Wednesday, August 06, 2025

 

Better access to technology can help African Americans bridge the healthcare gap




University of California - Santa Barbara





(Santa Barbara, Calif.) — Researchers at UC Santa Barbara have found that better access to technology can go a long way toward achieving equity in healthcare for African Americans in the United States. According to Sharon Tettegah and Ebenezer Larnyo, both researchers at UCSB’s Center for Black Studies Research (CBSR), leveraging health technology is a promising strategy for addressing longstanding healthcare disparities “by enhancing access to care, improving its quality and reducing inequities.”

“Our study shows that improving access to technology like broadband internet and smartphones, and healthcare technology use like telehealth and health-related social media platforms, can significantly reduce healthcare disparities among African Americans,” said Larnyo, the lead author of a paper published in the journal Frontiers in Public Health.

‘Evidence matters’
African Americans  today continue to face an inordinate amount of difficulty in accessing healthcare, and tend to have worse healthcare outcomes than white counterparts. Tettegah recalled one particularly conspicuous case — that of tennis champion Venus Williams, who throughout her career was plagued with bouts of severe pelvic pain.

“She had uterine fibroids and had gone to several doctors and nobody was giving her the right response,” said Tettegah, who directs CBSR and focuses her research at the intersection of social science and STEM. “They were dismissing her.”

Indeed, despite the pain and the bleeding, in interviews Williams herself notes that while she knew she had fibroids (African American women are disproportionately affected by the noncancerous tumors), her doctors never connected the condition and her pain, telling her that her symptoms were a “normal” part of her menstrual cycle. Williams ultimately found a team that took her complaints seriously and because of this experience, now advocates for women’s health.

Williams’ experience of being glossed over by doctors is unfortunately too common for African Americans in the U.S. healthcare system, stemming from a history of systemic racism and historical patterns of exclusion, the researchers said. While she was able to eventually find the appropriate care, many others continue to struggle to be seen.

“So the question becomes, ‘How do we get the medical community of people who are not people of color to understand that we really do have different needs?,’” Tettegah said. “And a lot of times that has to come from the patient. But not every patient can advocate for themselves.”

Socioeconomic status is another major factor. Healthcare in the US takes money, whether it’s for health insurance, hospital and clinic visits, medicine and other supplies. Even the ongoing boom in healthcare technologies, such as internet-based telemedicine, wearables or precision medicine, which have great potential for leveling the healthcare playing field, are limited to who can afford them.

“Higher socioeconomic status individuals are more likely to have technology access, and when they do have access, they experience fewer healthcare disparities,” Larnyo said. “So tackling both digital and structural barriers is key to achieving equity.”

In their paper, the researchers explore the complex relationship between technology inequity and healthcare disparities among African Americans, and uncover statistical connections between socioeconomic status, technology access and health technology use.

“Evidence matters,” Larnyo said. “Having hard numbers allows us to move beyond assumptions and demonstrate precisely how socioeconomic factors influence healthcare access in the digital age. It helps us understand the underlying mechanisms through which technology inequity reinforces and perpetuates healthcare disparities and allows us to be able to highlight the role of structural racism in shaping economic opportunities and digital inclusion, thus making a case for structural changes rather than individual solutions.”

Analyzing data from a survey of 815 African Americans on their access to and use of health-related information and health-related behaviors, perceptions and knowledge, the research collaboration, which includes teams from Jiangsu University in China and Teesside University in the UK, elucidated this intricate dance of variables. They found  a statistically significant relationship between socioeconomic status and technology access (the higher one’s socioeconomic status, the more access to technology they have), and a positive association between technology access and health technology use (the more access to technology, the more likely to use health technology). 

Conversely, they found a negative association between tech access and healthcare disparities — the less access to health technology, the larger the healthcare disparities. The influence that socioeconomic status, technology access and health disparities have on each other indicates that “addressing both socioeconomic disparities and technology access is crucial in reducing healthcare disparities,” according to the paper.

