Sunday, April 12, 2026

 

One in ten experience facial pain – New method can reveal the cost





Umea University
Anna Lövgren 

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Anna Lövgren, Associate Professor, Department of Odontology, Umeå University

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Credit: Photo: Hamdija Comic





Facial pain is one of the most common forms of chronic pain. Despite this, there has previously been no standardized burden measurements, such as impact on the individual and healthcare costs across countries and in relation to other diseases. A new international research collaboration, led by researchers at Umeå University, has now developed lay descriptions that make it possible to visualize the global burden of disease caused by facial pain.

“We can now, for the first time, compare the burden of living with facial pain to conditions such as diabetes—that is, how much a person is affected over the course of their life by having this condition,” says Anna Lövgren, Associate Professor at the Department of Odontology at Umeå University and one of the researchers leading the study.

Facial pain is often caused by overloading of the muscles or joints in the jaw, which then become painful. The condition affects everyday activities such as eating and speaking and is often long-lasting. Many individuals also experience concurrent problems, including headaches and disturbed sleep. Data from Sweden further show that people with facial pain are more likely to have long periods of sick leave. However, the total costs of this condition have so far been difficult to quantify.

“Now that we can estimate the disease burden of facial pain, we can also link it to health data and evaluate, for example, how many people are affected and what consequences this has for society. We can also estimate the cost of management in terms of healthcare visits, examinations, and treatment,” says Anna Lövgren.

Anna Lövgren is currently working to develop an initial estimate of the global disease burden of facial pain. Her hope is that care for patients with facial pain will become better and more accessible when it can be more easily compared to other diseases.

“We argue that this facial pain and related symptoms should be included in healthcare fee systems so that patients can afford the treatment they would benefit from. This is an undertreated condition,” says Anna Lövgren.

About the Study

Lövgren, A., Liv, P., Allison, J. R., et al. (2026). Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates. BMC Medicine, 24, 165. https://doi.org/10.1186/s12916-026-04790-3

 

Soundscapes from nearby forests are more uplifting than those from faraway places




German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
Robin redbreast singing 

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The local high-diversity audio recording that the participants listened to included a singing robin redbreast. The experiment revealed that soundscapes from local temperate forests were more uplifting than those recorded in tropical Panama.

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Credit: Corey Callaghan





Listening to one-minute-long audio recordings of forests had positive effects on people’s short-term wellbeing, especially when the recordings were from local temperate forests. This is the key finding of an experiment led by the German Centre for Integrative Biodiversity Research (iDiv), the Helmholtz Centre for Environmental Research (UFZ), the Friedrich Schiller University Jena, Leipzig University, the Martin Luther University Halle-Wittenberg, and the University of Freiburg. Study participants residing in Germany perceived soundscapes as more awe-inspiring and restorative when recorded in nearby forests than soundscapes that came from the tropics; higher or lower levels of animal diversity only had small effects on short-term wellbeing. The study has been published in the Journal of Environmental Psychology.

Many of us feel better when walking in a forest or spending time outdoors; however, scientists still do not fully understand whether and how the diversity of animals and plants contributes to wellbeing. So far, results have been mixed, especially when it comes to what we hear. Do forests with more bird and insect sounds make people feel better? And does it matter whether those sounds come from familiar, local forests or from faraway places?

Sounds are a big part of how we experience nature and biodiversity

“Sounds are a big part of how we experience nature and biodiversity — like birds singing when you walk through a forest,” says co-first author Kevin Rozario, a doctoral researcher at iDiv, UFZ, and the University of Jena. “However, we still don’t really know how the diversity and complexity of sounds affects how people feel, or why some sounds may be more uplifting than others.”

To shed light on these issues, the researchers carried out an experiment with 195 students in Germany. Participants listened to one-minute-long audio clips of forests that differed in two ways:

  • how many animal sounds they contained (few vs. many species), and

  • whether they came from local temperate or from faraway tropical forests.

