Tuesday, May 05, 2026

 

The rush for critical minerals echoes oil extraction injustice as harms fall on world's most vulnerable, UN scientists warn



The race to build EVs, renewable energy systems and AI infrastructure, with benefits flowing mainly to wealthy nations, is driving severe, largely hidden costs borne disproportionately by the poor in Africa and South America, UN University investigation 



United Nations University

Critical Minerals and Their Roles in Energy Transition and Technology 

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Critical minerals and their functional roles in energy transition and advanced technologies (source: UNU-INWEH)

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Credit: United Nations University Institute for Water, Environment and Health (UNU-INWEH)





Richmond Hill, Ontario, Canada – Mining critical minerals such as lithium and cobalt fuels the ‘green’ energy and digital transitions essential to meeting climate goals. But building the technologies that enable a sustainable future is generating severe, hidden environmental and health crises that the world is failing to track or address, warns a new report by the United Nations University Institute for Water, Environment and Health (UNU-INWEH), known as the UN’s Think Tank on Water.

The investigation finds that systemic global failures are allowing the costs of critical minerals extraction to fall disproportionately on some of the world's most vulnerable communities, while the benefits accumulate elsewhere in the form of electric vehicles (EVs), renewable energy systems, and artificial intelligence (AI) infrastructure. The report does not question the need for clean energy systems or the digital infrastructure underpinning them. Instead, it asks who is paying for and benefitting from humanity’s progress in those areas, and finds a deeply unjust answer.

“Technological disruptions are needed and useful. But we should be aware of and proactively address their unintended consequences if we want the whole world to equally benefit from them,” says UNU-INWEH Director Kaveh Madani, who led the investigation team. “You cannot call a transition green, sustainable, and just if it simply moves the environmental harm from the rich to the poor, and from one group of people or region to another.”

The report, Critical Minerals, Water Insecurity and Injustice, underlines the intense water requirements of critical minerals extraction and that communities living closest to mining operations are paying a steep price in contaminated water, water scarcity, lost livelihoods, and serious health consequences. 

In 2024, the report says, global lithium output of roughly 240,000 tonnes consumed an estimated 456 billion litres of water, equivalent to the annual domestic water needs of 62 million people in sub-Saharan Africa, roughly the population of Tanzania.

In Chile's Salar de Atacama, lithium mining alone accounts for up to 65% of regional water usage, intensifying competition with agriculture and domestic needs and driving dramatic groundwater depletion. Between 1990 and 2015, water tables in areas with brine wells dropped by up to nine metres. 

And lithium mining in Bolivia's Uyuni region is making it increasingly difficult for communities to grow quinoa, their economic and nutritional staple. 

Globally, about one-sixth (16%) of critical minerals reserves are located in high water-stress regions, while 54% of energy transition minerals sit on or near indigenous territories.

The environmental damage extends well beyond water consumption. For every tonne of hard-to-extract rare earth minerals produced, approximately 2,000 tonnes of toxic waste are generated. In 2024, global rare earth production generated an estimated 707 million metric tonnes of toxic waste, enough to fill about 59 million garbage trucks – a number of trucks that could form a queue circling the equator 13 times.

The 21st century’s oil

The Paris Agreement gives urgency to the extraction of critical minerals to reduce the carbon-intensity of human activities. Yet this creates a new ‘paradox’: meeting global climate targets would require a ninefold increase in lithium demand and a doubling of cobalt and nickel demand by 2040. 

“Without effective control mechanisms, the very targets designed to protect the planet can accelerate water, and health, and injustice crises in the communities least responsible for causing climate change,” says Prof. Madani, recently named the Stockholm Water Prize Laureate for 2026. “The world is rushing to build a cleaner energy future, and we support that urgency. But our investigation proves that the mining operations powering that transition are contaminating drinking water, destroying agricultural livelihoods, and exposing children to toxic heavy metals in some of the world's most vulnerable communities.”

Demand for graphite and other minerals essential to the energy and digital transition is projected to rise four or five times by 2050.

