Tuesday, December 16, 2025

Jeonbuk National University researchers explore the impact of different seasonings on the flavor perception of Doenjang soup


Researchers examine how different seasonings shape kokumi perception in doenjang soup and influence consumer acceptance



Jeonbuk National University, Sustainable Strategy team, Planning and Coordination Division

How do different seasonings in doenjang soup affect consumer perception? 

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Monosodium glutamate significantly enhances umami and kokumi characteristics in the soup compared to nucleotide-based seasonings, thereby improving consumer satisfaction.

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Credit: Professor Mina K. Kim from Jeonbuk National University





Doenjang is a traditional Korean fermented soybean paste made from meju—naturally fermented soybean blocks—mixed with salt and aged through long-term fermentation. Unlike Japanese miso, Korean doenjang does not use koji; its flavor develops entirely from the natural fermentation of meju. It is prepared via fermentation and aging with microbial cultures, which produce umami compounds that improve its palatability. While umami is a well-understood concept, kokumi—a term used to describe attributes like mouthfulness, richness, and flavor continuity—is surrounded by divergent views. Some perceive kokumi as a sensory amplification of flavor, whereas others define it by the presence of specific compounds such as glutathione and γ-glutamyl peptides. These kokumi-active compounds exist in various fermented foods, including doenjang.

In a recent study, researchers from the Department of Food Science and Human Nutrition and the K-Food Research Center at Jeonbuk National University, Republic of Korea, led by Professor Mina K. Kim, the Director of the K-Food Research Center at Jeonbuk National University, examined how monosodium glutamate (MSG) and nucleotide-based seasonings influence kokumi perception in doenjang soup and affect consumer acceptance. Their findings were made available online on 5 May 2025 and have been published recently in Volume 131 of the journal Food Quality and Preference on 1 October 2025.

The researchers applied a consumer-centered approach using 113 untrained panelists, who completed liking assessments and Check-All-That-Apply questions after testing doenjang soup samples containing different seasonings a follow - none, 1% MSG, 1% disodium 5′-inosinate, 1% disodium 5′-guanylate, and 1% disodium 5′-ribonucleotide.

They found that even within the same category of seasonings, MSG, an amino acid–based seasoning, and nucleotide-based seasonings influence doenjang soup in different ways. While MSG boosts both umami and kokumi, nucleotide-based seasonings mainly increase umami alone, showing that these two types of flavor enhancers work differently even in the same food system. “Our results show that umami is a major sensory driver of kokumi perception—shaping how consumers experience depth, richness, and lingering flavor in doenjang soup. These insights offer a clear, evidence-based direction for formulating more impactful seasoning systems and advancing premium doenjang-based product development,” remarks Prof. Kim.

Beyond traditional Korean doenjang, this research offers broader insights into how kokumi can be enhanced in many kokumi-rich foods found around the world, such as aged cheeses, long-simmered broths, miso, soy sauce, parmesan, and even certain seafood-based dishes. Since kokumi contributes to body, richness, and lingering taste, these findings can also be applied to improving the flavor quality of soup-based products and savory beverages. In addition, by strengthening kokumi while maintaining umami balance, this study provides a useful strategy for developing products with reduced-sodium without sacrificing their taste.

“Our research can help develop fermented foods that retain the complex flavors of traditional doenjang while meeting modern consumer expectations. By showing how umami and kokumi interact in consumer evaluations, our findings support flavor-standardization efforts and the creation of healthier, more satisfying fermented products. As kokumi research progresses, we expect the industry to adopt more precise, evidence-based approaches to enhancing flavor depth and persistence,” concludes Prof. Kim.

