Monday, July 14, 2025

Here’s how we help an iconic California fish survive the gauntlet of today’s highly modified waterways


New ‘facilitated migration’ framework gives water managers a playbook for getting more juvenile Chinook salmon from the Central Valley to the sea




University of California - Santa Cruz

Chinook salmon 

image: 

Member of the UC Santa Cruz Fisheries Collaborative Program holds a live adult Chinook salmon from the Sacramento River in 2022.

view more 

Credit: Photo by Jeremy Notch




SANTA CRUZ, Calif.—Imagine a world where just six out of every 100 newborns make it to their teenage years, the rest unable to survive post-apocalyptic environmental conditions that have become too strange and dangerous for human life. That’s the plight of California’s once-thriving Chinook salmon, a population that now sees 94% of its juveniles die within the few weeks they spend trying to reach the sea from the freshwater sources where they first hatched.

This tragic reality is almost entirely due to how their native waterways in the state’s Central Valley have been turned into a system of levees, channels, and large high-head dams that are tightly managed almost exclusively for human needs. In terms of how water is allocated, wildlife is essentially an afterthought.

But the Central Valley Salmon Ecology Group, a team of researchers that bridge academia and resource management facilitated by the Fisheries Collaborative Program (FCP) at the University of California, Santa Cruz, has come up with a playbook for how water managers can tweak the timing, temperature and volume of releases to dramatically increase the odds of juvenile salmon surviving the perilous journey to the open ocean.

The approach, called “facilitated migration,” is detailed in a paper published on July 3 by the Ecological Society of America’s journal Ecological Applications.

“We’re already playing God with these ecosystems,” said the paper’s lead author, Benjamin Burford, an assistant project scientist at the Institute of Marine Sciences (IMS) at the University of California, Santa Cruz. “Can we play God a little bit better for a couple weeks out of the year to help more fish survive the migration? Yes, we absolutely can.”

Like other members of his group, Burford has a dual affiliation with UC Santa Cruz and the Fisheries Ecology Division of the National Oceanic and Atmospheric Administration (NOAA). The group collaborates with the U.S. Fish and Wildlife Service, U.S. Geological Survey, California Department of Fish and Wildlife, UC Davis, and other partners whose shared mission is to produce applied research that can help state and federal water managers in the Central Valley make more informed decisions that serve both people and wildlife—a contentious issue, historically.

Conceptual and practical guidance

The paper’s authors present both a conceptual framework, which could apply to other species that migrate in highly modified environments, and practical steps spelled out in operational terms that water managers can understand and implement. The study shows that the approach can increase successful juvenile-salmon migrations by 40 to 400 percent.

Even before the paper was published, water managers used its approach last spring to design the most optimal pulse flows for juvenile salmon migrating in the Sacramento River, according to the paper’s senior author, Cyril Michel, an associate project scientist at IMS. This real-time fish-tracking website has a preliminary assessment of that effort.

Fundamental to the framework they developed is the breakdown of migration into three distinct phases and the measures water managers can implement:

  • Preparation – During this phase, juvenile salmon undergo biological changes for the transition from freshwater to saltwater habitats. At this stage, managers can cue these physiological adjustments by releasing reservoir water to adjust river temperature.
  • Initiation – This is when fish decide to start migrating, often in response to environmental cues like changes in flow. At this stage, managers can schedule pulse flows—abrupt surges in river flow—to synchronize and trigger migration at the best time. The magnitude of these pulse flows could range from about 11,000 to 13,000 cubic feet per second.
  • Passage – This is the migration journey itself, where success depends on flow conditions. At this stage, managers can give the young fish more of a fighting chance by releasing extra water into the river. This increases habitat volume, dilutes predator concentrations, and speeds migration by pushing fish through the system faster.

Flows should be held at high levels for about one to two weeks, the typical duration of the downstream journey, according to Burford. And once the migration ends, flows can be dropped back down to normal levels to preserve precious water resources for other uses. Doing this just a few times a year, tailored to different salmon populations and migration timings, is what would lead to the 40 to 400% increase in juvenile-salmon survival that the paper’s authors project.

They say this approach is remarkably straightforward from a management perspective, and despite its simplicity, the impact is potentially enormous. By facilitating juvenile-salmon migrations in this manner, the team estimates this could result, on average, in an extra 20,000 of them reaching the ocean. 