Some of the most powerful solutions are already within reach.

“To begin with, broadband internet is foundational; it needs to be affordable, accessible and reliable,” Larnyo said. “That goes hand-in-hand with affordable smartphones.”

In addition, to effectively take advantage of the technology, culturally tailored telehealth, simple-to-use mental health apps and health-related social media platforms are needed, the researchers said.

“We definitely need to do more work to raise awareness that people of color have different needs that have to be addressed and not just passed off,” Tettegah said, pointing out that ethnic minorities have differing likelihoods for various diseases and conditions. “We need to build a narrative that highlights that with advocacy and information because often you don’t know that you don’t know.”

Nanoparticles that self-assemble at room temperature could transform vaccine delivery



Researchers from UChicago Pritzker Molecular Engineering created drug delivery nanoparticles that self-assemble with a simple temperature shift



University of Chicago

Nanoparticles figure 

image: 

Researchers designed nanoparticles that can self-assemble at room temperature and deliver RNA (green) to living cells (nuclei shown in blue), offering a new pathway to vaccine and biologic drug design.

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Credit: Courtesy of Hossainy et al.





In a discovery that could broaden access to next-generation biologic medicines and vaccines, researchers at the University of Chicago Pritzker School of Molecular Engineering (UChicago PME) have engineered polymer-based nanoparticles that form with a simple temperature shift—no harsh chemicals, no specialized equipment, and no processing needed. 

The new nanoparticles, described in Nature Biomedical Engineering, self-assemble at room-temperature in water and, because of these gentle conditions, can deliver proteins, which are unstable in many existing nanoparticle formulations. 

“What excites me about this platform is its simplicity and versatility. By simply warming a sample from fridge temperature to room temperature, we can reliably make nanoparticles that are ready to deliver a wide variety of biological drugs,” said co-senior author Stuart Rowan, the Barry L. MacLean Professor for Molecular Engineering Innovation and Enterprise at UChicago Pritzker Molecular Engineering and a staff scientist Argonne National Laboratory.

From problem to platform

Nanoparticles are key to protecting delicate drugs like RNA and proteins from being degraded in the body before they reach the right cells. Lipid nanoparticles (LNPs), made of fatty molecules, enabled the COVID-19 mRNA vaccines, for instance. But LNPs rely on alcohol-based solvents and sensitive manufacturing steps—making them poorly suited for protein delivery and hard to scale.

“We wanted to make a delivery system that could work for both RNA and protein therapies—because right now, most platforms are specialized for just one,” said first author Samir Hossainy, a UChicago PME graduate student. “We also wanted to make it scalable, without needing toxic solvents or complicated microfluidics.”

Hossainy hypothesized that polymer-based nanoparticles could offer a more robust, customizable alternative. He outlined the required characteristics; the immune system will only respond to particles with certain sizes, shapes, and charges. Then, he used chemical tools to begin designing new nanoparticles from scratch. 

After trying, and fine-tuning, more than a dozen different materials, he found one that worked. In cold water, the polymer—and any desired protein—remained dissolved. But when heated to room temperature, the polymer self-assembled into uniformly sized nanoparticles (or “polymersomes”) surrounding the protein molecules. 

“Our particle size and morphology is dictated only by the chemistry of the polymers that I designed from the bottom up,” explained Hossainy. “We don’t have to worry about different particle sizes forming, which is a challenge with a lot of today’s nanoparticles.”

Carrying versatile cargo

To test the new polymersomes, Hossainy worked with colleagues in Rowan’s lab as well as with former UChicago PME Prof. Jeffrey Hubbell, now at New York University. First, they showed that the particles can encapsulate more than 75% of protein and nearly 100% of short interfering RNA (siRNA) cargo—far higher than most current systems—and they can be freeze-dried and stored without refrigeration until needed.

