Friday, October 14, 2022

Ultrasound treatment may blast away kidney stones without pain

By Alan Mozes, HealthDay News

A non-surgical and minimally painful treatment enlists two types of ultrasound to zap "ureteral stones," causing them to break up, dislodge and reposition in order to make passing the stones easier and faster. Photo by Africa Studio/Shutterstock


A new ultrasound treatment for kidney stones might provide pain-free relief while the patient is awake, researchers say.

Kidney stones are often excruciatingly painful. In most cases, patients are told to just ride it out, sometimes for weeks, in the hope the stone will eventually pass through the urinary tract -- from kidney to bladder -- on its own. But for roughly one in four patients that never happens, triggering surgical intervention.

However, a small new study suggests there may be another way: a non-surgical and minimally painful treatment that enlists two types of ultrasound to zap "ureteral stones," causing them to break up, dislodge and reposition in order to make passing the stones easier and faster.

"The two-pronged approach is to first break the stone into fragments and then move the fragments toward the exit so they will pass," explained study author Dr. M. Kennedy Hall. He is a professor in the emergency medicine department at the University of Washington School of Medicine, in Seattle.

The goal, said Hall, is "to remove the stone right away, when you first come to the doctor, so you don't sit home in pain and anxiety," unsure if invasive surgery -- complete with anesthesia -- is in the offing.

In the study, Hall's team focused on the potential of combining two different ultrasound tools: ultrasonic propulsion (UP) and burst wave lithotripsy (BWL).

The idea stemmed from a NASA-led effort to develop a non-sedation approach to kidney stones for astronauts on long-haul trips.

RELATED Change of diet may reduce chance of kidney stones, study shows

Ultrasonic propulsion is designed to help move and reposition the problem stone, while BWL is deployed to break up the stone into smaller pieces.

The authors pointed out that a third procedure -- called shock wave lithotripsy -- is already a go-to when surgery is called for. But it requires sedation, and is decidedly not pain-free.

Dr. Arash Akhavein is a urologist with Cedars-Sinai Medical Center in Los Angeles. He said the shockwave approach is essentially an invasive way to "pulverize the stone and allow passage."

RELATED  Ultrasound 'bursts' may treat kidney stones in a doctor's office

Other standard treatments include the insertion of "a special endoscope through the urethra and urinary channels to find and break the stones with a laser, and/or to remove stone fragments with a special basket through the scope," added Akhavein, who was not involved in the study.

And for particularly large stones, "we puncture a small hole in the back into the kidney to break the stone and remove the pieces," he noted.

"Each method has indications and is suitable for certain cases. All require a trip to the operating room, almost always with general anesthesia," Akhavein explained.

By contrast, ultrasonic propulsion and BWL can be performed while patients are awake, whether in an emergency room or a clinic setting. And according to Hall and his associates, both techniques are essentially "painless."

To see how well the dual ultrasound approach might work, the investigators enlisted 29 patients in 2018, treating 16 with propulsion alone and 13 with it and BWL.

Both techniques utilize different buttons on the same ultrasound machine, Hall noted.

In the new study, ultrasonic propulsion triggered stone movement in 19 of 29 patients. In two cases, the stones were actually pushed out of the urinary tract all the way into the bladder, providing immediate relief in one patient.

The team also found that BWL had effectively broken stones up in seven out of 13 UP/BWL patients, typically in 10 minutes or less, Hall noted.

And over two weeks following ultrasound treatment, stones passed out of the body in 18 out of 21 patients, all of whom had stones closer to their bladder than to their kidney. For this group, on average, full stone passage took four days post-procedure.

No serious side effects were observed, and pain levels were markedly lower after ultrasound, overall. Those who did not get the desired result went in for standard surgery.

The team cautioned that the findings are preliminary, and more study will be needed with a larger group of patients.

Hall said if all goes well, he could see the two techniques becoming a viable patient option within two to three years.

And that will likely be of help for kidney stone patients, Akhavein said, particularly for those with relatively small stones.

The findings were published in the November issue of The Journal of Urology.

More information

There's more on kidney stones at the National Kidney Foundation.

Copyright © 2022 HealthDay. All rights reserved.



Cholera protection gaps in U.S.: No new vaccine supply, no national stockpile


1/5
Vaccine expert Dr. Peter Hotez calls it "shortsighted" of the U.S. government not to keep a national cholera vaccine stockpile.
Photo courtesy of Dr. Peter Hotez

WASHINGTON, Oct. 13 (UPI) -- Shortages of U.S. cholera vaccine have raised concerns among some of the nation's top infectious disease doctors, who fear Americans could become highly vulnerable to a public health threat that can spread and kill quickly.

"We got caught flat-footed with monkeypox. This is a wake-up call -- we can't get caught flat-footed again with cholera," Dr. Peter Hotez, co-director of Texas Children's Hospital Center for Vaccine Development, told UPI in a phone interview.

Right now, only one Food and Drug Administration-approved cholera vaccine exists. The U.S. government wants to expand this travel vaccine's use to include children, as well as adults, who head to cholera hotspots.

But it sits on the U.S. drug shortages list and has been unavailable for nearly two years. And no federal vaccine supply exists as backup in case of a disaster-related mass cholera outbreak in this country.

Rising poverty, urbanization, political instability and conflict, along with climate change that spurs natural disasters, are 21st century influences that contribute to cholera outbreaks in other parts of the world, including most recently in Haiti, said Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine.

"We'll see more cases of cholera, monkeypox and coronavirus-like illnesses" globally, Hotez said, citing his 2021 book, Preventing the Next Pandemic.