“These are 20,000 fish born in the wild, whose genetic characteristics have helped them survive in this highly modified ecosystem,” said Burford, an adjunct faculty member in UC Santa Cruz’s Ecology and Evolutionary Biology Department. “Also, California is at the thermal limit of the temperature range for Chinook salmon—meaning these fish are the most heat-tolerant and, therefore, vital for climate adaptation.”

What’s so special about salmon?

The practice of intervening in animal migrations to protect a species is not new. For example, during unusually warm years, Indigenous tribes were known to cool salmon-bearing streams with fire smoke, or to physically pick these very same salmon out of the water and carry them to cooler upstream river reaches.

And now, even though alterations and engineering have completely transformed the state’s waterways, resource managers have an instruction manual for how to adjust conditions using the controls at their fingertips—a guide to taking a more purposeful, premeditated role in migratory species conservation.

“Almost every single drop of water that’s ever released from reservoirs for a wildlife intent is ultimately used by humans,” Burford said. He added that another reason to support the survival of Chinook salmon—designated a threatened species by the state—is that only 20% of their original freshwater habitat is accessible to them, and almost all of it altered dramatically to store and route water to humans.

Because of their anadromous (from freshwater, to sea, to freshwater) life cycle, Chinook and other species of salmon depend on the entire watershed from top to bottom, and therefore are an iconic example of ecosystem health and human stewardship—or failure. Healthy salmon runs indicate healthy watersheds that provide critical benefits such as groundwater recharge, natural water treatment, and riparian-forest irrigation.

“Healthy salmon populations and healthy watersheds go hand in hand; and this isn’t to say their only worth is an indicator species,” Burford said. “They are an iconic and compelling species—people love salmon.”

As with Indigenous communities before European settlement, salmon can sustain present-day cultural ties to rivers and prompt hands-on caretaking, which is essential for long-term conservation, and humanity’s persistence in California.

While he prefers not to frame the significance of salmon in terms of them as a food source, Burford points out that our symbiotic relationship is reason enough to help them survive and thrive. “We don’t even need to get in a boat to catch them,” he said. “They swim out of the ocean and literally deliver themselves to us.”

Other co-authors of the paper include Jeremy Notch, also jointly affiliated with UC Santa Cruz and NOAA, and William Poytress, at the U.S. Fish and Wildlife Service’s office in Red Bluff, Calif. 

A wild juvenile Chinook salmon in the Sacramento River watershed prior to oceanward migration.

Credit

Photo by Anton Sorokin

 

Theory for aerosol droplets from contaminated bubbles bursting gives insight into spread of pollution, microplastics, infectious disease



University of Illinois Grainger College of Engineering
Cap Rupture 

image: 

A cap rupture on a bubble coated with oil. Surface waves cause the surface oil to be ejected in an aerosol jet. (10.1103/PhysRevLett.134.214001)

view more 

Credit: The Grainger College of Engineering at the University of Illinois Urbana-Champaign




Bubbles burst when their caps rupture. Children discover this phenomenon every summer day, but it also underpins key mechanisms for the spread of pollutants, contaminants, and even infectious disease through the generation of aerosol droplets. While bubble bursting has been extensively studied in pure substances, the impact of contaminants on bursting dynamics has not received widespread attention.

Researchers in The Grainger College of Engineering at the University of Illinois Urbana-Champaign have conducted a systematic study to investigate bubble bursting jets – aerosol particles sprayed when bubble surfaces rupture – when surface contaminants are present. The laboratory of mechanical science and engineering professor Jie Feng developed a model predicting the influence of contaminants on jet size and experimentally confirmed it. The study was published in the journal Physical Review Letters, where it was selected as an Editors’ Suggestion.

“Bubbles are commonly formed or intentionally used in many natural and engineered settings,” Feng said. “As they rise due to buoyancy, they become coated with surrounding chemicals, such as micro- and nano-plastics, bio-surfactants, and even bacteria and viruses, and they spread through the fluid jets and the resulting aerosol droplets created when the bubbles burst at an air-liquid interface. This mechanism is crucial in understanding phenomena like airborne contaminants from oil spills and the spread of respiratory diseases, but there have been no systematic studies to date for size quantification of the contaminant-laden droplets. We aim to perform controlled experiments and develop a theoretical framework to predict their size.”