 

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Reference
DOI: 
10.1016/j.foodqual.2025.105579

 

About Jeonbuk National University
Founded in 1947, Jeonbuk National University (JBNU) is a leading Korean flagship university.Located in Jeonju, a city where tradition lives on, the campus embodies an open academic community that harmonizes Korean heritage with a spirit of innovation.Declaring the “On AI Era,” JBNU is at the forefront of digital transformationthrough AI-driven education, research, and administration.JBNU leads the Physical AI Demonstration Project valued at around $1 billion and spearheads national innovation initiatives such as RISE (Regional Innovation for Startup and Education) and the Glocal University 30, advancing as a global hub of AI innovation.
Website: https://www.jbnu.ac.kr/en/index.do

 

About the author
Dr. Mina K. Kim is the Director of the K-Food Research Center and a Professor of Food Science at Jeonbuk National University. Her research team studies flavor chemistry and sensory perception of traditional Korean fermented foods, including doenjang, soy sauce, and kimchi, focusing on kokumi and gu-soo—the savory, nutty–roasty depth of aged doenjang. Her work integrates instrumental analysis with trained panel vocabulary and consumer preferences, bridging sensory evaluation and chemical data and advancing healthier, globally appealing fermented food innovation.

A rapid diagnostic breakthrough against a silent global threat

Detecting resistance and virulence—at the same time



Koç University

Prof. Dr. Füsun Can 

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Prof. Dr. Füsun Can (left) from Koç University School of Medicine and a colleague at work in the laboratory, developing a novel diagnostic approach that enables the rapid and simultaneous detection of both antibiotic resistance and high virulence in Klebsiella pneumoniae.

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Credit: Koç University



Antibiotic resistance is one of the most pressing—and quietly advancing—challenges facing modern medicine. Among the most dangerous bacterial pathogens driving this crisis is Klebsiella pneumoniae, a microorganism capable of causing severe infections while evading both antibiotics and the human immune system.

Now, a research team led by Prof. Dr. Füsun Can at Koç University School of Medicine has developed a novel diagnostic approach that enables the rapid and simultaneous detection of both antibiotic resistance and high virulence in Klebsiella pneumoniae. The research has been recognized with the 2025 Nature MDx Impact Award, highlighting its scientific originality and strong potential for real-world clinical impact.

Detecting Resistance and Virulence—At the Same Time

Klebsiella pneumoniae normally exists harmlessly in the human gut and on the skin. However, in vulnerable patients—particularly those in hospital settings—it can cause life-threatening conditions such as pneumonia, bloodstream infections, and sepsis. In recent years, especially concerning strains have emerged that combine multidrug resistance with hypervirulence, making infections both harder to treat and more severe.

Prof. Dr. Can’s team focused on precisely these strains. Their newly developed diagnostic system identifies, in a single and rapid test, the genetic markers responsible for both pathogenicity and antibiotic resistance. Until now, these features could only be assessed separately, often through time-consuming procedures that delayed effective treatment.

The ability to capture this critical information simultaneously represents a significant advance in molecular diagnostics.

Why Speed Matters in Antibiotic Resistance

Unlike viral outbreaks, bacterial resistance does not erupt suddenly—but its cumulative impact is profound. Delayed or inappropriate antibiotic treatment increases mortality risk, prolongs hospital stays, and accelerates the spread of resistant strains.

Rapid, accurate diagnosis is therefore central to effective clinical decision-making. By enabling clinicians to identify the most dangerous Klebsiella strains at an early stage, this new approach supports timely, targeted therapy and strengthens infection-control strategies in healthcare settings.

International Recognition from Nature

The Nature MDx Impact Award is presented to research that not only advances diagnostic science but also addresses urgent clinical needs. In its evaluation, Nature highlighted the project’s originality, translational relevance, and potential for broad implementation.

The study’s selection underscores the growing importance of molecular epidemiology and precision diagnostics in confronting the global antibiotic resistance crisis. The project is supported by international industry collaboration, further strengthening its pathway toward clinical application.

Looking Ahead: From Diagnosis to New Therapies

Beyond diagnostics, Prof. Dr. Can’s research program aims to unravel how Klebsiella pneumoniae evades the immune system—a key step toward developing next-generation treatment strategies. Understanding these mechanisms could enable the design of novel therapeutic molecules, potentially supported by artificial intelligence–driven drug discovery.

As antibiotic resistance continues to challenge healthcare systems worldwide, this work offers a timely and concrete step forward—transforming molecular insight into tools that can save lives.

