Wednesday, June 25, 2025

 

Your smartwatch might know you’re sick before you do — and it might help stop pandemics



Texas A&M research shows wearable health tech can detect infections like COVID-19 and flu within hours — enabling faster isolation, treatment and prevention




Texas A&M University

Dr. Martial Ndeffo-Mbah 

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Dr. Martial Ndeffo-Mbah, an assistant professor in the Texas A&M College of Veterinary Medicine and Biomedical Sciences’ (VMBS) Department of Veterinary Integrative Biosciences, is doing research on how smartwatches can help with future pandemics.

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Credit: Texas A&M University





Smartwatch features that measure heart rates, oxygen levels, fitness levels and sleep quality have been marketed as valuable tools for people who are eager to monitor their health.

But what if these features could do more than detect potential health issues — what if they could prevent potential health disasters such as pandemics?

Recent studies have demonstrated that smartwatches’ health apps and sensors provide enough information to accurately predict when a person has become infected with a disease like COVID-19 or the flu, even within as few as 12 hours after infection. 

In a study published this March in PNAS Nexus, researchers at Texas A&M University and Stanford University used a computational model to estimate how smartwatch-based detection could help control the spread of pandemics such as COVID-19 and pandemic influenza. 

Their findings suggest that smartwatch detection could lower pandemic transmission risk by nearly 50% by providing early warnings to people with potential infections, prompting them to isolate and greatly lowering their chances of spreading disease.  

“Even before a person starts showing symptoms of disease, there are physiological changes that happen to their body — like an increase in temperature or a change in sleeping pattern — that are usually too subtle for a person to notice but that can be detected by a smartwatch,” said Dr. Martial Ndeffo-Mbah, an assistant professor in the Texas A&M College of Veterinary Medicine and Biomedical Sciences’ (VMBS) Department of Veterinary Integrative Biosciences. 

As a result, if used at scale, smartwatches could effectively end pandemics before they begin by warning people to take precautions — including getting an official diagnosis through traditional testing — much earlier in the infection cycle than they would normally.

“Research on influenza from the Centers for Disease Control and Prevention indicates that most people initiate treatment quite late, many days after the onset of symptoms, when they should ideally begin treatment before symptoms begin,” Ndeffo said. “Even in the presymptomatic stage, infected individuals are often contagious; studies have shown that as much as 44% of COVID-19 infections were transmitted by presymptomatic individuals.”

Using smartwatches, then, could make the problem of disease transmission more personal and encourage more people to take practices like isolating and getting tested more seriously, increasing the overall efficacy of existing tools.

“The protocols for COVID-19 included steps like isolating even after being in contact with someone who is sick, but many people tend to ignore that advice if they don’t feel sick themselves,” Ndeffo said. “With a smartwatch, you could find out in real time — with a high degree of accuracy — if you are starting to get ill, which would hopefully give you a stronger motivation to follow protocols.

“Additionally, while we focused our recent publication on two respiratory diseases, there is a lot of potential to use smartwatches as a preventative tool for many other illnesses, including RSV,” he said. “Whenever the immune system responds to infection, there will be physiological changes that a smartwatch could help detect.”

Transforming Disease Diagnosis

Testing remains one of the most important tools for stopping the spread of disease because people are more likely to take precautions once they have a diagnosis. But even with high-quality tests easily available to most people, there is room for improvement.

“During the COVID-19 pandemic, at-home testing kits became very popular, which is a good thing because they’re a great public health tool,” Ndeffo said. “But there is a problem with how they are used — people might only use a test if they feel sick or are about to travel, and they probably only test themselves once. That’s not frequent enough to catch every infection, especially if you want to catch them early.” 

Early detection with smartwatches could be the key to catching more infections, and it can also prompt people to seek early treatment.

“If you can seek treatment early, you may be able to prevent the worst symptoms from occurring, which is particularly important for high-risk and immunocompromised individuals,” Ndeffo said.

Creating A Personal Stake In Prevention

One of the challenges of developing new public health tools is motivating large numbers of people to comply with disease-prevention protocols.

“If you wake up in the morning and feel a little tired, you’re probably not going to assume that you need to get tested for COVID-19 or the flu, especially when some of the tests involve nose swabbing and other hassles,” Ndeffo said. “So, we are considering how smartwatches may give people more information that will help them see the benefits of reducing contact and getting tested. We hope it will reach people who are not reached by traditional testing alone.”

While research teams are already making headway toward being able to use smartwatches on a large scale for disease prevention, there is still work to be done.

