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Friday, December 05, 2025

 Microplastics Make Up Majority of US National Park Trash, Waste Audit Finds


“Even in landscapes that appeared untouched,” volunteers found “thousands of plastic pellets and fragments that pose a clear threat to the environment, wildlife, and human health,” said a 5 Gyres Institute spokesperson.


Trash is seen strewn along the road at Joshua Tree National Park in California, on October 10, 2025, on the 10th day of the federal government shutdown.
(Photo by Frederic J. Brown/AFP)


Stephen Prager
Dec 04, 2025
COMMON DREAMS


More than half the trash polluting America’s national parks and federal lands contains hazardous microplastics, according to a waste audit published Thursday.

As part of its annual “TrashBlitz” effort to document the scale of plastic pollution in national parks and federal lands across the US, volunteers with the 5 Gyres Institute collected nearly 24,000 pieces of garbage at 59 federally protected locations.

In each of the four years the group has done the audit, they’ve found that plastic has made up the vast majority of trash in the sites.

They found that, again this year, plastic made up 85% of the waste they logged, with 25% of it single-use plastics like bottle caps, food wrappers, bags, and cups.

But for the first time, they also broke down the plastics category to account for microplastics, the small fragments that can lodge permanently in the human body and cause numerous harmful health effects.

As a Stanford University report from January 2025 explained:
In the past year alone, headlines have sounded the alarm about particles in tea bags, seafood, meat, and bottled water. Scientists have estimated that adults ingest the equivalent of one credit card per week in microplastics. Studies in animals and human cells suggest microplastics exposure could be linked to cancer, heart attacks, reproductive problems, and a host of other harms.

Microplastics come in two main forms: pre-production plastic pellets, sometimes known as “nurdles,” which are melted down to make other products; and fragments of larger plastic items that break down over time.

The volunteers found that microplastic pellets and fragments made up more than half the trash they found over the course of their survey.

“Even in landscapes that appeared untouched, a closer look at trails, riverbeds, and coastlines revealed thousands of plastic pellets and fragments that pose a clear threat to the environment, wildlife, and human health,” said Nick Kemble, programs manager at the 5 Gyres Institute.

Most of the microplastics they found came in the form of pellets, which the group’s report notes often “spill in transit from boats and trains, entering waterways that carry them further into the environment or deposit them on shorelines.”

The surveyors identified the Altria Group—a leading manufacturer of cigarettes—PepsiCo, Anheuser-Busch InBev, the Coca-Cola Company, and Mars as the top corporate polluters whose names appeared on branded trash.

But the vast majority of microplastic waste discovered was unbranded. According to the Coastal & Estuarine Research Federation, petrochemical companies such as Dow, ExxonMobilShell, and Formosa are among the leading manufacturers of pellets found strewn across America’s bodies of water.

The 5 Gyres report notes that “at the federal level in the United States, there is no comprehensive regulatory framework that specifically holds these polluters accountable, resulting in widespread pollution that threatens ecosystems and wildlife.”

The group called on Congress to pass the Reducing Waste in National Parks Act, introduced in 2023 by Sen. Jeff Merkley (D-Ore.), which would reduce the sale of single-use plastics in national parks. It also advocated for the Plastic Pellet Free Waters Act, introduced last year by Rep. Mike Levin (D-Calif.) and then-Rep. Mary Peltola (D-Alaska), which would prohibit the discharge of pre-production plastic pellets into waterways, storm drains, and sewers.

“It’s time that our elected officials act on the warnings we’ve raised for years—single-use plastics and microplastics pose an immediate threat to our environment and public health,” said Paulita Bennett-Martin, senior strategist of policy initiatives at 5 Gyres. “TrashBlitz volunteers uncovered thousands of microplastics in our nation’s most protected spaces, and we’re urging decisive action that addresses this issue at the source.”


Microplastics filter inspired by fish



Researchers at the University of Bonn want to make wastewater cleaner



University of Bonn

Inside the mouth 

image: 

of this anchovy, plankton particles are captured by the gill arch system. 

