Wednesday, August 27, 2025

 

Strong, evidence-based leadership at CDC essential in wake of director’s exit, says SHEA





Society for Healthcare Epidemiology of America





SHEA is deeply disappointed by the sudden departure of the CDC Director so soon after her confirmation, at a time when the agency most needs stability and authority to carry out its vital mission of protecting the health and safety of all Americans. 

The United States stands at a critical crossroads, where strong, trusted public health leadership is essential to restoring confidence through evidence-based practices and guidance. In an era marked by increasing assaults on science and public health, CDC must be empowered to rise above politics and remain focused on their core purpose: safeguarding and improving the health of communities. While there may be differing perspectives on how best to achieve this goal, it is clear that qualified, steady leadership is indispensable to guiding the path forward. We urge the Administration and Senate leadership to move swiftly to appoint a highly qualified leader who can steer the CDC through today’s urgent challenges and prepare for those to come, including any future pandemics. The CDC is not only central to protecting Americans from health threats but also to strengthening health outcomes and ensuring a healthier future for all.


 

Birdwatching tourism is booming. Some countries are benefiting, while others are left behind



University of California - Santa Cruz







Deep in a forest in the Andes, high atop a tall tree, there’s a quick, colorful flash of plumage in vivid shades of yellow, green, and blue. A high-pitched musical chirp rings out. Through a carefully trained pair of binoculars, a beautiful little bird comes into view. It’s a multicolored tanager, a species that lives only in the mountains of Colombia. Seeing it in person for the first time feels like the thrill of discovery. Watching it search for fruit across the treetops brings a sense of peace and connection to nature. 

Experiences like these are what motivate birdwatchers to travel the globe, in hopes of seeing as many different types of birds as possible in one lifetime. Along the way, they visit many beautiful places, meet new friends, make memories, and develop a deeper appreciation for the incredible biological diversity of our planet. Increasingly, they also play a role in protecting that biodiversity.

The popularity of birdwatching has exploded in the past decade, so much so that the hobby is helping to drive global ecotourism. Birdwatching tourism is a form of sustainable development that incentivizes the preservation of habitats and can be especially beneficial for countries in the tropics, which have high bird biodiversity, large numbers of unique species, and generally lower levels of economic development, meaning that an inflow of tourist dollars can have an outsized impact, especially in rural communities.

However, new research from the University of California, Santa Cruz shows that, so far, not all countries have benefited equally from the growth of birdwatching tourism. Scientists wanted to understand what might be affecting tourists’ choice of destinations, so they used data from eBird, a popular birding app, to model how birding tourism growth was affected by a range of ecological and socioeconomic factors across 155 countries. The results identify clear challenges and prominent success stories, which may offer lessons for countries looking to promote birdwatching.

Harnessing birdwatching data

UC Santa Cruz conservation ecologist Natalia Ocampo-Peñuela, lead author of the new study, is from Colombia, a country that has had notable success in developing birdwatching tourism. She and fellow UC Santa Cruz ecologist and study coauthor Scott Winton have done many birdwatching trips in Colombia and elsewhere and became curious about how the industry was developing globally. 

“We had long wondered about birdwatching as a way to achieve both conservation and economic development,” Ocampo-Peñuela recalls. “It’s something we’ve often discussed with other birdwatchers on trips, so these research questions were really born from some of those conversations in the field.”

“Over the years, we’ve seen Colombia really explode as a birdwatching destination, and we often asked ourselves why more countries aren’t similarly recognized as great places for birdwatching,” Winton added. “So we wanted to systematically look at some easily measurable factors that could be influencing trends in visitation.”

Researchers suspected there were certain conditions that positioned a country to take full advantage of birdwatching tourism. One seemingly obvious prerequisite: interesting birds. The team believed birders were being drawn to places with high “bird capital,” where they could see many different types of birds in one trip, including many species found only in a very specific area. But birders likely also needed some level of basic infrastructure and safety measures in place to support tourism. 