When the cap of a bubble ruptures, a mechanism is triggered by which the focusing of surface waves cause fluid to be ejected – so-called “Worthington jets.” This phenomenon has been studied for decades, but a significant knowledge gap remains. Most research focuses on the case when the bubble surface consists of a pure substance, but many of the most important occurrences involve bubbles with impurities or contaminants.

“For instance, in wastewater treatment ponds contaminated with viruses or bacteria, bubbles formed by mechanical agitation will rise and collect microorganism on their surfaces,” Feng said. “When they escape into the atmosphere and burst, they spray fine droplets that contain these pathogens. Bubble bursting jets pose significant environmental and safety concerns in the area surrounding contaminated aquatic environments, and cleanup efforts need to understand and account for it.”

Finding that there was limited data available and no theoretical work, Feng’s laboratory turned to its capabilities in multi-phase flows to study the phenomenon. To mimic a contaminated bubble, the researchers used a specialized coaxial orifice system that injects gas into water to form bubbles and then coats them with silicone oil. By varying the properties of the oil, the impact of its characteristic on jet features could be studied with a high-speed camera.

“My research has been focusing on fluid mechanics and environmental impacts related to bubble bursting,” said Zhengyu Yang, a graduate student in Feng’s laboratory and the study’s lead author. “We had already established the experimental capabilities required to generate high-quality data on this problem. From there, it was a question of building the right theory to explain what we found.”

The results showed that the size of the ejected aerosol droplets depends on the thickness of the oil layer, the oil’s viscosity and surface tension. To develop a mathematical model explaining this behavior, the researchers introduced a new parameter accounting for the presence of the oil layer. They call this parameter the “revised Ohnesorge number” after the classical Ohnesorge number governing the dynamics of pure bubble bursting jets.

“Our results are valuable for understanding and mitigating airborne transmission of contaminants mediated by bubbles and drops,” Feng said. “To realize their full power, our next step is to consider collective bubble bursting – studies of many bubbles producing aerosol jets at once, which is a more practical scenario in the real world. We hope the tools and knowledge obtained in this research will be broadly applicable to elucidate the mechanistic influence of a variety of contaminated interfaces on multiphase flows.”


Yang Liu of Tsinghua University also contributed to this work.

The study, “Jet Size Prediction in Compound Multiphase Bubble Bursting,” is available online. DOI: 10.1103/PhysRevLett.134.214001

Support was provided by the National Science Foundation and the Campus Research Board of the University of Illinois Urbana-Champaign.

Jie Feng is an Illinois Grainger Engineering assistant professor of mechanical science and engineering in the Department of Mechanical Science and Engineering. He is a research affiliate of the Materials Research Laboratory.

 

 

Vapes more effective for smoking cessation than nicotine gum and lozenges



American College of Physicians




 Monday 14 July 2025   

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.    

----------------------------    

1. Vapes more effective for smoking cessation than nicotine gum and lozenges

Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-24-03531

URL goes live when the embargo lifts             

A randomized controlled trial (RCT) evaluated whether vaporized nicotine products (VNPs) are more effective than nicotine replacement therapies (NRT) for smoking cessation among people experiencing social disadvantage. The researchers found that VNPs were more effective than NRT for smoking cessation in a low socioeconomic status (low-SES) population. As this population is disproportionately affected by the harms of smoking, VNPs may have a critical role in promoting smoking abstinence. The study is published in Annals of Internal Medicine.

 

Researchers from the National Drug and Alcohol Research Centre (NDARC), UNSW Sydney, AU and colleagues conducted a two-group, open-label RCT of 1,045 low-SES participants in New South Wales, AU between March 30, 2021 and December 8, 2022. Eligible participants smoked daily, were aged 18 years and over, were willing to make a quit attempt within two weeks of screening and were receiving a government pension or allowance (indicator of low-SES). They were randomly assigned to the VNP or NRT group in a 1:1 ratio. The NRT group had the choice of receiving 8 weeks’ supply of either nicotine gum or lozenges, and the VNP group received 8 weeks’ supply of nicotine e-liquid to use in either a tank device or a pod device. VNP participants could receive the e-liquid in tobacco, menthol, and fruit flavors. All participants received behavioral support via automated text messages for five weeks. The primary outcome was six-month continuous abstinence from smoking. The researchers found that the six-month continuous abstinence was 9.6% in the NRT group and 28.4% in the VNP group. Subgroup analyses of age, sex, nicotine dependence and mental illness also found that VNP was more effective than NRT. The results suggest VNPs may have a role in promoting smoking abstinence among groups experiencing socioeconomic disadvantage, as well as the general population.

