Monday, September 15, 2025

  

Humans and machines learn differently



Bielefeld researchers publish article in “Nature Machine Intelligence”



Bielefeld University

Professors Dr Benjamin Paaßen and Dr Barbara Hammer from Bielefeld University are involved in the publication. 

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Professors Dr Benjamin Paaßen and Dr Barbara Hammer from Bielefeld University are involved in the publication. 

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Credit: TRR 318 and Bielefeld University




How do humans manage to adapt to completely new situations and why do machines so often struggle with this? This central question is explored by researchers from cognitive science and artificial intelligence (AI) in a joint article published in the journal “Nature Machine Intelligence”. Among the authors are Professor Dr. Barbara Hammer and Professor Dr. Benjamin Paaßen from Bielefeld University.

“If we want to integrate AI systems into everyday life, whether in medicine, transportation, or decision-making, we must understand how these systems handle the unknown,” says Barbara Hammer, head of the Machine Learning Group at Bielefeld University. “Our study shows that machines generalize differently than humans and this is crucial for the success of future human–AI collaboration.”

Differences between humans and machines
The technical term “generalization” refers to the ability to draw meaningful conclusions about unknown situations from known information, that is, to flexibly apply knowledge to new problems. In cognitive science, this often involves conceptual thinking and abstraction. In AI research, however, generalization serves as an umbrella term for a wide variety of processes: from machine learning beyond known data domains (“out-of-domain generalization”) to rule-based inference in symbolic systems, to so-called neuro-symbolic AI, which combines logic and neural networks.

“The biggest challenge is that 'Generalization' means completely different things for AI and humans,” explains Benjamin Paaßen, junior professor for Knowledge Representation and Machine Learning in Bielefeld. “That is why it was important for us to develop a shared framework. Along three dimensions: What do we mean by generalization? How is it achieved? And how can it be evaluated?”

Significance for the future of AI
The publication is the result of interdisciplinary collaboration among more than 20 experts from internationally leading research institutions, including the universities of Bielefeld, Bamberg, Amsterdam, and Oxford. The project began with a joint workshop at the Leibniz Center for Informatics at Schloss Dagstuhl, co-organized by Barbara Hammer.

The project also highlights the importance of bridging cognitive science and AI research. Only through a deeper understanding of their differences and commonalities will it be possible to design AI systems that can better reflect and support human values and decision-making logics.

The research was conducted within the collaborative project SAIL – Sustainable Life-Cycle of Intelligent Socio-Technical Systems. SAIL investigates how AI can be designed to be sustainable, transparent, and human-centered throughout its entire life cycle. The project is funded by the Ministry of Culture and Science of the State of North Rhine-Westphalia.

Why AI is never going to run the world


Researcher explains how ‘primal intelligence’ helps humans succeed


Ohio State University






COLUMBUS, Ohio – The secret to human intelligence can’t be replicated or improved on by artificial intelligence, according to researcher Angus Fletcher.

Fletcher, a professor of English at The Ohio State University’s Project Narrative, explains in a new book that AI is very good at one thing: logic. But many of life’s most fundamental problems require a different type of intelligence

“AI takes one feature of intelligence – logic – and accelerates it. As long as life calls for math, AI crushes humans,” Fletcher writes in the book “Primal Intelligence.”

“It’s the king of big-data choices. The moment, though, that life requires commonsense or imagination, AI tumbles off its throne.  This is how you know that AI is never going to run the world – or anything.”

Instead, Fletcher has developed a program to help people develop their primal intelligence, a program that has been successfully used with groups ranging from the U.S. Army to elementary school students.

At its core, primal intelligence is “the brain’s ancient ability to act smart with limited information,” Fletcher said.

In many cases, the most difficult problems people face involve situations where they have limited information and need to develop a novel plan to meet a challenge.

The answer is what Fletcher calls “story thinking.”

“Humans have this ability to communicate through stories, and story thinking is the way the brain has evolved to work,” he said.

“What makes humans successful is the ability to think of and develop new behaviors and new plans. It allowed our ancestors to escape the predator.  It allows us to plan, to plot our actions, to put together a story of how we might succeed.”