He added: "When epidemics occur, they're quite explosive, and a lot of people can perish very quickly. You can't wait six months for a company to gear up. ... This is the problem with not adequately stockpiling this [cholera vaccine in the United States], and nobody is looking [at the issue from] an aerial view."


Surges during disasters


Cholera, a severe diarrheal illness caused by the bacterium Vibiro cholerae, may surge in the wake of man-made or natural disasters in areas that lack clean water, adequate hygiene and proper sanitation.

Worldwide, about 1.3 million to 4 million people develop cholera annually, and 21,000 to 143,000 die from it, according to the Centers for Disease Control and Prevention.

RELATEDWater shortage threatens thousands affected by volcanic eruption in DRC

The CDC says cholera rarely occurs in the United States, though it was common in the 1800s, because its spread was basically eliminated by modern water and sewage treatment systems.

Yet, the United States is not immune to a problem that constantly ravages so many countries, Hotez said. He noted, for example, that the Texas Gulf Coast, where he lives, could be vulnerable to a cholera outbreak after a hurricane.

"So," Hotez said, "I think it's shortsighted the U.S. government doesn't provide stockpiling [of cholera vaccine]. ... The U.S. needs to catch up with more stockpiling than it currently does."

Nearly all cholera cases reported in the United States arise from international travel, according to the CDC. But when outbreaks occurred in countries near the United States, such as Haiti in 2010, the number of U.S. cholera cases increased. Imported, contaminated seafood also has caused infections.

Globally, an emergency stockpile of oral cholera vaccine was established in 2013 by the World Health Organization's International Coordinating Group and partners.

Since the stockpile's creation, WHO spokeswoman Amna Smailbegovic told UPI, more that 123 million doses have been shipped to 23 countries -- from Bangladesh to Zimbabwe.

After a production increase, the amount of cholera vaccine shipped from the global stockpile rose to 27 million doses in 2021, up from 200,000 doses in 2013, according to WHO.

"All countries are eligible to request vaccines from the global stockpile. However, the risk of a cholera outbreak in high-income countries is very low, so we do not expect this to be the case," WHO said in an emailed statement.

Not tested in U.S.

However, Shanchol and Euvichol-Plus, the two-dose cholera vaccines currently available for mass vaccination campaigns through WHO's global stockpile, were not tested or made in the United States, which experts say the FDA prefers.

CDC spokeswoman Candice Hoffmann underscored the United States' "strong and reliable drinking water systems, adequate sanitation, hygiene and sewage infrastructures" in an emailed statement to UPI on Wednesday.

"In the unlikely event such an outbreak [of cholera] were to occur, CDC would work closely with FDA to seek emergency use licensing for Shanchol and Euvichol-Plus cholera vaccines using data from its usage overseas," Hoffman said.

To allow emergency use authorization, the FDA said it thoroughly evaluates available safety, effectiveness and manufacturing quality information -- a process that may hamper fast response to a public health emergency.

When Pfizer Inc. sought permission for emergency use of its COVID-19 vaccine at the end of 2020, for example, the process took three weeks.

To date this year, 23.5 million doses of cholera vaccine have shipped from the global stockpile, another 8 million doses required for the second dose of the two-dose regimen are pending shipment and more requests are under review, WHO said.

No vaccine in stockpile


By contrast, there isn't a single dose of cholera vaccine in the U.S. Strategic National Stockpile in case of outbreaks, spokeswoman Dawn Young told UPI in an email. This stockpile distributed ventilators and personal protective equipment at the peak of COVID-19, and stores two types of monkeypox vaccine.

The only cholera vaccine approved by the FDA, Vaxchora, has been on the FDA's national drug shortage list for well over a year. And until 2016, when Vaxchora received FDA's go-ahead for use in adults ages 18 through 64, no cholera vaccine had been available for decades for U.S. travelers are risk.


Maryland-based Emergent BioSolutions, which manufactures Vaxchora, told UPI its last batch of the one-dose oral cholera vaccine for U.S. international travelers had been shipped in December 2020.

"Given the unprecedented impact and halt in global travel during the pandemic, we proactively decided to discontinue production of Vaxchora ... [but] continued to diligently monitor travel health trends in preparation for production ramp-up," Jonathan Wong, Emergent Travel Health's general manager and global vice president, said in an email.

Emergent told UPI it resumed Vaxchora's production "in third quarter 2022," but won't have more supply available until early 2023. The vaccine, which costs about $300 per dose, is made at Emergent's plant in Bern, Switzerland.

Emergent -- the target of a congressional probe into the manufacture of COVID-19 vaccines -- said it plans to produce a supply of cholera vaccine "that will meet full year (2023) forecasted demand."

The call for storing a cholera vaccine In the United States dates back more than a decade.


Humanitarian resource

In 2010, Hotez, Dr. Matthew Waldor and Dr. John D. Clemens co-authored a New England Journal of Medicine article that urged creation of a national cholera vaccine stockpile as a "humanitarian and diplomatic resource."

That never materialized, though WHO's global stockpile began a few years later.

Waldor, a professor of medicine at Brigham and Women's Hospital and Harvard Medical School, told UPI in a telephone interview that cholera remains problematic in many parts of the world, but there's been "just the occasional imported case" domestically over the past 20 years that hasn't led to outbreaks.

Cholera is "usually treatable" with fluids and antibiotics, he said, describing the risk to most U.S. international travelers as "very low," aside from aid and healthcare workers, "so it's not a disaster there's not enough cholera vaccine for travelers."

