Tuesday, September 30, 2025

 

Physicists tighten the net on elusive dark matter



Results from the LUX-ZEPLIN experiment, led in part by UC Santa Barbara, mark a major step in defining what dark matter can — and cannot — be




University of California - Santa Barbara

LZ Outer Detector 

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The outer detector of the LZ dark matter experiment

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Credit: Matt Kapust/Sanford Underground Research Laboratory





Determining the nature of dark matter, the invisible substance that makes up most of the mass in our universe, is one of the greatest puzzles in physics. New results from the world’s most sensitive dark matter detector, LUX-ZEPLIN (LZ), have narrowed down the possibilities for one of the leading dark matter candidates: weakly interacting massive particles (WIMPs).

“While we always hope to discover a new particle, it is important for particle physics that we are able to set bounds on what the dark matter might actually be,” said UC Santa Barbara experimental physicist Hugh Lippincott. Scientists have suspected the existence of dark matter for decades, but it remains a mysterious substance — one that nevertheless plays a fundamental role in the structure of the universe.

LZ hunts for dark matter from a cavern nearly one mile underground at the Sanford Underground Research Facility (SURF) in South Dakota. The experiment’s new results explore weaker dark matter interactions than ever searched before and further limit what WIMPs could be. The results analyze 280 days’ worth of data: a new set of 220 days (collected between March 2023 and April 2024) combined with 60 earlier days from LZ’s first run. The experiment plans to collect 1,000 days’ worth of data before it ends in 2028.

The inner portion of the LZ detector consists of two nested titanium tanks filled with ten tonnes of transparent pure liquid xenon, which is so dense it creates a highly isolated environment, free from the “noise” of the outside world and perfect for capturing the faintest of faint signals that could be indicative of a WIMP. The hope is for a WIMP to knock into a xenon nucleus, causing it to move, much like a hit from a cue ball in a game of pool. By collecting the light and electrons emitted during interactions, LZ captures potential WIMP signals alongside other data. This liquid xenon core is surrounded by a much larger Outer Detector (OD) — acrylic tanks filled with gadolinium-loaded liquid scintillator.

LZ’s sensitivity comes from the myriad ways the detector can reduce backgrounds, the false signals that can impersonate or hide a dark matter interaction. Deep underground, the detector is shielded from cosmic rays coming from space. To reduce natural radiation from everyday objects, LZ was built from thousands of ultraclean, low-radiation parts. The detector is built like an onion, with each layer either blocking outside radiation or tracking particle interactions to rule out dark matter mimics. And, sophisticated new analysis techniques help rule out background interactions.

UCSB was one of the founding groups in LZ, led by UCSB physicist Harry Nelson, who hosted the first LZ meeting at UCSB in 2012. The team currently consists of faculty members Lippincott and Nelson, postdoctoral researchers Chami Amarasinghe and TJ Whitis, and graduate students Jeonghwa Kim, Makayla Trask, Lindsey Weeldreyer, and Jordan Thomas. Other contributors to the result include recent Ph.D. recipient Jack Bargemann, now a postdoctoral researcher at Pacific Northwest National Laboratory, and former undergraduate researcher; Tarun Advaith Kumar, now a graduate student at the Perimeter Institute. The physics coordinator for the result was Scott Haselschwardt, who received his Ph.D. from UCSB in 2018 and is now an assistant  professor at the University of Michigan. 

Neutrons, subatomic particles that exist in every atom save hydrogen, are among the most common confounders of WIMP signals. Nelson and UCSB led the design, fabrication, and commissioning of the OD, the critical component that allows the collaboration to rule out these particles and enable a real discovery.

“The tricky thing about neutrons is that they also interact with the xenon nuclei, giving off a signal identical to what we expect from WIMPs,” Trask said. “The OD is excellent at detecting neutrons, and confirms a WIMP detection by not having any response.” Presence of a pulse in the OD can veto an otherwise perfect candidate for a WIMP detection.

Radon is also a WIMP mimic, for which the scientists must be vigilant. “Radon undergoes a particular sequence of decays, some of which could be mistaken for WIMPs,” Bargemann said. “One of the things we were able to do in this run was look out for the whole set of decays in the detector to identify the radon and avoid confusing them for WIMPs.”

To enable a strong result and eliminate unconscious bias, the LZ collaboration applied a technique called “salting,” which adds fake WIMP signals during data collection. By camouflaging the real data until “unsalting” at the very end, researchers can avoid unconscious bias and keep from overly interpreting or changing their analysis.