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Credit: Photo: Jens Hamann





Wastewater from washing machines is considered a major source of microplastics – tiny plastic particles that are suspected of harming human and animal health. Researchers at the University of Bonn now have developed a filter to curb this problem. Their filter was inspired by the gill arch system in fish. In initial tests, the now patent-pending filter was able to remove over 99 percent of plastic fibers from washing machine wastewater. The results now have been published in the journal npj Emerging Contaminants.

Wastewater from a washing machine in a four-person household produces up to 500 grams of microplastics each year, mainly caused by textile abrasion. The household appliances are thus one of the most important sources of the tiny particles. Microplastics currently make their way directly into the sewage sludge of wastewater treatment plants. As this sludge is often used as fertilizer, the fibers ultimately end up on the fields.

Many manufacturers have thus been searching for ways to remove microplastics from washing water to prevent them from entering the environment. “The filter systems available so far, however, have various disadvantages,” explains Dr. Leandra Hamann from the Institute for Organismic Biology at the University of Bonn. “Some of them quickly become clogged, others do not offer adequate filtration.”

Looking inside the mouths of fish

The scientist, alongside her doctoral supervisor Dr. Alexander Blanke and colleagues, has thus turned to the animal kingdom in her search for possible solutions. The team focused on fish that can be considered true masters of filter technology – and have evolved this filtration over hundreds of millions of years.

Some fish feed by means of filtration; these include, for example, mackerel, sardines, and anchovies. They swim through the water with their mouths open and sift out the plankton with their gill arch system. “We took a closer look at the construction of this system and used it as the model for developing a filter that can be used in washing machines,” says Blanke, who is a member of the transdisciplinary research areas “Life & Health” and “Sustainable Futures” at the University of Bonn.

During their evolution these fish have developed a technique similar to cross-flow filtration. Their gill arch system is shaped like a funnel that is widest at the fish’s mouth and tapers towards their gullet. The walls of the funnel are shaped by the branchial arches. These feature comb-like structures, the arches, which are themselves covered in small teeth. This creates a kind of mesh that is stretched by the branchial arches.

Self-cleaning: plankton rolls towards the gullet

“During food intake, the water flows through the permeable funnel wall, is filtered, and the particle-free water is then released back into the environment via the gills,” explains Blanke. “However, the plankton is too big for this; it is held back by the natural sieve structure. Thanks to the funnel shape, it then rolls towards the gullet, where it is collected until the fish swallows, which empties and cleans the system.”

This principle prevents the filter from being blocked – instead of hitting the filter head-on, the fibers roll along it towards the gullet. The process is also highly effective, as it removes almost all of the plankton from the water. Both are aspects that a microplastic filter must also be able to deliver. The researchers thus replicated the gill arch system. In doing so, they varied both the mesh size of the sieve structure and the opening angle of the funnel.

Filter achieves high efficiency

“We have thus found a combination of parameters that enable our filter to separate more than 99 percent of the microplastics out of the water but not become blocked,” says Hamann. To achieve this, the team used not only experiments but also computer simulations. The filter modelled on nature does not contain any elaborate mechanics and should thus be very inexpensive to manufacture.

The microplastics that it filters out of the washing water collect in the filter outlet and are then suctioned away several times a minute. According to the researcher, who has now moved to the University of Alberta in Edmonton, Canada, they could then, for example, be pressed in the machine to remove the remaining water. The plastic pellet created in this manner could then be removed every few dozen washes and disposed of with general waste.

The team from the University of Bonn and the Fraunhofer Institute for Environmental, Safety, and Energy Technology UMSICHT has already applied for a patent for its development in Germany; EU-wide patenting is currently underway. The researchers now hope that manufacturers will further develop the filter and integrate it into future generations of washing machines. This would stem the spread of microplastics from textiles, at least to some extent. And that is also necessary: analyses indicate that the particles may cause serious damage to health. They have already been found in breast milk and in the placenta – and even in the brain.