Referring to critical minerals as the ‘oil of the 21st century,’ the report draws a sobering parallel to the fossil fuel era, noting that the benefits of past resource extraction rarely reached the communities that bore its costs. Without deliberate policy intervention, it warns, the energy transition risks repeating that pattern, creating new "sacrifice zones" in mineral-rich but economically-marginalised regions.

Health burden falls hardest on women and children

Mining-related water contamination is creating serious public health emergencies. In the Democratic Republic of Congo (DRC), for example, a major cobalt producer, 72% of people living near mining sites reported skin diseases, and 56% of women and girls reported gynecological problems. 

Birth defect rates in maternal wards near DRC mining areas are markedly elevated compared to those farther away, including neural tube defects (which can lead to serious infant brain and spine defects) at a rate of 10.9 per 10,000 births and lower limb defects at 8.8 per 10,000 births. 

The psychosocial toll is also documented. Residents of mining communities in Calama, Chile and Mibanze, DRC describe living in constant fear, anxiety, and a sense of being 'sacrificed' so that wealthier regions can advance. Studies link water insecurity and chronic pollution exposure to elevated rates of anxiety, depression, and in extreme cases, suicide.

And approximately 30% of mining sites in the DRC employ children, who typically lack basic health and safety protections.

In the DRC, more than 80% of mineral output is controlled by foreign industrial mines, limiting local economic gains. Despite the country's vast mineral wealth, over 70% of the DRC's population lives on less than $2.15 per day.

“The green energy transition is among the most important undertakings of our time. But the evidence we've gathered shows that the communities doing the actual digging, breathing the dust, and losing access to clean water are largely excluded from its benefits,” says UNU-INWEH scientist Dr. Abraham Nunbogu, the report’s lead author. “If we don't correct the governance failures driving this, we will have built the clean energy economy of the future on the same extractive injustices as the fossil fuel economy of the past.”

Urgent policy action required

The report calls for a fundamental shift in how the global community governs critical mineral supply chains. 

Key recommendations include mandatory international due diligence standards to replace voluntary compliance, legally binding mechanisms for ethical sourcing and environmental justice, strict pollution and wastewater controls including zero-discharge systems, and independent monitoring of water use and heavy metal contamination.

The report also calls for investment in circular economy solutions, including advanced recycling of batteries, electronics, and renewable energy components, to reduce pressure on primary extraction.

The report notes that the issues bear directly on progress towards UN Sustainable Development Goals 6 (clean water and sanitation), 3 (good health and well-being), 1 (no poverty), 7 (affordable and clean energy), and 10 (reduced inequalities).

“This rigorous, evidence-based investigation by UNU scientists addresses a problem the world urgently needs to confront,” says Prof. Tshilidzi Marwala, UN Under-Secretary-General and Rector of the United Nations University. “A transition that deepens poverty, undermines access to clean water, and concentrates health burdens on the world's most marginalized communities is not a transition toward the UN’s Sustainable Development Goals. It is a step away from them. We cannot give up on the digital transition but we need to do it right.”

Drawing on empirical analyses, scientific studies, and field evidence from the Lithium Triangle, the Democratic Republic of the Congo, and other high-risk extraction regions, the report presents what the authors describe as one of the most overlooked injustices of the global sustainability transition.

Importantly, the report makes clear this is not exclusively a problem of distant or developing regions. The Thacker Pass lithium mine in Nevada, the largest known lithium deposit in the United States, would require up to 3.5 billion litres of water annually, largely by diverting water rights from farming communities in the Quinn River Valley. 

In Canada, the 2014 Mount Polley copper/gold mine disaster in British Columbia released roughly 25 million cubic metres of toxic waste into rivers and lakes, contaminating drinking water sources and devastating Indigenous communities. The report calls it one of Canada's worst mining-related environmental failures.

“Water insecurity is not a side effect of critical mineral mining, it is a systemic outcome of how the global supply chain is currently designed and governed,” says Prof. Madani. “Without binding international standards, mandatory disclosure, and genuine community co-governance, the demand surge projected for the coming decades will make the current situation dramatically worse.”