In the context of vaccination, Hossainy and his collaborators found that the polymersomes could effectively carry a protein and, when injected into mice, lead the animals’ immune systems to generate long-lasting antibodies against that protein. Another experiment showed that the nanoparticles could also carry proteins designed to prevent an immune response in the context of allergic asthma. And a third showed that injecting polymersomes into tumors could block cancer-related genes and suppress tumor growth in mice. 

“The exciting thing is that we didn't need to tailor a different system for each use case,” said Hossainy. “This one formulation worked for everything we tried—proteins, RNA, immune activation, immune suppression, and direct tumor targeting.”

A scalable solution for worldwide vaccines

One of the biggest advantages of the new polymersomes over current LNPs is the potential for low-tech, decentralized production. Hossainy says he imagines being able to ship freeze-dried formulations of the nanoparticles to anywhere in the world. When they need to be used, they can be mixed in cold water, warmed up, and will be ready to deliver to patients. 

“Being able to store these dry drastically improves the stability of the RNA or protein,” said Hossainy. 

The group is continuing to work on fine-turning the particles to carry more types of cargo, including messenger RNA like that used in the COVID-19 vaccines (generally much larger than the siRNA used in the current trial). They also plan to collaborate on pre-clinical trials to apply the polymersomes to real-world vaccine or drug delivery challenges.

Citation: “Thermoreversibly Assembled Polymersomes for Highly Efficient Loading, Processing, and Delivery of Protein and siRNA Biologics,” Hossainy et al, Nature Biomedical Engineering, August 6, 2025. DOI: 10.1038/s41551-025-01469-7

Funding: This work was supported by the National Institute of Allergy and Infectious Diseases (75N93019C00041) and the Chicago Immunoengineering Innovation Center. 

First author Samir Hossainy, a UChicago PME graduate student, works in the lab of Prof. Stuart Rowan.

Credit

Photo by Jason Smith

 

With just a few messages, biased AI chatbots swayed people’s political views





University of Washington





If you’ve interacted with an artificial intelligence chatbot, you’ve likely realized that all AI models are biased. They were trained on enormous corpuses of unruly data and refined through human instructions and testing. Bias can seep in anywhere. Yet how a system’s biases can affect users is less clear.

So a University of Washington study put it to the test. A team of researchers recruited self-identifying Democrats and Republicans to form opinions on obscure political topics and decide how funds should be doled out to government entities. For help, they were randomly assigned three versions of ChatGPT: a base model, one with liberal bias and one with conservative bias. Democrats and Republicans were both more likely to lean in the direction of the biased chatbot they talked with than those who interacted with the base model. For example, people from both parties leaned further left after talking with a liberal-biased system. But participants who had higher self-reported knowledge about AI shifted their views less significantly — suggesting that education about these systems may help mitigate how much chatbots manipulate people.

The team presented its research July 28 at the Association for Computational Linguistics in Vienna, Austria.

“We know that bias in media or in personal interactions can sway people,” said lead author Jillian Fisher, a UW doctoral student in statistics and in the Paul G. Allen School of Computer Science & Engineering. “And we’ve seen a lot of research showing that AI models are biased. But there wasn't a lot of research showing how it affects the people using them. We found strong evidence that, after just a few interactions and regardless of initial partisanship, people were more likely to mirror the model’s bias.”

In the study, 150 Republicans and 149 Democrats completed two tasks. For the first, participants were asked to develop views on four topics — covenant marriage, unilateralism, the Lacey Act of 1900 and multifamily zoning — that many people are unfamiliar with. They answered a question about their prior knowledge and were asked to rate on a seven-degree scale how much they agreed with statements such as “I support keeping the Lacey Act of 1900.” Then they were told to interact with ChatGPT 3 to 20 times about the topic before they were asked the same questions again.