 

Media contacts: For an embargoed PDF, please contact Gabby Macrina at gmacrina@acponline.org. To contact corresponding author Ryan J. Courtney, PhD, please email the NDARC media team at NDARC.media@unsw.edu.au.    

----------------------------     

2. Risk for GERD is higher with GLP-1 RA use compared to SGLT-2 inhibitor use

Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-24-03420   

URL goes live when the embargo lifts             

A population-based cohort study emulating a target trial estimated the effect of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) compared with sodium-glucose cotransporter-2 (SGLT-2) inhibitors on the risk for gastroesophageal reflux disease (GERD) and its complications in patients with type 2 diabetes. The study found that incidence of GERD and its complications was higher among GLP-1 RA users, risk of GERD-related complications higher for smokers, patients with obesity, and patients with gastric-related comorbidities. The results are published in Annals of Internal Medicine

 

Researchers from McGill University and Lady Davis Institute, Jewish General Hospital in Montreal used the U.K. Clinical Practice Research Datalink to create a target trial emulation framework that evaluated the risk for GERD and its complications in patients aged 18 years or older with type 2 diabetes initiating GLP-1 RAs or SGLT-2 inhibitors. The study included 24,708 new users of GLP-1 RAs who had a median follow-up of 3 years and 89,096 new users of SGLT-2 inhibitors who had a median follow-up of 2.7 years. The primary outcome was diagnosis of GERD and secondary outcome was complications of GERD. The researchers found that during follow-up the incidence rate for GERD was 7.9 per 1,000 person years. 138 total complications of GERD were observed, with over 90% of them being Barrett esophagus. At three-year follow-up, the risk ratio (RR) was 1.27 for GERD and 1.55 for GERD complications in GLP-1 RA users compared with SGLT-2 inhibitor users. Secondary analyses found that risks for GERD were higher overall for each GLP-1 RA type except lixisenatide, and risks for GERD complications were higher in ever-smokers, patients with obesity, and patients with gastric comorbidities. The results suggest the risk for GERD and its complications is higher among patients with type 2 diabetes using GLP-1 RAs versus SGLT-2 inhibitors. Clinicians and patients should be aware of the possible adverse effect of GLP-1 RAs on GERD. 

 

Media contacts: For an embargoed PDF, please contact Gabby Macrina at gmacrina@acponline.org. To contact corresponding author Laurent Azoulay, PhD, please email John Johnston at john.johnston@ladydavis.ca.    

----------------------------      

3. Pilot hospital-based violence intervention program suggests a more sustained, multi-dimensional approach is needed to prevent violent reinjury

Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-24-01576

URL goes live when the embargo lifts             

A multicenter, retrospective, observational cohort study evaluated violent reinjury one year after an initial violent injury among participants in the St. Louis area hospital-based violence intervention program (HVIP), Life Outside of Violence (LOV), during its pilot phase. The findings did not provide informative evidence of differences in reinjury probability for LOV participants; however, they suggest that the overwhelming risk of violent reinjury cannot be overcome by an individual-level approach. The study is published in Annals of Internal Medicine.  

 

The LOV program is a unique patient care partnership between Washington University in St. Louis, Saint Louis University, and their four associated adult and pediatric level 1 trauma hospitals and is the first multisystem, region-wide HVIP in the United States. A study team from Washington University in St. Louis and Saint Louis University evaluated the implementation and reinjury outcomes among 233 participants aged 8 to 24 years in the LOV program between 15 August 2018 (the program’s start) and 31 December 2022. Eligible participants had to live in the St. Louis, MO area, present to a LOV partner hospital with a nonfatal violent injury (firearm, stabbing, blunt assault), and enroll in the program. Control participants were violently injured patients who were eligible for LOV but did not enroll in the program. After violent injury, LOV case managers were connected with eligible program participants and their families. Case managers worked with participants for six to 12 months after injury to coordinate medical care, develop goals for an individual treatment plan, provide counseling, and connect them to community resources. The final participant sample included 198 LOV-enrolled participants matched to 388 nonenrolled control participants. LOV-enrolled participants had a median age of 18 years, were most likely non-Hispanic Black, male, had Medicare or Medicaid, and had a firearm injury. 8% of LOV participants experienced violent reinjury within one year compared with 7% of matched control participants. 60% of LOV participants were reinjured by firearms. Estimates for 1-year probability of reinjury were 7.6% among LOV participants and 7.4% among control participants. The results suggest that patient engagement in HVIPs is a substantial challenge, and reducing reinjury rates may require a more sustained, multidimensional approach at the individual, community, and systemic levels. The researchers note that systems and programs should address the health and behavioral issues associated with violence and the social inequities that contribute to community violence, such as unemployment, poverty, and unsafe housing.  