Humans have four “primal powers” that allow us to act smart with little information.

Those powers are intuition, imagination, emotion and commonsense. In the book, Fletcher expands on each of these and the role they have in helping humans innovate.

In essence, he says these four primal powers are driven by “narrative cognition,” the ability of our brain to think in story. Shakespeare may be the best example of how to think in story, he said.

Fletcher, who has an undergraduate degree in neuroscience and a PhD in literature, discusses in the book how Shakespeare’s innovations in storytelling have inspired innovators well beyond literature. He quotes people from Abraham Lincoln to Albert Einstein to Steve Jobs about the impact reading Shakespeare had on their lives and careers.

Many of Shakespeare’s characters are “exceptions to rules” rather than archetypes, which encourages people to think in new ways, Fletcher said.

What Shakespeare has helped these pioneers – and many other people – do is see stories in their own lives and imagine new ways of doing things and overcoming obstacles, he said.

That’s something AI can’t do, he said.  AI collects a lot of data and then works out probable patterns, which is great if you have a lot of information.

“But what do you do in a totally new situation? Well, in a new situation you need to make a new plan. And that’s what story thinking can do that AI cannot,” he said.

The U.S. Army was so impressed with Fletcher’s program that it brought him in to help train soldiers in its Special Operations unit.  After seeing it in action, the Army awarded Fletcher its Commendation Medal for his “groundbreaking research” that helped soldiers see the future faster, heal quicker from trauma and act wiser in life-and-death situations.

In the book, Fletcher gave an example of how one Army recruit used his primal intelligence to overcome obstacles in the most literal sense.

As part of its curriculum, Army Special Operations had a final test for recruits: an obstacle course of logs and ropes. The recruits were told they had the ring the bell at the end of the course before time expires in order to pass the test.

This particular recruit knew he couldn’t beat the clock. At the starting line, he thought of a new plan: he ran around the obstacle course, rather than through it, ringing the bell in record time.

While other military schools would have flunked him, Special Operations passed him, based on his ingenuity in passing the test, Fletcher said.  As the Army monitored his career after graduation, it found he outperformed many of his classmates on field missions.

The value of primal intelligence works in all walks of life, including business. While business often emphasizes management, Fletcher said primal intelligence shines when leadership is needed.

“Management is optimizing existing processes. But the main challenge of the future is not optimizing things that already work,” Fletcher said.

“The challenge of the future is figuring things out when we don’t know what works. That’s what leadership is all about, and that’s what story thinking is all about.”

In business and elsewhere, Fletcher said AI has a role. But it should not be seen as a replacement for human intelligence.

“Humans are able to say, this could work but it hasn’t been tried before. That’s what primal intelligence is all about,” he said.

“Computers and AI are only able to repeat things that have worked in the past or engage in magical thinking. That’s not going to work in many situations we face.”

Study: Reviewers increasingly divided on the use of generative AI in peer review




IOP Publishing
Global reviewer survey 

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Global reviewer survey shows growing divide on use of AI in peer review

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Credit: IOP Publishing





new global reviewer survey from IOP Publishing (IOPP) reveals a growing divide in attitudes among reviewers in the physical sciences regarding the use of generative AI in peer review. The study follows a similar surveyconducted last year showing that while some researchers are beginning to embrace AI tools, others remain concerned about the potential negative impact, particularly when AI is used to assess their own work.  

Currently, IOPP does not allow the use of AI in peer review as generative models cannot meet the ethical, legal, and scholarly standards required. However, there is growing recognition of AI’s potential to support, rather than replace, the peer review process. 

Key Findings: 

  • 41% of respondents now believe generative AI will have a positive impact on peer review (up 12% from 2024), while 37% see it as negative (up 2%). Only 22% are neutral or unsure—down from 36% last year—indicating growing polarisation in views.  
  • 32% of researchers have already used AI tools to support them with their reviews. 
  • 57% would be unhappy if a reviewer used generative AI to write a peer review report on a manuscript they had co-authored and 42% would be unhappy if AI were used to augment a peer review report. 
  • 42% believe they could accurately detect an AI-written peer review report on a manuscript they had co-authored. 