But Waldor said "it's OK [for U.S.-based international travelers] to be super safe and get it [cholera vaccine], and conceded he may be "overly sanguine" about the U.S. cholera vaccine gap.

"Out of an abundance of caution, it might be good to have some in the stockpile, but I don't think there's a major risk for cholera in the United States," he said.

Waldor underscored the overall importance of cholera vaccines, noting that his laboratory plans to begin a phase 1 clinical trial of its own vaccine candidate, probably in November in Boston.

He said he anticipates his vaccine, if proven safe and effective, will join the global stockpile -- and be distributed and manufactured in countries that need it the most.
Canada would back 'economically viable' new LNG terminals -Finance Minister

By Steve Scherer

Canada's Finance Minister Chrystia Freeland holds a 
news conference before delivering the 2022-23 budget, in Ottawa
© Reuters/BLAIR GABLE

OTTAWA (Reuters) -Canada will look at supporting more liquefied natural gas (LNG) terminals as long as they are economically feasible because they are needed to keep the world from burning coal again amid the current energy crunch, Finance Minister Chrystia Freeland said on Friday.

LNG "is an important transition fuel," Freeland told reporters in Washington at the end of annual IMF and World Bank meetings. "We will always be looking at economically viable LNG projects."

German Chancellor Olaf Scholz visited in August, looking for Canada - the world's fifth largest producer of natural gas - to play a "major role" in filling the shortfall brought on by Russia's invasion of Ukraine, but went home with no promises.

When Scholz was in Canada, Prime Minister Justin Trudeau said "there has never been a strong business case" for LNG on the country's east coast.

On Friday, Freeland appeared to leave the door open to the possibility, as has Natural Resources Minister Jonathan Wilkinson, saying that she had heard finance ministers in Washington this week say they were having to burn more coal because of the soaring cost of LNG.

"'I want to burn less coal,' one minister said quite movingly," Freeland said, but cannot because "LNG is too expensive right now."

Two east coast projects being discussed are Repsol's intake facility in New Brunswick, which could be retooled for exports, and Pieridae Energy's proposed Goldboro LNG facility in Nova Scotia.

Separately, Freeland indicated that Canada would need to spend far more to compete to become the "best and fastest" at creating green-transition industries after the U.S. passage of the Inflation Reduction Act.

When asked if Canada was increasing its incentives to scale up green technologies in order to match the United States, she responded: "It is something we are very, very focused on."

"We need to act even more energetically and aggressively than we have hitherto," she said. "We need to find ways to attract even more private capital."

(Reporting by Steve Scherer, with additional reporting by Julie GordonEditing by Chris Reese and Marguerita Choy)
Gazprom CEO says big part of Nord Stream may need to be replaced

Reuters


The logo of the Nord Stream 2 gas pipeline project is seen on a pipe at the Chelyabinsk pipe rolling plant in Chelyabinsk, Russia, February 26, 2020. REUTERS/Maxim Shemetov/File Photo

MOSCOW, Oct 14 (Reuters) - Gazprom CEO (GAZP.MM) Alexei Miller told Russia's State TV Channel One late on Thursday that a big section of the damaged Nord Stream pipelines might need to be replaced, while Russia plans boosting gas exports via the Black Sea and Turkey.

Both Nord Stream 1 and Nord Stream 2 gas pipelines, which were built to transport gas from Russia to Germany via the bed of the Baltic Sea, were damaged last month, spewing out a large amount of gas.

Investigation into the incidents is under way. Russia called it an "act of international terrorism", pointing the finger at the West, while the European Union called it a "sabotage".

Both pipelines, stretching more than 1,000 km (620 miles) under the sea, were idle at the time of the ruptures.

"Experts say that in order to restore work after such a terrorist act, it is necessary to actually cut off a very large piece of pipe, at a great distance, and in fact build a new section on this section," Miller told the TV station.
"And in order to restore integrity, it must be raised, this pipe. And you understand, it is one thing when the pipe is hollow, yes, and another thing when it is filled with sea water for hundreds of kilometres."

On Wednesday, Miller, head of the Russian state-controlled natural gas monopoly, said repairs to the damaged Nord Stream pipelines would take more than one year.

TURKEY HUB


Russian President Vladimir Putin touted Turkey earlier this week as the best route for redirecting gas supplies to the European Union after Nord Stream pipeline leaks. He proposed to set up a gas hub in Turkey.

Miller said that Russia will start "concrete" talks with Turkey next week on the proposals.

He said Russia could boost gas supplies to Turkey by constructing new pipelines in parallel to the currently operational TurkStream pipeline via the Black Sea, adding that the project design documentation has already been prepared.

Miller said the gas supplies via the Black Sea may reach 63 billion cubic metres (bcm) per year. That's compared to 55 bcm of each of Nord Stream's capabilities and 31.5 bcm of TurkStream's transport capacity.
CRIMINAL CAPITALI$M
Elon Musk is under federal investigations, Twitter says in court filing









By Tom Hals and Sheila Dang

WILMINGTON, Del., Oct 13 (Reuters) - Elon Musk is being investigated by federal authorities over his conduct in his $44 billion takeover deal for Twitter Inc (TWTR.N), the social media company said in a court filing released on Thursday.

While the filing said he was under investigations, it did not say what the exact focus of the probes was and which federal authorities are conducting them.

Twitter, which sued Musk in July to force him to close the deal, said attorneys for the Tesla Inc (TSLA.O) CEO had claimed "investigative privilege" when refusing to hand over documents it had sought.

