nitrogen dioxide (NO2) established by the WHO were used as a reference. For those indicators for which there was no reference value, the value of the city with the best result was used as a reference.

Once the data for all the cities had been obtained for each of the 13 indicators, they were compared with the target value and converted to a score between 0 and 10 depending on the result. The HUDI scores were calculated by applying weights to the 13 indicators and were subsequently used to rank cities within their respective city clusters.

The team hopes to improve the HUDI in the future by including other relevant indicators in the context of urban health, such as socioeconomic indicators, transport modal share, or access to and diversity of services and amenities. “The use of all open source data is an important first step. We are making the codes available and hope that cities can use the evidence to understand the links between urban planning and health. The HUDI helps cities not only see the indicators at the city level but also at high spatial resolution, which is important for equity as there can be large differences across neighbourhoods”, says Carolyn Daher, co-author of the study and coordinator of the ISGlobal Urban Planning, Environment and Health Initiative.

“The HUDI is a useful tool and also a call to action for cities to look at the data and distributions, and use their own data to validate findings, define targeted interventions strategies, and contribute with better data to improve the indicators and mapping in the near future”, concludes Natalie Mueller

Instructions for accessing the HUDI website

The IDUS pages will be made public once the embargo is completed.

Reference

Federica Montana, Natalie Mueller, Evelise Pereira Barboza, Sasha Khomenko, Tamara Iungman, Marta Cirach, Carolyn Daher, TC Chakraborty, Kees de Hoogh, Alice Battiston, Rossano Schifanella, Mark Nieuwenhuijsen. Building a Healthy Urban Design Index (HUDI): how to promote health and sustainability in European cities. The Lancet Planetary Health, June 2025.

 

A stress memory effect in olivine at upper mantle pressures and temperatures



Ehime University
Fig.1: Subducting slab and intermediate earthquakes underneath Honshu island 

image: 

Intermediate earthquakes occur in the subducting slabs at depths of 50-300 km. Hypocenters of intermediate earthquakes form seismic zones.

view more 

Credit: Tomohiro Ohuchi, Ehime University




The Kaiser effect, which is known as a stress memory effect, predicts that seismic events occur only when the previous maximum stress is exceeded. Therefore, the Kaiser effect has been applied for the estimation of the magnitude of ‘in situ’ stress on crustal rocks in the community of geotechnical engineering (including forecasting earthquakes). Geodetic observations have revealed that the time dependency of seismicity synchronized with inflation/deflation of a volcano is well explained by the Kaiser effect. However, the Kaiser effect has only been tested at room temperature in laboratories. Here, we performed deformation experiments on natural olivine at high pressures and high temperatures via a state-of-the-art technology large-volume deformation apparatus combined with a microseismicity monitoring technique. We have successfully confirmed a stress memory effect (corresponding to the Kaiser effect in a broad meaning) in strongly deformed olivine at high pressures and high temperatures. The observed memory effect could be effective in the seismic zones of subducting slabs.


A cubic pressure medium (pink) is surrounded by six anvils. Transducers, which are used for the detection of P-waves, are pasted on the rear side of each anvil.

Differential stress and strain increased during the deformation periods (white areas). Differential stress decreased when the deformation was halted (stress-relaxation periods: blue areas). Radiation of acoustic emissions (AEs) occurred during the deformation periods, though AEs ceased during the stress-relaxation periods. These results show the manifestation of the Kaiser effect. However, radiation of AEs proceeded at higher strains (> 0.2) even though the differential stress was below the maximum value (i.e., breakdown of the Kaiser effect).

Credit

Tomohiro Ohuchi, Ehime University