Tuesday, August 26, 2025

 

On tap: What makes beer foams so stable?



Research into stability of foams finds a valuable test subject in a tall glass of beer




American Institute of Physics

Wave interference (interferometry) images of beer bubbles, superimposed onto a glass of foamy beer 

image: 

Wave interference (interferometry) images of beer bubbles, superimposed onto a glass of foamy beer.

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Credit: AIP/Chatzigiannakis et al.





WASHINGTON, August 26, 2025 – Beer is one of the world’s most popular drinks, and one of the clearest signs of a good brew is a big head of foam at the top of a poured glass. Even brewers will use the quality of foam as an indicator of a beer having completed the fermentation process. However, despite its importance, what makes a large, stable foam is not entirely understood.

In Physics of Fluids, from AIP Publishing, researchers from ETH Zurich and Eindhoven University of Technology investigated the stability of beer foams, examining multiple types of beer at different stages of the fermentation process.

Like any other foam, beer foam is made of many small bubbles of air, separated from each other by thin films of liquid. These thin films must remain stable, or the bubbles will pop, and the foam will collapse. What holds these thin films together may be conglomerates of proteins, surface viscosity, or the presence of surfactants, which are molecules that can reduce surface tension and are found in soaps and detergents.

While the researchers have spent years studying the formation of foams, they realized beer could serve as a perfect testing ground.

“The idea was to directly study what happens in the thin film that separates two neighboring bubbles,” said author Emmanouil Chatzigiannakis. “And the first thing that comes to mind when thinking of bubbles and foams is beer.”

Turning to a collection of scientific imaging and rheometry techniques, the team was able to determine how these thin films could hold together to make a stable foam.

“We can directly visualize what's happening when two bubbles come into close proximity,” said Chatzigiannakis. “We can directly see the bubble’s protein aggregates, their interface, and their structure.”

They found that for single fermentation beers, foams are held together primarily through the surface viscosity of the beer. However, for double-fermented beers, the proteins in the beer come together to form a two-dimensional structure, giving the thin films an elastic quality that keeps them intact longer.

With the multiple different ways beer foams hold together, the researchers believe that beer provides an excellent platform to study the stability of foams in general, with applications in everything from oil separation to firefighting chemicals and treating varicose veins.

“This is an inspiration for other types of materials design, where we can start thinking about the most material-efficient ways [of creating stable foams],” said author Jan Vermant. “If we can't use classical surfactants, can we mimic the 2D networks that double-fermented beers have?”

The authors also hope that their work will make its way to the brewers that inspired them, and that in the future the team will identify ways to increase or decrease the amount of foam so everyone can pour a perfect glass of beer every time.

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The article “The hidden subtlety of beer foam stability: A blueprint for advanced foam formulations” is authored by Emmanouil Chatzigiannakis, Alexandra Alicke, Lea Le Bars, Lucas Bidoire, and Jan Vermant. It will appear in Physics of Fluids on Aug. 26, 2025 (DOI: 10.1063/5.0274943). After that date, it can be accessed at https://doi.org/10.1063/5.0274943.

ABOUT THE JOURNAL

Physics of Fluids is devoted to the publication of original theoretical, computational, and experimental contributions to the dynamics of gases, liquids, and complex fluids. See https://pubs.aip.org/aip/pof.

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WAIT, WHAT?!

Overweight older adults face lower risk of death after major surgery



The findings challenge current weight guidelines for “normal” BMI for older adults heading into surgery




University of California - Los Angeles Health Sciences





Older adults who are overweight may face a lower risk of death in the first 30 days following major elective surgery compared with those who have a normal body mass index (BMI), new research suggests.

The study, to be published August 26 in the peer-reviewed JAMA Network Open, examined outcomes in older surgical patients and found that being overweight (BMI 25–29.9) was associated with the lowest short-term mortality rates. In contrast, normal and underweight patients had significantly higher risk of death.