In late September, Musk's attorneys had provided a "privilege log" identifying documents to be withheld, Twitter said. The log referenced drafts of a May 13 email to the U.S. Securities and Exchange Commission (SEC) and a slide presentation to the Federal Trade Commission (FTC).

"This game of 'hide the ball' must end," the company said in the court filing.

The court filing, which asked Delaware judge Kathaleen McCormick to order Musk's attorneys to provide the documents, was made on Oct. 6 - the same day that McCormick paused litigation between the two sides after Musk reversed course and said he would proceed with the deal.

Alex Spiro, an attorney for Musk, told Reuters that Twitter's court filing was a "misdirection" and asserted: "It is Twitter's executives that are under federal investigation."

Twitter declined to comment on Spiro's statement. It also declined comment when asked by Reuters about its understanding of any investigation into Musk.
Tesla founder Elon Musk attends Offshore Northern Seas 2022
 in Stavanger, Norway August 29, 2022. 
NTB/Carina Johansen via REUTERS/File Photo

The SEC did not immediately respond to a request for comment and the FTC declined to comment.

The SEC has questioned Musk's comments about the Twitter acquisition, including whether a 9% stake he had built up before announcing his bid had been disclosed late and why it indicated that he intended to be a passive shareholder. Musk later refiled the disclosure to indicate he was an active investor.

In June, the SEC asked Musk in a letter whether he should have amended his public filing to reflect his intention to suspend or abandon the deal.

The Information, a tech news site, reported in April that the FTC was scrutinizing whether Musk failed to comply with the antitrust reporting requirement relating to an investor's intentions of being a passive or active shareholder.

Twitter said in June, however, that the takeover deal with Musk had cleared an antitrust waiting period for review by the FTC and U.S. Justice Department. read more

McCormick has given Musk until Oct. 28 to close the acquisition. If the deal does not get done by then, a trial date will be set for November.
CRIMINAL CAPITALI$M; BANK ROBBERY
Wells Fargo profit falls on sales scandal costs, higher reserves

By Lananh Nguyen
and Noor Zainab Hussain


Wells Fargo Bank branch is seen in New York City, U.S., March 17, 2020. 
REUTERS/Jeenah Moon

Oct 14 (Reuters) - Wells Fargo & Co (WFC.N) on Friday reported a 31% decline in third-quarter profit as the bank racked up costs related to a fake accounts scandal and boosted its loan loss reserves in preparation for a potential slowdown.

The bank posted $2 billion in operating losses related to litigation, customer remediation, and regulatory matters associated with the now six-year-old scandal over its sales practices.

"Outstanding litigation, customer remediation and regulatory matters still remain and will likely result in additional expense in the coming quarters, which could be significant," Chief Financial Officer Mike Santomassimo said.

"Our top priority remains strengthening our risk and control infrastructure which includes addressing open historical issues and issues that are identified as we advance this work," Chief Executive Officer Charlie Scharf said in a statement.

"We remain at risk of setbacks as we work to complete the work and put these issues behind us and expenses this quarter reflect our ongoing efforts." Excluding items, the fourth-largest U.S. lender earned $1.30 per share, beating analyst expectations of $1.09 per share, according to Refinitiv IBES data.

Wells Fargo shares rose 4% to $43.99 in afternoon trade. They have dropped around 12% so far this year, as of last close.

Meanwhile, the bank set aside $784 million in the quarter for credit losses, compared with a $1.4 billion release a year earlier, when extraordinary government stimulus helped the economy to rebound from the pandemic hit.

The provisions included a $385 million increase in the allowance for credit losses reflecting loan growth and a less favorable economic environment, the bank said.

Banks are building up rainy day funds again amid worries that aggressive interest rate increases by the Federal Reserve to tame stubbornly high inflation will tip the U.S. economy into a recession.

The outlook has been further clouded by the Russia-Ukraine war and fading stimulus measures. Higher borrowing costs have also shackled demand for mortgages and car loans, crimping banks' revenues.

Non-interest expense rose 8%, while net interest income jumped 36%, primarily due to the impact of higher interest rates and higher loan balances.

The Fed raised interest rates by 150 basis points in the third quarter taking its key rate to the 3.00%-3.25% range, the highest level since 2008, helping banks earn more from loans.

Wells Fargo's average loans rose to $945.5 billion from $854 billion a year earlier.

The bank reported a profit of $3.53 billion, or 85 cents per share, for the quarter ended Sept. 30, compared with $5.12 billion, or $1.17 per share, a year earlier.

Wells Fargo's net interest income will rise 24% this year, up from its previous guidance of 20%, Santomassimo told reporters on a conference call.

"Both consumer and business customers remain in a strong financial condition, and we continue to see historically low delinquencies and high payment rates across our portfolios," Scharf said.

He said the bank was closely monitoring risks related to the continued impact of high inflation, increasing interest rates, as well as the broader geopolitical risks.

"While we do expect to see continued increases in delinquencies and ultimately credit losses, the timing remains unclear," Scharf continued.
Small modular reactors, energy transition key parts of Türkiye-US energy dialogue: Official

Ankara, Washington committed to cooperate on overcoming immediate challenges on gas supply issues, says senior US official

Nuran Erkul Kaya |13.10.2022


ISTANBUL

Türkiye and the US can focus more on small modular reactors in nuclear energy and transitioning from fossil fuels to low-carbon energy sources in their longer-term dialogue, a senior American official said on Thursday.