Participating institutions and funding:

In addition to the University of Bonn, the Fraunhofer Institute for Environmental, Safety, and Energy Technology UMSICHT was also involved in the study. The work was supported with funding from the Federal Ministry of Research, Technology and Space (BMFTR) and the European Research Council (ERC). The protection and marketing of the invention is supported by the Transfer Center enaCom at the University of Bonn in close cooperation with PROvendis GmbH, a service provider of the NRW university network for knowledge and technology transfer “innovation2business.nrw.”

Publication: Leandra Hamann et. al. (2025): A self-cleaning, bio-inspired high retention filter for a major entry path of microplastics; npj Emerging Contaminants; DOI: https://doi.org/10.1038/s44454-025-00020-2

the gill rakers are covered with denticles forming a mesh structure that catches the particles.

Credit

Photo: Leandra Hamann



imitates the gill arch system of the fish. The filter housing enables periodic cleaning and installation in washing machines. 

Credit

Illustration: Christian Reuß/Leandra Hamann

front Dr. Leandra Hamann, right Dr. Alexander Blanke, center material researcher Christian Reuß, left biologist Dr. Hendrik Herzog.

Credit

Photo: Peter Rühr/Uni Bonn

Tuesday, December 02, 2025

 

Unraveling the fungi-cancer connection




Research






Background

A growing body of evidence indicates that the microbiome within the gut and tumors significantly influences cancer initiation, progression, and treatment response. Current research primarily focuses on bacteria, whilst the role of fungi is only now gaining attention.

The authors address key questions that have caused confusion and hindered clinical translation: (a) Why should we value the role of mycobiome in oncological research? (b) What will the relationship between fungi and bacteria be in cancer progression? (c) How will the fungi impact cancer? (d) Can we target fungi for development of intervention strategies in anticancer treatment? (e) Will the effort and investment pay back in mycobiome-driven cancer research?

Research Progress

Despite their low abundance in tumor tissues (approximately 4%~13.3%), fungi exhibit widespread distribution, high signal activity, and type-specificity across multiple cancers, including lung, breast, colorectal, and pancreatic cancers. Through highly sensitive techniques such as ITS sequencing and single-cell sequencing, tumor-associated fungi including CandidaMalassezia, and Aspergillus have been identified. These fungi may promote tumour progression by activating immunosuppressive pathways (e.g., Dectin-1/CARD9, IL-1β/MDSC axis) or secreting carcinogens (e.g., aflatoxins). Concurrently, fungi and bacteria exhibit synergistic or antagonistic interactions within the microbiome, influencing the immune microenvironment and therapeutic response. Modulating the fungal microbiome (e.g., via antifungal agents, heat-killed fungi, or combined immunotherapy) may enhance antitumour immunity. Preliminary validation of this therapeutic potential has emerged from certain preclinical and clinical trials (e.g., itraconazole, ketoconazole).

Future Prospects

Future fungal cancer research will progress from “correlation” towards “causation”, utilizing single-cell sequencing and spatial omics to identify pro- or anti-cancer fungi, while integrating multi-kingdom interaction maps encompassing bacteria, viruses and archaea. Technologically, standardized protocols for ITS, 18S and metagenomic sequencing will be established, alongside developing fungal enrichment sequencing and multi-omics AI models, culminating in a tumor fungal ecosystem database. Clinically, fungal-bacterial combined biomarkers will be promoted for early screening, prognosis, and immunotherapy response prediction. Repurposed antifungal drugs like itraconazole and ketoconazole will be utilized, alongside developing low-toxicity nanoformulations and fungal metabolite adjuvants.

Research will explore fecal fungal transplantation, attenuated engineered fungi, and personalized ‘fungal prescriptions’. Industrial advancement will drive synthetic biology-engineered medicinal fungi, targeted delivery systems, and mycobiome diagnostic kits. Societal efforts must overcome the bias of ‘prioritizing bacteria over fungi’ by establishing interdisciplinary fungal-cancer alliances. Government investment should concurrently develop ethical frameworks, antimicrobial resistance surveillance, and toxicity assessment protocols. Ultimately, this will realize mycobiome-driven precision diagnostics and therapeutics, benefiting cancer patients.

Sources: https://spj.science.org/doi/10.34133/research.0931

Thursday, November 27, 2025

 D.E.I.