To determine how these factors might be affecting global industry development trends, Ocampo-Peñuela and Winton enlisted the help of computer scientists and a quantitative ecologist to unlock the secrets of a massive treasure trove of community science data from eBird, an app that bird watching hobbyists use to track their observations. More than 100 million bird sightings are contributed by eBird users around the world each year.

UC Santa Cruz Computer Science and Engineering Professor Luca de Alfaro led students Katarina Bjegovic and Sam de Alfaro in wrangling user-submitted eBird data from 2010 through 2022. This was then used by Environmental Studies Postdoctoral Scholar Monte Neate-Clegg to run statistical models analyzing the growth of birding over time on a country-by-country basis. 

“What we computer scientists injected into this research was an ability to analyze a huge amount of data in a very efficient way, which enables us to look at these statistics at this scale for the first time,” Alfaro explained. 

To estimate how much of the global growth in birding came from tourism, the team first determined the most likely country of residence for each individual user—based on where they submitted the most bird checklists—then categorized the user’s activity in other countries as tourism. They then compared trends over time in each country’s relative share of birdwatching tourism. And across 155 countries, researchers modeled the influence on birdwatching tourism trends from four major variables: total bird biodiversity, the number of small-range bird species, the Human Development Index, and the Global Peace Index.

Disparities in tourism trends

Results from the team’s data analysis showed lots of potential for the development of birdwatching tourism across the tropics, but a complicated picture of which countries were best equipped to capitalize. 

Since 2010, overall global birdwatching activity on eBird has increased dramatically, particularly in countries with the highest numbers of small-range birds. Colombia had the most explosive growth, with 40 times more birding days reported in 2022 than 2010. When looking at tourist activity specifically, Colombia still took the top spot, while South Africa showed the second highest growth rate overall.

However, other countries across the tropics, like the Democratic Republic of Congo and Venezuela, experienced essentially no growth in tourist activity over the 12-year period. And while the overall number of birdwatching tourists grew in most other tropical countries, the proportion of global birding tourism they captured was either flat or declining. Colombia was the one exception, achieving a doubling in market share prior to the pandemic and a steady post-pandemic rebound.

Some countries, like Canada and Western European countries, had disproportionately high levels of visitation compared to their bird capital, while countries like Venezuela, Bolivia, Madagascar, the Democratic Republic of Congo, and Papua New Guinea had disproportionately low levels of birding tourism. Countries that had both high visitation and high levels of bird capital included Costa Rica, Mexico, Colombia, Peru, Ecuador, Brazil, and Australia.

A possible explanation for some of these trends is that researchers discovered birds were not the most important factor driving birdwatching tourism decisions. A country’s Human Development Index actually explained 41.4% of the variation in visitation, followed by total species richness at 22.4%, relative small-range richness at 15.3%, and relative Global Peace Index at 1.4%. 

Still, some countries with relatively similar ecological and socioeconomic profiles, like Colombia and Venezuela, had vastly differing outcomes. Mexico was also a notable overachiever relative to its bird resources, indicating that there may be additional factors driving tourism decisions, like public perception, visa requirements, political affinities, and ease and affordability of travel from major tourist source countries like the United States, where the researchers found most birding tourists come from. 

Creating birding destinations

Based on the team’s findings, the research paper proposes a few strategies that might help countries increase their appeal as birdwatching destinations. 

For developing countries that struggle with conflict or crime, it may be encouraging that the Global Peace Index on its own was not a major factor in tourists’ choice of destinations. This may be because what matters most to ecotourists is not necessarily the overall safety and development of a country, but that of the specific tourist locales. This means ecotourism can be a great initial type of tourism to start building out in developing countries. 

In Colombia’s case, the country’s meteoric and relatively recent rise in birdwatching tourism seems to be linked to the success of a major marketing campaign by the country’s tourism development agency. Meanwhile, Costa Rica, which was an overachiever in bird watching tourism relative to its bird resources, is a well-established ecotourism destination that offers a model for how to prioritize building a green economy over extractive industry by investing in specialized tourism infrastructure, guides, and safety.  