Besides the immediate challenges of the energy crisis, gas supplies, and Russia's war on Ukraine, the two countries are also committed to “the longer-term issue of transition,” said Geoffrey Pyatt, assistant secretary of state for energy resources, on a three-nation tour to Bulgaria, Romania, and Türkiye.

After meeting with Alparslan Bayraktar, the Turkish deputy minister of energy and natural resources, as well as other officials and energy sector leaders, Pyatt told Anadolu Agency that he had “a very rich round of discussions” in Türkiye, where he was visiting as part of a three-nation tour on Oct. 10-14 that also included Bulgaria and Romania.

“I found a very high degree of agreement with my Turkish counterparts on this visit regarding the importance of stability in the market, importance of our dialogue that we have established between Washington and Ankara on all of the issues around the geopolitics of global energy and energy transition,” the US official said in the exclusive interview on the sidelines of the Atlantic Council's Regional Clean Energy Outlook Conference in Istanbul.

The Turkish government has the understanding that the name of the game is more wind, solar, hydro, and small modular nuclear reactors, he noted, explaining that nuclear power has a critical role in the US, while recent legislation had paved the way to extend the operation of domestic reactors.

Washington supports ongoing discussions in Europe on how to bring new projects to scale and to market as quickly as possible, Pyatt underlined. He also said that small modular nuclear reactors would be part of the solution to the world’s current energy-related conundrums.

"It is a challenge that we are committed to work together on between the US and Türkiye, issues like the regulatory environment for these reactors, in order to ensure and to assure communities that these projects can be rolled out safely. But it also has to make commercial sense," he said, pointing out that there was a clear revival of interest in nuclear power in many parts of the world.

Nuclear accounts for about 20% of the US’ total energy mix as a clean and sustainable power source, Pyatt added.

US companies could invest in LNG infrastructure in Europe

On the current natural gas crisis and its impacts, Pyatt said the current situation was "caused uniquely by (Russian President) Vladimir Putin and the Russian government" which he accused of weaponizing its energy resources.

"That disruption (in gas supplies) is being felt around the world, literally, in every corner of the globe in terms of inflation, commodity prices. Europe is particularly vulnerable because of how Europe over time had evolved its industrial structures to be linked, in particular to Russian gas supplies," Pyatt said.

He pointed out that Europe acknowledges that Russia has been able to take advantage of its position of dependency.

"I am convinced that no one will ever see Russia as a reliable energy supplier, as long as Russia is doing what it is doing to Ukraine today," Pyatt said.

The US has increased its liquified natural gas (LNG) exports to Europe to ease the gas crisis, with 15 billion cubic meters of American LNG earmarked for this year and the country on track to be the world's largest LNG exporter this year, he added.

"We will continue to stay in lockstep with all of our European partners,” said the official, adding that this would also be important to Türkiye, as well as its non-EU neighbors.

The Western Balkans are in a position of “particular vulnerability,” as those countries get “100% of their gas from Russia," Pyatt said, adding that US LNG companies have been successfully working with Türkiye as an LNG buyer.

US companies also have plans to invest in LNG infrastructure in Europe, Pyatt said. "It is not the US government. It is our companies (that) have built the very expensive infrastructure that is required for liquification on the US side and the companies that are involved in the marketing," he explained, pointing out to the importance of building supportive and cooperative infrastructure among countries of the region.

“This is how we can most effectively push back on what Russia has tried to do by weaponizing its energy resources,” Pyatt noted.

‘Unfortunate’ production cut decision by OPEC+

On a recent decision by the Organization of Petroleum Exporting Countries (OPEC) and allies, known as OPEC+, to cut oil output, Pyatt said the US government had made clear at the most senior level, including the national security adviser, how disappointed it was in this decision.

OPEC+ agreed on Wednesday to cut production by 2 million barrels per day (bpd) from the August 2022 required production levels, starting November.

The decision by is a “clear” sign that the bloc is siding with Russia amid a growing power rivalry with the West, the White House said last Wednesday after the announcement of the move.

“How unfortunate we think it is in light of global oil markets and exactly the moment when the international community is trying to grow itself out of the COVID-19 crisis and the economic slowdown that produced and this huge shock caused by Vladimir Putin's invasion of a sovereign Ukraine,” Pyatt said.

He concluded, however, by saying that he did not want to speculate on the Saudi motivation on the decision.

SEE





The Exploited Labor Behind Artificial Intelligence

Supporting transnational worker organizing should be at the center of the fight for “ethical AI.”


Nash Weerasekera for Noema Magazine



OCTOBER 13, 2022
Adrienne Williams and Milagros Miceli are researchers at the Distributed AI Research (DAIR) Institute. Timnit Gebru is the institute’s founder and executive director. She was previously co-lead of the Ethical AI research team at Google.


The public’s understanding of artificial intelligence (AI) is largely shaped by pop culture — by blockbuster movies like “The Terminator” and their doomsday scenarios of machines going rogue and destroying humanity. This kind of AI narrative is also what grabs the attention of news outlets: a Google engineer claiming that its chatbot was sentient was among the most discussed AI-related news in recent months, even reaching Stephen Colbert’s millions of viewers. But the idea of superintelligent machines with their own agency and decision-making power is not only far from reality — it distracts us from the real risks to human lives surrounding the development and deployment of AI systems. While the public is distracted by the specter of nonexistent sentient machines, an army of precarized workers stands behind the supposed accomplishments of artificial intelligence systems today.

