Tuesday, May 12, 2026

 

Can new research findings help overcome challenges to malaria treatment?




Wiley






Research published in The FEBS Journal may help overcome challenges to the treatment of malaria—a tropical disease caused by infection of red blood cells with Plasmodium parasites, which are transmitted through infected mosquito bites. The research is based on a strategy that targets an enzyme specific to the parasite, Falcipain-2 (FP2), which is essential for parasite survival and growth within the host.

FP2 allows the parasite to digest human hemoglobin so that it can replicate inside red blood cells, which leads to severe malaria symptoms, including red blood cell destruction. Although FP2 is parasite-specific, it is highly similar to a class of human enzymes called cathepsins. This study therefore sought to determine the detailed structural and functional characterizations of FP2 so that it could be targeting without harming cathepsins.

Previously, the researchers identified that polyethylene glycol (PEG) can form stable interactions with FP2. In this latest study, they focused on how different PEG molecules bind to FP2 and its target, hemoglobin. Their computational analyses identified a binding region, or pocket, of a particular PEG called PEG400 with FP2. This pocket exhibits minimal conservation in human cathepsins. PEG400 was capable of binding FP2 and affecting its digestion of hemoglobin.

“The findings pave the way for designing and incorporating new small molecule inhibitors of FP2 activity, suggesting opportunities for selective antimalarial therapies with a cumulative benefit of reducing off-target specificity,” said corresponding author Sampa Biswas, PhD, who conducted this work while at the Saha Institute of Nuclear Physics, in India, and is currently at InBOL (Indian Barcode of Life) Health Care.

URL upon publication: https://onlinelibrary.wiley.com/doi/10.1111/febs.70546

 

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About the Journal
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BRIGHT and LanzaTech launch new partnership to accelerate carbon to value biotechnology in Europe



A multi-year collaboration will establish a next-generation C1 biofoundry at DTU to convert industrial carbon emissions into fuels, chemicals, and materials



Technical University of Denmark

Biofoundry inside 

image: 

Biofoundry inside. Photo: BRIGHT.

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Credit: BRIGHT





SKOKIE, IL., May 5, 2026 - BRIGHT, the Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition at the Technical University of Denmark (DTU), and LanzaTech Global, Inc. (NASDAQ: LNZA) (“LanzaTech”), a global leader in gas fermentation, have entered a multi‑year agreement to accelerate development of technologies that convert carbon emissions into valuable products.

The partnership runs until April 2028 and includes the design and installation of a next‑generation C1 biofoundry at DTU. This allows LanzaTech to extend its world-class synthetic biology expertise, leveraging BRIGHT’s infrastructure, talent, and regional reach. At the same time, DTU will gain the tools and expertise needed to establish Denmark and Europe as an important player in the emerging field of carbon‑to‑value biotechnology, accelerating innovation in the field of circular and competitive bioeconomy.

“DTU has a history of driving innovation from the lab to commercial deployment. Our new partnership with LanzaTech emphasizes our commitment to accelerate bio-solutions innovation for the benefit of Denmark, Europe and beyond,” says DTU provost, Christine Nellemann.

 

From carbon emissions to sustainable products

The new biofoundry will use gas fermentation, in which microbes convert CO₂, CO, and methane into fuels, chemicals, and materials. The technology is emerging as a key pathway for reducing industrial emissions and enabling circular, climate‑positive solutions. Engineering these specialized microbes is, however, difficult, requiring advanced automation, AI, robotics, gas‑handling and high‑throughput strain‑development tools.

“This partnership brings unique capabilities to Denmark and accelerates our ambition to turn carbon emissions into valuable products. Working with LanzaTech strengthens our ability to drive sustainable innovation with real impact,” says Luuk van der Wielen, Director of BRIGHT.

LanzaTech has spent more than 15 years developing world‑leading synthetic biology capabilities for carbon‑fixing, gas‑fermenting organisms, including the first dedicated biofoundry for these challenging microbes. LanzaTech’s unique biofoundry solution is purpose-built for non-model organisms with highly customized anaerobic and gas-handling capabilities and advanced workflows validated through many years of operation.

“We are delighted to partner with BRIGHT, whose vision, expertise, and commitment to transformative research make them the ideal partner for LanzaTech. This marks a significant milestone in our transformation. By creating a dedicated team that consolidates our biotechnology know-how, we can focus the broader team on our commitment to delivering commercial sustainable aviation fuel and biorefining projects,” says LanzaTech CEO Jennifer Holmgren.

Under the new agreement, a LanzaTech team will develop tailored methods and workflows for BRIGHT’s research missions, provide a non‑exclusive license to relevant IP for tools and biofoundry workflows, and design and install a customized C1 biofoundry at DTU.

 

FACTS

Why this partnership matters

Recent advances in C1 biofoundry design at LanzaTech have created new opportunities to develop production strains more efficiently, enabling conversion of CO, CO₂ and methane off‑gases into valuable fuels, chemicals and materials. Access to these capabilities is currently limited, slowing research and technology development worldwide.

Establishing a next‑generation C1 biofoundry at BRIGHT will close this gap and create a shared platform for researchers, partners and innovation activities in Denmark and across Europe.

A C1 biofoundry specialized in microbes that utilize C1 gases will enable:

  • Faster strain development cycles
    Automation and parallelization allow thousands of microbial designs to be generated and tested at once.
  • Reduced innovation risk
    High‑throughput workflows enable testing many more variants, helping teams fail faster and optimize sooner.
  • Integration of AI‑driven design tools
    Data from large-scale strain screening feeds into models that guide the next design cycle, accelerating the Design–Build–Test–Learn loop.
  • Safe, high‑precision research on challenging organisms
    Working with non-model, often anaerobic microbes — and with flammable or toxic gases — requires specialized equipment and know‑how.

Biofoundry Outside 

Biofoundry Outside. Photo: BRIGHT.

Credit

BRIGHT

About BRIGHT

BRIGHT is a research center at the Technical University of Denmark (DTU) focused on enabling transformative research and innovation for a circular and competitive bioeconomy. Through cutting‑edge science, leading research infrastructure, interdisciplinary collaboration, and strong industry partnerships, BRIGHT develops next‑generation biological solutions for foods, materials, and chemicals.

https://bright.dtu.dk/

About LanzaTech

LanzaTech is a global leader in gas fermentation and carbon recycling. With over 15 years of experience engineering carbon‑fixing microbes and operating the world’s first biofoundry for gas‑fermenting organisms, the company develops technologies that turn waste carbon into sustainable fuels, chemicals, and materials.

https://lanzatech.com/

 

Telemedicine has not led to increased use of medical care or higher health care costs




The findings could ease concerns that the expansion of telemedicine would trigger spikes in usage and the nation’s already high health care costs




University of California - Los Angeles Health Sciences






New UCLA-led research finds that use of telemedicine has not significantly increased visits and medical spending across all payer types.

The findings, to be published May 11 in the peer-reviewed journal JAMA Network Open, could ease concerns among lawmakers that the telemedicine expansion that occurred during the COVID pandemic would result in large utilization and spending increases.

With the declaration of the COVID pandemic in 2020, the Centers for Medicare & Medicaid Services (CMS) changed key policies regarding telemedicine flexibility, such as introducing payment parity with in-person visits, waiving geographic restrictions, and eliminating out-of-pocket cost sharing. Once the pandemic was declared over, however, lawmakers extended these changes to analyze how telemedicine impacted healthcare use and spending. Those CMS flexibilities are due to expire in 2027, and lawmakers continue to debate whether to permanently extend or modify them.

While supporters had hoped that the new, wider availability of telemedicine would reach people without easy access to doctors, others were concerned that the new flexibility would increase its use and drive up healthcare costs, said study lead Dr. John N. Mafi, associate professor-in-residence of medicine, division of general internal medicine and health services research at the David Geffen School of Medicine at UCLA.

“Our findings suggest neither prediction came true on a national scale,” Mafi said. “As telemedicine use grew, visits and spending in heavy users tracked closely with patterns in lighter users. That is reassuring for anyone worried about ballooning costs, but more sobering for anyone hoping telemedicine would close longstanding gaps in access. At least so far, it looks more like a substitute for in-person care than a true expansion of it.”

Previous research has raised the possibility that telemedicine could worsen health disparities, and others have found geographic differences in telemedicine use. In addition, a previous study published in JAMA and led by UCLA found that Americans’ use of common outpatient health services dipped sharply at the outset of the COVID-19 pandemic, then rebounded to near-normal levels by the end of 2020, only to decline again during the second surge in January–February 2021. This study prompted the researchers to examine the effect of telemedicine’s adoption among different population groups.

With these questions in mind, the researchers sought to quantify the association between telemedicine use, visits and health spending. They used multi-payer medical claims data from MedInsight’s database for more than 3 million US adults who were continuously enrolled in Medicare fee-for-service, Medicare Advantage, dual-eligible Medicaid or commercial insurance from January 1, 2019 through December 31, 2023.

Overall, the researchers found that telemedicine visits fell 2.4% and spending dropped 0.5%. However, the findings “crossed the null,” meaning that these changes were not statistically significant over the time period covered. In other words, the authors cannot rule out that the changes observed could simply be due to chance. Importantly, while the confidence intervals could not rule out small changes in either direction, they did rule out large ones, indicating that any true effect on overall visits or spending was modest at most.

They also did not find any significant changes across the subgroups they examined. For example, urban populations had 4.4% fewer visits and 2.3% lower spending, 2.5% lower spending among Medicaid-insured people, 5.3% lower spending among dual-eligible individuals, 3% less spending among those with Medicare Advantage, and 1.5% lower spending among socially vulnerable populations, but none of these changes were statistically significant.

They also found there were 3.4% more visits and 3.8% higher spending in rural areas, 1.1% more spending among commercially insured patients, 1% more expenses among people with Medicare fee-for-service insurance, and 4.5% higher spending among people who were the least socially vulnerable, but again, none of these changes were statistically significant.

Among the study’s limitations, aggregated results may not apply to individuals, the results may not apply to the entire country or to people who lack insurance, and the study design could not lead to any causal inferences.

Senior author Dr. Katherine Kahn, distinguished professor of medicine at the David Geffen School of Medicine at UCLA and senior natural scientist at RAND, said the findings should be viewed as an early read on a still-evolving policy.

“Our analysis runs only through late 2023, when telemedicine use was still settling into a new equilibrium,” Kahn said. “Much more work is needed to understand telemedicine’s longer-term effects on quality of care, health outcomes, and spending, and whether those effects differ across the diverse populations who depend on it. Policymakers should keep monitoring closely as the evidence base matures.”

Study co-authors are Sitaram Vangala, Manying Cui, Artem Romanov, Ziyi Li, Chi-Hong Tseng, and Dr. Catherine Sarkisian of UCLA; Jonathan Cantor and Cheryl Damberg of RAND; Melody Craff, Dale Skinner, and Michael Hadfield of MedInsight, Milliman Inc.; Michelle Rockwell of Virginia Tech, and Dr. A. Mark Fendrick of University of Michigan. Mafi and Kahn are also affiliated with RAND

Arnold Ventures funded this study with additional support from the National Institutes of Health and a National Institute on Aging research Career Development award (K76AG064392-01A1).

 

Exeter leads rare disease global genetic testing project, improving access and saving young lives




University of Exeter




An international partnership designed to improve equality in access to genomic medicine for a rare disease has now provided potentially life-saving genetic testing for over 1,100 families across the world.  

Congenital Hyperinsulinism affects the pancreas, causing blood sugar (glucose) levels to drop dangerously low. Genetic testing ensures children are on the best treatment for them.  Importantly, testing can also predict whether a baby has a form of disease in which the entire pancreas produces too much insulin, or a smaller region in the pancreas oversecretes insulin, known as focal disease. Focal disease can be cured by a surgery to remove these cells. Getting this surgery early reduces risk of a brain injury caused by low blood glucose levels. Around 40 per cent of children with congenital hyperinsulinism have neurologic damage resulting from a brain injury, which can be life-threatening in the most severe cases.  

Now, a new correspondence article published in Nature Health marks the success of the Open Hyperinsulinism Genes Project, a partnership between the University of Exeter, the Royal Devon University Healthcare NHS Foundation Trust, and the US-based charitable organisation Congenital Hyperinsulinism International. Co-founded and led by the mother of a child with the condition, the organisation provides funding for genetic testing for people from countries where such services would otherwise be inaccessible.  

Professor Sarah Flanangan, of the University of Exeter Medical School, leads the research programme. She said: “In Exeter, we are committed to ensuring that every child born with congenital hyperinsulinism, wherever they are in the world, can benefit from rapid, state-of-the-art genetic testing something that has not previously been possible. This project combines Exeter’s world-leading genetics expertise with knowledge of the condition and funding from Congenital Hyperinsulinism International.  

Dr Jayne Houghton, lead Clinical Scientist for this project at the Royal Devon University Healthcare NHS Foundation Trust said “This alliance is unlocking access to rapid genomic testing for families across the world, giving children the best chance in life and expanding research to be more inclusive. We believe this model should be expanded to other rare diseases.”  

Exeter provides genetic testing for families across the world who cannot access these services in their own countries. Since its launch in 2018, the Open Hyperinsulinism Genes project has funded comprehensive, rapid genetic testing for over 1,100 families living with the condition, from 63 countries across six continents. The Exeter team have delivered a genetic diagnosis for 593 (52 per cent) of these children. These results confirmed diffuse disease, where the entire pancreas oversecretes insulin, in 438 children, and predicted focal disease, where insulin is secreted from a small region in the pancreas, in 155 children. Those with focal disease can be cured by surgery. For 29 of the infants, a syndromic form of hyperinsulinism was diagnosed, enabling more appropriate clinical monitoring for the development of other symptoms.  

Exeter also leads on research into the condition, inviting all of the families to be involved in genetic studies they could not otherwise access. By recruiting people from populations that are underrepresented in genomic studies, the project increases genetic diversity and strengthens the power of the resulting findings for a global population. Research via the project has already deepened understanding of the genetic basis of congenital hyperinsulinism and advanced knowledge of the biology of insulin secretion and the regulation of genes.   

Global impact inspired by Ben 

While some countries, including the UK, offer government funded genetic testing and treatment at specialist centres, many others do not. In the US most individuals with a confirmed medical diagnosis of congenital hyperinsulinism have genetic testing covered by - insurance.  

Julie Raskin’s son Ben was born with congenital hyperinsulinism. The early signs were missed, and diagnosis took a week, leaving him with a brain injury that caused low vision and epilepsy and learning disabilities and fine motor issues. Her campaign for better diagnosis led her to join with other parents to found Congenital Hyperinsulinism International, of which she is now CEO.  

Julie, from Glen Ridge, New Jersey, “As a mother who knows intimately the effect of congenital hyperinsulinism on my son and entire family, I see the enormous value of understanding its genetic cause. It sets expectations for how the future will unfold; which treatment options to pursue, and which will not be fruitful.”  

“Research and humanitarian components of this project are vital to end preventable and lifelong brain injuries. Our project enables families from every country access to a world-leading laboratory with specific expertise in congenital hyperinsulinism. These families are also counted in research, which is essential to increasing the overall understanding of the condition. By participating, these families are part of the reason scientific research breakthroughs are made, and they can feel pride in knowing they advanced knowledge, and human health more generally.” 

The research is also supported by the Exeter NIHR Biomedical Research Centre.  The paper is titled ‘The Open Hyperinsulinism Genes Project bridges global disparities in access to genomic medicine’, and is published in Nature Health.  

 

State-level differences in HPV vaccine uptake among 13- to 17-year-old adolescents



JAMA Pediatrics




About The Study: 

This cross-sectional study demonstrates substantial state-level variation in human papillomavirus (HPV) vaccine uptake among U.S. adolescents, even after adjustment for key sociodemographic factors. Several Northeastern states, including Massachusetts, Rhode Island, and New Hampshire, exhibited significantly higher odds of HPV vaccination compared with the reference state, Alabama, whereas multiple Southern states, particularly Mississippi, Georgia, Oklahoma, Kentucky, and West Virginia had significantly lower odds of uptake. 



Corresponding Author: To contact the corresponding author, Chinenye Lynette Ejezie, PhD, MPH, email cejezie@towson.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamapediatrics.2026.1338)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Embed this link to provide your readers free access to the full-text article 

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Expanding Medicaid coverage lowered death rates for young adults with kidney failure



A study led by Brown University researchers suggests that expanded health insurance coverage may significantly improve survival and care quality in this high-risk population.





Brown University





PROVIDENCE, R.I. [Brown University] — Among young adults with kidney failure, the expansion of Medicaid following the Affordable Care Act signed into law in 2010 was associated with substantial declines in one-year death rates, researchers from Brown University found in a new study.

“The biggest takeaway from this study is that health insurance is critically important for survival among individuals with a high and constant need for medical care,” said lead author Shailender Swaminathan, an adjunct professor of health services, policy and practice at the Brown University School of Public Health.

The researchers found that for young adults with kidney failure, Medicaid expansion led to improvements in pre-dialysis care, increased use of dialysis and longer dialysis sessions — all factors that can improve long-term health outcomes. The study, published in JAMA Pediatrics, focused on young adults for two main reasons.

“Young adults have historically been underinsured, but the Medicaid expansions under the Affordable Care Act were able to address that issue quite quickly,” Swaminathan said. “Thus, we were able to find a large shift in health insurance coverage for young adults before and after Medicaid expansions. Second, unlike for older adults, benefits of Medicaid for young adults can potentially accrue over multiple years.”

Prior to the Affordable Care Act, young adults had the highest rates of uninsurance of any age group in the United States. This was driven by several factors, including the loss of childhood eligibility for Medicaid coverage at age 19 and disproportionate employment in jobs that do not offer health insurance.

In 2010, the Affordable Care Act expanded Medicaid coverage for lower-income adults and required insurers to cover dependents on their parents’ employer-provided insurance plans until age 26. As a result, uninsurance rates for young adults ages 19 to 25 fell from 31.5% in 2009 to 13.1% in 2023 — the biggest change among any age group.

To find out how the expansion affected the mortality rates of young adults, the Brown research team zeroed in on the high-risk population of young adults with kidney failure, whose death from heart disease is 500 times greater than that of their peers. The team studied 7,139 patients, comparing young adults affected by Medicaid expansion (ages 19 to 23) with adolescents whose eligibility was unchanged (ages 14 to 18). The study period extended from 2010 through 2019.

They found that one-year mortality among 19- to 23-year-olds initiating dialysis declined by a statistically significant 1.8 percentage points after insurance expansion.

Health insurance coverage and access is one of the central health policy issues currently facing the country, said study author Dr. Amal Trivedi, a professor of health services, policy and practice at Brown. Between 5 million and 10 million Americans are projected to lose Medicaid coverage by 2028 as a result of H.R.1 (the One Big Beautiful Bill Act) signed into law in July 2025.

As we approach these issues, it’s important to keep in mind that Medicaid expansion was associated with substantial reductions in mortality among young adults with kidney failure initiating dialysis,” Trivedi said. “This suggests that expanded health insurance coverage may improve survival and care quality in this high-risk population.”

The research was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK113298, R01DK129388) and the National Institute of Minority Health and Health Disparities (R01MD017080).