The report argues that without binding global rules, the current system will continue to externalize environmental and health costs.

Key recommendations include:

  • Mandatory international due diligence standards to replace voluntary compliance, with legally binding mechanisms for ethical sourcing and environmental justice
  • Strict pollution and wastewater controls, including zero-discharge systems, and independent monitoring of water use and heavy metal contamination
  • Investment in circular economy solutions -- including advanced recycling of batteries, electronics, and renewable energy components -- to reduce pressure on primary extraction
  • Legally mandated benefit-sharing agreements that direct a fair share of mining revenues to affected communities for health, water, and education services
  • Legal enshrinement of Free, Prior and Informed Consent (FPIC) for Indigenous communities whose lands are affected by extraction
  • Robust public health systems and mandatory Health Impact Assessments in mining regions, with companies required to contribute financially
  • Investment in low-water extraction technologies such as direct lithium extraction (DLE) to reduce freshwater consumption

“The data collected for this report makes a stark case, documenting severe health and environmental outcomes in communities that will probably never own an electric vehicle or benefit from the technologies their land is being destroyed to build, in the foreseeable future” says Dr. Nunbogu. “These hidden costs of the energy transition remain largely invisible to regulators and the public because reliable, publicly accessible data on water usage and pollution at specific mining sites remains scarce. Without open and verifiable data, we cannot hold supply chains accountable, and we cannot ensure that the transition is equitable. That is not a technical failure, it is a governance failure.”

By the numbers

Demand

  • Demand for critical minerals tripled between 2010 and 2023
  • Lithium demand rose 30% in 2022 alone; cobalt and nickel demand grew 70% and 40% respectively from 2017 to 2022
  • Total global trade value of critical minerals exceeded USD 320 billion by 2022
  • Demand projected to more than double by 2030 and quadruple by 2050
  • Graphite, lithium, and cobalt demand could rise by nearly 500% by 2050 relative to 2020 levels
  • Meeting Paris Agreement targets would require a ninefold increase in lithium demand and a doubling of cobalt and nickel demand by 2040

Water

  • 1.9 million litres of water required to produce one tonne of lithium
  • An average lithium mine producing 11,000 tonnes annually uses roughly 20 billion litres of water -- enough to cover the annual domestic water needs of 2.8 million people in sub-Saharan Africa
  • 2024 global lithium output (excluding US): ~240,000 tonnes, requiring an estimated 456 billion litres of water -- equivalent to the annual domestic water needs of 62 million people in sub-Saharan Africa
  • Lithium mining accounts for up to 65% of regional water usage in Chile's Salar de Atacama
  • Thacker Pass mine (Nevada, USA) would require up to 3.5 billion litres of water annually
  • Water table in Atacama brine-well areas dropped by up to 9 metres from 1990 to 2015
  • 16% of critical mineral mining sites are in areas already classified as water-stressed
  • 54% of energy transition mineral projects are on or near indigenous peoples' lands

Toxic waste

  • Each tonne of rare earth elements produced generates ~2,000 tonnes of toxic waste overall, plus 1 tonne of radioactive residue and 75 cubic metres of wastewater
  • 2024 global rare earth production generated an estimated 707 million metric tonnes of toxic waste -- equivalent to ~59 million loaded garbage trucks, or the annual municipal waste of approximately 1.4 billion people
  • ~70% of that waste (490 million metric tonnes) was generated in China

Concentration of reserves and production

  • Africa holds 30% of the world's critical mineral reserves
  • DRC, Madagascar, and Morocco hold over 50% of global cobalt deposits; DRC's global cobalt production share has remained above 60% from 2020 to 2024
  • South Africa holds ~90% of global platinum reserves and accounts for ~70% of global production
  • The Lithium Triangle (Argentina, Bolivia, Chile) holds over 50% of world lithium reserves
  • Indonesia holds 42% of global nickel reserves and in 2023 accounted for 51% of global nickel production
  • Over 80% of DRC mineral output is controlled by foreign industrial mines; Indonesian companies control less than 10% of national nickel production