Many of these systems are developed by multinational corporations located in Silicon Valley, which have been consolidating power at a scale that, journalist Gideon Lewis-Kraus notes, is likely unprecedented in human history. They are striving to create autonomous systems that can one day perform all of the tasks that people can do and more, without the required salaries, benefits or other costs associated with employing humans. While this corporate executives’ utopia is far from reality, the march to attempt its realization has created a global underclass, performing what anthropologist Mary L. Gray and computational social scientist Siddharth Suri call ghost work: the downplayed human labor driving “AI”.

Tech companies that have branded themselves “AI first” depend on heavily surveilled gig workers like data labelers, delivery drivers and content moderators. Startups are even hiring people to impersonate AI systems like chatbots, due to the pressure by venture capitalists to incorporate so-called AI into their products. In fact, London-based venture capital firm MMC Ventures surveyed 2,830 AI startups in the EU and found that 40% of them didn’t use AI in a meaningful way.

Far from the sophisticated, sentient machines portrayed in media and pop culture, so-called AI systems are fueled by millions of underpaid workers around the world, performing repetitive tasks under precarious labor conditions. And unlike the “AI researchers” paid six-figure salaries in Silicon Valley corporations, these exploited workers are often recruited out of impoverished populations and paid as little as $1.46/hour after tax. Yet despite this, labor exploitation is not central to the discourse surrounding the ethical development and deployment of AI systems. In this article, we give examples of the labor exploitation driving so-called AI systems and argue that supporting transnational worker organizing efforts should be a priority in discussions pertaining to AI ethics.

We write this as people intimately connected to AI-related work. Adrienne is a former Amazon delivery driver and organizer who has experienced the harms of surveillance and unrealistic quotas established by automated systems. Milagros is a researcher who has worked closely with data workers, especially data annotators in Syria, Bulgaria and Argentina. And Timnit is a researcher who has faced retaliation for uncovering and communicating the harms of AI systems.

Treating Workers Like Machines

Much of what is currently described as AI is a system based on statistical machine learning, and more specifically, deep learning via artificial neural networks, a methodology that requires enormous amounts of data to “learn” from. But around 15 years ago, before the proliferation of gig work, deep learning systems were considered merely an academic curiosity, confined to a few interested researchers.

In 2009,however, Jia Deng and his collaborators released the ImageNet dataset, the largest labeled image dataset at the time, consisting of images scraped from the internet and labeled through Amazon’s newly introduced Mechanical Turk platform. Amazon Mechanical Turk, with the motto “artificial artificial intelligence,” popularized the phenomenon of “crowd work”: large volumes of time-consuming work broken down into smaller tasks that can quickly be completed by millions of people around the world. With the introduction of Mechanical Turk, intractable tasks were suddenly made feasible; for example, hand-labeling one million images could be automatically executed by a thousand anonymous people working in parallel, each labeling only a thousand images. What’s more, it was at a price even a university could afford: crowdworkers were paid per task completed, which could amount to merely a few cents.


“So-called AI systems are fueled by millions of underpaid workers around the world, performing repetitive tasks under precarious labor conditions.”


The Image

Net dataset was followed by the ImageNet Large Scale Visual Recognition Challenge, where researchers used the dataset to train and test models performing a variety of tasks like image recognition: annotating an image with the type of object in the image, such as a tree or a cat. While non-deep-learning-based models performed these tasks with the highest accuracy at the time, in 2012, a deep-learning-based architecture informally dubbed AlexNet scored higher than all other models by a wide margin. This catapulted deep-learning-based models into the mainstream, and brought us to today, where models requiring lots of data, labeled by low-wage gig workers around the world, are proliferated by multinational corporations. In addition to labeling data scraped from the internet, some jobs have gig workers supply the data itself, requiring them to upload selfies, pictures of friends and family or images of the objects around them.

Unlike in 2009, when the main crowdworking platform was Amazon’s Mechanical Turk, there is currently an explosion of data labeling companies. These companies are raising tens to hundreds of millions in venture capital funding while the data labelers have been estimated to make an average of $1.77 per task. Data labeling interfaces have evolved to treat crowdworkers like machines, often prescribing them highly repetitive tasks, surveilling their movements and punishing deviation through automated tools. Today, far from an academic challenge, large corporations claiming to be “AI first” are fueled by this army of underpaid gig workers, such as data laborers, content moderators, warehouse workers and delivery drivers.

Content moderators, for example, are responsible for finding and flagging content deemed inappropriate for a given platform. Not only are they essential workers, without whom social media platforms would be completely unusable, their work flagging different types of content is also used to train automated systems aiming to flag texts and imagery containing hate speech, fake news, violence or other types of content that violates platforms’ policies. In spite of the crucial role that content moderators play in both keeping online communities safe and training AI systems, they are often paid miserable wages while working for tech giants and forced to perform traumatic tasks while being closely surveilled.

Every murder, suicide, sexual assault or child abuse video that does not make it onto a platform has been viewed and flagged by a content moderator or an automated system trained by data most likely supplied by a content moderator. Employees performing these tasks suffer from anxiety, depression and post-traumatic stress disorder due to constant exposure to this horrific content.

Besides experiencing a traumatic work environment with nonexistent or insufficient mental health support, these workers are monitored and punished if they deviate from their prescribed repetitive tasks. For instance, Sama content moderators contracted by Meta in Kenya are monitored through surveillance software to ensure that they make decisions about violence in videos within 50 seconds, regardless of the length of the video or how disturbing it is. Some content moderators fear that failure to do so could result in termination after a few violations. “Through its prioritization of speed and efficiency above all else,” Time Magazine reported, “this policy might explain why videos containing hate speech and incitement to violence have remained on Facebook’s platform in Ethiopia.”