“Traditional surgical guidelines often emphasize having a normal BMI before surgery, but our findings suggest that these recommendations may need to be reconsidered for older adults,” said lead author Dr. Cecilia Canales, assistant professor in the Department of Anesthesiology & Perioperative Medicine at the David Geffen School of Medicine at UCLA. “Older adults have different physiological considerations, and moderate excess weight may actually be protective in the short term after surgery.”

The researchers analyzed data from 414 adults aged 65 and older undergoing major elective surgery at a large academic center in Southern California between February 2019 and January 2022. Patients were categorized by BMI and compared for 30-day and one-year mortality, postoperative delirium, discharge disposition, and complications.

Patients in the overweight category had a 0.8% 30-day all-cause mortality rate, compared to 18.8% for those with a normal BMI, a difference that remained significant after adjusting for factors such as age, frailty, and comorbidities - including whether a patient had cancer. Underweight patients had a 15.0% 30-day mortality rate.

“This study adds to a growing body of evidence on the so-called ‘obesity paradox,’ where a higher BMI appears to be linked with better survival in certain older adult populations,” said co-author Dr. Catherine Sarkisian, professor of medicine in the division of general internal medicine and health services research at the Geffen School. “It’s important to tailor preoperative evaluation to the physiology of older patients.”

The authors note that these findings may have implications for preoperative counseling and BMI-based surgical risk calculators, which are often derived from younger or mixed-age populations. They recommend further research to explore the biological and clinical mechanisms behind this association and to inform surgical guidelines for older adults.

Study co-authors include Myles Anderson, Dr. David Elashoff,Tristan Grogan MS,; Dr. Marcia Russell, Dr. Victor Duval, Dr. Robert Whittington, Dr. Maxime Cannesson, and Dr. Catherine Sarkisian of UCLA.

 

Medical school admissions after the US Supreme Court’s 2023 Affirmative Action ruling





JAMA Network Open



About The Study: 

In this study, underrepresented in medicine (URiM) student matriculation into U.S. medical schools declined after the 2023 Supreme Court of the United States (SCOTUS) ruling, with an emergent disparity in acceptance rates of URiM applicants relative to Asian and white students. The decline in URiM student matriculation was concentrated in states without a preexisting state-level affirmative action ban, suggesting that there may be an association between the SCOTUS ruling and demographic changes in matriculation.


Corresponding author: To contact the corresponding author, Mytien Nguyen, M.S., email mytien.nguyen@yale.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi: 10.1001/jamanetworkopen.2025.27008)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Embed this link to provide your readers free access to the full-text article 

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

"Fatigue" strengthen steels



New technique doubles fatigue limit of high-strength steel by suppressing crack initiation




National Institute for Materials Science, Japan

Figure. 

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Correlation between tensile strength and fatigue limit in steels

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Credit: Kazuho Okada, National Institute for Materials Science






A NIMS research team has discovered a unique phenomenon that the fatigue limit of steel is improved by prior cyclic deformation (fatigue) training. Based on this finding, the research team developed a novel “pre-fatigue training” technique, which successfully doubled the fatigue limit of high-strength steel by suppressing crack initiation. This strategy offers a versatile approach to improving fatigue limit in general steels, providing an effective alternative to tempering heat treatment that inevitably sacrifices tensile strength. This research was published in Advanced Science on June 30, 2025.

Background

Fatigue limit—the stress level below which a material can endure for an infinite or sufficiently large number of loading cycles without failure— increases proportionally with tensile strength in steels. However, when the tensile strength exceeds 1.4 GPa (gigapascals), further increases in the tensile strength do not improve or rather decrease the fatigue limit, that is, the “fatigue limit ceiling”. In addition, martensitic steel, a representative high-strength steel, generally exhibits a low fatigue limit in the as-quenched state with the highest strength level. As a result, before practical applications, martensitic steels are typically tempered to improve fatigue performance, sacrificing the strength level. The detailed mechanism behind the fatigue limit ceiling remains unclear, and there has been a strong demand for materials design strategies to overcome the ceiling.

