HPV vaccination among young adults before and during the pandemic

JAMA Network Open

Peer-Reviewed Publication

JAMA NETWORK

About The Study: The results of this study suggest that human papillomavirus (HPV) vaccination coverage among young adults did not increase during the COVID-19 pandemic compared with prior years. This finding likely reflects pandemic-related disruptions in initiating the HPV vaccine among young adults. 

Authors: Kalyani Sonawane, Ph.D., of the Medical University of South Carolina in Charleston, is the corresponding author. 

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

(doi:10.1001/jamanetworkopen.2023.56875)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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JOURNAL

JAMA Network Open

Socioeconomically advantaged individuals less likely to seek out HPV vaccination for their children, Hollings researchers find

Peer-Reviewed Publication

MEDICAL UNIVERSITY OF SOUTH CAROLINA

 

IMAGE: 

DR. SONAWANE SAID THAT HPV VACCINE HESITANCY AMONG SOCIOECONOMICALLY ADVANTAGED PARENTS COULD AFFECT AN ENTIRE AGE COHORT. 

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CREDIT: MUSC HOLLINGS CANCER CENTER

The parents of millions of teens have no intention of getting their children vaccinated against the human papillomavirus (HPV). Parents with higher socioeconomic status are less likely than parents of lower income or educational attainment to plan to vaccinate their children.

HPV can cause six types of cancer in both males and females, which is why public health advocates want to see more people vaccinated. The U.S.’s Healthy People 2030 set a goal of 80% of adolescents receiving the full vaccine series, but that rate has stagnated at about 63% for teens.

Researchers from MUSC Hollings Cancer Center, aware of the so-called “reverse disparity,” in which people from low-income or minority communities have better HPV vaccination coverage than people from more advantaged communities, wanted to understand the level of vaccine hesitancy and uncover the reasons that might lead to differences in vaccination coverage. They used the survey results of the National Immunization Survey-Teen, an annual telephone survey that covers several routine adolescent vaccines. Their findings are published this week in The Lancet Regional Health – Americas.

The researchers found that a majority of socioeconomically advantaged parents – 65% – did not intend to seek out the vaccine for their teens, compared with 40% of parents in the disadvantaged group.

The reasons differed by group. Advantaged parents generally cited safety concerns, while disadvantaged parents cited lack of knowledge about the vaccine, lack of recommendation by a primary care provider or the feeling that the vaccine isn’t necessary.

“Parents from socioeconomically advantaged households could be undermining HPV infection risk for their child,” said lead author Kalyani Sonawane, Ph.D., a Hollings researcher and an associate professor in the Department of Public Health Sciences. “The side effects of HPV vaccine are also possibly exaggerated in the minds of parents.”

Senior author Ashish Deshmukh, Ph.D., co-leader of the Cancer Control Research Program at Hollings, noted that white parents, regardless of whether they were advantaged or disadvantaged, showed a “pervasive” lack of intent to vaccinate.

Given that just over half of all adolescents are white, their parents’ vaccination decisions have a significant impact on the herd immunity of the entire age group.

“It has implications at the population level because if most adolescents are white and from middle- or high-income families, and if their parents perceive the vaccine not to be safe, then that impacts vaccine coverage,” Sonawane said.

Previous studies have indicated that minority parents were more likely to accept the vaccine and perceive the threat of HPV infection to be greater. They are not necessarily wrong – Black and Hispanic women have higher rates of both incidence and death from cervical cancer, which is almost always caused by HPV.

At the same time, Deshmukh has published studies over the past year showing that incidence rates of cervical cancer are increasing among white women in low-income counties and among women in their early 30s. Problems accessing preventive care and treatment could be behind the higher death rates of all of these groups.

The HPV vaccine was first approved in 2006. It is recommended for adolescents but can be given as a catch-up vaccine up to age 26. Because HPV is so widespread – the Centers for Disease Control and Prevention notes that nearly everyone will be exposed at some point – the recommendation is to give the vaccine well before one is likely to be exposed. However, after discussion with a doctor, it can be given to adults up to age 45.

There are hundreds of strains of HPV, most of which the human body will clear on its own. Some of those strains, however, can go on to develop into cervical, head and neck, anal, penile, vaginal or vulvar cancer.

Sonawane said that future studies may further subdivide the advantaged group by income or education. This study included a middle group, in which the parents either had less than a high school education or made less than 200% of the federal poverty level. In that mixed group, the researchers found that a higher education level contributed to HPV vaccine hesitancy more than income.

About  MUSC Hollings Cancer Center 

MUSC Hollings Cancer Center is South Carolina’s only National Cancer Institute-designated cancer center with the largest academic-based cancer research program in the state. The cancer center comprises more than 130 faculty cancer scientists and 20 academic departments. It has an annual research funding portfolio of more than $44 million and sponsors more than 200 clinical trials across the state. Dedicated to preventing and reducing the cancer burden statewide, the Hollings Office of Community Outreach and Engagement works with community organizations to bring cancer education and prevention information to affected populations. Hollings offers state-of-the-art cancer screening, diagnostic capabilities, therapies and surgical techniques within its multidisciplinary clinics. Hollings specialists include surgeons, medical oncologists, radiation oncologists, radiologists, pathologists, psychologists and other clinical providers equipped to provide the full range of cancer care. For more information, visit hollingscancercenter.musc.edu. 

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JOURNAL

The Lancet Regional Health - Americas

DOI

10.1016/j.lana.2024.100694 

ARTICLE TITLE

Factors associated with parental human papillomavirus vaccination intentions among adolescents from socioeconomically advantaged versus deprived households: a nationwide, cross-sectional survey

ARTICLE PUBLICATION DATE

19-Feb-2024

COI STATEMENT

Drs. Sonawane and Deshmukh have provided consultancy to Value Analytics Labs on unrelated projects. Dr. Giuliano received honoraria, and grant funding, and served as a member of the scientific advisory board on unrelated projects for Merck Sharp and Dohme. All other authors declare no competing interests.