Tuesday, September 30, 2025

POSTMODERN ALCHEMY

Steel making could get a makeover




University of Minnesota

Green steel making 

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Ph.D. student, Jae Hyun Nam, worked in the University of Minnesota Characterization Facility to complete these nanometer scale observations.

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Credit: Kalie Pluchel, University of Minnesota




Researchers investigate clean and efficient new method for iron production

MINNEAPOLIS / ST. PAUL (09/29/2025) — A research team at the University of Minnesota Twin Cities has investigated a new method to produce iron, the main component of steel. For the first time, the researchers were able to observe chemical reactions and iron formation in real-time at the nanometer scale. 

This breakthrough has the potential to transform the global iron and steel production industry by improving energy efficiency and lowering costs. The study was recently published in Nature Communications, a peer-reviewed, high impact scientific journal.

According to the paper, the iron and steel industry is the largest industrial emitter of carbon dioxide, responsible for approximately 7 percent of the total global carbon dioxide emissions. Traditional methods for producing iron are pollution-heavy, relying on coke–a type of coal–to remove oxygen from iron ore—a process that has remained largely unchanged for centuries.

This method eliminates the CO2 emissions that have traditionally come from iron-making that can be performed at room temperature. This makes it potentially more efficient and desirable to industry and opens new pathways to innovation in the U.S. based manufacturing industry.

The new process uses hydrogen gas plasma, an ionized gas which dissociates the hydrogen gas producing an abundance of highly reactive hydrogen atoms. When the iron is exposed to this plasma, the highly reactive hydrogen atoms strip the oxygen from the ore producing pure iron and water vapor.

“We developed a new technique that allows us to monitor plasma-material interactions at the nanometer scale, which has never been done before,” said Jae Hyun Nam, first author on the paper and a Ph.D. student in the University of Minnesota Department of Mechanical Engineering.

The team partnered with Hummingbird Scientific, a company that builds products for electron, X-ray and ion microscopy, to create a specialized holder that fits inside of an transmission electron microscope. 

"Overcoming the technical challenges of this research was one of the most difficult experiments we've done," said Peter Bruggeman, a senior author on the paper and University of Minnesota Distinguished McKnight University Professor in the Department of Mechanical Engineering. “Generating plasmas on a scale around the size of a human hair, which is required to obtain the nanometer resolution, creates significant engineering challenges which we collaboratively tackled with Hummingbird Scientific.”

Previous optical methods could only be viewed at a few hundred nanometers—about a thousand times smaller than the diameter of a human hair. This new method will allow researchers to see things at a nanometer resolution, which is 100 times better than previous research. 

“Creating plasma could be energetically a lot more efficient than heating the material," said Andre Mkhoyan, a senior author on the paper and professor and Ray D. and Mary T. Johnson Chair in the University of Minnesota Department of Chemical Engineering and Materials Science. “This innovation could lead to materials being modified with lower energy consumption, ultimately making processes more economically efficient.”

Read the full paper entitled, “Revealing the mechanisms of non-thermal plasma-enabled iron oxide reduction through nanoscale operando TEM” on the Nature Communications website.

PREHISTORIC ALCHEMY

Europe's oldest blue pigment found in Germany



In a ground-breaking discovery that illuminates new insights into the early prehistoric origins of art and creativity, a new study led by re-searchers from Aarhus University have identified the earliest known use of blue pigment in Europe.



Aarhus University






At the Final Palaeolithic site of Mühlheim-Dietesheim, Germany, archaeologists from Aarhus University found traces of a blue residue on a stone artifact dating back around 13,000 years. Using a suite of cutting-edge scientific analyses, they confirmed the traces were from the vivid blue mineral pigment azuritepreviously unseen in Europe’s Palaeolithic art. 

“This challenges what we thought we knew about Palaeolithic pigment use”, sais Dr. Izzy Wisher, the lead author of the study. 

Until now, scholars believed Palaeolithic artists predominantly used red and black pigments – practically no other colours are present in the art of this period. This was thought to be due to a lack of blue minerals or limited visual appeal. Given the absence of blues in Palaeolithic art, this new discovery suggests that blue pigments may have been used for either body decoration or dyeing fabrics – activities that leave few archaeological traces.

 “The presence of azurite shows that Palaeolithic people had a deep knowledge of mineral pigments and could access a much broader colour palette than we previously thought – and they may have been selective in the way they used certain colours”, Izzy Wisher says. 

The stone bearing the azurite traces was originally thought to be an oil lamp. Now, it appears to have been a mixing surface or palette for preparing blue pigments — hinting at artistic or cosmetic traditions that remain largely invisible today.

The findings urge a rethink of Palaeolithic art and colour use, opening new avenues for exploring how early humans expressed identity, status, and beliefs through materials far more varied and vibrant than previously imagined.

The study was conducted in collaboration with Rasmus Andreasen, James Scott and Christof Pearce at the Department of Geoscience, Aarhus University, as well as Thomas Birch who is affiliated with both the Department of Geoscience, AU, and the National Museum of Denmark, alongside colleagues from Germany, Sweden and France. 

The full study is published in Antiquity:

https://doi.org/10.15184/aqy.2025.10184 

PARACELSUSIAN ALCHEMY

New insight into the response mechanism of arsenic in treating acute promyelocytic leukemia




Science China Press
Abstract of Single-cell omics analysis reveals tumor microenvironment rewiring after arsenic trioxide therapy in acute promyelocytic leukemia 

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Abstract of Single-cell omics analysis reveals tumor microenvironment rewiring after arsenic trioxide therapy in acute promyelocytic leukemia

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Credit: ©Science China Press






In this study, researchers from Harbin Medical University conducted a comprehensive characterization of the tumor microenvironment in APL patients undergoing arsenic trioxide (ATO) therapy using single-cell sequencing. Initially, APL cells were classified into distinct subpopulations, revealing several groups with diverse characteristics. Notably, one LSC-like subpopulation, marked by high expression of stemness-related genes and a pronounced LSC signature, was identified as the root of differentiation arrest in APL. This subpopulation was largely eradicated following treatment, offering novel insights into how ATO affects APL cells.