Each participant listened to two recordings and answered questions about how they felt, how stressed they were, and how well they could focus before and after listening. They also rated how pleasant and familiar the sounds seemed, and estimated how many different animals they could hear. This allowed the team to assess how familiar the sounds felt and to compare the effects of the actual number of species in the recordings, with what participants thought they heard, i.e., the “perceived animal diversity”.

The strongest effects came from sounds that felt familiar

Overall, just listening to one-minute-long recordings of forest sounds — even through headphones — made people feel better: they reported more positive emotions, better focus, and less stress. But the strongest effects came from sounds that felt familiar. Recordings from local forests were rated as more pleasant and more restorative, and they also triggered stronger feelings of awe than sounds from tropical forests.

Having more different animal sounds only helped in some cases—for example, it increased feelings of awe when people listened to local forest recordings. What mattered more was what people thought they heard: when participants believed they could hear more animal species, they felt better overall and less negative. In contrast, sounds that felt complex but were not clearly linked to animals could even reduce positive feelings.

“Our findings show that it is not just about how many species are out there,” says senior author Prof. Aletta Bonn, research group head at the UFZ, iDiv, and the University of Jena. “Sounds that remind people of forests they know — like the birds they hear on a walk close to home — seem to have a much stronger positive effect. This provides amazing new insights into the complex ways in which biodiversity and mental wellbeing are connected.”


Cuckoo in oak tree 

In the experiment, participants could also hear a cuckoo.

Credit

Gabriele Rada


 

Chemical coatings can change mosquito net performance, highlighting need for broader evaluation





Liverpool School of Tropical Medicine






Different chemical coatings used on mosquito nets can affect how well they perform, which means that nets should be assessed on more than just their insecticide content alone, new research shows.

Insecticide-treated nets remain one of the most important tools in malaria prevention. They act both as a physical barrier and as an insecticidal surface that kills or disables mosquitoes before they can transmit the parasite.

A study led by Liverpool School of Tropical Medicine developed a new evaluation platform combining chemical analysis, surface imaging and mosquito behavioral tracking to test the performance of insecticide-treated nets made with and without insecticide binder containing per- and polyfluoroalkyl substances (PFAS).

PFAS-based coatings are a group of synthetic fluorinated chemicals that have been valued for stability and performance in a range of sectors. However, their environmental persistence and potential health risks have made their removal an important priority.

Against this background, the study asked whether replacing these coating materials affects how well nets perform, particularly against malaria mosquitoes from sub-Saharan Africa, where insecticide resistance is already widespread.

Published in Science Advances, the case study found that, although nets without PFAS coatings met specifications for deltamethrin pyrethroid insecticide content, removing PFAS altered how well a net worked. Crucially, the effect varied across mosquito populations and levels of insecticide resistance. The clearest differences were seen in resistant strains, whereas the impact was small or not significant in the susceptible strain.

The findings indicate that efficacy is shaped not only by how much insecticide is present, but also by how it is presented on the fiber surface and how readily it is transferred to the mosquito. The researchers found that PFAS-based coatings possessed smaller, more evenly distributed, deltamethrin particulates, while PFAS-free coatings showed larger, coarser and less evenly distributed particulates. These surface differences were linked to changes in mosquito behaviour, including reduced irritancy and reduced knockdown in resistant strains, showing that coating chemistry can alter insecticide bioavailability and ultimately net performance.

The researchers argue that this case study shows insecticide content alone does not fully explain how a net performs. They suggest that evaluation of insecticide-treated nets should not just consider bulk chemical content, but a more integrated framework combining conventional bioassays with surface chemistry, imaging, and behavioral analysis. This approach could strengthen product development, regulatory evaluation and post-market surveillance by detecting meaningful performance differences that standard testing may miss.

Dr Hanafy Ismail, lead author and Group Leader of the Chemical Biology Group, Department of Vector Biology, Liverpool School of Tropical Medicine, said: “Malaria kills hundreds of thousands of people each year, and insecticide-treated nets remain one of the most effective and affordable tools we have against the disease. At the same time, the environmental rationale for moving away from persistent fluorinated chemicals is real and should not be ignored. Environmental sustainability and malaria control must move forward together.