Countries wanting to develop birding tourism can offer tax abatements, subsidies, or loans to build birding infrastructure like canopy towers, trails, and hides. They can also support the training of local guides and conservation of bird habitats and offer certification programs and tax benefits for sustainable, community-led tourism businesses.

But the study’s authors acknowledge that the natural habitats bird watching tourism relies upon face competing land uses like logging, agriculture, or mining. These extractive uses can produce substantial short-term profits, while the benefits of ecotourism are more of a long game. So promoting that long-term vision may require support from strong land-use policies and community co-management of resources. 

Ultimately, the decision of whether and how to engage in any form of tourism, including birdwatching, should always reside with local and Indigenous communities. When done well, Ocampo-Peñuela believes the results can be transformative. 

“Just as I’ve seen birding tourism change people’s lives in my native Colombia, I hope other tropical countries can come together to conserve and showcase their amazing bird capital,” she said.

 

Researchers leverage advanced bioengineering techniques to develop plastics made from sustainable biomaterials 




Purdue University

Karthik Sankaranarayanan operates protein isolation equipment 

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Karthik Sankaranarayanan, assistant professor of agricultural and biological engineering, operates a fast protein liquid chromatography system, which isolates and purifies proteins from a mixture. 

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Credit: Purdue University/John Underwood





WEST LAFAYETTE, Ind. — Plastic products frequently pile up in landfills or spill into natural habitats where they occupy space and endanger wildlife. To combat this problem, a team of university and industry researchers have been awarded funding from the U.S. National Science Foundation (NSF) to develop mechanisms to produce sturdy and reusable bioplastics. In addition to their ecological benefits, these bioplastics — cultivated from domestic raw materials — may help to strengthen U.S. supply chains and manufacturing.

Plastic production is a nearly $1 trillion industry with over 400 million metric tons produced in 2022. However, only about 10% of plastics are recycled. Karthik Sankaranarayanan, assistant professor of agricultural and biological engineering at Purdue University, and his collaborators jointly received a $7 million grant from NSF to design novel enzymes — a type of protein that speeds up chemical reactions — that convert various biomaterials into biodegradable plastics.

The enzymes developed by this research program will have similar levels of toughness and malleability to the types of plastics that currently dominate the market. However, rather than relying on petroleum-based chemicals, these new bioplastics — polyhydroxyalkanoates (PHAs) — would be generated using domestically produced feedstocks such as corn, sugar or agricultural waste.

“Nearly 99% of the plastics produced today are made from petrochemicals derived from oil or gas, which often must be imported from outside the United States,” Sankaranarayanan said. “We want to take advantage of locally available materials, such as those commonly used throughout the state of Indiana.”

Additionally, while retaining their mechanical strength, Sankaranarayanan claims they would be infinitely recyclable.

“You can take these polymers and break them down into their individual units and reuse them again and again,” Sankaranarayanan said. “PHAs were discovered nearly a century ago, but they can be fragile and unstable at high temperatures, hindering their widespread use in consumer goods or medical devices. Our platform will enable the tuning of the chemical structure of the final polymer to have the proper level of mechanical strength and thermal stability. This will open the door for applications that range from packaging to biomedical devices.”

The primary focus of this three-year project is on biocatalysis — using enzymes to speed up highly specific reactions that produce desired products without harsh chemicals or extreme conditions. Biocatalysis makes biomanufacturing a more sustainable and efficient alternative to traditional chemical manufacturing. Creating the computational tool to identify opportunities for biocatalysis is the key to unlocking its potential.

Purdue researchers are developing algorithms to select the enzymes and the reactions required for creating the desired bioplastics. Then, researchers at the University of California, San Francisco (UCSF) will engineer these enzymes using advanced protein computational design methods that harness deep learning, a machine learning technique that mimics how the brain recognizes patterns.

