Tuesday, April 22, 2025

 

Beyond words



Study reveals the hidden musical grammar of natural speech


PYTHAGOREAN THEORY

Weizmann Institute of Science




The AI revolution, which has begun to transform our lives over the past three years, is built on a fundamental linguistic principle that lies at the base of large language models such as ChatGPT. Words in a natural language are not strung together in random patterns; rather, there is a statistical structure that allows the model to guess the next word based on what came before. Yet these models overlook a crucial dimension of human communication: content that is not conveyed by words. In a new study being published today in Proceedings of the National Academy of Sciences, USA (PNAS), researchers from Prof. Elisha Moses’s lab at the Weizmann Institute of Science reveal that the melody of speech in spontaneous conversations in English functions as a distinct language, with a “vocabulary” of hundreds of basic melodies and even rules of syntax that can be used to predict the next melody in the sequence. The study lays the foundation for an artificial intelligence that will understand language beyond words.

The melody, or music, of speech, referred to by the linguistic term “prosody,” encompasses variations in pitch (intonation), loudness (for example, for emphasis), tempo and sound quality (such as a whisper or creaky voice). This form of expression predates words in evolution: Recent studies reveal that both chimpanzees and whales incorporate complex prosodic structures in their communication. In human communication, prosody adds a nuanced layer of meaning beyond words. A brief pause, much like a comma, can change the meaning of a sentence (“Let’s eat Grandma”) and the tempo of spoken text can generate suspense. Linguists specializing in prosody have traditionally studied literary texts and ways in which prosody reflects historical changes. This meant that, despite prosody’s critical importance for the understanding of human language, its study remained a niche field for years, devoid of applications and filled with conflicting ideas about prosody’s structure and significance.

"Our study lays the foundation for an automated system to compile a ‘dictionary’ of prosody for every human language and for different speaker populations"

Prosody, however, is an inherent part of every conversation. It assigns linguistic function to words – for instance, whether they pose a question or state a fact – and reveals the speakers’ attitude toward what they say. In the new study, led by linguist Dr. Nadav Matalon and neuroscientist Dr. Eyal Weinreb from Moses’s lab in Weizmann’s Physics of Complex Systems Department, the researchers analyzed prosody as an unfamiliar language, aiming to deliver a data-driven explanation for the linguistic mystery of prosody’s structure and meaning. Rather than relying on literature, they used two massive collections of audio recordings of spontaneous conversations, one of telephone conversations between two participants and the other of face-to-face conversations in various locations, such as a kitchen or classroom.

The first task for the research team was to compile a dictionary of the short melodies that function as “words” in English-language prosody and to assign each of them a function and a meaning. “To understand why there is no prosodic dictionary yet, it’s worth remembering that there wasn’t even a comprehensive English dictionary until the nineteenth century,” Moses says. “When the University of Oxford was tasked with compiling one, it asked the public to help with the workload by sending quotes showing the historical changes in the meaning of words. One of the main contributors was a prisoner who spent more than 20 years reading books and sending quotes. In our study, instead of collecting information by ourselves over the course of decades, we analyzed massive collections of audio recordings, using AI.”

The melody of each person’s speech is unique, but the AI model found several hundred basic patterns that recur, with slight variations, in all spontaneous English conversations. While written words are sequences of letters, a prosodic “word” is a short melody, that is, a short sequence of sounds with varying pitch, lasting about a second on average. To work out the meaning of these “words,” Matalon sampled 20 basic melodic patterns and then listened to the recordings again. “We discovered that each pattern has several linguistic functions,” he explains. “For example, depending on the context, a pattern can define whether someone is asking a question or making a statement. However, each pattern typically conveys one specific attitude of the speaker – such as curiosity, surprise or confusion – toward what’s being said. One common prosodic ‘word’ is a sharp rise of the pitch followed by a quick drop. This pattern signals enthusiasm and, depending on the context, can express strong agreement or acknowledgment of receiving important new information.”