Health impacts in DRC

  • 72% of respondents near DRC mining sites reported skin diseases
  • 56% of women and girls reported gynecological issues; 14% reported similar issues among teenage girls
  • Neural tube defects near DRC mining areas: 10.9 per 10,000 births
  • Lower limb defects: 8.8 per 10,000 births; cleft lip/palate: 7.2 per 10,000; abdominal wall defects: 6.4 per 10,000
  • Cobalt concentrations found to be higher in umbilical cord blood than in maternal blood at delivery
  • ~30% of DRC mining sites employ children, often without basic health or safety protections; children as young as seven work without protective equipment

Poverty and inequality

  • 73.5% of DRC's population lives on less than $2.15 per day
  • 64% of DRC's population lacked basic drinking water access in 2024 -- despite the country holding more than 50% of Africa's freshwater reserves
  • Namibia, Zambia, and DRC hold over 30% of world critical mineral deposits, but most profits flow to multinational corporations and mining companies in the Global North
  • Indonesia: domestic companies control less than 10% of national nickel production

 

Report Information

Nunbogu, A., Farsi, A., Matin, M., Madani, K. (2026). Critical Minerals, Water Insecurity and Injustice. United Nations University Institute for Water, Environment, and Health (UNU-INWEH), Richmond Hill, Ontario, Canada, doi: 10.53328/INR25ABN002

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About UNU-INWEH

Marking its 30th anniversary of operation in 2026, the United Nations University Institute for Water, Environment and Health (UNU-INWEH) is one of 13 institutions that comprise the United Nations University (UNU), the academic arm of the UN. 

Known as 'The UN’s Think Tank on Water', UNU-INWEH addresses critical water, environmental, and health challenges around the world. Through research, training, capacity development, and knowledge dissemination, the institute contributes to solving pressing global sustainability and human security issues of concern to the UN and its Member States. 

Headquartered in Richmond Hill, Ontario, UNU-INWEH has been hosted and supported by the Government of Canada since 1996. With a global mandate and extensive partnerships across UN entities, international organizations, and governments, UNU-INWEH operates through its UNU Hubs in Calgary, Hamburg, New York, Lund, and Pretoria, and an international network of affiliates.

unu.edu/inweh

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Scientists pave the way for fast, cost-effective custom enzyme development



Their SMART method accelerates enzyme evolution by reducing the selection period for superior variants from several weeks to a few days, and decreases overall enzyme engineering campaign costs by eliminating the need for specialized equipment.



Nagoya University

SMART single-molecule display model 

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The SMART single-molecule display model, predicted by Alphafold3, shows SpDAAO (red) linked to a puromycin linker (magenta) through puromycin incorporation into the growing polypeptide. The mRNA (gray) is hybridized and chemically joined to the linker, connecting it to its protein, SpDAAO. An auxiliary unit is added using ORC hairpin DNA (blue) with APEX2-scCro fusion protein (green).

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Credit: Hideo Nakano and Jasmina Damnjanović







Enzymes are proteins that catalyze chemical reactions in living organisms. They are widely applied in industries such as food production, detergents, pharmaceuticals, and chemicals. However, for commercial use, natural enzymes often need improved stability, substrate specificity, or catalytic efficiency.

Directed evolution is a Nobel Prize-winning strategy for improving proteins. It introduces artificial mutations into their genes and then selects superior variants. This approach mimics natural evolution over several weeks instead of millions of years.

A significant challenge of this approach is that artificially induced mutations can generate up to 100 trillion candidate variants, which renders the screening process extremely time-consuming and expensive.

To address this challenge, researchers at Nagoya University and their colleagues have developed SMART (Single-Molecule Assay on Ribonucleic acid by Translated product), an in vitro selection platform.

Their study demonstrated that SMART identifies improved enzyme variants much more rapidly and cost-effectively than conventional methods. The findings were published in the journal ACS Synthetic Biology.