Once the enzymes are engineered, they will be sent to researchers at Stanford University to test their functionality and then to Purdue, where researchers will analyze the speed of their reactions as well as their ability to tune the chemical structure of the polymer. Finally, researchers at the University of California, Berkeley will determine their properties and commercialization potential, as well as how microorganisms can be engineered to scale up for biomanufacturing.

Sankaranarayanan cites finding adaptable enzymes as one of the major challenges associated with this project.

“The enzymes that we’re working with — polyketide synthases (PKSs) — are sophisticated enzymes capable of catalyzing sequential chemical reactions in an assembly-line fashion to produce complex antibiotics,” Sankaranarayanan said. “However, they aren’t designed to work in the types of industrial processes that create bioplastics. So we’re trying to figure out how we can both alter their natural chemical reaction to produce desired bioplastics and simultaneously improve the stability of the engineered enzymes so that they’re amenable to biomanufacturing at scale.”

Another challenge to using these enzymes in a manufacturing setting is the makeup of their DNA. PKSs have a high content of guanine and cytosine — two of the four bases that carry genetic information in DNA — which poses significant challenges for synthetic manufacturing of the DNA for subsequent enzyme production. Twist Bioscience, an additional partner on the project, has developed the technology that will enable researchers to engineer the necessary enzymes.

“Working with Purdue elucidates real-world applications of complex sequences, which allows Twist to further advance our ability to manufacture difficult and previously hard-to-make sequences at scale, turning what was once considered difficult into routine,” said Emily Leproust, CEO and co-founder of Twist Biosciences. “This project provides a powerful example of how innovation and partnership can expand the boundaries of discovery for multiple real-world applications.”

In addition to the team’s contributions to biomanufacturing, they will provide research opportunities for students as well as resources for the broader scientific community. Three graduate students have already been hired to work on the project, and researchers will be recruiting undergraduate students in agricultural and biological engineering, computer science, chemistry, and chemical engineering.

Sankaranarayanan said they will also provide open-source access to all their tools and workflows since, with some minor tweaks, they can be applied to pharmaceuticals, agrochemicals, pesticides or herbicides, and even other types of biomaterials, such as rubber. They will also develop a workshop on protein design led by UCSF with Purdue contributing modules on designing step-by-step enzyme processes.

“One thing I really enjoy about this grant is we have investigators, postdocs and graduate students from all these different universities, each of whom bring a unique set of strengths,” Sankaranarayanan said. “So, this opportunity for students here at Purdue to interact with some of these other faculty members and their lab members is quite exciting.”

This project is funded by the NSF’s Directorate for Technology, Innovation and Partnerships through the Use-Inspired Acceleration of Protein Design initiative.

 

Be it feast or famine, orangutans adapt with flexible diets



Rutgers-led researchers find survival strategies of the great apes offer lessons for human health and diet management




Rutgers University

Bornean Orangutan 

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Orangutans living in the wild adapt to different foods, depending on availability, maintaining an overall healthy balance.

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Credit: Ilya Raskin/Rutgers University






Humans could learn a thing or two from orangutans when it comes to maintaining a balanced, protein-filled diet.

Great apes native to the rainforests of Indonesia and Malaysia, orangutans are marvels of adaptation to the vagaries of food supply in the wild, according to an international team of researchers led by a Rutgers University-New Brunswick scientist. The critically endangered primates outshine modern humans in avoiding obesity through their balanced choices of food and exercise, the scientists found.

The researchers reported their findings, based on 15 years of firsthand observations of wild orangutans in the jungles of Borneo, in Science Advances.

“These findings show how wild Bornean orangutans adapt to changes in their environment by adjusting their nutrient intake, behavior and energy use,” said Erin Vogel, the Henry Rutgers Term Chair Professor in the Department of Anthropology in the School of Arts and Sciences, who led the study. “The work highlights the importance of understanding natural dietary patterns and their impact on health, both for orangutans and humans.”