"Oxford’s first full English dictionary came out in the 19th century, with the public helping manage the workload –  including a prisoner who contributed for 20 years"

ext, the researchers tried to identify syntactic rules governing the order of these prosodic patterns, which can potentially allow future language learning models to understand and use prosody. “We noticed that there are patterns that tend to appear next to each other, in pairs, in spontaneous speech,” Weinreb explains. “It’s a simple statistical system, in which the correct choice of the next unit in a sequence depends solely on the previous one. This system works well for spontaneous conversation because it requires planning only a few seconds ahead, which is just as long as short-term memory lasts.” These pattern pairs, the researchers discovered, act as simple sentences, expressing “one new idea,” so that each pair relates to a specific topic, adding a single piece of information about it – for example, referring to a fact mentioned in the conversation and providing positive feedback.

“Our study lays the foundation for the development of an automated system that will compile a ‘dictionary’ of prosody and identify its syntactic rules for every human language and for different speaker populations,” Moses says.

“Prosody can vary depending on social status, historic events and the age of the speakers, and these variations can even manifest themselves in literary works that carefully reflect spontaneous speech,” Matalon adds. “We analyzed audiobooks as part of the study and discovered that prosodic patterns are longer in scripted speech and that the simple paired syntax of spontaneous conversation has disappeared. There are other differences, too. It’s safe to assume that the aging process and the acquisition of language in childhood are also accompanied by quantifiable prosodic changes. Moreover, there is evidence that prosody is important in internal speech – the language of thought – and that we can deepen our understanding of the existing prosody of robotic voices that are produced by speech-generating devices. The model we created promises to close the gaps that emerged over the centuries in research into expression beyond words.”

A major future application of an automated prosodic dictionary might be the development of AI capable of understanding and conveying messages through the melody of speech rather than words alone. “Imagine if Siri could understand from the melody of your voice how you feel about a certain subject, what’s important to you or whether you think you know better than her,” Weinreb adds, “and that she could adapt her response to make it sound enthusiastic or sad. We already have brain implants that convert neural activity into speech for people who can’t speak. If we can teach prosody to a computer model, we’ll be adding a significant layer of human expression that robotic systems currently lack.”

Science Numbers

While English speakers use thousands of words a day in spontaneous conversation, this study reveals that their speech is complemented by only 200 to 350 basic prosodic patterns.

Also participating in the study were Dr. Dominik Freche from Weizmann’s Physics of Complex Systems Department; Dr. Erez Volk from NeuraLight Inc., Tel Aviv; Dr. Tirza Biron from Weizmann’s Computer Science and Applied Mathematics Department; and Prof. David Biron from the University of Chicago.

 

 

People’s functional status improved in all labour market groups during the first year of the COVID-19 pandemic





University of Eastern Finland





There were no major changes in the functional status of older working-aged Europeans in 2004–2022, a recent study finds. Among both women and men, the unemployed have more functional limitations than the employed. Surprisingly, the likelihood of functional limitations decreased in all labour market groups during the first year of the COVID-19 pandemic, and this was most evident in countries where COVID-19 related restrictions were moderate.

Functional limitations of European women and men aged 55–69 were investigated in a study carried out at the University of Eastern Finland and Laurea University of Applied Sciences. Analyses were also conducted according to labour market group for the employed, the unemployed, the retired, the disabled, and for homemakers.

Between the years 2004 and 2022, functional limitations slightly increased among men. No change was detected among women.

“Functional limitations are linked to work ability. When aiming to extend working careers, it is important to know where we are going with these in different population groups,” notes researcher Inna Lisko from the University of Eastern Finland.

Comparisons between labour market groups revealed that compared to the employed, functional limitations were 60 percent more likely for unemployed women, and 88 percent more likely for unemployed men.

“The observation of the unemployed having, on average, more functional limitations than the employed is not a new one. However, I think that more attention should be paid to this regarding the services offered to the unemployed, and also from the perspective of prevention,” says Lisko.

A novel finding in the study was that the likelihood of functional limitations decreased during the first year of the COVID-19 pandemic. In countries where the COVID-19 related restrictions were moderate, the decreases were statistically significant in all labour market groups.