Women tend to feel less positive about the potential of AI compared with men, suggesting a gendered difference in the usefulness of AI in peer review. Meanwhile, more junior researchers appear more optimistic about the benefits of AI, compared to their more senior colleagues who express greater scepticism. 

When it comes to reviewer behaviour and expectations, 32% of respondents reported using AI tools to support them during the peer review process in some form. Notably, over half (53%) of those using AI said they apply it in more than one way. The most common use (21%) was for editing grammar and improving the flow of text and 13% said they use AI tools to summarise or digest articles under review, raising serious concerns around confidentiality and data privacy. A small minority (2%) admitted to uploading entire manuscripts into AI chatbots asking it to generate a review on their behalf. 

Interestingly, 42% of researchers believe they could accurately detect an AI-written peer review report on a manuscript they had co-authored. 

“These findings highlight the need for clearer community standards and transparency around the use of generative AI in scholarly publishing. As the technology continues to evolve, so too must the frameworks that support ethical and trustworthy peer review”, said Laura Feetham-Walker, Reviewer Engagement Manager at IOP Publishing and lead author of the study. 

“One potential solution is to develop AI tools that are integrated directly into peer review systems, offering support to reviewers and editors without compromising security or research integrity. These tools should be designed to support, rather than replace, human judgment. If implemented effectively, such tools would not only address ethical concerns but also mitigate risks around confidentiality and data privacy; particularly the issue of reviewers uploading manuscripts to third-party generative AI platforms,” adds Feetham-Walker. 



 

Mount Sinai study reveals genetic clues explaining why obesity affects people differently




The Mount Sinai Hospital / Mount Sinai School of Medicine






New York, NY (September 15, 2025) — An international team of researchers led by Icahn School of Medicine at Mount Sinai and the University of Copenhagen in Denmark has pinpointed some of the reasons why obesity does not affect everyone in the same way. Their study, published today in Nature Medicine, identifies genetic differences that help explain why some people with obesity remain relatively healthy while others develop serious conditions like diabetes and heart disease.

The team analyzed genetic data from 452,768 people and discovered variants in 205 regions of the genome linked to higher body fat but better metabolic health. Using these discoveries, they developed a genetic risk score that adds up the impact of these variants. Individuals with higher scores were more likely to develop obesity—but were less likely to suffer from complications such as high blood pressure, high cholesterol, diabetes, or heart disease. This is due, in part, to the way fat cells behave in different people.

Importantly, these protective genetic effects were already visible in children. Kids carrying the protective variants were more likely to develop obesity but did not show the expected warning signs of metabolic disease.

“Our study shows that obesity is not a single condition—it is made up of different subtypes, each with its own risks,” said Nathalie Chami, PhD, first author on this paper and Instructor of Environmental Medicine, and Artificial Intelligence and Human Health, at the Icahn School of Medicine. “By uncovering these genetic differences, we can start to understand why obesity leads to different health outcomes in different individuals. This could eventually change how we predict, prevent, and treat obesity and its complications.”

The research also identified eight distinct obesity subtypes, each linked to unique health risks. “These insights could eventually help doctors predict which patients are most vulnerable to complications and inform new treatments that mimic the protective genetic effects found in some people,” said Dr. Chami.

The research team cautions that the findings do not mean obesity is harmless. “Most people with obesity still face health challenges, and lifestyle factors such as diet and exercise remain critical for overall health” said Zhe Wang, PhD, co-first author on this paper, and Adjunct Assistant Professor of Artificial Intelligence and Human Health, at the Icahn School of Medicine; and Assistant Professor at the University of Alabama at Birmingham.

The study was conducted in individuals from the UK Biobank, comprising people of European ancestry, and future work will extend to more diverse populations. It leveraged this data to perform a comprehensive multi-trait genome-wide screen. The team wanted to find new genes that affect body fat without being linked to cardiometabolic comorbidities by analyzing three adiposity and eight cardiometabolic traits, including lipid, glycemic, and blood pressure traits.

