Friday, September 05, 2025

 

Teen loneliness triggers ‘reward seeking’ behaviour




University of Cambridge

Isolation room 

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Adolescents spent time alone and completed various tasts to test their response to short periods of isolation.

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Credit: Emily Towner





\A study has found that adolescents become highly motivated to seek rewards after just a few hours of social isolation. This may be beneficial in driving them towards social interaction, but when opportunities for connection are limited could lead them to pursue less healthy rewards like alcohol or drugs.

When we feel socially isolated, our brain motivates us to seek rewards. Current theory holds that this is a beneficial evolutionary adaptation to help us reconnect with others.

The University of Cambridge-led study found that people in their late teens are very sensitive to the experience of loneliness. After just a few hours without any social interaction, adolescents make significantly more effort to get rewards.  

This increased motivation to seek rewards can help with social reconnection. But when connecting with others is not possible, the behaviour change might be problematic – for example, by making some people more prone to seek out rewards such as alcohol or recreational drugs.

The study found that the effect was stronger in adolescents who reported feeling lonelier while in isolation. When study participants were allowed to interact with others on social media during isolation, they reported feeling less lonely – and their reward-seeking behaviour changed less dramatically as a result.

The report is published today in the journal Communications Psychology.

“Our study demonstrates just how sensitive young people are to very short periods of isolation,” said Dr Livia Tomova, first author of the report, who conducted the study while in the Department of Psychology at the University of Cambridge.

“We found that loneliness significantly increases adolescents’ motivation to seek out rewards – whether that’s more social contact, money, or something else,” added Tomova, who is now based at the University of Cardiff.

Studies suggest that adolescent loneliness has doubled worldwide over the past decade. Social media has been suggested as the culprit, but the researchers say many other changes in society could also be to blame.

“Social media can lead to loneliness in some adolescents, but our study suggests that this relationship is complex,” said Professor Sarah-Jayne Blakemore in the University of Cambridge’s Department of Psychology, senior author of the report.

She added: “Virtual interaction with others seems to make isolated teens less driven to seek external rewards, compared to when they are isolated without access to social media. That suggests social media might reduce some of the negative effects of isolation – but of course we don’t know what potentially harmful effects it might have at the same time.”

While study participants got less bored and lonely in isolation if they had access to social media, they still experienced the same decrease in positive mood as those without access.

Social interaction is a basic human need, and lack of it leads to loneliness. Until now there has been very limited understanding of how loneliness affects adolescent behaviour, with most scientific experiments carried out in animal models.

HOW WAS THE STUDY DONE?

Researchers recruited young people from the local area in Cambridge, UK, conducting extensive screening to gather a group of 40 adolescents aged 16-19 who had good social connections, no history of mental health problems, and average levels of loneliness for their age group.

Participants were given initial tests to establish their baseline score for each task. Then on two different days, they were asked to spend between three and four hours alone in a room before completing the same computer-based tasks again.

On one of the isolation days participants had no social interaction at all, but on the other they had access to virtual social interactions through their phone or laptop.

The study found that when virtual interactions were available, almost half the participants spent over half their time online – predominantly using Snapchat, Instagram and WhatsApp to message their friends.

Overall, the study found that participants became more motivated to look at images of positive social interactions, and to play games where they could win money, after being in isolation for around four hours. They were also better at learning how to get these rewards in ‘fruit machine’-type games.

If they could interact virtually with others while in isolation, they reported feeling less lonely. They were also less inclined to make an effort in the tasks than when they didn’t have virtual social interaction during their isolation.

 

Clean air, natural spaces, healthy diets and strong social bonds linked to lower inflammation in childhood



Early-life environments influence immune regulation at the protein and cellular level, supporting cardiometabolic, respiratory, and neurodevelopmental health




Barcelona Institute for Global Health (ISGlobal)





According to a new study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by ”la Caixa” Foundation, in collaboration with INSERM - Université Grenoble Alpes, better indoor air quality, proximity to natural spaces, healthy diets, and strong social networks are associated with reduced and better-regulated inflammation in childhood. The findings, published in Environment International, offer new insights into how early-life environmental exposures shape long-term immune function and overall health.

