Tuesday, July 08, 2025

 

People can accurately judge biodiversity through sight and sound





British Ecological Society
High biodiversity forest 

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High biodiversity forest

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Credit: Kevin Rozario




People’s intuitive perception of biodiversity through visual and audio cues is remarkably accurate and aligns closely with scientific measures of biodiversity. This is according to new research published in the British Ecological Society journal, People and Nature.

In a new study led by researchers at the German Centre for Integrative Biodiversity Research (iDiv), the Helmholtz Centre for Environmental Research (UFZ) and the Friedrich Schiller University Jena, participants with no ecological training were asked to sort images and audio recordings of forests based on perceived biodiversity.

The researchers found that the biodiversity levels that participants perceived from the images and audio recordings closely matched the actual biodiversity of the forests.

How we perceive the natural world has implications for our health. Previous research has suggested that it is perceived biodiversity, rather than measured biodiversity, that is linked to our wellbeing.

Lead author Kevin Rozario, iDiv, said: “Because it’s suspected that perceived biodiversity translates into mental health benefits, it’s important to identify what people perceive with regards to biodiversity, what the contribution of the different senses could be, and under which circumstances people’s perception of biodiversity best aligns with what ecologists measure.”

To understand what indicators of biodiversity people were perceiving, the researchers also asked the study participants to sort the images and audio recordings according to any criteria that stood out to them.

Visually, people noticed vegetation density, light conditions or colour. Acoustically, people noticed birdsong characteristics, volume or emotions that the audio evoked.

“Not only are we experiencing an extinction of species, but also and extinction of biodiverse experiences.” said Kevin Rozario.

“We recommend to conserve and restore diverse forests characterised by a variety of tree species and structures to also provide habitats for different vocalising bird species. These conservation measures will have the dual benefit of meeting conservation goals while also increasing people’s experience of biodiversity and therefore likely increasing mental wellbeing.”

In each of the two sorting studies, 48 participants were presented with 57 photographs or 16 audio recordings of forest patches throughout Germany, Belgium and Poland with varying levels of biodiversity.

The actual biodiversity of the forests in the photographs was assessed using a combination of four commonly used forest diversity indicators: tree species richness, forest structural diversity, understory structural diversity and understory abundance. Actual biodiversity in the audio files was measured via bird species richness.

In the study, the researchers asked participants to sort the images and audio recordings based on anything that stood out to them when looking at or listening to the forest stimuli and then sort them based on perceived visual or acoustic diversity, respectively.

The researchers caution that people’s abilities to accurately perceive biodiversity may be reliant on them being able to directly compare environments with different biodiversity levels. They point to similar studies that found that participants could not easily perceive biodiversity when they were asked to rate one environment on its own.

The researchers also note that the majority of their study participants were university educated women and that future studies could look to replicate their methods with more representative samples of the general population.

-ENDS-


1 bird species [AUDIO] |


4 bird species [AUDIO] | 

 

How artificial light at night damages brain health and metabolism



Randy Nelson's research links light exposure to inflammation, mood disorders, and metabolic dysfunction




Genomic Press

Randy J. Nelson, PhD, West Virginia University, USA. 

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Randy J. Nelson, PhD, West Virginia University, USA.

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Credit: Randy J. Nelson, PhD





MORGANTOWN, West Virginia, USA, 8 July 2025 – In a comprehensive Genomic Press Innovators & Ideas interview published today, distinguished neuroscientist Dr. Randy J. Nelson shares insights from his pioneering research on how disrupted circadian rhythms affect brain function and overall health. The interview, published in Brain Medicine, traces Dr. Nelson's unconventional path from farm work and autopsy assistant to becoming one of the world's leading authorities on biological rhythms.

Dr. Nelson, who chairs the Department of Neuroscience at West Virginia University, has spent the past decade uncovering the hidden dangers of artificial light exposure. His research demonstrates that light at night doesn't just affect sleep quality; it fundamentally alters immune function, triggers neuroinflammation, disrupts metabolism, and influences mood regulation.

From Turkey Processing Plant to Top Research Institution

The interview reveals Dr. Nelson's remarkable journey to academic prominence. After working night shifts at a turkey processing plant during high school and later conducting postmortem examinations at two Cleveland hospitals, he eventually found his way to the University of California, San Diego, through an unexpected job opportunity at the San Diego Zoo.

"My path to academia is typical in the sense that it is not 'typical,'" Dr. Nelson reflects in the interview. His unique background, including becoming the first person in the United States to simultaneously earn two separate PhDs (in Psychology and Endocrinology from UC Berkeley), shaped his integrative approach to neuroscience research.