“By revealing new biological pathways that separate obesity from related diseases, the findings may pave the way for more personalized care, better-targeted therapies, and earlier prevention strategies—even from childhood,” said Ruth Loos, PhD, corresponding author, and Professor of Environmental Medicine at Icahn School of Medicine, and Professor at the University of Copenhagen in Denmark.

The DOI number for this paper is 10.1038/s41591-025-03931-0.

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About the Icahn School of Medicine at Mount Sinai 

The Icahn School of Medicine at Mount Sinai is internationally renowned for its outstanding research, educational, and clinical care programs. It is the sole academic partner for the seven member hospitals* of the Mount Sinai Health System, one of the largest academic health systems in the United States, providing care to New York City’s large and diverse patient population.  

 

The Icahn School of Medicine at Mount Sinai offers highly competitive MD, PhD, MD-PhD, and master’s degree programs, with enrollment of more than 1,200 students. It has the largest graduate medical education program in the country, with more than 2,600 clinical residents and fellows training throughout the Health System. Its Graduate School of Biomedical Sciences offers 13 degree-granting programs, conducts innovative basic and translational research, and trains more than 560 postdoctoral research fellows. 

 

Ranked 11th nationwide in National Institutes of Health (NIH) funding, the Icahn School of Medicine at Mount Sinai is among the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges.  More than 4,500 scientists, educators, and clinicians work within and across dozens of academic departments and multidisciplinary institutes with an emphasis on translational research and therapeutics. Through Mount Sinai Innovation Partners (MSIP), the Health System facilitates the real-world application and commercialization of medical breakthroughs made at Mount Sinai.

 

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* Mount Sinai Health System member hospitals: The Mount Sinai Hospital; Mount Sinai Brooklyn; Mount Sinai Morningside; Mount Sinai Queens; Mount Sinai South Nassau; Mount Sinai West; and New York Eye and Ear Infirmary of Mount Sinai.  

 

Stress in the strands: Hair offers clues to children’s mental health



University of Waterloo study shows long-term stress levels may signal mental health risks in children with chronic physical illnesses and guide early intervention



University of Waterloo





Long-term stress levels, measured through hair samples, may provide important clues about mental health risks in children with chronic physical illnesses (CPI), according to new research from the University of Waterloo.  

The study highlights how high hair cortisol, a type of steroid hormone, acts as a powerful early warning sign that could help identify children who live with CPI and who could be most at risk of mental health challenges, helping guide prevention and treatment strategies to better support their health and well-being. 

An estimated 40 per cent of children in Canada live with a CPI — a number that has been rising steadily for decades. These children face a much higher risk of developing mental health problems than their healthy peers, putting them at greater risk for poor quality of life, suicidal thoughts and increased reliance on health-care services.  
 
“Living with a chronic illness means facing daily challenges such as taking medications, missing school and adjusting activities, all of which can take a serious emotional toll,” said Emma Littler, a Waterloo PhD candidate in Public Health Sciences and lead author of the study.  

“Our findings suggest that chronically high stress, measured through hair samples, could help identify children with CPI at the highest risk for developing mental health problems. This opens the door to earlier and more targeted support.” 
 
The study followed 244 Canadian children with chronic physical illnesses over four years, measuring stress using hair cortisol — a biological marker that reflects stress levels over time. Researchers found that more than two-thirds of these children had persistently high cortisol levels. Those children were also more likely to show symptoms of depression, anxiety, or other mental health concerns compared to peers whose cortisol levels decreased over time. 

When the researchers compared these patterns to reports of emotional and behavioural difficulties, they found that children whose cortisol levels declined over time showed fewer symptoms of anxiety, depression and behaviour problems than those whose cortisol levels stayed high.  

“Identifying these risk factors early could help doctors and families intervene before emotional and behavioural difficulties take hold,” said Dr. Mark Ferro, a professor in Waterloo’s School of Public Health Sciences and co-author of the study.  

“Hair cortisol offers a non-invasive, easy-to-collect biomarker that could one day be used to screen children and track whether treatments or support programs are helping to reduce stress.”  

The study, Association between hair cortisol and psychopathology in children with a chronic physical illness, was recently published in Stress and Health. 