“Our findings show that chemical compliance is not the same thing as biological performance. What matters is how the insecticide is presented on the fibre surface, how bioavailable it is to the mosquito, and how mosquitoes respond on contact. As malaria control tools evolve, we need integrated evaluation systems that can detect meaningful performance shifts early and help ensure that environmentally sustainable products remain effective for the communities that depend on them.”

Prof. Rasmita Raval, co-corresponding author from the University of Liverpool, said: “This study shows that surface chemistry is not a minor formulation detail. Two nets can contain similar amounts of insecticide yet behave very differently at the point of mosquito contact. By linking surface presentation to mosquito response, we can better understand how to design formulations that are both environmentally responsible and biologically effective.”

 

New framework reveals how vulnerable small businesses are to supply chain shocks




KeAi Communications Co., Ltd.
Fig. 2. Schematic of the case enterprise’s supply chain Note: This schematic was developed with the assistance of ChatGPT, an AI language model produced by OpenAI. 

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Fig. 2. Schematic of the case enterprise's supply chain Note: This schematic was developed with the assistance of ChatGPT, an AI language model produced by OpenAI.

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Credit: Ghosh, S., Bandyopadhyay, D., Bhowmik, C., Sinha, S., & Ray, A. / Risk Sciences




Small and medium-sized enterprises (SMEs) form the backbone of developing economies, yet they are disproportionately hit when supply chains break down. In India, past disruptions have harmed the vast majority of small firms, with manufacturers suffering the most — with many still struggling to recover.

In a study published in the KeAi journal Risk Sciences, a team of researchers developed a novel quantitative framework that enables SMEs to systematically assess their supply chain risks and take proactive steps to build resilience.

"Most existing risk assessment methods were designed for large corporations with rich historical data and dedicated risk management teams," explains corresponding author Sudipta Ghosh from the Indian Institute of Packaging. "SMEs in developing economies simply do not have those luxuries. Hence, we need a framework that could work with expert knowledge alone and still deliver actionable results."

To that end, the team combined two established methods — the Analytic Hierarchy Process (AHP) for prioritizing hazards based on expert judgment and Hazard Identification and Risk Assessment (HIRA) for scoring risks by their likelihood and severity — and  tested this integrated approach through a real-world case study of a manufacturing SME in India that experienced a complete supply chain disruption during the pandemic.

Through literature review and consultation with a panel of 30 experts from industry and academia, the researchers identified 11 key hazards across the supply chain — from the scarcity of raw materials and inventory stockouts to distribution network breakdowns and demand uncertainty.

The results were striking: the case enterprise's overall supply chain fell within the high-risk zone, with internal risks — particularly in procurement and production — posing a greater threat than external ones. The scarcity of raw materials, inventory stockouts, and distribution network breakdowns emerged as the most severe hazards.

"What surprised us was the extent to which internal operational risks outweighed external ones," notes co-author Deeya Bandyopadhyay from Durgapur Institute of Advanced Technology and Management. "This tells SME managers that strengthening their own procurement strategies and inventory management can make a significant difference."

The study also proposed targeted control measures for each high-risk hazard, including supplier diversification, buffer stock strategies, and multi-channel distribution synchronization. After applying these measures, the residual risk levels dropped to acceptable thresholds — demonstrating that proactive management can dramatically improve resilience.

The framework is designed to be practical and accessible: it does not require expensive software, advanced technical training, or large datasets, making it particularly suited for resource-constrained SMEs in emerging economies. 

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Contact the author:

Sudipta Ghosh

Indian Institute of Packaging, Kolkata, West Bengal 700091, India

Email: ra2kol.iip@iip-in.com

The publisher KeAi was established by Elsevier and China Science Publishing & Media Ltd to unfold quality research globally. In 2013, our focus shifted to open access publishing. We now proudly publish more than 200 world-class, open access, English language journals, spanning all scientific disciplines. Many of these are titles we publish in partnership with prestigious societies and academic institutions, such as the National Natural Science Foundation of China (NSFC).