Circadian Disruption: A Modern Health Crisis

Dr. Nelson's laboratory has published groundbreaking findings on how exposure to artificial light at night affects multiple body systems. The research goes beyond simple sleep disturbance to reveal profound effects on physiological processes that evolved over millions of years to function in sync with natural light-dark cycles.

Key areas of impact identified by Dr. Nelson's research include immune system dysfunction, where light exposure at inappropriate times can suppress typical immune responses or trigger excessive inflammation. The work also demonstrates clear links between circadian disruption and metabolic disorders, potentially contributing to the obesity epidemic. Perhaps most concerningly, the research shows direct effects on mood regulation, with implications for understanding depression and anxiety disorders.

What specific wavelengths of light are most disruptive to circadian rhythms? How quickly can the body recover from chronic light exposure? What is the contribution of time-of-day as a biological variable? These questions drive ongoing investigations in Dr. Nelson's laboratory.

Translating Discovery to Clinical Practice

Moving beyond foundational research, Dr. Nelson's team currently conducts clinical trials examining whether blocking disruptive light effects can improve outcomes for intensive care patients. Two major trials focus on stroke recovery and cardiac surgery patients, populations particularly vulnerable to the harsh lighting conditions typical of hospital ICUs.

"Circadian rhythms are a fundamental aspect of biology, and much is known from foundational science about them," Dr. Nelson explains. "However, little of this foundational science has been translated to clinical medicine."

The research also extends to healthcare workers themselves. A third clinical trial investigates whether bright blue light visors can help night shift nurses reset their circadian rhythms, potentially improving their sleep quality, cognitive performance, and mood. Could similar interventions help other shift workers across various industries maintain better health despite irregular schedules?

Time as a Biological Variable

One of Dr. Nelson's most provocative proposals involves recognizing time-of-day as a crucial biological variable in all research. He argues that experimental results can vary dramatically depending on when studies are conducted, yet this information rarely appears in scientific publications.

"The answer to an experimental question may depend in part on the time-of-day when the question is asked," Dr. Nelson notes. This observation has profound implications for research reproducibility and could explain why some studies fail to replicate previous findings.

Building the Next Generation of Neuroscientists

Throughout his career at Johns Hopkins University, Ohio State University, and now West Virginia University, Dr. Nelson has mentored 25 PhD students and 16 postdoctoral researchers. His leadership philosophy emphasizes creating supportive environments where young scientists can thrive. His mentoring philosophy has been featured in a recent Society for Neuroscience Neuronline podcast (https://podcasts.apple.com/us/podcast/joy-and-curiosity/id1765339956?i=1000696714548).

As current president of the Association of Medical School Neuroscience Department Chairs, Dr. Nelson advocates for resources and policies that support early-career researchers. He particularly values helping faculty members navigate the challenging early stages of their careers through strategic resource allocation and mentorship.

What role might circadian rhythm research play in addressing the mental health crisis among graduate students and postdocs? How can academic institutions better support work-life integration for researchers studying around-the-clock biological processes?

A Vision for Healthier Living

Dr. Nelson's research carries immediate practical implications for public health. Simple interventions like reducing evening screen time, using warmer light colors after sunset, and maintaining consistent sleep schedules could significantly impact population health. His work suggests that respecting our evolutionary heritage by aligning modern life more closely with natural light patterns could prevent numerous chronic health conditions.  He recently published a trade book with Oxford University Press entitled, “Dark Matters,” to help the general public appreciate the importance of good circadian hygiene for health and wellness.

The interview also touches on Dr. Nelson's personal interests, including travel, biking, and gardening, activities that keep him connected to natural rhythms. His favorite place remains Southern California, where his academic journey began through that serendipitous opportunity at the San Diego Zoo decades ago. Dr. Randy J. Nelson's Genomic Press interview is part of a larger series called Innovators & Ideas that highlights the people behind today's most influential scientific breakthroughs. Each interview in the series offers a blend of cutting-edge research and personal reflections, providing readers with a comprehensive view of the scientists shaping the future. By combining a focus on professional achievements with personal insights, this interview style invites a richer narrative that both engages and educates readers. This format provides an ideal starting point for profiles that explore the scientist's impact on the field, while also touching on broader human themes. More information on the research leaders and rising stars featured in our Innovators & Ideas – Genomic Press Interview series can be found in our publications website: https://genomicpress.kglmeridian.com/.

The Genomic Press Interview in Brain Medicine titled "Randy J. Nelson: Disruption of circadian rhythms on brain function and health," is freely available via Open Access on 8 July 2025 in Brain Medicine at the following hyperlink: https://doi.org/10.61373/bm025k.0083.

About Brain MedicineBrain Medicine (ISSN: 2997-2639, online and 2997-2647, print) is a high-quality medical research journal published by Genomic Press, New York. Brain Medicine is a new home for the cross-disciplinary pathway from innovation in fundamental neuroscience to translational initiatives in brain medicine. The journal's scope includes the underlying science, causes, outcomes, treatments, and societal impact of brain disorders, across all clinical disciplines and their interface.