“This was a very surprising finding. Many studies examining the impacts of the COVID-19 pandemic show that the pandemic had negative health consequences, and that physical activity mainly decreased. However, there was variation in different population groups and in different phases of the pandemic,” Lisko says.

This finding suggests that 55–69-year-old Europeans made positive lifestyle changes during the first year of the COVID-19 pandemic. However, during the second year of the pandemic, the changes in functional limitations mainly reverted, although not statistically significantly in many places.

 

The observation may also be influenced by the index used for functional limitations in the study, the Global Activity Limitation Index (GALI), as it asks about health problems in activities people usually do. In the study, the researchers discuss that due to the COVID-19 related restrictions, the activities people usually do may have become on average physically less demanding.

“The finding related to the COVID-19 pandemic requires further investigation. Unfortunately, we did not have another suitable measure for physical functioning, or a measure for physical activity at the most interesting point of the study, i.e., a year after the start of the pandemic,” Lisko says.

Data from a large longitudinal study, Survey of Health, Ageing and Retirement in Europe (SHARE), was used in the study. The data included ca. 245,000 observations collected in nine different measurement waves during the years 2004–2022.

The study is part of the Functional Ability, Rehabilitation and Income Transfers of the Aging Population in 2017–2021project (Ikäkyky), conducted by Laurea University of Applied Sciences in 2023–2024.

 

New index shows: bureaucracy in Germany still growing


GOVERNMENT SERVICES BY ANY OTHER NAME



ESMT Berlin
Bureaucracy Index Federal Legislation 

image: 

Bureaucracy index by Prof. Dr. Stefan Wagner

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Credit: ESMT Berlin





Bureaucracy continues to burden Germany. The bureaucracy index developed by Professor Dr. Stefan Wagner from the University of Vienna, in collaboration with ESMT Berlin and the legal platform www.buzer.de, shows that the volume of federal legislation continues to rise and has reached a new all-time high.

In 2010, the body of federal law comprised 1,082 individual statutes totaling approximately 24,775 pages. By early 2025, that number had grown to 1,306 statutes and about 39,536 pages of legislation. This represents an increase in legislative volume of around 60 percent over 15 years. When compared to the previous year, the index has risen by another 2.5 percent, despite ongoing political pledges to reduce bureaucracy. Regulation in Germany is not decreasing; instead, it continues to grow. 

A closer look at the four most extensive areas of law (as classified by the official citation system) reveals that the increase in bureaucracy since 2010 has been largely driven by disproportionate growth in financial regulation (+88 percent) and business law (+110 percent). In contrast, the expansion of administrative law (+54 percent) and social legislation (+46 percent) has been significantly slower.  

Bureaucratic obstacles affect not only businesses but also individuals. Wagner cautions, “The current focus on federal legislation only tells part of the story. An even greater amount of bureaucracy can be found regulation implementation, state laws, and EU legislation. The true bureaucratic burden is therefore much higher.” 


Bureaucracy index by Prof. Dr. Stefan Wagner

Credit

ESMT Berlin

 

Helmholtz Launches Task Force to Strengthen Prevention Research




Helmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))





An Interdisciplinary Approach to Global Challenges

As Germany's largest scientific organization, the Helmholtz Association encompasses six health research centers with approximately 10,000 employees. Its researchers develop strategies for early disease detection and risk assessment across various conditions, including infectious diseases, cancer, metabolic disorders, and neurodegenerative diseases. The newly established task force unites experts from all six Helmholtz Health centers and the German National Cohort (NAKO) to propel prevention research.

“By bringing together top experts across disciplines, we can transform prevention into a powerful tool for better health worldwide,” says Prof. Matthias Tschöp, CEO at Helmholtz Munich, who helped to initiate the task force as former Helmholtz Health Vice President. “Our goal is to move beyond treatment and fundamentally rethink how we predict, prevent, and mitigate disease before it occurs.”

