Tuesday, April 22, 2025

 

Adolescents who sleep longer perform better at cognitive tasks




University of Cambridge







Adolescents who sleep for longer – and from an earlier bedtime – than their peers tend to have improved brain function and perform better at cognitive tests, researchers from the UK and China have shown.

But the study of adolescents in the US also showed that even those with better sleeping habits were not reaching the amount of sleep recommended for their age group.

Sleep plays an important role in helping our bodies function. It is thought that while we are asleep, toxins that have built up in our brains are cleared out, and brain connections are consolidated and pruned, enhancing memory, learning, and problem-solving skills. Sleep has also been shown to boost our immune systems and improve our mental health.

During adolescence, our sleep patterns change. We tend to start going to bed later and sleeping less, which affects our body clocks. All of this coincides with a period of important development in our brain function and cognitive development. The American Academy of Sleep Medicine says that the ideal amount of sleep during this period is between eight- and 10-hours’ sleep.

Professor Barbara Sahakian from the Department of Psychiatry at the University of Cambridge said: “Regularly getting a good night’s sleep is important in helping us function properly, but while we know a lot about sleep in adulthood and later life, we know surprisingly little about sleep in adolescence, even though this is a crucial time in our development. How long do young people sleep for, for example, and what impact does this have on their brain function and cognitive performance?”

Studies looking at how much sleep adolescents get usually rely on self-reporting, which can be inaccurate. To get around this, a team led by researchers at Fudan University, Shanghai, and the University of Cambridge turned to data from the Adolescent Brain Cognitive Development (ABCD) Study, the largest long-term study of brain development and child health in the United States.

As part of the ABCD Study, more than 3,200 adolescents aged 11-12 years old had been given FitBits, allowing the researchers to look at objective data on their sleep patterns and to compare it against brain scans and results from cognitive tests. The team double-checked their results against two additional groups of 13-14 years old, totalling around 1,190 participants. The results are published today in Cell Reports.

The team found that the adolescents could be divided broadly into one of three groups:

Group One, accounting for around 39% of participants, slept an average (mean) of 7 hours 10 mins. They tended to go to bed and fall asleep the latest and wake up the earliest.

Group Two, accounting for 24% of participants, slept an average of 7 hours 21 mins. They had average levels across all sleep characteristics.

Group Three, accounting for 37% of participants, slept an average of 7 hours 25 mins. They tended to go to bed and fall asleep the earliest and had lower heart rates during sleep.

Although the researchers found no significant differences in school achievement between the groups, when it came to cognitive tests looking at aspects such as vocabulary, reading, problem solving and focus, Group Three performed better than Group Two, which in turn performed better than Group One.

Group Three also had the largest brain volume and best brain functions, with Group One the smallest volume and poorest brain functions.

Professor Sahakian said: “Even though the differences in the amount of sleep that each group got was relatively small, at just over a quarter-of-an-hour between the best and worst sleepers, we could still see differences in brain structure and activity and in how well they did at tasks. This drives home to us just how important it is to have a good night’s sleep at this important time in life.”

First author Dr Qing Ma from Fudan University said: “Although our study can’t answer conclusively whether young people have better brain function and perform better at tests because they sleep better, there are a number of studies that would support this idea. For example, research has shown the benefits of sleep on memory, especially on memory consolidation, which is important for learning.”

The researchers also assessed the participants’ heart rates, finding that Group Three had the lowest heart rates across the sleep states and Group One the highest. Lower heart rates are usually a sign of better health, whereas higher rates often accompany poor sleep quality like restless sleep, frequent awakenings and excessive daytime sleepiness.

Because the ABCD Study is a longitudinal study – that is, one that follows its participants over time – the team was able to show that the differences in sleep patterns, brain structure and function, and cognitive performance, tended be present two years before and two years after the snapshot that they looked at.

Senior author Dr Wei Cheng from Fudan University added: “Given the importance of sleep, we now need to look at why some children go to bed later and sleep less than others. Is it because of playing videogames or smartphones, for example, or is just that their body clocks do not tell them it’s time to sleep until later?”