 

The hidden trap in ocean sanctuaries: When conservation backfires with toxic pollution


KeAi Communications Co., Ltd.

Graphic Abstract 

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Graphic Abstract

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Credit: Huan Zhong, Chengjun Li





The global push for the "30×30" biodiversity target has spurred an unprecedented expansion of no-take marine reserves (NTRs), yielding major ecological dividends such as the recovery of fish biomass, body size, and trophic structure. However, in a new perspective article published in Water & Ecology, Huan Zhong from Nanjing University and Chengjun Li from Guangzhou University unveils a critical yet overlooked "protection-pollution paradox": the very biological traits that signify conservation success—extended lifespans, larger body sizes, and elongated food webs—inadvertently transform protected populations, especially apex predators, into highly efficient sinks for legacy polychlorinated biphenyls (PCBs).

The authors point out that without integrating pollution and climate considerations into marine spatial planning, these sanctuaries risk becoming “toxic traps” that undermine both biodiversity goals and human food security.

The mechanisms driving this paradox are rooted in fundamental ecological principles. Within NTRs, the cessation of fishing allows individuals to live longer and attain larger sizes, which directly increases their capacity for pollutant accumulation. "For every 1-cm increase in fish length, the concentration of PCB-118 in their bodies can increase by 2.3%," shares Zhong. "Furthermore, the recovery of apex predators elongates food webs, intensifying biomagnification."

In pelagic systems, PCB-153 concentrations can increase by an average factor of 6.2 per trophic step, meaning that the restored trophic complexity inside reserves inherently amplifies contaminant burdens compared to the truncated food webs outside.

Climate change amplifies this threat through both environmental and physiological pathways. Extreme weather events remobilize legacy PCBs from marine sediments, where approximately 75% of anthropogenic PCBs reside, while ocean warming accelerates the metabolic and respiratory rates of ectotherms, increasing their uptake of dissolved pollutants.

"The ecological dividends of no-take policies inadvertently position these protected species at the intersection of amplified climate stress and heightened PCB toxicity, severely undermining their resilience," explains Zhong. "This multi-stressor environment—where warming, acidification, and pollution converge—compromises immune function and energy allocation, leaving restored populations uniquely vulnerable."

To resolve this paradox, the authors proposed an integrated management framework that moves beyond static spatial boundaries. "Key strategies include climate-smart dynamic ocean management to identify 'toxicological refugia', advanced biomonitoring using biomarker-based indices to target PCB-responsive pathways, and targeted remediation techniques such as in-situ activated carbon capping to sequester pollutants," adds Zhong. 

Ultimately, the authors call for a fundamental shift in conservation metrics: rather than focusing solely on biomass recovery or area coverage, effectiveness evaluations must integrate ecosystem health and pollutant exposure. "Marine protected areas cannot remain static lines drawn on a map—they must function as genuinely healthy sanctuaries that are resilient not only to climate extremes but also to the pervasive PCB threats that accompany them," Zhong notes.

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Contact the author:

Huan Zhong

-School of Environment, Nanjing University, Nanjing 210023, China.

zhonghuan@nju.edu.cn

Chengjun Li

-Institute of Environmental Research at Greater Bay Area, Guangzhou University, Guangzhou 510006, China.

-Huanghuai Laboratory, Zhengzhou 450046, China

lichengjun12345@gmail.com.

The publisher KeAi was established by Elsevier and China Science Publishing & Media Ltd to unfold quality research globally. In 2013, our focus shifted to open access publishing. We now proudly publish more than 200 world-class, open access, English language journals, spanning all scientific disciplines. Many of these are titles we publish in partnership with prestigious societies and academic institutions, such as the National Natural Science Foundation of China (NSFC).