 

Media contacts: For an embargoed PDF, please contact Gabby Macrina at gmacrina@acponline.org. To contact corresponding author Kristen L. Mueller, MD please email Kristen.Mueller@wustl.edu.            

----------------------------           

Also new this issue:

Single-Arm Trials Can Provide Randomized Real-World Evidence: The Random Invitation Single-Arm Trial Design

Perrine Janiaud, PhD; John P.A. Ioannidis, MD, DSc; Benjamin Kasenda, MD, PhD; Atle Fretheim, MD, PhD; Steven N. Goodman, MD, PhD; and Lars G. Hemkens, MD, MPH

Research and Reporting Methods

Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-24-02979

 

 

Aluminum exposure from childhood vaccines not linked to increased risk of autoimmune, allergic, or neurodevelopmental disorders




American College of Physicians





Below please find a summary of a new article that will be published in the next issue of Annals of Internal Medicine. The summary is not intended to substitute for the full article as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.    

---------------------------- 

Aluminum exposure from childhood vaccines not linked to increased risk of autoimmune, allergic, or neurodevelopmental disorders 

Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-25-00997  

URL goes live when the embargo lifts               

A nationwide cohort study of Danish children examined the association between cumulative aluminum exposure from early childhood vaccination and the risk for development of autoimmune, atopic or allergic, and neurodevelopmental disorders. The study found no evidence supporting an increased risk for these disorders associated with exposure to early childhood aluminum-adsorbed vaccines. The findings help close the evidence gap of human data around the association between aluminum-adsorbed vaccines with adverse events, particularly neurological disorders. The findings are published in Annals of Internal Medicine.  

 

Researchers from the Statens Serum Institut leveraged national changes in the Danish Childhood Vaccination Program over a 24-year period, during which vaccines with varying aluminum content were introduced. They included 1,224,176 children born in Denmark between 1997 and 2018 and used the Danish nationwide health registries to obtain information on the cumulative aluminum exposure from childhood vaccines administered to each child before age 2 and incident events of 50 different chronic disorders. Specifically, they examined the development of 36 autoimmune, 9 atopic or allergic, and 5 neurodevelopmental related disorders. Children were followed from 2 years of age for study outcome events until 31 December 2020, or until they reached age 5, died, or were lost to follow-up. Cox proportional hazards regression models were used to estimate adjusted hazard ratios representing how much the hazard changed when a child received one additional milligram of aluminum in their vaccines by age two compared to a child who received one milligram less. The researchers found a hazard ratio for autoimmune outcomes of 0.98 [95%CI 0.94 to 1.02] per 1-milligram increase in the cumulative aluminum exposure from childhood vaccination. The hazard ratio was 0.99 [95%CI 0.98 to 1.01] for atopic or allergic disorders and 0.93 [95%CI 0.90 to 0.97] for neurodevelopmental disorders. For the specific disorders of autism spectrum disorder and attention-deficit/hyperactivity disorder, the hazard ratios per 1-milligram increase in the cumulative aluminum exposure from childhood vaccination before age two were 0.93 [95%CI 0.89 to 0.97] and 0.90 [95%CI 0.84 to 0.96], respectively. This nationwide study did not find evidence supporting an increased risk for autoimmune, atopic or allergic, or neurodevelopmental disorders associated with early childhood exposure to aluminum-adsorbed vaccines. 

 

Media contacts: For an embargoed PDF, please contact Gabby Macrina at gmacrina@acponline.org. To contact corresponding author Niklas Worm Andersson, please email the Press Office of Statens Serum Institut at presse@ssi.dk.