“Teams are working on the science and epidemiology side, and developers are working on the technology,” Ndeffo said. “Because there is so much potential good that this technology can do, we are working hard to make sure we get it right.”

By Courtney Price, Texas A&M University College of Veterinary Medicine and Biomedical Sciences

 

New PET tracer identifies diverse invasive mold infections behind life-threatening illnesses in cancer and transplant patients



Society of Nuclear Medicine and Molecular Imaging
Representative 18F-FDS PET/CT and PET/MRI images of patients with pulmonary and cerebral invasive mold infections. 

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Figure 1. Representative 18F-FDS PET/CT and PET/MRI images of patients with pulmonary (n = 3) and cerebral (n = 2) invasive mold infections.

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Credit: Images created by Ruiz-Gonzalez et al., Johns Hopkins University School of Medicine, Baltimore, MD.





NEW ORLEANS (June 23, 2025)—A novel PET radiotracer can accurately detect a wide range of mold species that are linked to dangerous infections, according to new research presented at the Society of Nuclear Medicine and Molecular Imaging 2025 Annual Meeting. The imaging agent has the potential to dramatically enhance the diagnosis and monitoring of invasive mold infections in patients.

Advances in cancer and immunosuppressive treatments have helped many patients live longer, but they also leave more people with weakened immune systems, making invasive mold infections increasingly common. With mortality rates of invasive mold infections reaching up to 85 percent, early and accurate diagnosis followed by timely treatment is critical to improving patient outcomes.

“Currently it’s very difficult to detect invasive mold infections,” said Carlos Ruiz-Gonzalez, MD, a postdoctoral research fellow at Johns Hopkins University Medical School in Baltimore, Maryland. “Definitive diagnosis often depends on invasive procedures or on biomarkers that lack sensitivity for many mold species. In this study, we aimed to develop a PET tracer capable of detecting a broad range of mold infections and distinguishing them from inflammation with high sensitivity and specificity.”

The imaging agent, 18F-FDS, was first evaluated in vitro to determine its ability to detect 30 different strains of disease-causing molds collected from infected patients. 18F-FDS PET/CT was then performed to identify fungal infections in mice with weakened immune systems, as well as in four human patients with confirmed invasive mold infections, and five control patients with inflammatory diseases or cancer, but no infections.

18F-FDS was found to quickly and specifically accumulate inside a wide range of disease-causing molds (including drug-resistant strains) while showing no uptake in heat-killed molds or human cells. Among mice, it accurately identified fungal infections in the lungs, brain, and sinuses, and was able to distinguish these from non-infectious inflammation. In patient studies, 18F-FDS PET safely detected and localized mold infections—including one missed by a previous brain MRI.

“This research demonstrates that 18F-FDS PET is a promising, noninvasive diagnostic tool to detect mold-related invasive fungal diseases,” noted Ruiz-Gonzalez. “What’s more, since 18F-FDS can be easily produced from 18F-FDG, it can be synthesized on demand and made available globally. This can have a real impact for patients around the world.”

Abstract 252079. “18F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections in patients,” Carlos Ruiz-Gonzalez, Oscar Nino-Meza, Medha Singh, Yuderleys Masias-Leon, Amy Kronenberg, Madelyn Shamble, Xueyi Chen, Mona Sarhan, Elizabeth Tucker, Laurence Carroll, Kenneth Cooke, Olivia Kates, Shmuel Shoham, Sean Zhang, and Sanjay Jain, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Link to Abstract

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All 2025 SNMMI Annual Meeting abstracts can be found online.

About the Society of Nuclear Medicine and Molecular Imaging
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.

SNMMI’s members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit 
www.snmmi.org.

 A game-changing wireless implant for personalized chronic pain relief



USC researchers have developed a groundbreaking ultrasound device that could reduce our reliance on addictive painkillers



University of Southern California

A Game-Changing Wireless Implant for Personalized Chronic Pain Relief 

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The new implantable device for chronic pain management is small and flexible

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Credit: The Zhou Lab at University of Southern California (USC).





51.6 million Americans live with chronic pain. A new device created by USC biomedical engineers could help sufferers avoid the need for opioids. Image/Karolina Grabowska, Pexels.

Chronic pain is a debilitating condition that severely impacts quality of life, often leading to reliance on opioid medications with their severe side effects and addiction risks. According to the U.S. Pain Foundation, 51.6 million Americans live with chronic pain. For over 17 million sufferers, their chronic pain is high-impact – frequently limiting their life or work activities. 