Unseen allies: symbiotic bacteria help clean wastewater, but there is a catch

Scientists identify new species of denitrifying endosymbionts in wastewater, highlighting their global prevalence – with an unexpected climate implication



Max Planck Institute for Marine Microbiology

The endosymbiont Candidatus Azoamicus mariagerensis and its ciliate host under the fluorescence microscope. 

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The endosymbiont Candidatus Azoamicus mariagerensis and its ciliate host under the fluorescence microscope. Visible is the endosymbiont (stained yellow), and the ciliate host (stained purple). The ciliate nucleus is stained with a DNA stain (in blue).

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Credit: Linus Matz Zeller/Max Planck Institute for Marine Microbiology





Wastewater treatment is essential for protecting public health and the environment. In sewage plants, a diverse microbial community removes pollutants from agricultural, industry and household wastewater. Most research has focused on free-living bacteria within this community, but a new study now reveals that microbial partnerships – bacteria living inside other microbes – are also widespread and active.

Microbes teaming up 

A few years ago, a team of researchers around Jana Milucka from the Max Planck Institute for Marine Microbiology in Bremen, Germany, discovered peculiar bacterial symbionts that associate with ciliates, single-celled organisms that can be found everywhere where there is water. The symbionts supply their hosts with energy, much like how mitochondria power our own cells – an until then unprecedented association. The researchers’ data indicated that these organisms might be especially common in wastewater, so the team decided to investigate this further.  

Common members of the wastewater microbiome

Analysing data from sewage plants all over the world, the scientists identified 14 new species of these endosymbiotic bacteria. “By performing denitrification, the bacteria contribute to nitrate removal, a key step in wastewater treatment. At the same time, they help their hosts generate energy by converting harmful nitrates into dinitrogen gas,” first author Louison Nicolas-Asselineau explains. The scientists detected these partnerships in up to half of the wastewater plants, suggesting they are a common but previously overlooked part of this ecosystem. And they might be even more abundant: “We see that the symbionts’ numbers fluctuate a lot over time within individual sewage plants, so it is possible we might have missed a few.” 

A climate concern

Denitrifying endosymbionts, including the newly identified wastewater species, typically encode a complete denitrification pathway that enables them to respire nitrate all the way to dinitrogen gas (N2). Additionally, most of these endosymbionts also possess an enzyme called cytochrome-cbb3 oxidase that allows them to respire oxygen in addition to nitrate. 

However, one species stands out: Candidatus Azoamicus parvus not only lacks the ability to breathe oxygen but it is also unable to further break down nitrous oxide (N₂O), an intermediate of the denitrification process. Instead of converting N2O into the harmless N2, it releases this potent greenhouse gas into the surrounding water. Nitrous oxide is 300 times more powerful than CO₂, and wastewater treatment is known to contribute to anthropogenic N2O emissions to the atmosphere. 

Worryingly, this species is widespread in sewage plants globally. “This is the first time we have ever found a denitrifying endosymbiont that produces nitrous oxide and it happens to be the one that is most widely distributed in wastewater treatment plants,” says Jana Milucka, the study's senior author. 

Why it matters 

Wastewater treatment is one of the largest applications of microbiology, essential for the preservation of natural environments as well as human health. The microbial partnerships now described in the journal ISME Communicationshave been widely overlooked. “We were very surprised that denitrifying endosymbioses were so abundant and prevalent in wastewater, given the dynamic conditions and intense ecological pressures in these systems”, says Nicolas-Asselineau. “Our study highlights the need to better understand the microorganisms involved in the wastewater processes, as they might be the key to improving wastewater treatment and reducing its environmental impact.”


It was mostly a desk job: After collecting data from international datasets as well wastewater treatment plants – among them the one in Bremen– PhD-student Louison Nicolas-Asselineau was busy evaluating and interpreting the data. 