For the second task, participants were asked to pretend to be the mayor of a city. They had to distribute extra funds among four government entities typically associated with liberals or conservatives: education, welfare, public safety and veteran services. They sent the distribution to ChatGPT, discussed it and then redistributed the sum. Across both tests, people averaged five interactions with the chatbots.

Researchers chose ChatGPT because of its ubiquity. To clearly bias the system, the team added an instruction that participants didn’t see, such as “respond as a radical right U.S. Republican.” As a control, the team directed a third model to “respond as a neutral U.S. citizen.” A recent study of 10,000 users found that they thought ChatGPT, like all major large language models, leans liberal.

The team found that the explicitly biased chatbots often tried to persuade users by shifting how they framed topics. For example, in the second task, the conservative model turned a conversation away from education and welfare to the importance of veterans and safety, while the liberal model did the opposite in another conversation.

“These models are biased from the get-go, and it’s super easy to make them more biased,” said co-senior author Katharina Reinecke, a UW professor in the Allen School. “That gives any creator so much power. If you just interact with them for a few minutes and we already see this strong effect, what happens when people interact with them for years?”

Since the biased bots affected people with greater knowledge of AI less significantly, researchers want to look into ways that education might be a useful tool. They also want to explore the potential long-term effects of biased models and expand their research to models beyond ChatGPT.

“My hope with doing this research is not to scare people about these models,” Fisher said. “It’s to find ways to allow users to make informed decisions when they are interacting with them, and for researchers to see the effects and research ways to mitigate them.”

Yulia Tsvetkov, a UW associate professor in the Allen School, is a co-senior author on this paper. Additional co-authors are Shangbin Feng, a UW doctoral student in the Allen School; Thomas Richardson, a UW professor of statistics; Daniel W. Fisher, a clinical researcher in psychiatry and behavioral services in the UW School of Medicine; Yejin Choi, a professor of computer science at Stanford University; Robert Aron, a lead engineer at ThatGameCompany; and Jennifer Pan, a professor of communication at Stanford.

For more information, contact Fisher at jrfish@uw.edu and Reinecke at reinecke@cs.washington.edu.

 

Three weekly servings of French fries linked to higher diabetes risk



But similar amounts of boiled, baked and mashed potatoes are not associated with a substantially increased risk, say researchers



BMJ Group





Eating three servings of French fries a week is associated with a 20% increased risk of developing type 2 diabetes, but eating similar amounts of potatoes cooked in other ways - boiled, baked or mashed - does not substantially increase the risk, finds a study published by The BMJ today. 

What’s more, replacing any form of potatoes with whole grains was associated with a lower type 2 diabetes risk, but swapping them for white rice was linked to an increased risk, the results show.

Potatoes contain several nutrients including fibre, vitamin C, and magnesium, but they also have a high starch content and therefore a high glycemic index, so have been linked to a higher risk of developing type 2 diabetes.

But neither the preparation method for potatoes nor specific foods that potatoes would replace have been considered, both of which are key to evaluating the overall health impact of potatoes.

To address this, researchers investigated the association between intake of potatoes prepared by different methods (boiled, baked, or mashed versus French fries) and risk of type 2 diabetes. They also looked at the impact on health of replacing potatoes with other major carbohydrates, such as whole grains and rice.

Their findings are based on more than 205,000 health professionals from three large US studies carried out between 1984 and 2021. Participants were free of diabetes, heart disease or cancer and completed detailed food questionnaires every four years.

During almost 40 years of follow up, 22,299 people were diagnosed with type 2 diabetes. 

After adjusting for lifestyle and dietary factors related to diabetes risk, the researchers found that for every three weekly servings of total potato, the rate of type 2 diabetes increased by 5% and for every three weekly servings of French fries, the rate increased by 20%. However, similar intake of baked, boiled, or mashed potatoes was not associated with a significantly increased risk.

Replacing three weekly servings of total potato with whole grains lowered the type 2 diabetes rate by 8%. Substituting baked, boiled, or mashed potatoes with whole grains lowered the rate by 4%, and replacing French fries lowered the rate by 19%.