Current implantable electrical stimulators offer an alternative by stimulating the spinal cord to block pain signals from reaching the brain. But these devices come with drawbacks like high cost, invasive surgery, and the need for frequent battery replacements. Now, researchers from the Zhou Lab in USC Viterbi’s Alfred E. Mann Department of Biomedical Engineering, in collaboration with the Jun Chen Group at UCLA, have developed a revolutionary solution: a flexible ultrasound-induced wireless implantable (UIWI) stimulator secured to the spine and designed for personalized, self-adaptive chronic pain management.

This groundbreaking device, detailed in Nature Electronics, represents a significant leap forward in pain therapy. While current spinal cord stimulators can be unwieldy and are hard-wired to batteries, the new device is designed to bend and twist with movement and is powered by a wearable ultrasound transmitter without the need for a battery. It also harnesses machine learning algorithms to customize treatment for each patient. The work was led by Zohrab A. Kaprielian Fellow in Engineering Qifa Zhou, who is also a professor of ophthalmology at the Keck School of Medicine of USC.

Pain Relief on Demand: How the Implantable Stimulator Works

At the heart of this innovation is its wireless power supply, eliminating the need for bulky batteries and complex wired interfaces that often require repeated surgeries. The UIWI stimulator receives its energy from an external, wearable ultrasound transmitter (WUT). Ultrasound offers a safe, effective non-invasive method for deep-tissue penetration. The device converts mechanical waves into electrical signals through a phenomenon called the piezoelectric effect. The core of the UIWI stimulator is a miniaturized piezoelectric element made from lead zirconate titanate (PZT), a highly efficient material for converting incoming ultrasound energy into the electrical power needed for stimulation.

“What truly sets this device apart is its wireless, smart and self-adaptive capability for pain management,” Zhou said. “We believe it offers great potential to replace pharmacological schemes and conventional electrical stimulation approaches, aligning with clinical needs for pain mitigation.”

Ph.D. candidate in the Zhou Lab and lead author Yushun (Sean) Zeng said the wireless smart miniaturized stimulator had the ability to produce sufficient electrical stimulation intensity by using ultrasound energy, resulting in a more personalized, targeted and localized treatment.

“This energy-converting type is critical for deep stimulation, as ultrasound is a non-invasive and highly penetrating energy in clinical and medical areas,” Zeng said. “By leveraging wireless ultrasonic energy transfer and closed-loop feedback system, this UIWI stimulator removes the necessity for bulky implanted batteries and allows for real-time, precisely adjustable pain modulation.”

“From a clinical standpoint, incorporating deep learning–based pain assessment enables dynamic interpretation and response to fluctuating pain states, which is essential for accommodating patient-specific variability.” added Zhou Lab Ph.D. candidate Chen Gong, also a lead author on the paper.

The device works by:

Detecting pain: The system continuously monitors brain recordings, specifically electroencephalogram (EEG) signals, which reflect a patient’s pain levels.
Harnessing AI to assess pain levels: A sophisticated machine learning model, based on a neural network called ResNet-18, analyzes these brain signals and classifies pain into three distinct levels: slight pain, moderate pain, and extreme pain. This AI model boasts a 94.8% overall accuracy in distinguishing between these pain states.
Adapting treatment as needed: Once a pain level is identified, the wearable ultrasound transmitter automatically adjusts the acoustic energy it transmits. The UIWI stimulator can then sense the propagated energy and convert it into electrical intensity, stimulating the spinal cord. This creates a closed-loop system that provides real-time, personalized pain management.
The UIWI stimulator itself is flexible, bendable, and twistable, allowing for optimal placement on the spinal cord. The electrical stimulation it provides to the spinal cord works by rebalancing the signals that transmit and inhibit pain, effectively suppressing the sensation of pain.

Demonstrated Success in the Lab
The Zhou Lab team tested the UIWI stimulator in rodent models, with results demonstrating its effectiveness for pain management.

Researchers successfully relieved chronic neuropathic pain caused by both mechanical stimuli (like a pin prick) and acute thermal stimuli (infrared heat).

Lab tests showed that treatment from the UIWI stimulator led to significant reductions in pain indicators. In one experiment to evaluate whether an animal associates an environment with pain relief, rodents showed a clear preference for the chamber where the pain management system was activated, further confirming the device’s effectiveness.

The Future of Personalized Pain Relief

The successful development and testing of the UIWI stimulator mark a pivotal moment in the quest for advanced pain management. The flexible design of the implant and its integration with sophisticated AI algorithms offer a dynamic and personalized treatment approach that can adapt to the fluctuating and highly individual nature of chronic pain.