As is well known, lymphocytes, including T cells, NK cells, and B cells, are key components of antitumor immunity. The researchers subsequently analyzed other immune components, with a particular focus on lymphocytes. They found that ATO treatment induced the enrichment of a CD8 T cell subpopulation, termed the CD8 ISG subtype, characterized by elevated expression of interferon-stimulated genes. Further analyses indicated that ATO treatment significantly enhanced both the effector functions and TCR clonotype expansion of this subtype. Additionally, through a constructed co-expression network, they revealed further functional characteristics of this CD8 subpopulation. For example, beyond its association with ISG genes, this subpopulation also exhibited signatures related to myeloid differentiation, arsenic response, and immune activation.

Subsequently, the researchers observed that NK cells in APL patients exhibited a dysfunctional state, which was largely reversed following ATO therapy. Notably, an activated NK cell subpopulation associated with the ATO response was identified, characterized by pronounced NFκB signaling and inflammatory activation. In addition, ATO treatment was found to remodel the distribution of immunoglobulin proteins, as revealed by integrated scRNA-seq and scBCR-seq analyses. Finally, the study elucidated the complex cellular communication network and identified the LT pathway as a key signaling axis mediating interactions between the CD8 ISG subtype and NK NFκB subtype with APL cells, contributing to myeloid differentiation and immune activation.

In conclusion, this study mapped the rewired hematopoietic lineage and notably identified two lymphocyte subpopulations associated with the response to ATO treatment: the CD8 ISG T cells and the NK NFκB cells, which provides a deeper insight into the underlying mechanisms in the context of ATO therapy for APL patients.

The authors acknowledge funding from the National Key Research and Development Program of China; the National Natural Science Foundation of China; the Natural Science Foundation of Heilongjiang Province (Key Program) and the project of scientific research business expenses of provincial research institutes.

 

Building better batteries with amorphous materials and machine learning




Indian Institute of Science (IISc)
Making ions move faster by making structures amorphous 

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Making ions move faster by making structures amorphous

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Credit: Vijay Choyal





Lithium-ion batteries power most electronics, but they have limited energy density – they can store only a certain amount of energy per mass or volume of the battery. “In order to store even more energy with the same mass or volume, you will have to explore alternative energy storage technologies,” says Sai Gautam Gopalakrishnan, Assistant Professor at the Department of Materials Engineering, IISc.

Gopalakrishnan and his team have studied how to boost the movement of ions in magnesium batteries, which can have a higher energy density. In a new study, using a machine learning model, they show that using amorphous materials as positive electrodes to build these batteries can significantly increase their rate of energy transfer.

Lithium ion or magnesium batteries contain a positive (cathode) and a negative (anode) electrode, separated by a liquid electrolyte. Each time a lithium or magnesium ion goes from the cathode to the anode or vice versa, energy is exchanged with the device. “In magnesium batteries, each magnesium atom can actually exchange two electrons, whereas each lithium atom can only exchange one electron with the external circuit. So, you can get close to twice the amount of energy per atom moved,” explains Gopalakrishnan. 

The cathodes need to act like a sponge – upon applying an external potential, they should absorb and release magnesium ions into the electrolyte. But the main bottleneck in commercialising magnesium batteries is the lack of good materials that can act as cathodes, Gopalakrishnan says. So far, scientists have largely been looking at crystalline materials, which have a periodically ordered arrangement of atoms. However, because magnesium moves very slowly within these materials, they are unable to absorb and release magnesium ions at a fast enough rate. 

”If we break the crystallinity and create something that is amorphous, haphazard, and chaotic, that may actually help magnesium to move fairly well within the structure,” Gopalakrishnan explains. 

The team built a computational model of an amorphous vanadium pentoxide material and calculated how fast magnesium ions can move within it. To build such models, scientists typically use a method called density functional theory (DFT), which accurately models systems at an electronic level. But it takes a long time to simulate amorphous systems using this method. Molecular dynamics (MD) simulations – in which one studies interactions between atoms – are faster but less accurate. “Modelling amorphous systems accurately is very difficult,” says Vijay Choyal, first author of the study and a former postdoctoral scholar at IISc.

To combine speed and accuracy, the team used a machine learning framework. They first used DFT to generate data on how the amorphous cathode would function at a small scale. After training their machine learning model on this data, they used the model to perform MD simulations. With MD, they were able to model the material at a larger scale – to get a better picture of how far the magnesium moves within the amorphous material and how long it takes. Compared to state-of-the-art crystalline magnesium materials, the team observed about five orders of magnitude improvement in the rate of magnesium movement in the amorphous form.

“Our work offers a completely different pathway to identify electrode materials for batteries and takes us a step closer to commercialisation of magnesium batteries,” says Gopalakrishnan. 

The team hopes that experimentalists can now work on this amorphous material and test its effectiveness in the lab. “One disadvantage is that we don't know how stable the amorphous materials can be when used in a practical battery,” says Debsundar Dey, co-author of the study and former MTech student at IISc. “The key takeaway is that using amorphous materials increases the mobility of ions, but we also need to experimentally validate our observations.”