Ferro and colleagues from Waterloo and McMaster University also published new research showing that biomarkers found in the blood of children with CPI may help predict future mental health challenges. The study, Inflammatory biomarkers predictive of psychopathology in children with physical illness, found that some blood signals were linked to children with CPI experiencing worsening mental health over time, while others were associated with improvements. The findings suggest that routine blood tests, combined with mental health check-ups, could help doctors identify children who may need extra support earlier. 

 

Matryoshka doll-like robot changes its shape in real time and in situ




Max Planck Institute for Intelligent Systems
Figure 1 

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Figure 1: Illustration of the real-time in-situ magnetisation reprogramming method. (A) nesting of multiple tubes containing magnetic units into an integrated tube; (B) expansion of the number of magnetic units in a single tube; (C) magnetisation profile varying with multi-tube reconfigurations. (D–G) Deformation under a constant magnetic field: (D, E) one-dimensional; (F) two-dimensional; (G) three-dimensional. The tube diameter is 1.9 mm in Fig. 1D and 2.6 mm in Fig. 1E.

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Credit: MPI-IS





Stuttgart, September 15, 2025 – Until now, when scientists created magnetic robots, their magnetisation profiles were generally fixed, enabling only a specific type of shape programming capability using applied external magnetic fields. Researchers at the Max Planck Institute for Intelligent Systems (MPI-IS) have now proposed a new magnetisation reprogramming method that can drastically expand the complexity and diversity of the shape-programming capabilities of such robots. They built a soft robot with a magnetisation profile that can be altered in real time and in situ. Their findings were published in Nature on 11 September 2025.

Led by Prof. Dr. Metin Sitti in the Physical Intelligence (PI) Department at MPI-IS in collaboration with Koç University in Istanbul, Turkey, the team stacked several tubes inside each other like Matryoshka dolls. As can be seen in Figure 1A, tube C is nested inside tube B, which in turn is nested inside tube A.

Each tube contains one or more magnetic units, and the magnetisation profile of each magnetic unit can be pre-programmed on demand (Figure 1B). When the tubes' stacking configuration changes via another non-magnetic actuation method, such as sliding the tubes apart or closer together, the relative position of the magnetic units, and consequently the magnetisation profile of the entire stack, alters (Figure 1C).

This real-time, in-situ generation and transformation of shapes has not been possible with previous magnetic robots. Now however, with the magnetic field kept constant, a tube can change from a straight line to a helix (Figure 1D), or deform in the opposite direction (Figure 1E). Moreover, this approach can be extended to two- and three-dimensional frameworks, enabling real-time switching between multiple deformation modes without altering the magnetic field (Figures 1F and 1G).

While the focus at Max Planck Institutes is primarily on curiosity-driven basic research, the team has also explored how this method could be applied in various scenarios, such as navigating around objects without undesired contact, reprogramming cilia arrays and coordinating multiple instruments either cooperatively or independently under the same magnetic field.

However, this research could also have practical applications one day. For example, in medicine – particularly in minimally invasive, image-guided treatments for vascular diseases. During these procedures, physicians guide a catheter and guidewire through the blood vessels to the target lesion for diagnosis or therapy. As the catheter navigates curved vessels, friction and contact with the vessel wall are inevitable, which can cause damage that delays recovery and, in severe cases, results in medical complications. Older patients in particular often decide against such procedures, opting for medication instead.

The new technology, which has now been published in Nature, offers a compelling alternative: by adjusting the catheter’s magnetisation profile in real time to match the path ahead, friction and contact could be greatly reduced – or even eliminated entirely – when navigating curved vessels. This would minimise damage to delicate tissue, promote faster recovery and make vascular interventions a viable option for patients who would otherwise be excluded from these procedures due to age or vessel fragility.

“This stack of tubes could become the guiding principle of a new catheter technology in the future. While this is basic research at its best, we see high potential for translating this work into diverse real-world applications in the near future,” says Sitti, formerly the Director of the PI Department at MPI-IS and now President of Koç University in Istanbul.

“Our initial goal was to develop a method that could alter a magnetisation profile in real time and in situ,” says Xianqiang Bao, the first author of the publication. “During the research, we discovered unexpected capabilities, such as shape retention and magnetic neutralisation, which open up new possibilities for technologies like catheter design and cilia array reprogramming.”