Closing the Gaps in Prevention Research

Despite its critical role in healthcare, prevention research faces significant challenges. A lack of a long-term, comprehensive strategy and insufficient funding have slowed progress. Additionally, the task force has identified key gaps: Health inequalities (i.e., differences in health among population groups due to social, economic, or geographical conditions) and environmental factors are often overlooked, limiting the effectiveness of preventive measures. Many diseases remain undetected in their early, symptom-free stages due to a lack of awareness and research – such as high blood pressure, which requires intervention before symptoms appear. Existing prevention programs are often inadequately monitored, leading to underutilization of valuable health data.

Prevention as a Pillar of Sustainable Healthcare

“Our goal is to make prevention a central pillar of a sustainable healthcare strategy,” says Prof. Eleftheria Zeggini, co-chair of the task force and Director of the Institute of Translational Genomics at Helmholtz Munich. “To tackle major health challenges – such as aging, multimorbidity, and the impact of climate change on human health – we must strengthen collaboration among researchers, healthcare providers, and policymakers.”

Harnessing the power of big data and advanced analytics, the task force will develop new frameworks for prevention strategies. “By integrating advanced technologies such as multi-omics, machine learning, and bioengineering, we aim to uncover personalized health trends and risk factors that enable earlier detection and intervention for common diseases,” explains Prof. Maike Sander, current Vice President of Helmholtz Health and Scientific Director of the Max Delbrück Center. “Through better data connectivity and sharing, we can transform research into predictive, effective, and lasting health solutions that improve lives.”

The experts are also dedicated to aligning their findings with public health strategies and fostering health-promoting environments. “We are committed to developing evidence-based recommendations that align with public health policies and promote healthier environments and behaviors," adds Prof. Ute Mons, task force co-chair and division head of Primary Cancer Prevention at the German Cancer Research Center (DKFZ). In addition to chronic diseases, the focus of the task force includes infectious disease prevention – through targeted immunization, preventive therapies for at-risk populations, and a One Health approach to reduce zoonotic risks.

Members of the Helmholtz Health Prevention Task Force
Chairs: Eleftheria Zeggini and Ute Mons
Helmholtz Munich: Janine Krüger, Erika von Mutius, Eleftheria Zeggini, Anette-Gabriele Ziegler
German Cancer Research Center (DKFZ): Anja Braun, Michael Hoffmeister, Ute Mons, Karen Steindorf
Max Delbrück Center for Molecular Medicine in the Helmholtz Association: Stan Gorski, Markus Landthaler, Young-Ae Lee, Gabriele G. Schiattarella
German Center for Neurodegenerative Diseases (DZNE): N. Ahmad Aziz, Monique M.B. Breteler, Sarah Jewell
Helmholtz Centre for Infection Research (HZI): Birgit Grün, Carlos Guzman, Berit Lange, Fabian Leendertz
Helmholtz-Zentrum Dresden-Rossendorf (HZDR): Sandra Haman, Nadja Knauthe
German National Cohort (NAKO): Annette Peters (Helmholtz Munich)

 

About Helmholtz Munich
Helmholtz Munich is a leading biomedical research center. Its mission is to develop breakthrough solutions for better health in a rapidly changing world. Interdisciplinary research teams focus on environmentally triggered diseases, especially the therapy and prevention of diabetes, obesity, allergies, and chronic lung diseases. With the power of artificial intelligence and bioengineering, researchers accelerate the translation to patients. Helmholtz Munich has around 2,500 employees and is headquartered in Munich/Neuherberg. It is a member of the Helmholtz Association, with more than 43,000 employees and 18 research centers the largest scientific organization in Germany. More about Helmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH): www.helmholtz-munich.de/en

 

Transgene-free genome editing in poplar trees: A step toward sustainable forestry


Scientists at the VIB-UGent Center for Plant Systems Biology and VIVES University College have developed a new method to genetically improve poplar trees without introducing foreign DNA into its genome.



Vlaams Instituut voor Biotechnologie




Scientists at the VIB-UGent Center for Plant Systems Biology and VIVES University College have developed a new method to genetically improve poplar trees without introducing foreign DNA into its genome. This advancement could pave the way for faster and more widely accepted use of gene-edited trees in forestry and the bio-based economy. The work appeared in New Phytologist.  