Key Findings

The research team successfully doubled the fatigue limit of as-quenched martensitic steel with a tensile strength of 1.6 GPa, thereby overcoming the fatigue limit ceiling. This was achieved through pre-fatigue training, which was performed under the loading condition that did not cause crack initiation. In-depth analysis revealed that the predominant factor of fatigue crack initiation in high-strength steels is the elastic misfit—i.e., the elastic strain mismatch in the loading direction—at grain boundaries. This study is the first in the world to demonstrate that fatigue deformation, conventionally considered harmful, can suppress the above crack initiation mechanism.

Future Outlook

Unlike tempering heat treatment, the pre-fatigue training improves fatigue limit with minimal reduction in tensile strength, making it a promising approach applicable to general high-strength steels. In addition, this study demonstrated that “suppressing crack initiation”, rather than the conventionally focused “crack termination, is the key to improve the fatigue limit of high-strength steels. The research team further aims to develop this “microstructural design strategy for crack-initiation-resistant material' and applying it to fracture phenomena in a wide range of materials including steels, which significantly contributes to making the social implementation of ultra-high-strength materials become more feasible.

Other Information

  • This study was conducted by a research team consisting of Kazuho Okada (Senior Researcher, Steel Research Group (SRG), Research Center for Structural Materials (RCSM), NIMS), Kaneaki Tsuzaki (former Research Fellow, SRG, RCSM, NIMS), Eri Nakagawa (PhD student, SRG, RCSM, NIMS), and Akinobu Shibata (Distinguished Leader, SRG, RCSM, NIMS).
    It was carried out as part of the JST ACT-X program under the research area “Trans-Scale Approach Toward Materials Innovation” (grant number: JPMJAX23D5).
  • This research was published in Advanced Science, an open-access journal, on June 30th, 2025.

 

Bacterial memory could be the missing key to beating life threatening pathogens



The Hebrew University of Jerusalem





Bacteria aren’t just mindless microbes. New research from the Hebrew University of Jerusalem reveals that single bacterial cells can carry a “memory” of their past environments—passing it down through generations—before eventually forgetting. Using a new technique called Microcolony-seq, scientists uncovered hidden subpopulations inside infections, each with different survival strategies. The finding could explain why antibiotics and vaccines sometimes fail—and may point the way toward more precise treatments.

[Hebrew University of Jerusalem]– Scientists at the Hebrew University of Jerusalem have designed a way to uncover a hidden dimension of bacterial life: the ability of single microbes to “remember” their past environments and pass that memory on to their offspring. The discovery, reported in Cell and led by postdoctoral researcher Dr. Raya Faigenbaum-Romm under the supervision of Prof. Nathalie Q. Balaban, and collaboration with Profs. Ilan Rosenshine and Maskit Bar-Meir, introduces a groundbreaking method called Microcolony-seq that captures microbial memory at the earliest stages of colony growth.

For decades, biologists have known that bacteria—though genetically identical—often behave differently. Some grow fast, some slow; some resist antibiotics while others succumb. But until now, it was unclear which of these differences were fleeting accidents and which represented genuine, heritable states.

“What we found is that even a single bacterium carries a long-lasting memory of where it’s been,” says Dr. Faigenbaum-Romm. “When it divides, its descendants preserve that memory—sometimes for 20 generations or more.”

Microcolonies as a Window Into Memory

The Microcolony-seq method works by isolating tiny colonies that sprout from individual bacteria, analyzing their RNA, genomes, and physical traits. This approach avoids the noise of even recent cutting-edge single-cell RNA sequencing methods, and reveals whether differences between cells are genetic mutations or epigenetically inherited phenotypes.

Using this method, the team uncovered surprising stabilities. Pathogens like Escherichia coli and Staphylococcus aureus were shown to split into stable subpopulations—even within a single infection. Some lineages activated virulence programs that help them cling to host cells, while others switched on genes that favored motility or survival in harsh conditions.

Intriguingly, the study showed that this microbial memory has limits. When bacteria reach “stationary phase”—the point when nutrients are depleted—the memory is erased, effectively resetting the population.

