Tuesday, March 31, 2026

 

Collaboration between ORNL, General Atomics to advance manufacturing for energy and security




DOE/Oak Ridge National Laboratory
Corson Cramer, R&D staff scientist in manufacturing science at ORNL 

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Corson Cramer, R&D staff scientist in manufacturing science at ORNL, is shown curing continuous silicon carbide fiber tubes at the Manufacturing Demonstration Facility.

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Credit: ORNL, U.S. Dept. of Energy / Amy Smotherman Burgess





The Department of Energy’s Oak Ridge National Laboratory and General Atomics Electromagnetic Systems have signed a memorandum of understanding to explore advanced manufacturing for extreme environment materials with energy and national security applications.

“This agreement gives us an opportunity to innovate with General Atomics, a leader in U.S. defense and energy manufacturing,” said Corson Cramer, an R&D staff scientist in manufacturing science at ORNL. “This is a first step in the goal of transitioning these advanced manufacturing technologies from the lab to real-world applications.”

The agreement establishes a framework for collaborating on advanced composite materials, including silicon carbide ceramics. Silicon carbide is a strong, lightweight material that can withstand high heat and radiation, but it can be difficult to manufacture at scale. Improving how these ceramics are made could expand their use in applications such as nuclear fuel cladding and thermal protection systems for aerospace.

Manufacturing methods also could be improved by combining 3D printing and other advanced techniques with digital technologies, such as a digital thread that links data across the manufacturing process. This allows monitoring in real time, tracking quality and reducing or eliminating defects and waste.

The research will take place at the Department of Energy’s Manufacturing Demonstration Facility at ORNL. The MDF is the nation’s largest advanced manufacturing research facility and works with U.S. manufacturers on early-stage research and development, offering unique capabilities to make manufacturing faster, more efficient and reliable.

UT-Battelle manages ORNL for the Department of Energy’s Office of Science, the largest supporter of basic research in the physical sciences in the United States. DOE’s Office of Science is working to address some of the most pressing challenges of our time. For more information, visit energy.gov/science.

 

Photonic chip packaging for extreme environments




National Institute of Standards and Technology (NIST)





Researchers at the National Institute of Standards and Technology (NIST) have developed a new way to package photonic integrated circuits — tiny chips that convey information using light instead of electricity — so they can survive and operate in extreme environments, from scorchingly hot industrial settings to ultracold vacuum chambers and the depths of outer space. 

“Our study marks a major step toward bringing the speed and efficiency of photonics into environments where conventional semiconductor chips powered by electric current and photonics chips packaged using traditional methods have not been able to operate,” said NIST physicist Nikolai Klimov, who led the project.

The results were just published in Photonics Research. 

In the world of chip manufacturing, “packaging” refers to the protective housing and connection system that surrounds a chip and links it to the outside world, including optical fibers, electrical contacts and other components. Good packaging allows the chips to be used in compact, reliable devices without damage or misalignment. 

Photonic integrated chips have a particular advantage because they transmit data at high speeds while consuming far less power than conventional chips — but only if the packaging can keep delicate optical connections perfectly aligned.

Photonic integrated chips already play a central role in telecommunications, medical diagnostics and advanced sensing. But their use in demanding environments has remained limited. Traditional packaging fails to maintain reliable connections between photonic chips and optical fibers in extreme conditions — such as intense radiation, ultrahigh vacuum, blistering heat or frigid temperatures.

Many quantum technologies, including several leading quantum computing platforms, require either ultrahigh vacuum environments, temperatures just a few degrees above absolute zero, or both. Space missions, nuclear reactor cores and particle accelerators expose instruments to intense radiation. Industrial and energy applications demand sensors that can withstand heat, pressure and corrosive environments.

To make it possible for photonic integrated chips to work in these extreme environments, the researchers overcame a surprisingly stubborn challenge: reliably attaching an optical fiber to a photonic chip. Today’s standard adhesives — organic polymer glues — tend to crack, outgas or degrade when exposed to extreme cold, intense radiation, vacuum or heat. Once that bond fails, the chip can no longer function. 