The SMART system was developed by a research group led by Associate Professor Jasmina Damnjanović and Professor Hideo Nakano of the Graduate School of Bioagricultural Sciences at Nagoya University, in collaboration with researchers from the Institute of Science Tokyo and Saitama University. This approach successfully combines mRNA display, next-generation sequencing, and bioinformatics.
 

Key features of the SMART system

Typically, proteins and genes are physically separate, making it difficult and time-consuming to identify which gene encodes a discovered enzyme.

In the SMART system, puromycin acts as a chemical bridge, linking the enzyme protein to its corresponding blueprint, messenger RNA (mRNA). This mRNA display technique enables precise tracking of the relationship between individual proteins and their encoding genes at the single-molecule level.

Nakano emphasized, "In principle, there is no method for enzyme screening that is more efficient than this system. Screening enzymes at the single-molecule level has rarely been attempted before."

SMART also incorporates an auxiliary unit for detecting enzyme activity. This study used engineered ascorbate peroxidase 2 (APEX2) as the auxiliary enzyme for oxidase screening. When the target oxidase is active and releases hydrogen peroxide (H₂O₂), APEX2 attaches a biotin marker to nearby molecules, enabling their isolation and capture.

 

Enzyme screening experiments using SMART

The researchers chose a yeast oxidase, SpDAAO, as a model enzyme because it has great potential for drug synthesis and diagnostics. The selection prioritized D-amino acids as enzyme substrates due to their growing relevance in medical applications.

The SMART method consists of several steps—creating a DNA library of enzyme variants, synthesizing enzymes in vitro, forming an mRNA display library, labeling catalytically active enzymes, isolating them with magnetic beads, and using sequencing data to guide subsequent rounds.

To assess the method, the team tested it on a simulated library with different ratios of active and inactive variants. After a single selection round, active variants were highly enriched, confirming SMART's effectiveness.

In practical experiments, the team generated a mutant library by substituting the essential 232nd amino acid with each of the 20 other amino acids. Next-generation sequencing analysis showed that the wild-type (original form) Y232 was clearly selected (p < 0.001), reinforcing the method's selectivity.

Initially, genetic analysis indicated selection of several variants, in addition to the original form. However, further statistical analysis identified these as experimental noise with minimal practical significance, supporting the method's specificity.

 

Conclusion and future perspectives

The experiments showed that SMART selection is highly effective. At the same time, the team recognized the need for rigorous statistical analysis and careful experimentation, rather than relying solely on initial results.

The researchers expect SMART to be applicable beyond oxidases. They aim to facilitate the integration of novel enzymes into industry, establishing the system as a foundation for future enzyme development and practical biocatalytic solutions.

 

 

Funding

This work was supported by Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Early-Career scientists [grant number JP18K14387 and JP22K14828] and Grant-in-Aid for Transformative Research Areas (A) (Publicly Offered Research) [grant number JP25H02263], the Collaborative Research Program by Network Joint Research Center for Materials and Devices (Ministry of Education, Culture, Sports, Science and Technology -Japan: MEXT), and Retention, Development, and Promotion Program Program Aiming at Maximizing the Career Potential of Female Researchers, Nagoya University, (MEXT's Initiative for Realizing Diversity in the Research Environment, Leadership training type for women) awarded to Jasmina Damnjanović, and in part by Pre-Research Unit System of the Institute of Integrated Research, Institute of Science Tokyo and JSPS Grant-in-Aid for Transformative Research Areas (A) (Publicly Offered Research) [grant number JP24H01123] awarded to Bo Zhu.

 

 

The handbook that can prepare countries for the next pandemic




Chalmers University of Technology
Covid-19 

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During the COVID-19 pandemic, heated debates arose, as researchers' calculations led to different conclusions about the spread of the infection and which measures would work best. Now, researchers at Chalmers and the University of Gothenburg have produced a new handbook on mathematical models, intended to pave the way for better decision-making and greater preparedness for the next pandemic.