UH researchers unveil X-ray breakthrough that captures 3 image-contrast types in a single shot


System could reveal early cancers, lung disease, hidden material defects and changes in porosity



University of Houston

Mini Das headshot 

image: 

Mini Das is a Moores professor at the University of Houston's Cullen College of Engineering and College of Natural Sciences and Mathematics.

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Credit: University of Houston




University of Houston researchers developed a new X-ray imaging method capable of revealing hidden features in a single shot, a breakthrough that could advance cancer detection, disease monitoring, security screening and material analysis.

This study, soon to be published in scientific journal Optica, introduces a system that captures far more detailed diagnostic information without requiring multiple exposures or complex mechanical movement. The research was led by physics researcher Jingcheng Yuan and Mini Das, Moores professor at UH’s Cullen College of Engineering and College of Natural Sciences and Mathematics.

Conventional X-ray and CT imaging rely solely on attenuation contrast, which shows how tissues and materials absorb X-rays.

While effective for bone and large-density differences, it struggles to reveal early-stage cancers or subtle changes in microstructures like the lung’s tiny air sacs. Emerging methods that aim to overcome these limitations need complex system designs and require long exposures to capture meaningful images, leading to higher radiation doses and difficulty to translate clinically.

“A lot of the methods being explored often need long imaging time because they require a system component to be moved multiple times — often over 10 or 20 times — to make these multiple image contrast,” Das said.

How It Works

To overcome these limitations, the UH team proposed and demonstrated new patent pending system designs and corresponding physics-based models.

The new configuration makes it possible to achieve three contrast types — attenuation, differential phase and dark field — from a single X-ray exposure. The design determines optimal placement of a single, slatted plate, or mask, between the X-ray source and detector.

The additional contrast types offer new insights:

  • Differential phase, which Das introduced in a 2024 paper, shows how X-rays bend, enhancing visibility of boundaries, shapes and structural variations that are otherwise hard to see.
  • Dark field captures how small-angle X-rays scatter from microstructures, revealing tiny structures such as lung air pockets or microscopic defects in materials.

Das said dark-field imaging may be especially promising for diagnosing lung diseases such as chronic obstructive pulmonary disease, where current imaging can’t detect the microstructural changes. One can also examine changes in lung cancer and their response to therapies.

“We know there will be benefit, but how much that will help clinicians diagnose, detect and follow up for therapy monitoring is an open avenue right now,” she said.

Why It Matters

The new single-shot and motion-free method produces images that are more informative, low-dose and faster — helping to lower patients’ dose of radiation, which can be especially beneficial for children and small animals.

The cost-effective design could be integrated into existing X-ray and CT systems with only minor modifications, making clinical translation feasible. The team’s next steps include adapting the system for small-animal studies and exploring clinical applications such as lung imaging and low-dose breast cancer screening.

“We expect that this will become practical, translatable,” Das said.

Beyond medicine, the technique could transform imaging for industries that rely on detecting internal defects or microstructures. Potential applications range from the petroleum industry and rock analysis, materials research and real-time monitoring of chemical or structural changes in engineered components.

Das has long been at the forefront of imaging innovation, previously advancing methods that investigated the wave nature of X-rays and applying photon-counting detectors with novel algorithms to allow for more precise 3D visualization.

Her motivation traces back to her early work in developing breast CTs where it became evident that the poor contrast in X-ray radiography and CT could not always reliably detect breast cancers. X-ray mammography has relied on the same contrast mechanism for over a century.

“This is the modality that millions of women are using today for breast screening around the world,” Das said. “I realized that this is really a big problem, so when I came to Houston for my position, one of my goals was to try to change this to see how we can contribute to this field by combining physics, optics and engineering.”

Das’s interdisciplinary research is funded through multiple agencies, including the National Science Foundation, Congressionally Directed Medical Research Programs and National Institutes of Health. She mentors students from physics, biomedical engineering and electrical engineering.

Das was also recently elected as a fellow of Optica, recognizing her distinguished contributions to the advancement of the field, and has been a fellow of the Society for Optics & Photonics (SPIE) since 2022.