To solve this problem, NIST scientists adapted a technique originally used by NASA to assemble large, ultrastable optical systems for both space-based and ground-based astronomical systems. The method, called hydroxide catalysis bonding (HCB), creates an inorganic, glasslike chemical bond between the optical fiber and the photonic chip. Instead of relying on glue, the process uses a tiny amount of sodium hydroxide solution to fuse the surfaces at the molecular level, forming a rigid, stable connection.

The NIST team demonstrated for the first time that the HCB technique can achieve the precise optical fiber alignment and efficient light coupling that photonic circuits require, while still forming a robust package able to withstand harsh environments. To test that resilience, the researchers exposed the packaged photonic chip to a series of extreme conditions. Even after the team chilled the assembly to cryogenic temperatures, plunged the material through rapid swings in temperature, bombarded it with intense ionizing radiation, and placed it under high vacuum, the HCB-bonded fiber connection remained intact. This allowed the team to verify that the chip itself continued to function normally.

Although high-temperature testing could not be performed directly on the packaged photonic chip due to limitations of the commercial optical fibers available, additional studies performed by the team showed that HCB-based photonic packaging remains mechanically stable at temperatures far higher than what conventional adhesives can withstand. Together, these results point to a packaging method with exceptional resilience across a remarkably wide environmental range.

“This approach creates a bond that is as resilient as the optical fiber itself,” said Klimov. “It allows photonic integrated circuits to go places they simply couldn’t go before.”

Although the current bonding process requires several days to complete, the researchers emphasize that this is an engineering issue rather than a fundamental barrier. With focused development, engineers could dramatically shorten the time, making the technique suitable for large-scale manufacturing.


Paper: Sarah H. Robinson, CH.S.S. Pavan Kumar, Ashutosh S. Rao, Daniel S. Barker, Fred B. Bateman, Kevin O. Douglass, Thinh Q. Bui, Glenn E. Holland, Daron A. Westly and Nikolai N. Klimov. Photonic Chip Packaging for Extreme Environments. Photonics Research. Published online March 27, 2026. DOI: 10.1364/PRJ.565679

 

Burnout may lead family doctors to leave medicine




Weill Cornell Medicine





Family physicians who report feeling burned out are nearly 1.5 times more likely to change practices or stop practicing medicine entirely than their peers who don’t report burnout, a study by Weill Cornell Medicine researchers found. Physician burnout can include emotional exhaustion, detachment from patients and colleagues, and feeling that work is no longer meaningful.

The findings, published March 30 in JAMA Internal Medicine, also highlight the consequences for patients: people who lose their family physician may be more likely to visit the emergency room, spend more on health care and be less satisfied with their care than those who keep their doctors.

“To our knowledge, this is the first national-level study examining the association between physician burnout and turnover,” said Dr. Amelia Bond, associate professor of population health sciences at Weill Cornell Medicine, who co-led the study.

To quantify burnout, Dr. Bond and her colleagues turned to the 2016-2020 American Board of Family Medicine surveys, which family physicians must complete to obtain and maintain board certification. As part of the survey, physicians are asked whether they feel burned out or callous.

The researchers then determined whether physicians changed practices or stopped practicing altogether in the subsequent year, based on billing patterns in de-identified Medicare data.

Of the nearly 20,000 physicians in the study, 43.5% reported burnout. Doctors under the age of 55 were more likely to report burnout than older doctors, and women were more likely to report burnout than men.

The research suggests that workplace stress may reduce physician retention. Among physicians who reported burnout, 4.8% changed practices versus 3.4% of physicians who did not report burnout; 5.4% of physicians with burnout stopped practicing entirely compared to 3.7% of physicians without burnout.

“These findings highlight the urgent need to address work conditions and professional satisfaction for both the stability of the physician workforce and the well-being of patients,” said Dr. Dhruv Khullar, associate professor of population health sciences at Weill Cornell Medicine and co-lead on the study.

Physician burnout and turnover have clinical, organizational and economic implications. “The issue definitely warrants more attention,” Dr. Bond said.

Further investigation could identify practices, systems and policy factors that may reduce rates of physician burnout and turnover. While this study found a correlation, additional work will be needed to establish a causal link between burnout and turnover.

 

Antimicrobial resistant genes found in wastewater samples from a South African city



Researchers from Stellenbosch University found evidence of genetic material from two major bacterial groups, commonly known to exhibit high-risk resistance profiles, in wastewater samples from a large South Africa city



Stellenbosch University

Collecting samples from a Wastewater Treatment Plant in Tshwane, South Africa 

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Researchers from Stellenbosch University collect water samples at a wastewater treatment facility in an urban centre in South Africa to investigate how antimicrobial resistance genes move through water systems.

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Credit: JP Makumbi

 




  • There is increased evidence that extracellular DNA – genetic material released from bacteria killed during the treatment process – may act as a previously underappreciated reservoir of antibiotic resistance.
  • Researchers from Stellenbosch University found evidence of genetic material from two major bacterial groups, commonly known to exhibit high-risk resistance profiles, in wastewater samples from a large South Africa city.

In South Africa, wastewater treatment plants (WWTPs) and connected river systems could serve as reservoirs of antibiotic resistance, raising fresh concerns about how antimicrobial resistance moves through ecosystems and into human populations.

Antimicrobial resistance (AMR) refers to the ability of disease-causing microbes to withstand treatments. Antibiotic resistance—a type of AMR—occurs when bacteria no longer respond to antibiotics. If current trends continue, estimates suggest that by 2050 deaths from AMR will rise to about 10 million people per year.

In a study led by researchers from the NRF-DSTI research chair in African Microbiome Innovation at Stellenbosch University (SU), scientists investigated how antimicrobial resistance genes behave in WWTPs and rivers in a large urban city in South Africa.

Dr John Paul Makumbi, a medical microbiologist and first author on the paper published in Cell Reports this week, says antimicrobial resistance in the environment occurs naturally, as bacteria continue to evolve to protect themselves against harmful pathogens and other pollutants.

In the context of WWTPs, however, this natural process is accelerated, over-exposing bacteria to a toxic melting pot of untreated effluent from abattoirs, hospitals and industry, mixed with raw sewage and other pollutants.

Moreover, while the older WWTPs were designed to remove harmful chemicals and kill bacteria, they were not designed to remove extracellular DNA – genetic material released from bacteria killed during the treatment process. There is increased evidence suggesting that exDNA may act as a previously underappreciated reservoir of antibiotic resistance.

Because of the lack of such studies in Africa, and the potential implications for water reuse, Dr Makumbi and his co-authors conducted a microbiome study to get a sense of what is happening at WWTWs and connected river systems in South Africa.

From samples taken from nine Wastewater Treatment Plants and connected river systems in Tshwane, they found evidence of genetic material from two major bacterial groups, commonly known to exhibit high-risk resistance profiles. These bacterial groups survived the treatment processes typically used in WWTPs. Both the Pseudomonadota and Bacteroidota groups are commonly associated with multi-drug-resistant behavior.

Makumbi explains: “Even though the bacteria themselves are killed, we found extracellular DNA carrying resistant genes in the effluent. These genes could still be transmitted and shared with other bacteria in the environment, continuing the cycle of antibiotic resistance.”

In essence, WWTWs may serve as ecological “superspreaders” of extracellular DNA-mediated antimicrobial resistance, thus shaping the genetic landscape of wastewater and freshwater environments.

According to Makumbi, although some WWTPs in South Africa and elsewhere are currently being upgraded with advanced technologies such as UV-treatment to reduce antimicrobial resistance genes, progress remains slow.

“If we want to protect our waterways and public health, and contain the spread of superbugs in the environment, we need to protect and upgrade WWTPs. We should protect our WWTWs by pretreating effluent from high-risk sources such as abattoirs, hospitals and industry before it enters the system. The same logic holds for treating effluent before it hits the environment.

“Everyone will benefit from less polluted water entering our rivers,” he adds.

For Prof. Thulani Makhlanyane, holder of the DSTI-NRF research chair in African Microbiome Innovation, we need more studies on the intersection between water security and antimicrobial resistance: “Future wars will in part be based on water security and AMR. This is especially true in Africa where aging infrastructure, poor management, and an inability to sufficiently integrate science into policymaking, is compounding the problem. We hope that the findings from this study will add to the call for action to ensure water security,” he concludes.

The findings were published in the journal Cell Reports in an article titled “Persistence of high-risk antimicrobial resistance genes in extracellular DNA along an urban wastewater-river continuum”.

 

How one ‘forever chemical’ can disrupt a baby’s facial development



Researchers discovered PFDA, a PFAS, is the most toxic during fetal development




University of Colorado Anschutz






Researchers have long associated per- and polyfluoroalkyl substances (PFAS), commonly known as “forever chemicals,” to certain severe birth defects, but exactly how these pollutants harm a developing fetus has remained mostly a mystery. New research now provides the first clear molecular explanation, showing how one PFAS, called perfluorodecanoic acid (PFDA), can trigger craniofacial abnormalities before birth.

The research was published today in ACS Chemical Research in Toxicology.

“Most people are exposed to small amounts of PFAS in everyday life but higher exposure can occur through contaminated water, living near manufacturing sites or certain jobs like firefighting and ski waxing, which is why it’s so important to understand the chemicals better,” said the paper’s senior author Jed Lampe, PhD, associate professor at University of Colorado Anschutz Skaggs School of Pharmacy and Pharmaceutical Sciences. “We wanted to understand which PFAS compounds are truly harmful during fetus development, especially for people with higher exposure, and how they cause damage.”

There are approximately 15,000 PFAS used in consumer and industrial products but scientists are increasingly finding that only some pose serious health risks. In this study, Lampe worked with the paper’s first author Michaela Hvizdak and co-author Sylvie Kandel to test 139 commonly found PFAS and discovered PFDA as the most toxic during fetal craniofacial development.

They found even tiny amounts of PFDA were enough to cause visible facial changes, with the risk increasing by 10% at extremely low exposure levels.

“This finding moves us beyond association by providing a clear explanation for how PFDA can interfere with fetal development. It’s a critical step toward understanding a vast and complex class of environmental chemicals,” said Lampe.

They found that PFAS disrupts retinoic acid, a molecule essential for shaping the face and head during early pregnancy. Retinoic acid regulates hundreds of genes and its levels must be controlled. Because a fetus cannot produce or safely eliminate excess retinoic acid, it relies entirely on the mother to maintain the homeostatic balance of the hormone.

The researchers discovered PFDA blocks CYP26A1, a key enzyme responsible for breaking down excess retinoic acid. When this enzyme is inhibited, retinoic acid levels can rise too high, disrupting normal facial development. PFDA also suppresses the genes that produce this enzyme through a separate biological pathway, delivering a “double hit” to the system that regulates early development.

“As a result, severe craniofacial abnormalities can develop, including underdeveloped eyes and abnormal jaw formation, which were the most common effects of PFDA exposure during fetal development,” said Lampe.

The researchers hope by providing a molecular explanation for this abnormality that the research and scientific community can work to develop targeted laboratory assays and computer‑based screening tools to quickly rank PFAS by risk. They say this could help regulators and manufacturers distinguish more dangerous compounds from safer alternatives and guide the design of less toxic chemicals in the future.

They also hope the research can open the door to practical interventions for people with higher exposure, such as firefighters and ski wax technicians. This could include looking into how to reduce exposure levels and whether strategies can be developed to lower PFDA during pregnancy to protect fetal development.

About the University of Colorado Anschutz
The University of Colorado Anschutz is a world-class academic medical campus leading transformative advances in science, medicine, education and patient care. The campus includes the University of Colorado’s health professional schools, more than 60 centers and institutes, and two nationally ranked independent hospitals - UCHealth University of Colorado Hospital and Children's Hospital Colorado - which see nearly three million adult and pediatric patient visits each year. Innovative, interconnected and highly collaborative, CU Anschutz delivers life-changing treatments, exceptional patient care and top-tier professional training. The campus conducts world-renowned research supported by $890 million in funding, including $762 million in sponsored awards and $128 million in philanthropic gifts for research.

 

Stopping algae blooms with bacteria-busting buoys




American Chemical Society
Stopping algae blooms with bacteria-busting buoys 

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These algae bloom-busting buoys come in small, medium and large sizes (left to right), allowing for efficient and targeted algaecide treatment.

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Credit: Adapted from ACS ES&T Water 2026, DOI: 10.1021/acsestwater.5c01257





Algae blooms make a pond’s surface shine in mesmerizing green hues. But if the microorganisms responsible are cyanobacteria, they can also release toxins that harm humans and wildlife alike. So, a team reporting in ACS ES&T Water has designed a “set it and forget it” system for distributing algaecide using specialized buoys tethered at the site of a bloom. In tests, the buoys removed nearly all cyanobacteria without the need for frequent reapplication.

Algae blooms occur when extra nutrients in the water — likely from fertilizer runoff — cause tiny microorganisms like algae and cyanobacteria to proliferate. In 2014, one such algae bloom in Lake Erie near Toledo, Ohio, rendered drinking water unsafe for hundreds of thousands of residents. And now, a team of researchers from the University of Toledo are looking to create an algaecide treatment system that puts a stop to a bloom before it has even started. The team, including Umberto Kober, Hanieh Barikbin, Youngwoo Seo, Yakov Lapitsky and colleagues, designed a system that releases algaecide steadily over a period of weeks or months, making it less expensive and more efficient than existing options that require frequent reapplication.

The team constructed small, medium, and large-sized buoys out of PVC pipes, forming either a “T” or cross shape. Hydrogel disks were inserted into the pipe openings to control the diffusion of the liquid algaecide into the surrounding water. The buoys were then filled with a commercial hydrogen peroxide-based algaecide, which, upon immersion, slowly diffused through the hydrogel disks. The buoys were also engineered so that once the algaecide was gone, the buoy fell to its side, visually indicating that a refill was needed.

To test their performance, the small, algaecide-loaded buoys were put in a beaker with 1 liter of cyanobacteria-containing water collected from Lake Erie and monitored for two weeks. Every day a small portion of water was replaced with new lake water to ensure the buoys were continually exposed to fresh cyanobacteria. This way, the team could evaluate whether the buoys provided sustained algicidal activity rather than killing the cyanobacteria early in the process. Researchers found that the cyanobacteria were almost entirely eliminated within a week, and other microbes remained largely unscathed. Researchers estimate that their buoys could reliably release algaecide for at least four consecutive release cycles, each lasting 35 days.

Though further research is needed, including enhancements to prevent microbe growth on the buoy’s surface, the researchers say that this work overcomes challenges in sustained and targeted algaecide treatment.

“If successfully scaled up, this concept could enable early mitigation of harmful algal blooms without the need for labor-intensive repeated algaecide applications,” says Lapitsky.

The authors acknowledge funding from the U.S. Army Corps of Engineers. The algaecide used in these experiments was provided by the SePRO Corporation, an algaecide manufacturer.

Authors Yakov Lapitsky, Umberto Kober and Youngwoo Seo have filed a patent application on this research.

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