“We’re pushing the boundary into a regime where people have not looked for dark matter before,” said Haselschwardt. “There’s a human tendency to want to see patterns in data, so it’s really important when you enter this new regime that no bias wanders in. If you make a discovery, you want to get it right.” 

With these results, the field of possibilities for what WIMPs may be has narrowed dramatically, allowing all scientists searching for dark matter to better focus their searches and reject incorrect models of how the universe operates. It’s a long game, with more data collection in the future and one that will do more than accelerate the search for dark matter.

“Our experiment is also sensitive to rare events with roots in diverse areas of physics,” Amarasinghe said. “Some examples are solar neutrinos, the fascinating decays of certain xenon isotopes, and even other types of dark matter. With the intensity of this result behind us, I’m very excited to spend more time on these searches.” 

“The UCSB Physics Department has a long history of devising searches for dark matter, starting with one of the first published results of a search in 1988,” Nelson said. Previous faculty members include David Caldwell (now deceased), and Michael Witherell, now director of the Lawrence Berkeley Laboratory. David Hale (now retired) pioneered many of the techniques for suppressing fake dark matter signals which are now employed throughout the field of dark matter searches. “UCSB, through the Physics Department, the College of Letters and Science, the administration, and through private donations, has strongly supported the dark matter effort for decades, and made substantial contributions to LZ.”

LZ is a collaboration of roughly 250 scientists from 38 institutions in the United States, United Kingdom, Portugal, Switzerland, South Korea, and Australia; much of the work building, operating, and analyzing the record-setting experiment is done by early career researchers. The collaboration is already looking forward to analyzing the next data set and extending our data analysis techniques to seek signals from lower-mass dark matter. Scientists are also thinking through potential upgrades to further improve LZ, and planning for a next-generation dark matter detector called XLZD.

LZ is supported by the U.S. Department of Energy, Office of Science, Office of High Energy Physics and the National Energy Research Scientific Computing Center, a DOE Office of Science user facility. LZ is also supported by the Science & Technology Facilities Council of the United Kingdom; the Portuguese Foundation for Science and Technology; the Swiss National Science Foundation, and the Institute for Basic Science, Korea. More than 38 institutions of higher education and advanced research provided support to LZ. The assistance of the Sanford Underground Research Facility has at all times been critical for UCSB efforts to LZ.

 

Group-based and online lifestyle counselling helped men improve their diets – risk of type 2 diabetes was lower especially among those genetically predisposed





University of Eastern Finland





Group-based and online lifestyle counselling can support middle-aged and older men in making health-promoting dietary changes. These dietary changes, in turn, reduce the risk of type 2 diabetes, especially among men with a high genetic risk, a study conducted at the University of Eastern Finland shows.

The T2D-GENE study investigated the effects of group-based and online lifestyle counselling on dietary changes among men living in the eastern part of Finland, and how these changes influenced their risk of type 2 diabetes. The study also examined whether a high genetic predisposition to type 2 diabetes has an impact on the benefits gained from dietary changes.

Men in the intervention group received lifestyle counselling over a three-year period. The study found that lifestyle counselling delivered in group sessions and through a web portal helped participants adopt healthier dietary habits.

Health-promoting dietary choices were associated with a lower risk of type 2 diabetes, particularly among individuals carrying a high number of diabetes-associated risk genes. Moreover, participants carrying the genetic variant TCF7L2, which is known to increase the risk of type 2 diabetes, benefitted most from a fibre intake that meets the nutrition recommendations.

Participants in the intervention group successfully increased their intake of fibre, whole grain products, berries, vegetables, fish and plant-based oils. At the same time, reported consumption of sausages, high-fat cheeses, low-fibre grain products, sweets and butter decreased. By the end of the study, those receiving lifestyle counselling were, in general, consuming more health-promoting foods than those in the control group.

Numerous previous studies have shown that type 2 diabetes can be prevented, or at least delayed, through health-promoting lifestyle habits.

“We need to find resource-efficient ways within health care to support these lifestyle changes. Group-based and online counselling is more resource-efficient than individual counselling,” Doctoral Researcher Ulla Tolonen of the University of Eastern Finland notes and adds:

“Our new findings show that group-based and online counselling is sufficient to support lifestyle changes among individuals with a high genetic risk of type 2 diabetes.”