Looking ahead, Zhou and his collaborators are hoping for even more advanced applications of the device. Zhou said that future designs could miniaturize the components further, enabling less invasive device implantation — for instance, with a syringe. The wearable ultrasound transmitter could also evolve into an untethered, miniaturized device or even a wearable ultrasound array patch, potentially combining imaging capabilities with energy delivery for real-time monitoring and targeted stimulation. Future iterations could also be controlled by smartphone software, offering even more robust personalized pain management.

Zhou said the aim of the device was to transform chronic pain management, moving beyond the limitations of current solutions to offer a truly personalized, intelligent, and effective pathway to pain relief.

“Our findings highlight the potential of ultrasonic implantable electronics in clinical and translational chronic pain management,” Zeng said.

ICYMI

Study casts doubt on ‘incestuous royalty’ in Neolithic Ireland




University of York

Newgrange monument 

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The Newgrange prehistoric monument in Ireland is a large circular mound containing a chamber. 

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Credit: Photo credit: TJP Finn CC BY-SA 4.0




New research has cast doubts over suggestions an incestuous social elite ruled over the ancient people of Ireland more than 5,000 years ago.

Researchers examined the evidence from burials of individuals at the Newgrange prehistoric monument in Ireland - a large circular mound containing a chamber where cremated and unburnt human remains were placed, the discovery of which led to speculation that those buried there must have been from an elite class or a royal family.

In 2020, the DNA analysis of a bone skull fragment found in the chamber, however, suggested that at least one of the individuals buried there was the result of a relationship between two siblings or a parent and child, and was also distantly related to others buried in the chamber.

It is believed that only particular individuals were buried in the chamber and therefore they must have held a ‘special’ position in society.  The assumption was that if an individual born of incest was placed in the chamber, that this practice must have been ‘accepted’ by society, possibly because it was ‘common’ among a ruling elite.

A research team, including the University of York and University College Dublin, however, have now shown that there is no corroborating evidence in nearby settlements, dietary practices, or trade, that an elite existed either economically or socially.

Researchers now believe the society at the time was more equal, based on the fact that they appeared to share and exchange resources, as well as live in similar dwellings.

Professor Penny Bickle from the University of York’s Department of Archaeology, said: “The evidence all points to a much more collective ethos. There are not wide disparities in diet, houses are relatively flimsy, and all similar to each other.  

“There are no large settlement systems or trade mechanisms, and we also don’t see production of craft on the scale that we see in other ancient societies such as in Ancient Egypt, where incest was  thought to be practiced by the ruling elite.

“We can only begin to understand these monuments and tombs if we examine the social lives or the communities that built and use them, and when we start to do this, this idea of a ‘social elite’ or a form of royalty starts to appear less likely.”

Older than Stonehenge and the Pyramids of Giza, Newgrange is believed to have been built by a farming community that prospered in the Boyne Valley, County Meath, some 5,000 years ago.  Newgrange was rediscovered in AD 1699 and its interior had been heavily disturbed prior to its modern excavation in the 1960s, and so researchers question whether this was even the original burial place of the skull fragment, referred to as NG10, dated to 3340 - 3020 BC.

The genetic clustering in passage tombs, such as at Newgrange, typically reflects very distant biological relationships - like second cousins or great-great-great-grandparents - rather than close familial ties.  To establish if the tombs were reserved for an elite, researchers say they would expect much closer genetic ties than they have seen at Newgrange. 

It is more likely that these tombs were places that reflect family, work, and other social relationships, rather than the mark of an elite family group. 

Associate Professor Jessica Smyth, from University College Dublin, said: “People were definitely being selected for burial in passage tombs - the whole community does not end up in these monuments. However, we don’t know the reasons behind this selection, and why they were thought to be special.

“Unlike today, bodies don’t tend to be buried ‘whole’ or ‘intact’ in this time period. Before they end up in megalithic monuments, bodies are broken down, sometimes cremated and even circulated around their communities.”

As so many of the dead found in these passage tombs were broken down and mixed with cremated remains, and possibly moved around to different places in the landscape, it is not clear the people who placed NG10 fragment in Newgrange knew who they were in life or who the parents of this individual were, casting further doubt on how ‘special’ the individual might have been. 

Professor Penny Bickle said: “It is by no means clear that the monument was the first burial site of NG10 and the tomb grew in stages, so tracing who this individual was is a very difficult task indeed.  As it stands the incestuous origins of NG10 is a one-off compared to all of the DNA data we have for Neolithic Ireland.

“There are still many questions to solve here, but building this picture means looking at the monument together with the society that was built up around it, and from this, we get a step closer to understanding a community that was much more inclusive and equal than previously thought.”

The research is published in the journal Antiquity.