Cognitive and emotional well-being of preschool children before and during the pandemic
JAMA Network Open
Peer-Reviewed PublicationAbout The Study: Pandemic-exposed children (assessment after March 11, 2020) had significantly higher problem solving and fine motor skills at 24 months of age but lower personal-social skills compared with non-exposed children in this study including data from the Ontario Birth Study. At 54 months of age, pandemic-exposed children had significantly higher vocabulary, visual memory, and overall cognitive performance compared with non-exposed children.
Authors: Mark Wade, Ph.D., C.Psych., of the University of Toronto, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2023.43814)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
JOURNAL
JAMA Network Open
Social determinants of health and perceived barriers to care in diabetic retinopathy screening
JAMA Ophthalmology
Peer-Reviewed PublicationAbout The Study: This study of 11,000 participants with type 2 diabetes found that food insecurity, housing insecurity, mental health concerns, and the perceived importance of practitioner concordance were associated with a lower likelihood of receiving eye care. Such findings highlight the self-reported barriers to seeking care and the importance of taking steps to promote health equity.
Authors: Sophia Y. Wang, M.D., M.S., of Stanford University in Palo Alto, California, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamaophthalmol.2023.5287)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JOURNAL
JAMA Ophthalmology
Environment and wallet benefit from redispensing cancer pills
Redispensing cancer drugs reduces both environmental impact and medical costs, according to research from Radboudumc pharmacy published in JAMA Oncology. The annual savings could amount to tens of millions.
Cancer drugs as pills are not always used up by patients. The drugs are mostly expensive and environmentally damaging, both in production and (waste) disposal. In her PhD research, Lisa-Marie Smale of Radboudumc investigated whether these unused drugs can be collected and reissued. Does such an approach ultimately lead to lower environmental impact and costs?
Redispense medication
When redispensing medications, the quality must be guaranteed. Therefore, in this study the medications were packaged separately and fitted with a sensor, which registers whether returned medications were kept within the required temperature. Smale: "If packaging, temperature and expiration date are in order, the returned medications can be redispensed. For two years we investigated this procedure in cooperation with the pharmacies of four Dutch hospitals; Radboudumc, UMC Utrecht, Jeroen Bosch hospital and St Antonius hospital. Over a thousand patients who were taking oral cancer medications at home participated in the study during that period."
Saving tens of millions
The results, published in JAMA Oncology, look promising. The investment in the method, such as packaging with a temperature sensor, amounts up to 37 euros per patient per year. This is offset by savings of 613 euros. Annually, this results in a net saving per patient of 576 euros. Smale: "In the Netherlands, we can save between 20 and 50 million euros annually with this redispensing of medication. Meanwhile, we have further optimized the process, making a net saving of 655 euros per patient possible. In the Netherlands, we have relatively low drug prices. If you look at the U.S., where the price of new drugs is over 300 percent higher, in principle much more money can be saved there."
Large-scale consequence
Of all wasted medicine packaging, two-thirds could be reissued. Project leader Charlotte Bekker of Radboudumc says, "Based on the results, the study will be expanded to 14 hospitals. Again, we are looking at cancer pills. Reissue is only allowed in the context of a scientific study because of European rules. We hope that the approach can eventually be used nationwide, as well as for other drugs."
Sustainability and social impact also benefit
"This approach is cost-effective for expensive drugs”, Smale says, "but ultimately there are other factors you want to consider, such as sustainability or social impact. Think of the environmental impact you can reduce by not destroying drugs but redispensing them; this can also be beneficial for drugs that are in short supply."
Broad interest
The study published in JAMA Oncology is, to our knowledge, the first to examine drug redispensing with guaranteed quality. The topic is attracting strong interest, not only in the medical community but also beyond. Several parties are committed to make further expansion possible. In addition to the participating hospitals, the Dutch Association of Hospital Pharmacists (NVZA) is also closely involved. And it is part of the Green Deal objectives to make healthcare more sustainable. Smale: "We are happy to work with all parties to address and reduce the cost and environmental impact of wasted medicines."
JOURNAL
JAMA Oncology
METHOD OF RESEARCH
Experimental study
SUBJECT OF RESEARCH
People
ARTICLE TITLE
Cost Savings and Waste Reduction Through Redispensing Unused Oral Anticancer Drugs. The ROAD Study
ARTICLE PUBLICATION DATE
16-Nov-2023
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