Visit the Genomic Press Virtual Library: https://issues.genomicpress.com/bookcase/gtvov/

Our full website is at: https://genomicpress.kglmeridian.com/

 

Pulsating microneedles a pain-free alternative to traditional needles




Griffith University

Microneedles 

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An array of microneedles sequentially produced by the pulsating in situ dried electro stretching method.

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Credit: Van Dau






A new transdermal drug delivery using pulsating, fabricated microneedles present a promising alternative to traditional subcutaneous injections.

The PIDES – pulsating in situ dried electro stretching - method, developed by Griffith University and University of Newcastle researchers, developed the needles to be less than 1mm in length to painlessly penetrate the outer layer of the skin and deliver medication into the body.

“Existing fabrication methods such as micro moulding, wet etching and 3D printing are often complex, expensive and may not be ideal for some temperature sensitive drugs,” said Luan Mai, a PhD candidate and co-author of the study.

"We wanted to make microneedle production simpler, more efficient and better suited for drug delivery,” said Dr Yuen Yong, a co-author from the University of Newcastle.

The team’s technique used pulsed electro hydrodynamic force generated between two metallic plates to stretch and shape polymer droplets into fine conical structures.

As the solvent evaporated, the polymer solidified into a microneedle with a sharp and rigid tip, ideal for painless skin penetration.

The researchers tested these microneedles on agarose gel and pig skins, confirming their mechanical strength and ability to pierce skin effectively.

They also tested drug encapsulation using curcumin, a model compound, and demonstrated a controlled time-dependent drug release profile, confirming the system's compatibility with physiological conditions.

“Our technique represents an alternative way in microneedle manufacturing,” said Dr Van Dau, from Griffith University’s School of Engineering and Built Environment.

“By integrating in situ drying with electrostretching, we’ve simplified the process while ensuring high performance, repeatability, and drug compatibility.

“The PIDES technique is low cost and scalable, allowing multiple microneedles to be fabricated without compromising quality.”

Looking ahead, the team planned to further optimise the technique and explore the development of an on-demand microneedle array system, aimed at enhancing flexibility and precision in drug delivery applications.

Dr Dau said it could lead to new pathways to more accessible and patient-friendly treatments for drug delivery, however the project was still in its early stages.

The study ‘Fabrication of Microneedles by Pulsating In Situ Dried Electrostretching for Transdermal Drug Delivery’ has been published in Small Methods.

 

Fertilizable rat sperm produced in a mouse body by blastocyst complementation






A novel, cost-effective strategy for generating genetically modified rats using ES cells




Niigata University

Flow chart of production of fertilizable sperm from rat ES cells by the blastocyst complementation method 

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Using the blastocyst complementation method, we produced rat embryonic stem (ES) cell-derived sperm in testicular hypoplasia mice and successfully generated rat offspring. This method can provide a cost-effective and efficient strategy for generating genetically modified rats, addressing various problems in genetic engineering with rats.

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Credit: Niigata University






Niigata, Japan -Rie Natsume and her collaborators have recently developed an innovative and cost-effective method for generating rats that inherit traits from embryonic stem (ES) cells. Unlike mouse ES cells, rat ES cells have unsuccessfully been established and maintained in culture without losing pluripotency. Moreover, producing germline-transmitting chimeric rats from ES cells has been a major challenge, resulting in only a handful of successful reports.

Although recent advances in genome editing technologies have made it easier to generate genetically modified rats, complex modifications such as long sequence insertions and conditional knockouts remain difficult. To address this issue, we focused on performing such complex genetic modifications in ES cells, followed by an efficient strategy to produce rats carrying these modified traits. Our approach involves injection of genetically modified rat ES cells into mouse blastocysts that lack the ability to form sperm. These chimeric mice subsequently produce functional rat sperm within their testes. The sperm can then be used for intracytoplasmic sperm injection (ICSI) to create rats that faithfully inherit the ES cell genotype. Because the host blastocysts are from infertile mice, all sperm derived in chimeras are exclusively from the introduced rat ES cells, eliminating the need for fluorescent labeling. Compared to conventional techniques that involve injecting rat ES cells into rat blastocysts, this method leverages mouse hosts, significantly reducing the cost and space required for animal husbandry. The paper also provides detailed protocols for establishing high-quality rat ES cell lines and conducting gene editing while maintaining their undifferentiated state—an invaluable resource for researchers in the field. Moreover, this blastocyst complementation technique using germline deficient hosts could be extended to other species. If pluripotent iPS cells can be established from endangered animals, this method may have far-reaching applications in conservation biology and reproductive medicine.