Implications for Medicine

The discovery carries urgent implications for human health. In urinary tract and bloodstream infections, Microcolony-seq revealed co-existing bacterial subgroups with distinct antibiotic resistance or virulence profiles. A conventional clinical test that samples just one colony could easily miss these hidden players—leading to treatments that fail.

Prof. Balaban explains: “An infection is rarely a uniform population of bacteria. It’s more like a coalition of different players, each with its own strengths. To design therapies that truly work, we need to understand—and target—all of them.”

This may help explain why so many experimental drugs and vaccines against S. aureus infections have stumbled in clinical trials: they targeted only one part of the bacterial population, leaving others untouched.

A New Era for Microbial Research

Beyond immediate medical relevance, Microcolony-seq opens new avenues for exploring microbial life. It provides a systematic way to study how bacteria diversify, hedge their bets, and adapt in real time. Future applications could extend to fungal pathogens, the gut microbiome, and even industrial fermentation.

As Dr. Faigenbaum-Romm notes, “We’ve been treating bacteria as if they’re all the same, but in reality, even a single cell carries a story of its past. Microcolony-seq lets us finally read that story.”

Estalishing power through divine portrayal and depictions of violence


In his new book, Prof. Ludwig Morenz shows how the world’s first territorial state was formed in Egypt




University of Bonn

Martial image of subjugation (drawing): 

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The ruler tramples a man (lying). The two round circular areas behind this are not balls, but rather decapitated heads. 

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Credit: Photo: Johann Thiele





Today a desert – as far as the eye can see. However, anyone looking more closely will discover hundreds of images carved into the rock. This ancient Egyptian graffiti attests to the fact that a new claim to sovereignty emerged here on the periphery over 5,000 years ago. One of these kings was known as Scorpion. He demonstrated his power with portrayals of himself as a divine ruler and with brutal depictions of violence. Together with Mohamed Abdelhay Abu Bakr, Egyptologist Prof. Dr. Ludwig Morenz from the University of Bonn has now published in his book the latest findings concerning the visualization of claims to sovereignty in pre-Pharaonic Egypt.

The landscape in the desert around Wadi el Malik to the east of Aswan has so far been the subject of little archaeological research. There are hundreds of images here and some particularly early hieroglyphs, which originate from the time before the dynasties from the late fourth millennium BC were formed. “The Egyptian state emerged during this period,” says Egyptologist Prof. Dr. Ludwig Morenz from the University of Bonn. “This was the world’s first territorial state.” It has been known for some time that the north-south extension of Egypt at that time was already around 800 kilometers.

One of the rulers over 5,000 years ago bore the name Scorpion. Little is known about him. His name is written alongside three other hieroglyphs in a rock inscription from a side wadi of the Wadi Abu Subeira to the east of Aswan: “Domain of the Horus King Scorpion.” A circular hieroglyph indicates that it is a place name. Morenz interpreted the inscription as the “world’s oldest known place name sign” several years ago. This news caused a sensation and was considered newsworthy by many media outlets. Alongside Mohamed Abdelhay Abu Bakr, he is now presenting his latest findings relating to this rocky landscape with its millennia-old inscriptions in his new book, “Culture and Power in Pre-Pharaonic Egypt, Visualizing Claims to Sovereignty in the Socio-Cultural Periphery of Wadi el Malik and Wadi Na’am during the Fourth Millennium.”

Royal rock art tableau

Scorpion was not the first ruler and is not the only person marked on the rock. Morenz speaks of a “royal rock art tableau”, as several rulers who reigned one after the other are linked here with their names and the image of a distinctive animal in a kind of matrix. Alongside Scorpion, the Protodynastic kings depicted also include King “Bull”, who reigned before him. The royal line begins with King Horus-Falcon. “Most early ruler names refer to dangerous animals that embody authority,” says the Egyptologist. Even before these rulers was “Scolopendra,” named after the venomous, and thus dangerous, centipede. This ruler’s name was discovered by Morenz.

Over 5,000 years ago, the region was a transit area for expeditions, contained mineral resources, and was also a sought-after hunting ground in those wetter times. “It is actually all about a grandiose presentation of the claim to sovereignty,” says Morenz, referring to the abundant rock carvings in this region. Wadi el Malik lay in the socio-cultural periphery of the Nile Valley and was evidently claimed as the domain for the still very new territorial state at that time.