Gerd Altmann has released this “Covid-19” image under Public Domain license

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Credit: Gerd Altmann has released this “Covid-19” image under Public Domain license. It means that you can use and modify it for your personal and commercial projects. If you intend to use an image you find here for commercial use, please be aware that some photos do require a model or a property release. Pictures featuring products should be used with care. License: CC0 Public Domain





As the COVID-19 pandemic wreaked havoc and lives were at stake, the advice experts gave to decision-makers became indispensable. At the same time, heated debates arose when researchers’ calculations led to differing conclusions on everything from face masks to school closures. A new handbook on mathematical models has now been produced jointly by Chalmers University of Technology and the University of Gothenburg, Sweden, and several Swedish government agencies. The handbook is intended to pave the way for better decision-making and greater preparedness for the next pandemic.

A mathematical model is a simplification of reality that can help us navigate a complex world. During the COVID-19 pandemic, mathematical models were used to simulate the spread of the virus, predict healthcare needs and assess the impact of various measures – from lockdowns to handwashing routines and face coverings.

By translating various factors into mathematical terms – such as data on risk groups and demographics, or information on those infected, those who recovered, and those who died – researchers were able to use mathematical tools to produce forecasts and advise decision-makers on key decisions.

Torbjörn Lundh is a professor of biomathematics at Chalmers University of Technology and the University of Gothenburg. During the pandemic, he helped Sahlgrenska University Hospital in Gothenburg, Sweden, to estimate the demand for intensive care beds on a week-by-week basis using mathematical modelling.

He is now one of the authors of a new handbook produced jointly between Chalmers University of Technology, the Public Health Agency of Sweden, the Swedish Defence Research Agency (FOI) and the Swedish Armed Forces. It provides practical guidance on how mathematical models can be used to inform decision-making, and how the results can be communicated in times of crisis when most things are uncertain – and time is of the essence.

‘This is a book I would have loved to have had myself during the COVID-19 pandemic. Then I could have been even more effective and confident in my work,’ says Torbjörn Lundh.

A model is not a definitive answer

Philip Gerlee, professor of biomathematics at Chalmers University of Technology and the University of Gothenburg, is the lead researcher for the handbook. He hopes that it will raise awareness of different models and how best to deal with them – and thereby pave the way for better preparedness for future pandemics.

‘No model can provide a definitive answer, but they can still be very useful. For us, the handbook arose out of frustration at the misconceptions and, at times, the harsh tone of exchanges between different groups that emerged in Sweden during the pandemic – and which also occurred in other countries. We want to show that all models are simplifications, but that with the right assumptions they can be helpful to decision-makers and that different models can complement one another. Hopefully, this will lead to better collaboration between experts so that we can provide better advice, more effectively, to decision-makers during the next pandemic,’ says Philip Gerlee.

Anders Tegnell, senior adviser at the Public Health Agency of Sweden and former Chief Medical Officer, is one of the co-authors. He recalls the challenges faced during the COVID-19 pandemic, when many organisations wanted to assist in what was a chaotic situation.

‘As everything happened so quickly and many people wanted to contribute their expertise, there was a certain amount of confusion over terminology and even mistrust between different groups. One example of how this played out was in opinion pieces in the Swedish media that were not particularly constructive,’ says Anders Tegnell.

Different models provide a broader picture

A chemist, a mathematician or a biologist will often use completely different models in their work, based on, for example, AI, differential equations or various data models. But, according to Torbjörn Lundh, the wide range of tools is not a problem. Quite the opposite, in fact.

‘Different models and results can provide a broader picture and a deeper understanding. It is rarely a good idea to rely solely on one model, and not all of them work as well across all stages. For example, AI models were difficult to use at the start of the COVID-19 pandemic when there was not yet enough data,’ he says.

If several models point in the same direction, the reliability of the results increases. Another important conclusion is that there are risks associated with relying on overly complex models. Torbjörn Lundh gives an example: the controversial report from Imperial College London in March 2020, which predicted hundreds of thousands of deaths and an overwhelmed healthcare system unless strict restrictions were introduced. Since then, several researchers have criticised the way in which the model underlying the report was used.