Credit

Hailey-Hannah Cottet/ Max Planck Institute for Marine Microbiology

Researchers show visual training dramatically improves cognitive function after concussion


Study shows new approach restores attention, memory and reading skills more effectively than standard therapies




University of California - San Diego

Brain Imaging Shows How Visual Training Improves Cognitive Function After Concussion 

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A recent study in Frontiers in Human Neuroscience shows a new approach called Perceptual Attention Therapy (PATH) restores attention, memory and reading skills more effectively than standard therapies. Here, MEG brain imaging provides evidence that individuals with mild traumatic brain injury have better working memory after the PATH treatment compared to the conventional approach.

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Credit: MEG Center at UC San Diego Qualcomm Institute





A new peer-reviewed study led by scientists at the Perception Dynamics Institute and the University of California San Diego demonstrates that a specific visual training program significantly outperforms standard programs designed to treat cognitive problems following a concussion.

The research, published in Frontiers in Human Neuroscience, reveals that a technique called Perceptual Attention Therapy (PATH) produces rapid improvements in reading, attention, memory and executive function.

“This study represents a paradigm shift in how we can effectively approach concussion rehabilitation,” said Teri Lawton, Ph.D., lead author and founder of the Perception Dynamics Institute. “By targeting foundational visual timing deficits—specifically motion discrimination at low levels of cognitive processing—we can dramatically improve higher-level cognitive functions.”

Mingxiong Huang, Ph.D., co-director of the MEG (Magnetoencephalography) Center at the UC San Diego Qualcomm Institute and senior author of the study, added, “The MEG functional brain imaging at our facility allowed us to see, in high-resolution in space and time, how the brain’s working-memory and attention networks reorganized after training. We could detect strengthened responses in many brain regions and confirm that the behavioral improvements reflected true functional recovery.”

Mild traumatic brain injury affects millions of Americans annually, with many experiencing persistent problems with concentration, memory and information processing that can last months or years. Current rehabilitation approaches often provide limited relief, leaving patients frustrated and unable to return to normal activities.

Comparing Three Approaches

PATH Neurotraining combines specialized eye-brain exercises that target movement discrimination—a function controlled by the dorsal visual pathways—with targeted working memory exercises. This two-stage approach addresses the underlying visual timing deficits before strengthening specific cognitive skills. These pathways are particularly vulnerable to concussion.

The research team compared three interventions for concussion-related attention, memory and thinking problems: PATH training; training targeting ventral (rather than dorsal) visual pathways; and working memory training. PATH demonstrated superior outcomes across multiple cognitive domains.

“Beyond the cognitive improvements, we’re seeing preliminary evidence that PATH training enhances emotional functioning and reduces post-concussive symptoms, meaningfully improving patients’ quality of life,” added John Shelley-Tremblay, Ph.D., co-author and director of the Experimental Event-related Potentials Laboratory at the University of South Alabama.

The research team is seeking National Institutes of Health funding for a Phase II multi-site trial beginning in fall 2026, seeking to further validate these findings with larger patient populations and longer-term follow-up.

Opportunities for Study Participation

Those wishing to participate in an upcoming Phase II clinical trial can join the waiting list by contacting Lawton at 310-903-6009 or tlawton@pathtoreading.com. The team plans to offer free PATH neurotraining to individuals ages 18-60 who have experienced a concussion, with sessions available once, twice or three times weekly for a total of 36 sessions (30 minutes each). Individuals interested in trying PATH can access a free seven-session trial at https://app.pathtoreading.com.

The full study, “Retraining dorsal visual pathways improves cognitive skills and executive control networks following mild traumatic brain injury” is available at Frontiers in Human Neuroscience (doi: 10.3389/fnhum.2025.1698605).

In addition to Lawton, Shelley-Tremblay and Huang (who is also affiliated with the Department of Electrical and Computer Engineering at the UC San Diego Jacobs School of Engineering and the Department of Radiology at the UC San Diego School of Medicine, as well as the VA San Diego Healthcare System), co-authors of the paper include Roland R. Lee of the UC San Diego School of Medicine Department of Radiology, VA San Diego Healthcare System and UC San Diego Qualcomm Institute.