The research was supported by the National Key R&D Program of China, National Natural Science Foundation of China, National Postdoctoral Foundation of China and Shanghai Postdoctoral Excellence Program. The ABCD Study is supported by the National Institutes of Health.

Reference

Ma, Q et al. Neural correlates of device-based sleep characteristics in adolescents. Cell Reports; 22 Apr 2025; DOI: 10.1016/j.celrep.2025.115565

 

A ‘dopamine detox’ is too simplistic, new study finds



How dopamine helps us learn to avoid bad outcomes



Northwestern University





  • Dopamine signals in different parts of the brain rise and fall in complex patterns as animals learn to avoid danger

  • Findings shed light on why the ‘dopamine detox’ trend is too simplistic

  • First study to track how dopamine signals evolve over time

  • The findings may help explain how dopamine signaling contributes to excessive avoidance in disorders like in anxiety and OCD, where individuals overestimate danger

CHICAGO --- Dopamine is the brain’s motivational spark, driving us to chase what feels good, say scrolling another reel on social media, and steer clear of what doesn’t, like touching a hot stove. 

But scientists haven’t fully understood how dopamine helps us learn to avoid bad outcomes — until now.

A new study from Northwestern University shows that dopamine signals in two key brain areas involved in motivation and learning respond differently to negative experiences, helping the brain adapt based on whether a situation is predictable or controllable. 

While previous research has shown that dopamine can respond to negative experiences, this is the first study to track how those signals evolve over time as animals move from novices to experts in avoiding them. 

The study will be published April 22 in the journal Current Biology. 

The study authors said the findings help explain how we learn from bad experiences, and why some people learn to avoid danger better than others. They also shed light on how excessive avoidance — a hallmark symptom of multiple psychiatric conditions such as anxiety, obsessive-compulsive disorder and depression — may come to be via alterations in dopamine function. This can lead to an overestimation of danger in the environment and a decreased quality of life as the brain prioritizes avoiding certain experiences. Finally, the study helps explain why the concept behind the recent “dopamine-detox” wellness trend is too simplistic.

“Dopamine is not all good or all bad,” said first author Gabriela Lopez, a doctoral candidate in the Interdepartmental Neuroscience Program at Northwestern University Feinberg School of Medicine. “It rewards us for good things but also helps us tune into cues that signal trouble, learn from consequences and continuously adapt our learning strategies in unstable environments.”

How the study worked

In the study, scientists trained mice to respond to a five-second warning cue that predicted an unpleasant outcome. If the mice moved to the other side of a two-chamber box during the warning cue, they could avoid the outcome entirely. As the mice learned the task, researchers recorded dopamine activity in two areas of the nucleus accumbens, a brain region involved in motivation and learning. Previous research had suggested that dopamine in the ventromedial shell of the nucleus accumbens increases during bad experiences, while dopamine in the core of the nucleus accumbens decreases. Therefore, the scientists wanted to understand how these different dopamine responses work together when the mice learn to avoid bad experiences. 

They found that the two areas of the nucleus accumbens responded differently:

  • In the ventromedial shell, dopamine levels initially surged in response to the unpleasant event itself. As the mice actively learned about the meaning of the warning cue, the dopamine response shifted to the cue itself. Eventually, though, the dopamine response faded away as the mice became skilled at avoiding the outcome.
  • In the core, dopamine decreased for both the unpleasant event and the warning cue. The reduction in dopamine in response to the warning cue steadily increased throughout training, especially as the mice became more successful at avoiding the event. 

“These responses are not only different in their sign — where in one area, dopamine goes up for something bad and, in the other area, it goes down for something bad — but we also saw that one is important for early learning while the other one is important for later-stage learning,” said corresponding author Talia Lerner, associate professor of neuroscience and psychiatry and behavioral sciences at Feinberg.