Orangutans are one of the closest living relatives to humans, sharing a common ancestor, Vogel said. This evolutionary relationship means that orangutans and humans have similar physiological and metabolic processes, dietary needs and behavioral adaptations. Studying orangutans can provide insights into the evolutionary adaptations that might also be relevant to humans, she said.

Humans also exhibit metabolic flexibility, Vogel said, but modern diets high in processed foods can disrupt this balance, leading to metabolic disorders such as diabetes.

While orangutans reduce physical activity during low fruit periods to conserve energy, Vogel said, humans, especially those with sedentary lifestyles, may not adjust their energy expenditure to match their caloric intake, leading to weight gain and associated health issues.

“Understanding these adaptations can help us learn more about how humans can manage their diets and health,” Vogel said. “It also highlights the importance of conserving orangutan habitats to ensure their survival.”

The research was conducted at the Tuanan Orangutan Research Station in the Mawas Conservation Area in Central Kalimantan, Indonesia, on the island of Borneo. The conservation area, a peat swamp forest, protects about 764,000 acres, an area roughly the size of Rhode Island. Peat forests are richly biodiverse, ancient ecosystems with landscapes dominated by waterlogged trees that grow on layers of dead leaves and plant material.

Understanding the dietary strategies of orangutans can inform better nutritional practices for humans, said Vogel, who also is director of the Center for Human Evolutionary Studies at Rutgers.

“In essence, the research on orangutans underscores the importance of dietary balance and metabolic flexibility, which are crucial for maintaining health in both orangutans and humans,” Vogel said. “It suggests that modern dietary habits, characterized by high consumption of processed foods rich in sugars and fats, can lead to metabolic imbalances and health issues.”

In earlier studies, Vogel and an international team of colleagues established the patterns by which orangutans fed. Orangutans prefer to eat fruit because it is rich in carbohydrates, but when fruit is scarce, they switch to eating more leaves, bark and other foods that can provide more protein but fewer sugary carbohydrates. In times of high fruit availability, orangutans still consume protein but get most of their energy from carbohydrates and fats in the fruit.

“We wanted to find out how their bodies handle these changes,” Vogel said. “We tested how the availability of fruit affects their diet and how their bodies adapt to avoid energy imbalance. We looked at how they switch between different types of fuel – like fats and proteins – when preferred food availability changes.”

To conduct the study, Vogel, research colleagues, students and a staff that mostly included field technicians indigenous to the island of Borneo collected data for more than a decade on what the orangutans ate daily and analyzed their urine to see how their bodies responded to any nutritional changes. This required staying in close proximity to the ape in the equatorial, humid jungle from dawn until night.

The scientists made a number of key findings:

  • Orangutans avoid obesity as part of a response to the significant fluctuations – in both magnitude and duration – in fruit availability in their natural habitat. Unlike humans in Western culture, who have constant access to high-calorie foods, orangutans experience periods of both abundance and scarcity. The periods of scarcity and resulting low caloric intake, similar to humans’ intermittent fasting, may help maintain their health by reducing oxidative stress.
  • During periods of fruit scarcity, orangutans exhibit metabolic flexibility, switching to using stored body fat and muscle protein for energy. This allows them to survive when food is scarce.
  • During periods of fruit scarcity, orangutans exhibit behavioral adaptability, relying on reduced physical activity as well as stored energy and muscles to conserve energy. They rest more, go to sleep earlier, travel less and spend less time with other orangutans. This flexibility enables them to use body fat and protein for fuel when needed. They rebuild fat reserves and muscle when fruit availability is high.
  • The orangutan diet also prioritizes a consistent level of protein, which contrasts with a modern Western diet, which often can be rich in low-cost, energy-dense, protein-poor foods. Those choices contribute to obesity and metabolic diseases in humans.

This research builds on a report published earlier this year in The American Journal of Biological Anthropology, led by doctoral student Will Aguado, as the first author. This study found that orangutans at Tuanan get most of their protein from the leaves and seeds of just one out of nearly 200 species in the diet -- a vine called Bowringia callicarpa. The protein in this plant fuels orangutans through seasons of fruit scarcity and likely allows orangutans at Tuanan to persist and for their population to grow.