The environment we grow up in plays a critical role in shaping our lifelong health. The exposome refers to the totality of environmental exposures from conception onward, including factors such as air pollution, nutrition, stress, and social context. While many studies have explored how individual environmental factors affect children’s health, few have examined their shared impact, particularly on immune system regulation, which is a central pathway in the development of chronic diseases such as obesity, diabetes, and respiratory disorders

This study is based on the Human Early Life Exposome (HELIX) cohort in the framework of the ATHLETE project, which includes 845 children from six population-based birth cohorts in the UK (BiB), France (EDEN), Spain (INMA), Lithuania (KANC), Norway (MoBa) and Greece (RHEA). “We investigated how a wide range of pre- and postnatal environmental exposures influence immune function in children and how those immune profiles relate to their cardiometabolic, respiratory/allergic, and neurodevelopmental health”, explains Léa Maitre, coordinator of the Exposome Hub at ISGlobal and last author of the study.

 

Assessing the impact of early-life environments

The authors examined 91 different environmental exposures occurring during pregnancy and childhood. These were grouped into 13 exposure families, including outdoor exposures, such as air pollution and surrounding green and blue spaces; indoor exposures, including household air pollutants and chemical agents; lifestyle factors, such as diet physical activity, sleep and tobacco exposure; and socioeconomic indicators, like parental education, income and social support.

“To assess immune health, we analyzed blood samples from each child using three biological layers: white blood cell composition, plasma protein concentrations and genome-wide DNA methylation of white blood cells”, says Ines Amine, researcher at INSERM - Grenoble Alpes University and first author of the study.

Advanced statistical models were used to identify immune “signatures”—patterns in the immune system—that were associated with a composite health score combining respiratory, metabolic, and cognitive outcomes. A high-dimensional reduction algorithm, Regularized Generalized Canonical Correlation Analysis (RGCCA), was utilized for this purpose. RGCCA is particularly well-suited for multi-omics data integration in exposome studies. This work was carried out in collaboration with the University Paris-Saclay, CNRS, CentraleSupélec.

 

Immune profiles associated with better health scores

The study found three types of immune signatures in children that were linked to better overall health. Two were based on proteins in the blood and showed lower levels of inflammation. The third pattern was based on white blood cells and showed a more balanced and well-regulated immune system. These beneficial immune signatures were linked to specific environmental exposures during childhood: better indoor air quality, proximity to blue spaces (e.g., lakes, rivers, coastlines), healthier dietary patterns and higher levels of social capital (e.g., social engagement, family and community support).

“Our findings emphasize the importance of these environmental factors in mitigating immunotoxicity related to child health,” concludes Léa Maitre. “Improving indoor air quality, supporting healthy diets, preserving access to natural spaces, and strengthening community support systems are actionable strategies that can promote better key inflammatory processes, which hold significant clinical relevance for cardiometabolic, respiratory and neurodevelopmental health in children.”

 

Reference

Amine, I., Anguita-Ruiz, A., Guillien, A., Basagaña, X., Bustamante, M., Borràs, E., Cirach, M., Dedele, A., Dobaño, C., Garcia-Aymerich, J., Granum, B., Grazuleviciene, R., González, J. R., Julvez, J., Keun, H., López-Vicente, M., McEachan, R., Moncunill, G., Nieuwenhuijsen, M., … Maitre, L. (2025). Early-life exposome and health-related immune signatures in childhood. Environment International202(109668), 109668. https://doi.org/10.1016/j.envint.2025.109668

 

The UJI reflects on the scientific evaluation system and presents its team's vision



The Universitat Jaume I in Castelló has published the results of a survey among its research staff on the current model of scientific evaluation





Universitat Jaume I

The UJI reflects on the scientific evaluation system and presents its team's vision 

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What really measures the quality of research? Beyond articles, citations, and journal impact, the way in which the work of research staff is evaluated is the focus of attention internationally. To bring this debate closer to society and the university community, the Universitat Jaume I in Castelló (UJI) has published the results of a survey conducted among its research staff on the current model of scientific evaluation.