Gene editing without the baggage 

Gene editing tools like CRISPR are revolutionizing plant science by allowing precise and targeted improvements to plant traits, such as wood quality, disease resistance, or drought tolerance. However, in many cases, the gene-editing ‘machinery’ is permanently integrated into the plant's DNA, creating regulatory obstacles to using the plants. 

In annual crops like maize or rice, this problem is often solved by crossing plants to remove the foreign DNA. But trees like poplar take years to reach maturity, rendering this approach slow and possibly leading to the loss of desirable traits. Now, researchers led by Prof. Wout Boerjan (VIB-UGent) have developed a new method that prevents this issue. 

A temporary CRISPR visit 

Instead of integrating the CRISPR system into the plant's genome, the researchers used a technique called transient transformation. Using Agrobacterium tumefaciens — a bacterium commonly used in plant biotechnology — they introduced the CRISPR molecules into poplar cells, where they temporarily performed genetic edits without becoming part of the tree’s DNA. 

“The key innovation,” says Prof. Boerjan, “is that the gene-editing tool does its job and then disappears without leaving a genetic trace behind.”

To ensure that no CRISPR traces remained, the team used an advanced technique called long-read whole-genome sequencing, which scans the entire genome for even the smallest fragments of foreign DNA. 

Dr. Lennart Hoengenaert (VIB-UGent), first author of the study, reports that nearly half of the regenerated poplar shoots were completely free of foreign DNA. “This is crucial,” he explains, “because it brings these gene-edited trees closer to being treated like conventionally bred plants under upcoming European regulations.” 

Toward a stronger bioeconomy 

“This method offers a clear and practical path to creating trees that are more sustainable, climate-resilient, and easier to regulate,” says Prof. Boerjan. “It could accelerate the deployment of genetically enhanced trees, with benefits for both the environment and the bio-based economy.” 

From volcano to Arctic: researchers track sulfur dioxide' s 2,000-kilometer journey




Hefei Institutes of Physical Science, Chinese Academy of Sciences
From Volcano to Arctic: Researchers Track Sulfur Dioxide' s 2,000-Kilometer Journey 

image: 

Impact of Icelandic volcanic eruption on the Arctic based on satellite, ground observations and PSCF analysis

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Credit: WU Kaili





A research team led by Prof. SI fuqi and Prof. LUO Yuhan from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has uncovered surprising evidence of cross-border pollution reaching the Arctic, originating from an Icelandic volcanic eruption. The researchers used a cutting-edge combination of satellite and ground-based monitoring to track sulfur dioxide emissions from the Sundhnukagigar volcano, which erupted in 2023. This toxic gas traveled over 2,000 kilometers to reach the Svalbard Islands, causing severe smog in the region.

The relevant results were published in The Innovation Geoscience.

"Our study highlights the far-reaching impact of volcanic eruptions on the environment," explained WU Kaili, a member of the team, "It's far beyond the immediate vicinity."

Volcanic eruptions act like "chemical spray bombs," spewing millions of tons of gases like sulfur dioxide into the atmosphere. These gases can transform into sulfate particles that contribute to acid rain and reflect sunlight, potentially causing global cooling. But fine volcanic ash particles, less than 2.5 microns in diameter, can penetrate deep into the lungs and trigger respiratory problems in humans.

The research team relied on advanced tools like the Environmental Trace Gases Monitoring Instrument, which is installed on two Chinese satellites. These satellites provide global daily scans, tracking pollutants with impressive precision. In addition to satellite data, the team also used measurements from China' s Yellow River Station in the Arctic, the only continuous atmospheric monitoring station in the region. This station tracks gases like sulfur dioxide, ozone, and bromine oxide, offering invaluable vertical profile data.

Their findings were striking: 80% of the sulfur dioxide pollution in Ny-Ålesund, a remote Arctic region, was traced directly to the volcanic eruption in Iceland. By combining satellite observation with ground-based measurements, the researchers created a detailed map of how the pollution traveled, providing insights into the source and impact of the eruption' s emissions.

The work paves the way for more precise, real-time environmental monitoring and response, protecting ecosystems and human health worldwide, according to the team.