The rulers were not simply ‘gods,’ but instead portrayed themselves as earthly representatives with a connection to the main gods. In the case of Scorpion, Bat and Min were the central divine couple in the Nile Valley in the second half of the 4th millennium. Bat was understood to be a celestial cow – depicted as a cow’s head with stars – and Min a man. Morenz: “They formed a divine couple, with Bat associated with the fertile land along the Nile and Min with the peripheral regions as a kind of hunting god.”

“Pharaoh-fashioning” as a divine portrayal

The Egyptologist refers to this as “pharaoh-fashioning,” by which he means the visualisation of distinct rulership. “The territorial state was still brand new at that time. As a result, ways to present such an unusual claim to sovereignty in images and text had to be found,” he says. Depicting victory over enemies was central to the ideology of sovereignty. Dominance was visualized within the rock art in scenes of violence – using the striking pattern of depicting oneself in stone as invincible while showing one’s enemies as small, subjugated figures. “The most extreme scene is the one showing the ruler trampling an enemy, with two decapitated heads visible in the background,” says the Egyptologist, indicating an image that he has recently discovered and interpreted.

The ‘boat of the gods’ carved into the rock also relates more specifically to religion. This is an extensive depiction of a boat hauled by 25 men. According to the researcher, the boat represents sacred processions that established the link between regions, specifically the Nile Valley and the desert wadi in this case.

New digital methods

The researchers used new digital technologies that analyze numerous photographs taken from various angles with a high level of computing power to reveal contours of the rock carvings that cannot be seen on site. The Egyptologist from the University of Bonn believes that research in this region is still in its infancy. “This is an important region when it comes to our understanding of the emergence of the state at the socio-cultural periphery in the late fourth millennium,” says Morenz. “We generally know much less about this than about the cultural centers.”

The researcher is hoping for a large-scale project aiming at further archaeological research within this region. When it comes to rock carvings, it is not only about the depictions themselves but also, as in an overall work of art, about their positioning in the surrounding landscape. “I consider this so important that this hot spot should also be made accessible to interested parties with tours and a visitor center,” says Morenz.

Participating institutions and funding:

The Transdisciplinary Research Area ‘Present Pasts’ and the Cluster of Excellence ‘Bonn Center for Dependency & Slavery Studies’ at the University of Bonn funded the work on this book. Ludwig Morenz thanks the Cluster for two research sabbaticals, which he used to write down his thoughts. The Argelander Scholarship from the University of Bonn enabled Mohamed Abdelhay Abu Bakr to complete a one-year research visit to the University of Bonn. Mohamed Abdelhay was also intensively involved in field surveys with the Lagna Daima concession in Cairo and as the inspector responsible for the Aswan Office (“Taftish”). Ludwig Morenz was responsible for cultural-historical hermeneutics. The two men were in close communication throughout the project.

Publication: Ludwig D. Morenz, Mohamed Abdelhay Abu Bakr: Kultur und Macht im vorpharaonischen Ägypten, Visualisierungen von Herrschaft in der sozio-kulturellen Peripherie des Wadi el Malik und des Wadi Na’am während des Vierten Jahrtausends (Culture and Power in Pre-Pharaonic Egypt, Visualizing Claims to Sovereignty in the Socio-Cultural Periphery of Wadi el Malik and Wadi Na’am during the Fourth Millennium), Katarakt, Assuaner Archäologische Arbeitspapiere 4, EB-Verlag, 244 pages, 39.80 euros. The book presents the findings in three languages: German, English, and Arabic.

The ruler tramples a man (lying). The two round circular areas behind this are not balls, but rather decapitated heads. 


Credit

Photo: Johann Thiele


The inscription of King “Bull” is on the top, the one with the placename in front. 

Credit

Photo: Ludwig Morenz

combined with the motif of defeating enemies.

Credit

Illustration: Johann Thiele/ Matthias Lang edited with GigaMesh