‘The more complex a model is, the harder it is to explain and understand. In addition, the results can vary greatly based on even very minor changes to the parameters you set,’ he says.

Swedish data modellers are gearing up for future pandemics

It is also important to ‘rehearse’ together during periods when the virus is not spreading, something that is currently taking place in Sweden as part of the national SEMAFOR – Swedish Epidemic Modelling and Force network.

‘We are a group of pandemic preparedness modellers from government agencies and universities in Sweden who meet to carry out realistic training exercises. For example, we held a mock press conference about dengue fever reaching Stockholm, in which Chief Medical Officer Anders Tegnell played himself. This network has broadened our perspective on all the tools available in pandemic preparedness modelling, and on how we can improve together,’ says Lundh.

More information about the handbook can be found in a news article on chalmers.se: New handbook aims to strengthen Sweden’s preparedness for future pandemics. The text may be used in its entirety.

More about the handbook:

The Handbook of Mathematical Modelling of Infectious Diseases for Decision-Making is part of a larger project funded by the Swedish Civil Contingencies Agency (MCF) (formerly MSB).

The authors are Philip Gerlee and Torbjörn Lundh from Chalmers University of Technology and the University of Gothenburg, Sweden, Lisa Brouwers and Anders Tegnell from the Public Health Agency of Sweden, and Oscar Björnham from the Swedish Defence Research Agency (FOI).

The project also organises exercises with a group of modellers from the SEMAFOR – Swedish Epidemic Modelling and Force network.

 

Swimming beats running for strengthening the heart, study finds



Research on mice conducted at the Federal University of São Paulo shows that training in water promotes more robust and healthy cardiac adaptations.




Fundação de Amparo à Pesquisa do Estado de São Paulo




A study conducted on an animal model by researchers at the Federal University of São Paulo (UNIFESP) in Brazil demonstrated that swimming is more effective than running in promoting healthy heart growth and improving the strength with which the heart muscle (myocardium) contracts.

“Swimming and running are two excellent ways to improve cardiorespiratory health and protect the heart muscle, but we wanted to know if one could be even more beneficial than the other. We found that, although both increase respiratory capacity, swimming goes a step further by combining functional and molecular adaptations that make the heart stronger and more efficient,” says Andrey Jorge Serra, a professor at UNIFESP and coordinator of the study supported by FAPESP

The study, published in the journal Scientific Reports, demonstrates that swimming promotes greater modulation of microRNAs that control various heart adaptations, such as cardiac cell growth, the formation of new blood vessels (angiogenesis), protection against cell death, and the regulation of contractility and responses to oxidative stress, compared to running training.

MicroRNAs are molecules that regulate the expression of messenger RNAs, which are responsible for protein synthesis.

“Although several studies had already examined the expression of microRNAs regulated by aerobic training in general, little was known about expression patterns when swimming and running were compared in the same experimental setting. Therefore, this study reveals that there’s a distinction in cardiovascular effects between these two modalities,” says Serra.

In the study, the mice underwent an eight-week training protocol consisting of daily 60-minute sessions five days a week. The rats were divided into three groups: one that did not train, one that only ran, and one that only swam. Since running and swimming are very different forms of exercise, the comparison between the training regimens was not based on the speed the animals reached but rather on the relative intensity of the effort, as measured by maximum oxygen consumption (VO₂ max) – an indicator that assesses the body’s ability to capture, transport, and utilize oxygen during physical activity.

According to the results, running and swimming improved physical fitness similarly: between the first and last training sessions, VO₂ max increased by more than 5%. However, only swimming promoted significant structural changes in the heart, such as increases in cardiac and left ventricular mass. Running did not show relevant differences compared to the sedentary animals.

“People’s choice of sport depends largely on personal preference, aptitude, and enjoyment. But our results show that swimming may have a special impact in situations involving myocardial recovery, cardiac rehabilitation, and above all, scientific research. This is also relevant because studies on aerobic exercise often use running and swimming interchangeably, and we now know that the effects aren’t the same,” Serra explains.