The current system is based mainly on quantitative indicators, such as the number of publications, the position of the journals in which they are published, and the number of citations received. This approach, which is the most widely used, seeks to measure scientific performance objectively, but often overlooks aspects such as quality, social relevance, interdisciplinarity and working conditions. For this reason, the UJI wanted to give its staff a voice through a survey that gauges how this model is perceived and what changes would be desirable.

According to the results report, a significant proportion of research staff believe that, although figures can guide and stimulate work, they do not always reflect the real value of research or its impact on society. Concern is also expressed about the effect this model may have on scientific diversity and staff well-being, as well as the widespread lack of awareness of international initiatives seeking to transform this culture of evaluation, such as the San Francisco Declaration on Research Assessment (DORA), to which the UJI is a signatory, or the Coalition to Advance Research Assessment (CoARA), of which it is an active member through its Spanish chapter.

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Credit: Universitat Jaume I of Castellón





What really measures the quality of research? Beyond articles, citations, and journal impact, the way in which the work of research staff is evaluated is the focus of attention internationally. To bring this debate closer to society and the university community, the Universitat Jaume I in Castelló (UJI) has published the results of a survey conducted among its research staff on the current model of scientific evaluation.

The current system is based mainly on quantitative indicators, such as the number of publications, the position of the journals in which they are published, and the number of citations received. This approach, which is the most widely used, seeks to measure scientific performance objectively, but often overlooks aspects such as quality, social relevance, interdisciplinarity and working conditions. For this reason, the UJI wanted to give its staff a voice through a survey that gauges how this model is perceived and what changes would be desirable.

According to the results report, a significant proportion of research staff believe that, although figures can guide and stimulate work, they do not always reflect the real value of research or its impact on society. Concern is also expressed about the effect this model may have on scientific diversity and staff well-being, as well as the widespread lack of awareness of international initiatives seeking to transform this culture of evaluation, such as the San Francisco Declaration on Research Assessment (DORA), to which the UJI is a signatory, or the Coalition to Advance Research Assessment (CoARA), of which it is an active member through its Spanish chapter.

With the aim of bringing this debate to its community and society in general, the UJI has organized the 6th Conference on Research Ethics on 24 September at the Doctoral School. The event will include the participation of Pilar Paneque Salgado, director of the National Agency for Quality Assessment and Accreditation (ANECA), who will explain the changes proposed in Spain; Senena Corbalán García, who will present the work of the Spanish chapter of CoARA; and Ángel Delgado Vázquez, who will address how to integrate quantitative and qualitative assessments in a more balanced way.

The session, promoted by the Vice-Rector's Office for Research in collaboration with the European CATALISI project, will be open to all interested parties. In addition, the complete results of the survey can be consulted in the university's institutional repository and on the CoARA-UJI chapter website (https://www.uji.es/investigacio/base/coara/), where you will also find the action plan prepared by the Universitat Jaume I as an institution affiliated with the coalition.

With this set of actions, the UJI reinforces its commitment to improving the scientific evaluation system, promoting more diverse, responsible research that is connected to social needs.

 

Beavers return to the forest landscape, reviving its natural environment




University of Helsinki
An inundated site caused by beavers 

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An inundated site caused by beavers and flowing into Keltaoja ditch in Evo, Finland. 

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Credit: Petri Nummi.





A long-term study spanning more than 50 years illustrates how the beavers that have returned to the Evo region in southern Finland have increased habitat biodiversity. This speaks to their significant role as ecosystem engineers, enabling a wider range of species in the area. 

Landscapes shaped by beavers provide favourable conditions for a number of species, including moose, voles and diving beetles. Beaver patches, or areas modified by beavers in nature – such as new and old inundated sites as well as beaver meadows formed after flooding – create diverse habitats that are at different stages of ecological succession, or the process of how species compositions change in ecological communities over time. As a result, a habitat suitability index calculated for different species and groups of species grew almost tenfold over a 54-year period. Thanks to beaver activity, the landscape develops to support a wider range of species and improves habitat connectivity. 

“While the positive effects of the changes brought about by beavers in the boreal region are significant, their long-term effects on biodiversity dynamics remain partly unknown. This is why long time series are needed to understand the far-reaching ecological effects of these changes,” says Senior University Lecturer Petri Nummi from the Department of Forest Sciences, University of Helsinki.