Later, the researchers tested what would happen when the outcome couldn’t be avoided, regardless of the mice’s actions. Under those conditions, dopamine patterns returned to what they looked like earlier in training — suggesting that these brain signals are sensitive to context and may help animals adapt their behavior when the environment changes.

“This shows that the dopamine signals are flexible, sensitive to task rules, and may help us adapt to changes in the environment,” Lopez said. 

Why a ‘dopamine detox’ is too simplistic

People have been singing the praises of the “dopamine detox” wellness trend — cutting out things that trigger a dopamine rush, like eating junk food or scrolling social media, to regain control over these behaviors. 

But this study helps explain why the concept of a “dopamine detox” is too simplistic. 

“We think of dopamine as a learning molecule that is important for normal behavior in everyday life,” Lopez said. “So, cutting it out completely can do more harm than good.”

Next steps

“The dopamine signals we are studying are important for representing aversive signals that are involved in problems like chronic pain, depression and withdrawal from addictive substances,” Lopez said. “Overactive avoidance learning may also be a pathway that contributes to obsessive-compulsive disorder and other clinical anxiety disorders. We hope to follow up on these basic research findings to address clinical problems affecting patients.”

 

Childhood exposure to air pollution, BMI trajectories and insulin resistance among young adults





JAMA Network Open




About The Study:

 In this cohort study of young adults, the long-term association between traffic-related air pollution and insulin resistance may be partially explained by higher body mass index (BMI) and accelerated BMI growth from early adolescence into young adulthood. These findings highlight the importance of weight management in children, particularly those residing in highly polluted areas.


Corresponding author: To contact the corresponding author, Shohreh F. Farzan, Ph.D., email sffarzan@usc.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

(doi: 10.1001/jamanetworkopen.2025.6431)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.6431?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=042225

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

Children face elevated kidney, heart, and gut risks for years after COVID infection





University of Pennsylvania School of Medicine





Long COVID can result in increased risk for a variety of serious health problems for young people, including those affecting the kidney, gut, and cardiovascular system, according to a group of new studies led by investigators at the Perelman School of Medicine at the University of Pennsylvania.

“While most public attention has focused on the acute phase of COVID-19, our findings reveal children face significant long-term health risks that clinicians need to monitor,” said senior author Yong Chen, PhD, a professor in the Department of Biostatistics and Epidemiology. The studies were conducted under the Researching COVID to Enhance Recovery (RECOVER) Initiative, a special project sponsored by the National Institutes of Health (NIH) that includes more than two dozen health care institutions. These medical centers pooled de-identified data from electronic health records dating back to the start of the COVID pandemic.

Kidney disease

Young patients with positive SARS-CoV-2 tests had a 17 percent higher risk of developing chronic kidney disease tested at stage 2 or higher, indicating mild kidney damage that still functioned well, and 35 percent higher risk of chronic kidney disease at stage 3 or higher, meaning there is mild to severe damage impacting kidney function, from one month to two years after infection.

Published in JAMA Network Open, the analysis covered electronic health records for 1,900,146 individuals under the age of 21. The researchers compared kidney-related outcomes in the post-acute phase in those who had positive SARS-CoV-2 tests to outcomes in individuals who had negative tests and no documented SARS-CoV-2 infection during the 2020-23 study period.

Patients with pre-existing chronic kidney disease who had a positive SARS-CoV-2 test had a 15 percent higher risk of developing any of several other kidney-related adverse outcomes, including a major decline in kidney filtration rate, dialysis, or kidney transplant. Children and adolescents who experienced a documented kidney injury during the acute phase of infection also had an elevated (29 percent higher) risk of adverse kidney outcomes from three to six months after infection, compared to those with no acute kidney injury.

Gastrointestinal effects

Another study published in JAMA Network Open, examined gastrointestinal problems such as abdominal pain, diarrhea, and irritable bowel syndrome in 1,576,933 children and adolescents.

Patients who had a positive SARS-CoV-2 test—compared to those with a negative test—had a 25 percent increased risk of developing at least one gastrointestinal symptom or disorder in the post-acute phase, and a 28 percent increased risk in the “chronic phase” from six months to two years after the SARS-CoV-2 test.