Before and after the training period, the researchers administered a series of tests to evaluate various aspects of cardiac health, including cardiorespiratory capacity, fitness, and the structure and function of the heart and myocardium.

The study also analyzed the gene expression and protein pathways involved in physiological cardiac hypertrophy and the mechanisms involved in identifying regulatory microRNAs.

“Although we don’t yet know why this change occurs at the molecular level, of the microRNA, we were able to delve deeply into and investigate the molecular pathways that control physiological hypertrophy,” the researcher adds.

About São Paulo Research Foundation (FAPESP)
The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe.

 

Spent hop derived from beer production is incorporated into sunscreen




Using industrial waste could enable the production of more sustainable and affordable cosmetics




Fundação de Amparo à Pesquisa do Estado de São Paulo

Spent hop derived from beer production is incorporated into sunscreen 

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“When we compared spent hops and hops that hadn’t gone through the brewing process, we found that the reused substance is more active, likely due to the elimination of volatile substances,” says Daniel Pecoraro Demarque of FCF-USP 

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Credit: André Rolim Baby/FCF-USP





Research conducted at the University of São Paulo (USP) in Brazil revealed that hops (Humulus lupulus L.) industrial waste from the brewing industry is a viable option for sunscreen formulation production.

The multidisciplinary study, which involved researchers from USP’s School of Pharmaceutical Sciences (FCF), was inspired by the large amount of waste generated and discarded during beer production. The study brought together complementary expertise in natural products and bioactive photoprotection.

Hops are added to beer in two stages: during the boiling of the wort and, in some recipes, after fermentation, a process known as dry hopping. The second phase is intended to impart aroma to the beverage, but not all of the substances in the pellets (dried, ground, and pressed hop flowers) are extracted. Thus, a significant fraction of bioactive compounds remains in the discarded material.

This makes the waste a rich source of bioactive compounds, such as bitter acids, polyphenols, and essential oils. Polyphenols have attracted special attention due to their strong antioxidant properties, which give them the potential to protect the skin from the harmful effects of ultraviolet rays.

For this reason, biomass from the brewing industry has become the focus of research supported by FAPESP (projects 24/01920-0 and 22/08191-9) and described in an article published in the journal Photochem.

In the stage conducted by the Pharmacognosy Laboratory, the hop residue underwent ethanol extraction. Then, the extract was dried and analyzed chemically. A second extract was prepared from hops that had not undergone the beer-making process to allow for comparison of the “pure” and reused materials.

In the Cosmetology Laboratory, the extracts were incorporated individually (at a concentration of 10%) into sunscreen cream formulations containing two traditional sunscreens: one with UVB protection and the other with UVA protection. “We also evaluated different combinations with cosmetic ingredients commonly used in sunscreens, such as purified water and emollients like isopropyl myristate, isopropyl palmitate, and capric-caprylic triglycerides, to investigate which composition would perform best,” says André Rolim Baby, an associate professor at FCF-USP and one of the coordinators of the study.

The photoprotective efficacy was determined using one of the most robust and internationally recognized in vitro methods: diffuse reflectance spectrophotometry with an integrating sphere. This technology can calculate the sun protection factor (SPF) and other parameters related to sun protection, such as broad-spectrum protection.

“When we compared spent hops and hops that hadn’t gone through the brewing process, we found that the reused substance is more active. This is likely due to the elimination of volatile substances involved in beer production, leaving behind compounds with the necessary chemical bonds for photoprotection,” says Daniel Pecoraro Demarque, also from FCF-USP and a participant in the research, which was part of the master’s project of Ana Gabriela Urbanin Batista de Lima. De Lima is from the faculty’s Graduate Program in Pharmaceuticals and Medicines.

According to Baby, although the results were obtained in an in vitro assay, the research represents promising proof of concept. “But for this idea to reach the market, further studies and validations are needed, such as the long-term stability of the sunscreen, standardizing the bioactive compounds, and clinically evaluating safety and efficacy,” he states.

About São Paulo Research Foundation (FAPESP)
The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe.