Wednesday, October 01, 2025

HOW BEETHOVEN PLAYED PIANO

Scientific evidence that pianists can change timbre through touch



High-precision sensors, data science, and psychophysical experiments unravel the relationship between delicate movements and higher perception



NeuroPiano Institute

Figure 1: Piano Keyboard Action Mechanism and Non-Contact Sensor 

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The mechanism of the HackKey non-contact sensor, which measures piano keyboard movement at a temporal resolution of 1000 fps. It utilizes light reflection to measure the position of the underside of the key.

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Credit: NeuroPiano Institute




A research group led by Dr. Shinichi Furuya of the NeuroPiano Institute and Sony Computer Science Laboratories, Inc. announced research findings that for the first time scientifically clarified how pianists’ manipulations of keys alters piano timbre.

Creativity in painting, music, and other arts is underpinned by the ability to create diverse perceptual experiences for audiences. However, whether timbre could actually be changed mid-instrumental performance, and what physical motor skills would be required to do so, remained unclear.

The research group developed a unique sensor system that can measure piano key movements at a temporal resolution of 1,000 fps, and measured key movements when professional pianists expressed various timbres on the piano. The results revealed that listeners could distinguish the pianists’ intended timbres, regardless of whether or not they had any piano performance training experience. The group further successfully identified the key movement features that produce these timbre differences.

This discovery addresses the over century-old question, “Can pianists alter timbre through touch?” by demonstrating that timbre manipulation through touch cultivated by pianists is not a mere sensory metaphor but a scientifically backed skill. These findings open the possibility of visualizing and teaching specific movement features that produce timbre, which would lead to more efficient practice and prevention of mislearning. They also reveal that high-level body motor control shapes artistic perception, suggesting potential applications across various disciplines, including rehabilitation, skill transfer, and human interface design.

These research findings will be published in the international scientific journal Proceedings of the National Academy of Sciences(PNAS) on 22 September 2025 (Eastern Time).

 

These results were obtained through the following program, research area, and research theme:

JST Strategic Basic Research Program (CREST)
 Research Area: Core Technologies for Trusted Quality AI Systems
 (Research Supervisor: Akiko Aizawa, Professor, Digital Content and Media Sciences Research Division, National Institute of Informatic, Research Organization of Information and Systems)
 Research Theme: Building a Trusted Explorable Recommendation Foundation Technology
 Research Director: Masataka Goto (Prime Senior Researcher, AIST)
 Research Period: October 2020 - March 2026

Moonshot Research & Development Program (MOONSHOT)
 Research Area: Realization of a society in which human beings can be free from limitations of body, brain, space, and time by 2050
 (Research Supervisor: Norihiro Hagita, Chair and Professor, Art Science Department, Osaka University of Arts)
 Research Theme: Liberation from Biological Limitations via Physical, Cognitive and Perceptual Augmentation
 Research Director: Ryota Kanai (Director, Corporate Planning & Innovation Co-Creation Unit, Advanced Telecommunications Research Institute International (ATR))
 Research Period: October 2020 - March 2026

 

<Background and History of the Research>

Musicians and other performing artists, surgeons, traditional craftsmen and others considered experts in various fields acquire their skills through years of extensive training. In particular, in the performing arts, it has long been thought that the mastering of physical motor skills that produce diverse perceptions is essential for embodying creativity. For instance, while pitch and volume in instrumental performance clearly depend on manipulation of the instrument, there had been no scientific evidence for cases where “an instrument that should produce a certain sound produces a different timbre”—a phenomenon that was widely believed possible among performers and educators. This question was discussed regarding the piano in Nature magazine in the early 20th century, but systematic perceptual experiments and data analysis had not been carried out to date, leaving the question unanswered. Thus, the means for acquiring skills that produce diverse expressions remained unknown, and problems during this process—such as misrecognition of personal limitations and risk of injury or disability arising during skill-acquisition training—persisted. An evidence-based understanding of the mechanisms of technical skill is essential for humans and systems to be able to recommend appropriate training methods, and for the resulting recommendations to be trusted by learners and teachers.

 

<Background and History of the Research>

A research team from the NeuroPiano Institute and Sony Computer Science Laboratories (Sony CSL) revealed that the timbral qualities pianists intended to express were conveyed to listeners, and that the high-precision control of fingertip movement was involved.

The research group used Hackkey, their proprietary high-precision non-contact sensor system, to measure the movements of all 88 keys at 1,000 fps (1 ms temporal precision) and 0.01 mm spatial resolution. This apparatus analyzed keyboard movements when 20 internationally renowned pianists performed with the intent to produce diverse timbral qualities, including bright/dark and light/heavy.

Additionally, the team carried out a psychophysical experiment, with 40 participants—including pianists and individuals with no musical experience—who listened to the recorded performances. The results revealed that the pianists’ intended timbres were consistently perceived by the listeners, regardless of their musical experience. The listeners who were pianists, in particular, were able to distinguish timbral differences with greater sensitivity. This timbral discernment was found to be possible even when controlling for volume and tempo, factors previously thought to influence timbral perception.

Data analysis using a linear mixed-effects (LME) model revealed that contributions to timbral differences are concentrated in a limited set of movement features (e.g., acceleration during escapement, deviation in hand synchronization). It was further experimentally confirmed that notes played by varying only one of these features were perceived by listeners as having a different timbre, providing the first empirical evidence of a causal relationship between key movement and timbre.

These findings have the following significance for musicians and educators:

  • Building a technical foundation to support artistic creativity:This research quantifies the “tacit knowledge” of how pianists produce timbre, paving the way for understanding an artist’s expressive intent and developing new educational methods and technologies that will maximize it. Furthermore, proving that the manipulation of timbre through touch cultivated by artists is a scientifically grounded skill rather than a mere sensory metaphor makes it possible to efficiently learn and acquire the skills to create timbral expressions—which had been difficult to verbalize in instruction to date—by applying it to recommendation systems that present the appropriate movement features to learners.

  • Illuminating the biological mechanisms that produce higher-order perception: The phenomenon in which the same sound can be perceived differently indicates advanced integration of human sensory and motor systems. This research clarifies how dexterous motor control produces higher-order perception and aesthetic experiences, opening new avenues for interdisciplinary research in neuroscience, psychology, and arts studies, and holds additional promise for applications across multiple fields, including skill transfer, rehabilitation, and human interface design.

 

<Future Developments>

This research has clarified the relationship between key movement features and piano timbre, suggesting the possibility for explicitly acquiring a repertoire of movements that can produce a diverse palette of perceptions. This is essential for recommending evidence-based body use and practice methods in physical education for the performing arts, and for empowering both teachers and learners to pursue learning with confidence. While perception research has until now focused mainly on lower-level perceptual information such as pitch, loudness, and rhythm, the advance of future research into timbre and other higher-level perceptual information is expected to lead to clarification of the underlying brain information processing mechanisms, as well as the development of training methods that skillfully utilize advanced technologies. Moreover, the thrill of using one’s body to improve and achieve something that was once impossible is something that is shared across disciplines beyond music performance, including sports, cooking, painting, and even surgery. This research holds promise for generating ripple effects across multiple disciplines.

The involvement of science and technology in music learning has lagged behind significantly,  compared to that in fields such as sports and medicine. As a result, many artists all over the world have long been beset with the problem of embodying artistic expression and creativity while being constrained by physical and mental limitations. The knowledge regarding the foundational skills for producing diverse expressions provided by this research will contribute to the creation of a future society where artists are liberated from physical and mental constraints and can fully embody their creativity. This will be achieved through the establishment of a new evidence-based form of music education grounded in dynaformics, the science of music performance.

Timbres are separated based on key movement feature values. Different colors represent different timbres. Key movement feature values include acceleration when key escapement is reached (acc-escapement), initial velocity when the key is struck (onset-noise), and temporal overlap of consecutive keystrokes (overlap).Different timbres are grouped at distinct positions within this space

 

Study links shift work to higher risk of kidney stones, influenced by lifestyle factors



Comprehensive analysis in Mayo Clinic Proceedings highlights the need for targeted strategies in the workplace to prevent kidney stone disease in shift workers



Elsevier

Lifestyle Factors in the Association of Shift Work with Kidney Stone Events 

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A study in Mayo Clinic Proceedings has revealed that shift workers have a 15% higher risk of developing kidney stones, especially younger workers and those with low levels of manual labor, with body mass index (BMI) and fluid intake playing key mediating roles.

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Credit: Mayo Clinic Proceedings / He et al.





Rochester, MN, October 1, 2025 – A study evaluating how various shift work patterns contribute to kidney stone risk has revealed that shift workers have a 15% higher risk of developing kidney stones, especially younger workers and those with low levels of manual labor. Body mass index (BMI), fluid intake, and other lifestyle factors play key roles contributing to the occurrence of kidney stones. The findings of the novel study in Mayo Clinic Proceedings, published by Elsevier, indicate that kidney stone prevention efforts should extend to shift workers.

Long-term shift work, identified as an irregular work schedule outside conventional daytime work hours, especially night shift work, could disrupt workers’ circadian rhythms, affect metabolism and hormone secretion, alter lifestyles, and lead to adverse health outcomes. The probability of developing chronic diseases, such as cardiovascular diseases, metabolic syndrome, and mental disorders, has been reported to be increased among shift workers. However, kidney stone disease among shift workers has rarely been investigated in prior studies.

Using data from over 220,000 participants from the UK Biobank Study, the researchers of the current study analyzed the association of shift work, including its type, frequency, and duration, with kidney stone events over a median follow-up period of 13.7 years. They also conducted mediation analyses to investigate whether various lifestyle behaviors could explain this relationship.

“This is the first population-based cohort study to comprehensively evaluate how various shift work patterns contribute to kidney stone risk,” explains lead investigator of the study “Lifestyle Factors in the Association of Shift Work with Kidney Stone Events” Yin Yang, PhD, Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. “We found that shift work is associated with a higher risk of kidney stone events; an association that is partially mediated by several lifestyle factors, including smoking, sleep, fluid intake, and BMI.”

The investigators also determined that participants with a longer history of shift work had a slightly lower risk of kidney stones. This may suggest a healthy worker effect or adaptation over time, which warrants further investigation.

Kidney stone disease is a common and preventable urological disease, with an estimated prevalence ranging from 1% to 13% in different regions across the world. It has been associated with an elevated risk of cardiovascular diseases, chronic kidney disease, and renal failure, all of which impose a substantial long-term disease burden. Kidney stone formation is influenced by several intrinsic and extrinsic factors, including genetics, dietary characteristics, physical activity, BMI, and other lifestyle behaviors.

“Kidney stones may be silent or cause acute complications, especially pain that may be sufficiently severe so as to necessitate hospitalization,“ notes Felix Knauf, MD, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, corresponding author of the accompanying editorial “Shift Work and the Risk of Kidney Stones,” pointing out that according to the study, the highest risk for kidney stones occurred in individuals involved with night shift work.

Dr. Knauf elaborates, “A central effect of shift work is the disruption of circadian rhythms. Homeostasis and health are underpinned by physiologic systems, virtually all of which are governed by the biologic clock that dictates the periodicity, tempo, and physiologic effects of circadian rhythms. This also applies to physiologic systems that regulate water balance and the homeostasis of solutes relevant to kidney stone formation. Thus, the observed effect of shift work in promoting kidney stone formation reflects, at least in part, its disruptive effect on circadian rhythms. The findings of this study highlight the need to explore initiatives that seek to remediate the risk factors for kidney stones, including greater flexibility in work schedules.”

Dr. Yang concludes, “Our findings come at a time when the effect of shift work on urological health is an urgent priority globally. Supporting healthy lifestyle habits among shift workers could have a meaningful impact on their urological health. Workplace health promotion initiatives could integrate educational programs emphasizing the importance of weight management, increased fluid intake, healthy sleep habits, reduced sedentary behavior, and smoking cessation. These interventions have the potential to alleviate the adverse effects of shift work on kidney stone formation and improve workers’ health.”

 

 

Stronger together: Community involvement is key for new transport adoption



Study reveals a gap between willingness and actual use among people with poor health




Osaka Metropolitan University

Demand responsive transportation in Senboku New Town, Osaka 

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Closing the mobility gap for the people with poor health

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Credit: Haruka Kato, Osaka Metropolitan University



Demand-responsive transport (DRT) is promoted as an inclusive solution to first- and last-mile mobility challenges, but little is known about the barriers to adoption among people with poor health.

Dr. Haruka Kato, a junior associate professor at Osaka Metropolitan University, examined the factors shaping this population's acceptance and use of DRT in Senboku New Town, Osaka. The study applied the Unified Theory of Acceptance and Use of Technology-3 (UTAUT-3) to assess the opportunities and challenges for using DRT.

The findings reveal that community involvement is a powerful driver of acceptance. The study showed that residents' intention to use DRT was strongly linked to citizen engagement, alongside personal habits and innovativeness. However, the research uncovered a critical gap for people with poor health: the willingness to use the service did not automatically lead to actual use. Many potential users faced practical barriers despite their high interest. The most significant hurdles were a lack of convenient mobility points near their homes and difficulties navigating smartphone-based booking systems. The findings strongly suggest that increasing the density of stops in residential areas is crucial to making DRT truly accessible.

“In Senboku New Town, DRT services operate through a cross-sector partnership program, where the DRT administrator and operator is partnered with 15 local commercial, amenity, and healthcare facilities to establish on-site mobility points and offer discounts to DRT users,” said Dr. Kato. “These cross-sector partnerships significantly strengthen the intention to use DRT by increasing citizen engagement.”

The findings were published in Transportation Research Interdisciplinary Perspectives.

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About OMU  

Established in Osaka as one of the largest public universities in Japan, Osaka Metropolitan University is committed to shaping the future of society through the “Convergence of Knowledge” and the promotion of world-class research. For more research news, visit https://www.omu.ac.jp/en/ and follow us on social media: XFacebookInstagramLinkedIn

 

Rare fossil reveals ancient leeches weren’t bloodsuckers



430-million-year-old fossil upends assumptions




University of California - Riverside

Leech comparison 

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The fossil leech compared with a modern leech. Double arrows indicate the large caudal sucker used for attachment, single arrows indicate body annulations. 

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Credit: Andrew J Wendruff/Otterbein University and Takafumi Nakano/Kyoto University





A newly described fossil reveals that leeches are at least 200 million years older than scientists previously thought, and that their earliest ancestors may have feasted not on blood, but on smaller marine creatures. 

“This is the only body fossil we’ve ever found of this entire group,” said Karma Nanglu, a paleontologist with the University of California, Riverside. He collaborated with researchers from the University of Toronto, University of São Paulo, and Ohio State University on a paper describing the fossil, which is now published in PeerJ.

Roughly 430 million years old, the fossil includes a large tail sucker — a feature still found in modern leeches — along with a segmented, teardrop-shaped body. But one important feature isn’t found in this fossil: the forward sucker that many of today’s leeches use to pierce skin and draw blood.

This absence, along with the fossil’s marine origin, suggests a very different early lifestyle for the group known as Hirudinida. Rather than sucking blood from mammals, reptiles, and other vertebrates, the earliest leeches may have roamed the oceans, consuming soft-bodied invertebrates whole or feeding on their internal fluids.

“Blood feeding takes a lot of specialized machinery,” Nanglu said. “Anticoagulants, mouthparts, and digestive enzymes are complex adaptations. It makes more sense that early leeches were swallowing prey whole or maybe drinking the internal fluids of small, soft-bodied marine animals.”

Previously, scientists believed leeches emerged about 150–200 million years ago. That timeline has now been pushed back by at least 200 million years, thanks to the fossil found in the Waukesha biota, a geological formation in Wisconsin known for preserving the bodies of soft tissue animals that usually decay before fossilization.

Preserving a leech fossil is no small feat. Leeches lack bones, shells, or exoskeletons that are most easily preserved over millions of years. Fossils like this require exceptional circumstances to preserve, often involving near-immediate burial, a low-oxygen environment, and unusual geochemical conditions.

“A rare animal and just the right environment to fossilize it — it’s like hitting the lottery twice,” Nanglu said.

The fossil came to light during a broader study of the Waukesha site by researchers at Ohio State University, who are co-authors on this paper. Though initially unrecognized for what it was, the specimen caught Nanglu’s eye during the early pandemic years. 

He consulted with leech specialists, including lead author Danielle de Carle of the University of Toronto, and the group worked together to confirm its identity. They were ultimately convinced they’d found a leech because of the tail sucker and the clear body segmentation, which is a combination only found in leeches.

Today’s leeches are found in freshwater, saltwater, and even on land. Their feeding behaviors are equally diverse, from scavenging to predation to parasitic blood feeding. But understanding their origin has been difficult because soft-bodied animals rarely leave fossils.

Nanglu, who studies creatures rarely found in the fossil record, said the find is part of a larger effort to trace the early history of complex life, and to challenge assumptions about the past.

“We don’t know nearly as much as we think we do,” he said. “This paper is a reminder that the tree of life has deep roots, and we’re just beginning to map them.”

“It’s a beautiful specimen,” Nanglu added. “And it’s telling us something we didn’t expect.”