Participants’ consumption of individual foods was assessed using a food frequency questionnaire, while fibre intake was evaluated both through food records and by measuring plasma alkylresorcinol, which is a biomarker of whole grain intake. The incidence of type 2 diabetes and blood glucose levels were measured by an oral glucose tolerance test. Genetic risk was assessed either by a risk score calculated on the basis of 76 risk genes, or by the genotype TCF7L2, a known risk gene for type 2 diabetes. All participants had impaired fasting blood glucose at baseline.

The findings were published in European Journal of Nutrition, and in Clinical Nutrition.

‘Alarming’ rise in newborn babies with antibiotic-resistant infections, researchers find



Sydney researchers urge for new testing and treatment guidelines and fast-tracked drug development.



University of Sydney





Researchers are calling for an urgent overhaul of diagnostic and treatment guidelines for infections in newborn babies, after a University of Sydney-led study revealed frontline treatments for sepsis are no longer effective to treat the majority of bacterial infections. 

 

The study, published in The Lancet Regional Health – Western Pacific, analysed almost 15,000 blood samples collected from sick babies in 2019 and 2020 at 10 hospitals across five countries in Southeast Asia, including Indonesia and the Philippines. 

 

It found that most infections were caused by bacteria unlikely to respond to the currently applied WHO recommended treatments. These were developed using data from high-income countries, instead of using localised data which could be more accurate and therefore effective. 

 

“Our study highlights the causes of serious infections in babies in countries across Southeast Asia with high rates of neonatal sepsis, and reveals an alarming burden of AMR that renders many currently available therapies ineffective for newborns,” said senior author Associate Professor Phoebe Williams, a Senior Lecturer and NHMRC Fellow in the Sydney School of Public Health.

 

“Guidelines must be updated to reflect local bacterial profiles and known resistance patterns. Otherwise, mortality rates are only going to keep climbing.”

 

The problem is further compounded by a lack of new antimicrobial medications in development for infants and babies, added co-author Michelle Harrison, PhD candidate and Project Coordinator of NeoSEAP in the Sydney School of Public Health. 

 

“It takes about 10 years for a new antibiotic to be trialled and approved for babies,” Harrison said.

 

“With so few new drug candidates in the first place, we need a significant investment in antibiotic development.”

 

WHY THE TYPE OF ‘BUG’ MATTERS

 

For the samples which tested positive for fungal or bacterial infections, the team analysed whether they were caused by gram-positive or gram-negative bacteria – referring to the structure of the bacteria’s cell wall which influences how likely it is to develop and acquire antibiotic resistance. 

 

Gram negative bacteria like E. coli, Klebsiella and Acinetobacter were responsible for nearly 80 percent of infections and are more likely to develop (and spread) antibiotic resistance. 

 

“These bugs have long been considered to only cause infections in older babies, but are now infecting babies in their first days of life,” said Associate Professor Williams. 

 

When treating babies, doctors don’t have time to wait for lab tests to confirm the exact cause of the infection, and often make an educated guess from published data, most often based on high-income populations, to guide treatment. These tests are also frequently delayed or falsely negative due to the difficulty of collecting blood samples.

 

Harrison explained that the findings showcase the importance of locally relevant data to guide routine medical decision-making.

 

“We need more region-specific surveillance to guide treatment decisions. Otherwise, we risk reversing decades of progress in reducing child mortality rates,” she said.

    

“Our results also revealed fungal infections caused nearly one in 10 serious infections in babies – a much higher rate than in high-income countries. 

 

“We need to ensure doctors are prescribing treatments that have the best chance at saving a baby’s life.”

 

WHAT DOES THIS MEAN FOR AUSTRALIA?

 

While this study didn’t involve cases from Australia, the authors note that these findings highlight the growing threat of AMR globally.

 

“Antibiotic resistance spreads across borders,” said Associate Professor Williams. “Thankfully in Australia we have robust data on infections, which will continue to play an important role in monitoring the appropriateness of our first-line therapies to treat serious infections as antibacterial resistance unfolds.

 

“We’re currently evaluating infection data across NSW hospitals to ensure our treatment strategies remain effective.”

 

Harrison added: “Australia’s close ties to Southeast Asia and the Western Pacific mean we must stay vigilant and proactive in updating guidelines and developing new treatments in the face of these alarming findings.”