Similar to social media platforms which would not function without content moderators, e-commerce conglomerates like Amazon are run by armies of warehouse workers and delivery drivers, among others. Like content moderators, these workers both keep the platforms functional and supply data for AI systems that Amazon may one day use to replace them: robots that stock packages in warehouses and self-driving cars that deliver these packages to customers. In the meantime, these workers must perform repetitive tasks under the pressure of constant surveillance — tasks that, at times, put their lives at risk and often result in serious musculoskeletal injuries.

“Data labeling interfaces have evolved to treat crowdworkers like machines, often prescribing them highly repetitive tasks, surveilling their movements and punishing deviation through automated tools.”


Amazon warehouse employees are tracked via cameras and their inventory scanners, and their performance is measured against the times managers determine every task should take, based on aggregate data from everyone working at the same facility. Time away from their assigned tasks is tracked and used to discipline workers.

Like warehouse workers, Amazon delivery drivers are also monitored through automated surveillance systems: an app called Mentor tallies scores based on so-called violations. Amazon’s unrealistic delivery time expectations push many drivers to take risky measures to ensure that they deliver the number of packages assigned to them for the day. For instance, the time it takes someone to fasten and unfasten their seatbelt some 90-300 times a day is enough to put them behind schedule on their route. Adrienne and many of her colleagues buckled their seat belts behind their backs, so that the surveillance systems registered that they were driving with a belt on, without getting slowed down by actually driving with a belt on.

In 2020, Amazon drivers in the U.S. were injured at a nearly 50% higher rate than their United Parcel Service counterparts. In 2021, Amazon drivers were injured at a rate of 18.3 per 100 drivers, up nearly 40% from the previous year. These conditions aren’t only dangerous for delivery drivers — pedestrians and car passengers have been killed and injured in accidents involving Amazon delivery drivers. Some drivers in Japan recently quit in protest because they say Amazon’s software sent them on “impossible routes,” leading to “unreasonable demands and long hours.” In spite of these clear harms, however, Amazon continues to treat its workers like machines.

In addition to tracking its workers through scanners and cameras, last year, the company required delivery drivers in the U.S. to sign a “biometric consent” form, granting Amazon permission to use AI-powered cameras to monitor drivers’ movements — supposedly to cut down on distracted driving or speeding and ensure seatbelt usage. It’s only reasonable for workers to fear that facial recognition and other biometric data could be used to perfect worker-surveillance tools or further train AI — which could one day replace them. The vague wording in the consent forms leaves the precise purpose open for interpretation, and workers have suspected unwanted uses of their data before (though Amazon denied it).

The “AI” industry runs on the backs of these low-wage workers, who are kept in precarious positions, making it hard, in the absence of unionization, to push back on unethical practices or demand better working conditions for fear of losing jobs they can’t afford to lose. Companies make sure to hire people from poor and underserved communities, such as refugees, incarcerated people and others with few job options, often hiring them through third party firms as contractors rather than as full time employees. While more employers should hire from vulnerable groups like these, it is unacceptable to do it in a predatory manner, with no protections.


“AI ethics researchers should analyze harmful AI systems as both causes and consequences of unjust labor conditions in the industry.”


Data labeling jobs are often performed far from the Silicon Valley headquarters of “AI first” multinational corporations — from Venezuela, where workers label data for the image recognition systems in self-driving vehicles, to Bulgaria, where Syrian refugees fuel facial recognition systems with selfies labeled according to race, gender, and age categories. These tasks are often outsourced to precarious workers in countries like India, Kenya, the Philippines or Mexico. Workers often do not speak English but are provided instructions in English, and face termination or banning from crowdwork platforms if they do not fully understand the rules.

These corporations know that increased worker power would slow down their march toward proliferating “AI” systems requiring vast amounts of data, deployed without adequately studying and mitigating their harms. Talk of sentient machines only distracts us from holding them accountable for the exploitative labor practices that power the “AI” industry.

An Urgent Priority For AI Ethics

While researchers in ethical AI, AI for social good, or human-centered AI have mostly focused on “debiasing” data and fostering transparency and model fairness, here we argue that stopping the exploitation of labor in the AI industry should be at the heart of such initiatives. If corporations are not allowed to exploit labor from Kenya to the U.S., for example, they will not be able to proliferate harmful technologies as quickly — their market calculations would simply dissuade them from doing so.

Thus, we advocate for funding of research and public initiatives that aim to uncover issues at the intersection of labor and AI systems. AI ethics researchers should analyze harmful AI systems as both causes and consequences of unjust labor conditions in the industry. Researchers and practitioners in AI should reflect on their use of crowdworkers to advance their own careers, while the crowdworkers remain in precarious conditions. Instead, the AI ethics community should work on initiatives that shift power into the hands of workers. Examples include co-creating research agendas with workers based on their needs, supporting cross-geographical labor organizing efforts and ensuring that research findings are easily accessed by workers rather than confined to academic publications. The Turkopticon platform created by Lilly Irani and M. Six Silberman, “an activist system that allows workers to publicize and evaluate their relationships with employers,” is a great example of this.

Journalists, artists, and scientists can help by drawing clear the connection between labor exploitation and harmful AI products in our everyday lives, fostering solidarity with and support for gig workers and other vulnerable worker populations. Journalists and commentators can show the general public why they should care about the data annotator in Syria or the hypersurveilled Amazon delivery driver in the U.S. Shame does work in certain circumstances and, for corporations, the public’s sentiment of “shame on you” can sometimes equal a loss in revenue and help move the needle toward accountability.