In contrast, replacing total potatoes or baked, boiled, or mashed potatoes with white rice was associated with an increased risk of type 2 diabetes. 

This is an observational study so no firm conclusions can be drawn about cause and effect and the researchers can’t rule out the possibility that other unmeasured factors may have influenced their results. Most participants were also health professionals of European ancestry, so findings may not apply to other populations.

Nevertheless, they conclude: “Our findings underscore that the association between potato intake and type 2 diabetes risk depends on the specific foods used as replacement. The findings also align with current dietary recommendations that promote the inclusion of whole grains as part of a healthy diet for the prevention of type 2 diabetes.”

So, are potatoes back on the plate? Well, it depends, say researchers in a linked editorial, who note that it is important to consider preparation method and replacement food when guiding the public or informing policy.

They point out that with their relatively low environmental impact and their health impact, baked, boiled, or mashed potatoes can be part of a healthy and sustainable diet, though whole grains should remain a priority, but say future studies from more diverse populations that account for both preparation methods and substitution analysis are needed.

 

Global hunt for ‘positive tipping points’





University of Exeter






Experts are calling for a global effort to identify “positive tipping points” to accelerate the green transition – and have devised a method to find them.

A tipping point is a threshold where a small change can trigger a significant, often irreversible, transformation.

With climate change becoming increasingly damaging and dangerous, positive tipping points in human societies and economies can spark rapid reductions in emissions and other environmental harm.

Positive tipping points are already happening – with solar power and electric vehicles rapidly displacing fossil-fuelled alternatives – but many more are needed to ensure a thriving, sustainable future.

“The global economy is decarbonising at least five times too slowly to meet the Paris Agreement target of limiting global warming to well below 2°C,” said Professor Tim Lenton, from the Global Systems Institute at the University of Exeter.

“The challenge now is to identify potential positive tipping points, and the actions that can bring them forward – while avoiding wishful thinking about their existence, or oversimplification of their nature, drivers and impacts.”

The paper – by an international team of researchers – sets out a methodology for identifying positive tipping points, assessing their proximity, identifying the factors that can influence them, and the actions that can trigger them.

This includes looking for evidence that a system, or a similar system, has “tipped” in the past.

Another factor is whether there is potential for “self-propelling uptake” of zero- or low-carbon behaviours, products and/or technologies.

For example, as more people buy electric cars, the performance, price and infrastructure improve – making it easier for others to follow, and thereby accelerating the transition.

“We know positive tipping can happen in sectors such as power and road transport, and we think the UK is close to a tipping point in the uptake of heat pumps,” said Dr Steve Smith, also from Exeter’s Global Systems Institute.

“In other sectors there is little sign of approaching tipping points and in a few, such as nuclear power and concrete production, we should not expect there to be tipping points at all.”

Dr Smith highlighted the potential for beneficial change that may seem unlikely before it happens – such as the banning of smoking in public places in the UK.

“Other transformations – such as a major shift away from meat consumption – might also be more likely than they appear,” he said.

“With supportive policies, meat-free options becoming cheaper and better, and social influence (behaviour spreading through the population), we could see a major impact on meat consumption – and potentially a tipping point with benefits for climate and health.”

The team’s methodology aims to establish a common framework for finding positive tipping points – and they invite fellow researchers to help refine it, and practitioners to apply it.

Professor Frank Geels, from the Manchester Institute of Innovation Research at the University of Manchester, added: “The increased understanding of positive tipping points and improved methods for investigating them are important because they provide empirically validated templates for accelerated net-zero transitions.

“These offer crucial antidotes to the doom and gloom that seems to permeate climate mitigation debates in policy and mass media.”

The paper, published in the journal Sustainability Science, is entitled: “A method to identify positive tipping points to accelerate low-carbon transitions and actions to trigger them.”