Evo, an area in Finland that also has been planned as a national science park, is suitable for beaver research, among other lines of study, offering a unique time series on the effects of the return of beavers. This study highlights the role of beavers as natural restorers that improve the habitats of many species and boost biodiversity. 

“Beavers are returning to many areas of Europe where they were once hunted to extinction. Whereas in our prior studies we observed patches shaped by beavers, this new study helps to understand the differences between landscapes in areas where beavers occur and where they are absent,” says University Lecturer Sonja Kivinen from the University of Eastern Finland.

 

Reconditioned pacemakers provide new hope for patients in low- and middle-income countries




European Society of Cardiology





Madrid, Spain – 1 September 2025: Procedure-related infection rates were similar with reconditioned and new pacemakers, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.1 

Explaining the rationale for Project My Heart Your Heart, Doctor Thomas Crawford from the University of Michigan, Ann Arbor, USA, said: “Patients in many low- and middle-income countries (LMICs) still have very limited access to cardiac pacing despite its routine use in higher-income countries. Indeed, access to pacemaker implantation is around 200-fold lower in Africa than in Europe.2 To facilitate the use of reconditioned devices, Project My Heart Your Heart has developed a comprehensive protocol for cleaning, functional testing and sterilisation, and has gained FDA approval for their export to countries whose governments have provided express permission for pacemaker importation.3 We initiated a clinical trial to investigate the safety of implanting pacemakers reconditioned using our protocol compared with new devices in several LMICs.” 

A randomised controlled trial was conducted in Kenya, Mexico, Mozambique, Nigeria, Paraguay, Sierra Leone and Venezuela from May 2022 to June 2024. Adult patients with life expectancy of at least two years, a class I indication for pacemaker therapy and no financial means to acquire a new device were randomised 1:1 to receive a reconditioned pacemaker or a new pacemaker. The primary endpoint was procedure-related infection at 12 months. 

The trial included 306 patients who had a mean age of around 71 years. Approximately half were female. Follow-up data at 12 months were available for 259 patients (84.9%). 

Over 12 months, there were two pocket infections requiring explantation in the reconditioned pacemaker group and three in the new pacemaker group. There was one case of superficial cellulitis responsive to antibiotics in the new pacemaker group. Overall, the incidence of procedure-related infections at 12 months was 1.6% in patients in the reconditioned pacemaker group and 3.1% in the new group. The upper bound of the 90% confidence interval for the difference in infection rates between the groups was 2.2%, which is within the pre-specified noninferiority margin of 5%. 

There were no device malfunctions in either group. Lead revisions occurred in nine patients in the reconditioned pacemaker group and five in the new group. Unrelated to the implantation procedure, there were four deaths in the reconditioned pacemaker group and two in the new group.  

Concluding, Doctor Crawford said: “Our trial demonstrates the safety of pacemakers reconditioned using a specific protocol, with noninferior infection rates to new pacemakers and no malfunctions. The work of Project My Heart Your Heart serves as a blueprint that can be replicated by other organisations to enable wider pacemaker reuse. We would also like to expand into reconditioned implantable cardioverter-defibrillator devices, which are even more expensive and out of reach for many patients across the world.”  

 

Notes to editor 

This press release accompanies a presentation at ESC Congress 2025.  

It does not necessarily reflect the opinion of the European Society of Cardiology. 

Funding: The project is funded by private philanthropic donations.  

Disclosures: Doctor Crawford has no disclosures to report related to this trial. 

References and notes: 

1‘Project MHYH: One-Year Results’ presented during HOT LINE 9 on 1 September 2025 at 08:59 to 09:11 in Madrid (Main Auditorium). 

2Bonny A, Ngantcha M, Jeilan M, et al. Statistics on the use of cardiac electronic devices and interventional electrophysiological procedures in Africa from 2011 to 2016: report of the Pan African Society of Cardiology (PASCAR) Cardiac Arrhythmias and Pacing Task Forces. Europace. 2018;20:1513–1526. 

3Crawford TC, Allmendinger C, Snell J, et al. Cleaning and sterilization of used cardiac implantable electronic devices with process validation: the next hurdle in device recycling. JACC Clin Electrophysiol. 2017;3:623–631.