Cardiovascular risk

Researchers found that those with SARS-CoV-2 infections had significantly higher risks of developing one or more cardiovascular conditions—including arrhythmias, heart inflammation, chest pain, palpitations, and hypertension—compared to those with negative tests and no documented history of SARS-CoV-2 infection. These risks were elevated regardless of whether the patient had a congenital heart defect (CHD).

While children with CHDs had higher absolute risks, the relative increase in risk of developing cardiovascular conditions associated with SARS-CoV-2 infection was consistent (a 63 percent increase) across both groups. However, among children without CHD, the risk of heart inflammation in the post-acute phase was strikingly higher—nearly tripled—in those who had SARS-CoV-2 infection.

The researchers examined post-acute cardiovascular problems in 1,213,322 pediatric patients and findings were published in Nature Communications.

Outcomes along racial and ethnic lines

There were some specific differences in post-acute outcomes for different racial and ethnic groups.

Researchers found, for example, that Asian American Pacific Islander (AAPI) children and adolescents, compared to non-Hispanic Whites, had mildly higher rates of developing any long-COVID outcomes in the post-acute phase after severe or non-severe COVID.

The data also showed that Hispanic patients had a greater risk of hair loss after severe COVID, while non-Hispanic Black patients had a mildly lower risk of long-COVID skin symptoms after severe COVID.

The researchers analyzed records pulled from 225,723 children and adolescents, comparing AAPIs, non-Hispanic Blacks, and Hispanics, to non-Hispanic Whites. The work was published in Nature Communications.

“Overall, these findings underscore the fact that clinicians need to monitor pediatric patients for long COVID signs and symptoms—and need to be prepared to treat these conditions”, Chen said.

These studies were funded principally by the National Institutes of Health (OT2HL161847-01).

 

Virtual singing brings connection and joy to isolated older adults, study finds



Those with neurocognitive disorders like dementia especially benefited from virtual singing




Northwestern University

Good Memories Choir performs in Chicago 

image: 

A Good Memories performance in the Buchanan Chapel at Fourth Presbyterian Church, Chicago. The Good Memories choir is for early-stage memory loss and their care partners to sing together. 

view more 

Credit: Sounds Good Choir





  • Singing can improve lung capacity, posture and overall physical health
  • Seniors in rural areas, those with mobility limitations or anyone experiencing social anxiety could benefit from virtual singing
  • Scientists collaborated with Illinois-based Sounds Good Choir, a singing program for adults 55 and older

CHICAGO --- American philosopher and psychologist William James once said, “I don’t sing because I’m happy. I’m happy because I sing.”

A new Northwestern University Feinberg School of Medicine study has found even when singing with others virtually, the benefits abound. 

In collaboration with Illinois-based Sounds Good Choir, the study assessed the feasibility of virtual group singing for adults over 55 — including those with neurocognitive disorders like dementia — during the COVID-19 pandemic when older adults were experiencing health declines due to isolation. It found virtual group singing can be an effective tool for promoting well-being and social connection during isolation. Listen to a virtual concert from spring 2020.

“Beyond the pandemic, the study suggests virtual singing could benefit individuals in rural areas, those with mobility limitations or those experiencing social anxiety,” said principal investigator Dr. Borna Bonakdarpour, director of the Northwestern Music and Medicine Program, associate professor of neurology at Feinberg and a physician with the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease. “We found virtual group singing could provide emotional, cognitive and social support through accessible, engaging music programs for diverse aging populations.”

The study was published April 22 in the Journal of Alzheimer’s Disease.

Singing engages diverse neurophysiological processes by activating a neural network involved in respiratory control, emotional regulation and motor control, Bonakdarpour said. Lung capacity, posture and overall physical health often improve through the practice of singing. And choral singing has been increasingly recognized as a therapeutic activity for both cognitively healthy older adults and individuals with dementia and neurocognitive disorders.