Supporting transnational worker organizing should be at the center of the fight for “ethical AI.” While each workplace and geographical context has its own idiosyncrasies, knowing how workers in other locations circumvented similar issues can serve as inspiration for local organizing and unionizing efforts. For example, data labelers in Argentina could learn from the recent unionizing efforts of content moderators in Kenya, or Amazon Mechanical Turk workers organizing in the U.S., and vice versa. Furthermore, unionized workers in one geographic location can advocate for their more precarious counterparts in another, as in the case of the Alphabet Workers Union, which includes both high paid employees in Silicon Valley and outsourced low wage contractors in more rural areas.

“This type of solidarity between highly-paid tech workers and their lower-paid counterparts — who vastly outnumber them — is a tech CEO’s nightmare.”

This type of solidarity between highly-paid tech workers and their lower-paid counterparts — who vastly outnumber them — is a tech CEO’s nightmare. While corporations often treat their low-income workers as disposable, they’re more hesitant to lose their high-income employees who can quickly snap up jobs with competitors. Thus, the high-paid employees are allowed a far longer leash when organizing, unionizing, and voicing their disappointment with company culture and policies. They can use this increased security to advocate with their lower-paid counterparts working at warehouses, delivering packages or labeling data. As a result, corporations seem to use every tool at their disposal to isolate these groups from each other.

Emily Cunningham and Maren Costa created the type of cross-worker solidarity that scares tech CEOs. Both women worked as user experience designers at Amazon’s Seattle headquarters cumulatively for 21 years. Along with other Amazon corporate workers, they co-founded the Amazon Employees for Climate Justice (AECJ). In 2019, over 8,700 Amazon workers publicly signed their names to an open letter addressed to Jeff Bezos and the company’s board of directors demanding climate leadership and concrete steps the company needed to implement to be aligned with climate science and protect workers. Later that year, AECJ organized the first walkout of corporate workers in Amazon’s history. The group says over 3,000 Amazon workers walked out across the world in solidarity with a youth-led Global Climate Strike.

Amazon responded by announcing its Climate Pledge, a commitment to achieve net-zero carbon by 2040 — 10 years ahead of the Paris Climate Agreement. Cunningham and Costa say they were both disciplined and threatened with termination after the climate strike — but it wasn’t until AECJ organized actions to foster solidarity with low-wage workers that they were actually fired. Hours after another AECJ member sent out a calendar invite inviting corporate workers to listen to a panel of warehouse workers discussing the dire working conditions they were facing at the beginning of the pandemic, Amazon fired Costa and Cunningham. The National Labor Relations Board found their firings were illegal, and the company later settled with both women for undisclosed amounts. This case illustrates where executives’ fears lie: the unflinching solidarity of high-income employees who see low-income employees as their comrades.

In this light, we urge researchers and journalists to also center low-income workers’ contributions in running the engine of “AI” and to stop misleading the public with narratives of fully autonomous machines with human-like agency. These machines are built by armies of underpaid laborers around the world. With a clear understanding of the labor exploitation behind the current proliferation of harmful AI systems, the public can advocate for stronger labor protections and real consequences for entities who break them.























India watchdogs halt production at plant linked to cough syrup deaths


Oct. 13 (UPI) -- The embattled Maiden Pharmaceuticals in India have been ordered to stop all manufacturing activities on Wednesday at a plant that produced four cough syrups connected with the death of 66 children in the Gambia.

India's Central Drug Standard Control Organization and the Haryana Food and Drug Administration announced the order in a joint statement as a committee was established to look into the production problems at the plant.

"In view of the seriousness of the contraventions observed during the investigation and its potential risk to the quality, safety and efficacy of the drugs being produced, all the manufacturing activities of the firm are being stopped with immediate effect," the two organizations said, according to the Deccan Herald.

The order comes on the heels of the World Health Organization issuing a warning last week against four cold and cough syrups. The organization released the alert for Promethazine Oral Solution, Kofexmalin Baby Cough Syrup, Makoff Baby Cough Syrup and Magrip N Cold Syrup, all made by Maiden Pharmaceuticals Limited in Haryana, India.

The WHO said laboratory analysis of samples of each of the four products confirms that they contain unacceptable amounts of diethylene glycol and ethylene glycol as contaminants.

Diethylene glycol and ethylene glycol are toxic to humans when consumed and can prove fatal. Toxic effects can include abdominal pain, vomiting, diarrhea, inability to pass urine, headache, altered mental state, and acute kidney injury which may lead to death.

For now, all drug production at the Sonepat unit of Maiden Pharmaceuticals has been stopped. Haryana officials have issued a show-cause notice to the company to explain "many contraventions" discovered during a probe by central and state drugs regulators.

FRESHWATER
Alligator caught swimming in the ocean in Florida

Oct. 13 (UPI) -- A wildlife trapper was summoned to a Florida beach to remove a massive alligator spotted taking a swim in the ocean.

The City of Delray Beach said in a Facebook post that a Florida Fish and Wildlife Conservation Commission trapper responded to the shoreline alongside the Delray Beach Police Department and Delray Beach Fire Rescue lifeguards when a large alligator was spotted taking a saltwater swim.

"While the American alligator prefers freshwater lakes, slow-moving rivers, and wetlands, they are occasionally seen in brackish water," the post said. "Alligators can tolerate saltwater for short periods."

The gator was not harmed and was taken to an alligator farm in the area.