“This fundamental work offers many potential application scenarios. In our future research, we aim to integrate this method into specific applications and explore its feasibility in other fields,” say Fan Wang and Jianhua Zhang, the two other co-first authors of the publication.

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The full paper can be accessed at https://www.nature.com/articles/s41586-025-09459-0

 

 Metin Sitti 

Prof. Metin Sitti, Copyright MPI-IS / W. Scheible

Credit

MPI-IS

 

Pregnancy-related anxiety and depression worsened by lack of screenings and inadequate support in healthcare system and workplace



A national study of caregivers with perinatal mood and anxiety disorders (PMADs) reveals gaps in healthcare screenings and follow-ups, lack of family networks, and insufficient paid leave




New York University





Experiencing intense anxiety, lethargy, irritability, or sadness can be debilitating when trying to accomplish a simple task. For the task as monumental as caring for a baby, these symptoms of perinatal mood and anxiety disorders (PMADs) affect one in five mothers, many who feel unsupported.

In a new study, researchers surveyed hundreds of caregivers across the US about their mental health; networks of support; and experiences with caregiving, the healthcare system, and the workplace. They found that caregivers broadly experienced a lack of support in terms of PMAD screenings and mental healthcare, access to specialists, a lack of familial support, and inadequate paid leave.

“These findings confirm what families and advocates have been saying for years: our fragmented system is failing parents at one of the most vulnerable times in their lives. Too often, caregivers experiencing PMADs suffer in silence. Our data show that many are never screened by their providers, leaving them to navigate serious mental health challenges on their own," says lead author Erin O’Connor, professor of education and director of NYU Steinhardt's Early Childhood Education Program.

O’Connor and her co-author, Robin Neuhaus, conducted the study through Nested, a nonprofit they co-founded to advance family wellbeing through research-driven solutions. The report—Missed Screenings, Missed Support—draws on data from more than 900 survey respondents and 17 in-depth interviews, and highlights the need for more training for healthcare providers, increased access to health services and supportive networks, and expanded paid leave.

 “I was bouncing between two babies in different parts of the NICU,” says Lisa, the wife of an active-duty Navy Special Forces officer and one of the women who provided interviews that supplemented the survey data for a comprehensive picture of ways caregivers are struggling. “My husband only got two weeks of paternity leave, so I was mostly alone.” 

As she sought therapy to address her heightened anxiety and isolation, Lisa says she felt judged and dismissed. “The command will say, oh, we support you in all the military spouse appreciation months. It's just talk…If you actually appreciated us, you’d staff hospitals and provide child care that works.”

Key Findings:

  • 40% of caregivers who experienced a PMAD were never screened during a follow-up appointment
  • 98% of non-birthing caregivers (e.g., fathers, same-sex partners) were never screened for PMADs, despite reporting symptoms
  • When caregivers were screened, they were often afraid to share mental health concerns for fear of judgment or being separated from their children
  • Parents of infants in intensive care were 73.5% more likely to experience a PMAD than those whose babies did not require intensive care
  • Families with more than 12 weeks of paid leave were 80% less likely to leave their jobs
  • Caregivers in rural and underserved areas reported difficulty connecting with PMAD specialists

The report says that supporting perinatal mental health care requires a coordinated effort to strengthen community resources and advance workplace and healthcare policy.

Recommendations:

  • More frequent and detailed screening systems to identify symptoms and foster trust
  • Federally provided paid leave for caregivers and families, and flexible return-to-work programs
  • Financial credits and assistance for families to address the high costs of childcare
  • Medicaid expansion to include comprehensive perinatal mental health services
  • Training for healthcare providers to better identify and treat PMADs
  • Telehealth services for remote areas
  • Online and in-person support groups for caregivers 

“We can no longer treat perinatal mental health as optional or secondary. Families need consistent screenings, accessible mental health and child care, and policies like paid leave that make it possible to recover and thrive,” O’Connor says. “These are not luxuries. They are essential investments in the health of parents, children, and communities.”