 

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Mirror image molecules reveal drought stress in the Amazon rainforest



New study by the Max Planck Institute for Chemistry shows: The ratio of certain forest scent molecules provides precise insights into the stress state of the rainforest



Max Planck Institute for Chemistry





In 2023, the Amazon rainforest experienced its worst recorded drought since records began. River levels dropped dramatically and vegetation at all levels deteriorated due to intense heat and water shortages. In such conditions, plants release increased amounts of monoterpenes—small, volatile organic compounds that act as a defense mechanism and help communication with their environment. Some molecules, such as α-pinene, which smells like pine, occur as mirror-image pairs, known as enantiomers. 

The ratio of these two forms changes measurably when plants are under stress, for example due to heat or water shortage. Researchers at the Max Planck Institute for Chemistry investigated how this ratio changed in the Amazon before, during, and after the drought period. The results show that under normal conditions a clear ratio was consistently measured, but with increasing drought stress it shifted to ever higher values. In the most extreme phase of the drought, the usual ratio of the two α-pinene variants even reversed. Thus, the mirror molecules of α-pinene can tell us how much stress an ecosystem is currently under. 

Giovanni Pugliese, a scientist from the Max Planck Institute for Chemistry who was on site during the measurement campaign, recalls: “The heat was unbearable when collecting the samples. The forest was clearly suffering; its leaves were yellowing and the dry clay soil was cracking”. The problem in 2023 was that the September to October dry season coincided with an El Niño event. This is part of the global climate oscillation ENSO, and in El Niño mode, it brings extremely low rainfall and high temperatures to the Amazon basin.

Measurements deep in the rainforest

At the measuring station of the Amazon Tall Tower Observatory (ATTO), 150 kilometers northeast of Manaus, the researchers collected air samples at a height of 24 meters directly in the forest canopy. In the laboratory in Mainz, they later determined the ratio of the two α-pinene forms using chiral gas chromatography-time-of-flight-mass spectrometry. 

“First, we determined the ratio in which the two variants occur under normal conditions,” explains Joseph Byron, researcher at the Max Planck Institute for Chemistry and first author of the study. “We then observed how this ratio shifted during the El Niño-impacted dry season and slowly returned to normal afterwards.” 

Plants in survival mode

Project leader Jonathan Williams is impressed by these vegetation responses and explains further, “It is amazing that we can read directly from the air how the rainforest is reacting to current conditions. During the worst part of the drought, when the ratio flipped at midday, we knew that the vegetation had had enough, it had stopped photosynthesizing and closed up its pores to stop losing precious ground water ”.  This work builds on an earlier experimental drought study conducted in an enclosed forest grown within a greenhouse. (See https://www.mpic.de/5265797/spiegelmolekuele-trockenstress). There the Max Planck Research team  then showed that the two mirror-image molecules are released via different processes in the plant: while one form of α-pinene is released immediately after photosynthesis , the mirror molecule comes from storage pools within the plant.  The indoor experiment revealed this relationship and now this behavior has been recorded in the real-world extreme drought situation in the Amazon rainforest.

Significance for climate models

The Amazon rainforest is the world's largest source of biogenic volatile compounds. Using the ratio of α-pinene molecules, these emissions and their changes under drought conditions can now be represented more realistically in climate models. This is crucial because researchers expect more frequent and severe El Niño-related droughts in future.

Background ATTO

ATTO is a German-Brazilian joint project which was launched in 2009. It is managed by the Max Planck Institutes for Biogeochemistry in Jena and for Chemistry in Mainz, as well as by the Brazilian INPA and the Amazon State University (UEA) in Manaus. The project is funded by the German Federal Ministry of Education and Research (BMBF), the Ministério da Ciência, Tecnologia e Inovações (MCTI), the Max Planck Society and the Brazilian organizations including FAPEAM and individual researchers bring funding from other scientific funding agencies. 

The tower aims to deliver groundbreaking findings which will be the basis for improved climate models. With a height of 325 meters, the tower extends the ground-level boundary layer, and provides information from approximately 100 square kilometers of the world´s largest forest area. 

More on ATTO: https://www.mpic.de/3538403/ATTO