For people with neurocognitive disorders — who frequently struggle with verbal communication — music and singing can offer alternative ways to express themselves, much like we see in individuals with aphasia,” Bonakdarpour said. “Singing familiar songs can help facilitate communication and create a comfortable, low-pressure environment for interaction and sharing.”

How the study worked

Previous research has focused on one group of singers and had fewer participants compared to this study, which compared two different group-singing interventions: a sing-along series with 52 weekly sessions of familiar music and a structured choir with rehearsals leading to a virtual concert. Of the 176 individuals surveyed, responses revealed high satisfaction, particularly in areas like anxiety reduction, social connection and physical well-being. The sing-alongs helped evoke emotional resonance through positive memories, while choir participation promoted intellectual engagement. 

The overall tone of the responses was overwhelmingly positive, with 86.9% of responses mentioning positive impacts on well-being as a result of participation. In at least 5% of free responses, respondents mentioned the following themes: emotional well-being (36%); social well-being (31%); intellectual well-being (18%); sense of normalcy or structure (12%); spiritual well-being (11%); physical well-being (7%); and connection to the past (5%).

“Participants in the group choir during the pandemic consistently described the activity as providing a sense of normalcy amid widespread disruption — a theme that emerged prominently and merits further investigation,” Bonakdarpour said. “For individuals living with dementia, irrespective of external circumstances, the erosion of normalcy profoundly impacts their sense of self and contributes to anxiety. This suggests that such interventions may help restore a feeling of normalcy, supporting psychological well-being and offering a means of reconnecting with a stable sense of self.”

The next step in the research will be a nationwide trial funded by the National Institutes of Health Music Dementia Research Network. 

This study is titled, “Virtual Group Singing Programs for Well-being in Healthy Older Adults and Persons with Neurocognitive Disorders During early COVID-19 Pandemic: A Perspective from Chicago.” 

Other Northwestern authors include Clara Takarabe, who co-directs the Northwestern Music and Medicine Program with Bonakdarpour; and Elena Barbieri, research assistant professor of physical medicine and rehabilitation at Feinberg. Sandy and Jonathan Miller, directors of the Sounds Good Choir, are co-authors on the study.  

Funding for the study was provided by Sounds Good Choir.

 UK

Treasures prove Thetford was pagan until 5th century




Cambridge University Press





Jewellery in a Roman treasure hoard found in Thetford Forest, East Anglia, indicates that Thetford was pagan until the 5th century, which is longer than previously believed, a new paper published by Cambridge University Press in Journal of Roman Archaeology reveals.

The Thetford treasure was first found by a metal detectorist trespassing on a construction site at Fison’s Way on Gallows Hill, Thetford in 1979. It consisted of 81 objects, including 22 gold finger-rings, other gold jewellery, and 36 silver spoons or strainers. It is now in the collections of the British Museum and can be seen on display there.

The author of the research, Professor Ellen Swift of University of Kent, argues that there is compelling evidence that the treasure was buried in the 5th century rather than the late 4th.

Swift says: “Since wider evidence found at the site confirms the religious context previously established by inscriptions on the spoons within the hoard, this means, remarkably, that the re-dating of the Thetford hoard suggests a pagan cult centre survived there into the 5th century.

“The site’s economic assets, indicated by the value and variety of the hoard, also show that it may have wielded significant power and authority locally.”

This new chronology is supported by detailed comparisons of multiple objects (both spoons and jewellery) with context-dated finds from continental Europe, and with objects from the 5th century Hoxne hoard in the British Museum, which was found more recently than the Thetford hoard and contains many similar items.

The paper also shows that Britain was less isolated than previously believed, with the items in the treasure originating from across the Roman empire.

The Thetford jewellery especially is highly varied in style, suggesting the different pieces originated in different places. Some of the latest-dating finger-rings in the hoard likely originated in northern Italy or adjacent regions, and the necklace with conical beads from the Balkans area of Europe.

Most of the jewellery is generically ‘Mediterranean Roman’ in style illustrating a geographically widespread shared culture among elites.