Other scientists on the study from Rutgers included Malcolm Watford, a professor in the Department of Nutritional Sciences, Rutgers School of Environmental and Biological Sciences; and former Rutgers doctoral student Rebecca Brittain, Tatang Mitra-Setia and Sri Suci Utami from Universitas Nasional in Indonesia, graduate students William Aguado, Astri Zulfa and Alysse Moldawer, all with the Department of Anthropology in the School of Arts and Sciences. Former graduate student Timothy Bransford, who also contributed to the study, is now at Eckerd College, St. Petersburg, Fla.

Researchers from the following institutions also contributed to the study: The Max Planck Institute of Animal Behavior and the University of Konstanz in Germany; Yale University; Jagiellonian University in Krakow, Poland; the University of Cincinnati; the University of Colorado; Eckerd College in St. Petersburg, Fla.; Universitas Nasional in Jakarta, Indonesia; National Research and Innovation Agency in Cibinong-Bogor, Indonesia; University of Zurich in Switzerland; Hunter College of the City University of New York; and the University of Sydney in Australia.

Explore more of the ways Rutgers research is shaping the future.

Orangutans native to the rainforests of Indonesia and Malaysia are being studied for their positive dietary habits by a Rutgers-led team of scientists.

Credit

Ilya Raskin/Rutgers University

Orangutan feeding [VIDEO] 

 

Insomnia patients report better sleep when taking cannabis-based medical products



Patients reported better sleep as well as decreased anxiety and pain over 18 months of treatment


]PLOSFacebook

Insomnia patients report better sleep when taking cannabis-based medical products 

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Cannabis flower 

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Credit: Photo by Jeff W on Unsplash (free to use under the Unsplash License)





Insomnia patients taking cannabis-based medical products reported better quality sleep after up to 18 months of treatment, according to a study published August 27 in the open-access journal PLOS Mental Health by Arushika Aggarwal from Imperial College London, U.K., and colleagues.

About one out of every three people has some trouble getting a good night’s rest, and 10 percent of adults meet the criteria for an insomnia disorder. But current treatments can be difficult to obtain, and the drugs approved for insomnia run the risk of dependence. To understand how cannabis-based medical products might affect insomnia symptoms, the authors of this study analyzed a set of 124 insomnia patients taking medical cannabis products. They examined the patient’s reports of their sleep quality, anxiety/depression, and quality of life changes between one and 18 months of treatment.

The patients reported improved sleep quality that lasted over the 18 months of treatment. They also showed significant improvements in anxiety/depression as well as reporting less pain. About nine percent of the patients reported adverse effects such as fatigue, insomnia, or dry mouth, but none of the side effects were life-threatening. While randomized controlled trials will be needed to prove that the products are safe and effective, the authors suggest that cannabis-based medical products could improve sleep quality in insomnia patients.

Co-author Dr. Simon Erridge, Research Director at Curaleaf Clinic, summarizes: “Over an 18-month period, our study showed that treatment for insomnia with cannabis-based medicinal products was associated with sustained improvements in subjective sleep quality and anxiety symptoms. These findings support the potential role of medical cannabis as a medical option where conventional treatments have proven ineffective, though further randomised trials are needed to confirm long-term efficacy.”

He adds: “Conducting this long-term study provided valuable real-world evidence on patient outcomes that go beyond what we typically see in short-term trials. It was particularly interesting to observe signs of potential tolerance over time, which highlights the importance of continued monitoring and individualised treatment plans.”

 

In your coverage please use this URL to provide access to the freely available article in PLOS Mental Healthhttps://plos.io/41g18VP

Citation: Aggarwal A, Erridge S, Cowley I, Evans L, Varadpande M, Clarke E, et al. (2025) UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia. PLOS Ment Health 2(8): e0000390. https://doi.org/10.1371/journal.pmen.0000390

Author Countries: United Kingdom

Funding: The authors received no specific funding for this work.