Showing posts sorted by date for query CALGARY USA. Sort by relevance Show all posts

Tuesday, May 05, 2026

The rush for critical minerals echoes oil extraction injustice as harms fall on world's most vulnerable, UN scientists warn

The race to build EVs, renewable energy systems and AI infrastructure, with benefits flowing mainly to wealthy nations, is driving severe, largely hidden costs borne disproportionately by the poor in Africa and South America, UN University investigation

United Nations University

Critical Minerals and Their Roles in Energy Transition and Technology — image:
Critical minerals and their functional roles in energy transition and advanced technologies (source: UNU-INWEH)
view more
Credit: United Nations University Institute for Water, Environment and Health (UNU-INWEH)

Richmond Hill, Ontario, Canada – Mining critical minerals such as lithium and cobalt fuels the ‘green’ energy and digital transitions essential to meeting climate goals. But building the technologies that enable a sustainable future is generating severe, hidden environmental and health crises that the world is failing to track or address, warns a new report by the United Nations University Institute for Water, Environment and Health (UNU-INWEH), known as the UN’s Think Tank on Water.

The investigation finds that systemic global failures are allowing the costs of critical minerals extraction to fall disproportionately on some of the world's most vulnerable communities, while the benefits accumulate elsewhere in the form of electric vehicles (EVs), renewable energy systems, and artificial intelligence (AI) infrastructure. The report does not question the need for clean energy systems or the digital infrastructure underpinning them. Instead, it asks who is paying for and benefitting from humanity’s progress in those areas, and finds a deeply unjust answer.

“Technological disruptions are needed and useful. But we should be aware of and proactively address their unintended consequences if we want the whole world to equally benefit from them,” says UNU-INWEH Director Kaveh Madani, who led the investigation team. “You cannot call a transition green, sustainable, and just if it simply moves the environmental harm from the rich to the poor, and from one group of people or region to another.”

The report, Critical Minerals, Water Insecurity and Injustice, underlines the intense water requirements of critical minerals extraction and that communities living closest to mining operations are paying a steep price in contaminated water, water scarcity, lost livelihoods, and serious health consequences.

In 2024, the report says, global lithium output of roughly 240,000 tonnes consumed an estimated 456 billion litres of water, equivalent to the annual domestic water needs of 62 million people in sub-Saharan Africa, roughly the population of Tanzania.

In Chile's Salar de Atacama, lithium mining alone accounts for up to 65% of regional water usage, intensifying competition with agriculture and domestic needs and driving dramatic groundwater depletion. Between 1990 and 2015, water tables in areas with brine wells dropped by up to nine metres.

And lithium mining in Bolivia's Uyuni region is making it increasingly difficult for communities to grow quinoa, their economic and nutritional staple.

Globally, about one-sixth (16%) of critical minerals reserves are located in high water-stress regions, while 54% of energy transition minerals sit on or near indigenous territories.

The environmental damage extends well beyond water consumption. For every tonne of hard-to-extract rare earth minerals produced, approximately 2,000 tonnes of toxic waste are generated. In 2024, global rare earth production generated an estimated 707 million metric tonnes of toxic waste, enough to fill about 59 million garbage trucks – a number of trucks that could form a queue circling the equator 13 times.

The 21st century’s oil

The Paris Agreement gives urgency to the extraction of critical minerals to reduce the carbon-intensity of human activities. Yet this creates a new ‘paradox’: meeting global climate targets would require a ninefold increase in lithium demand and a doubling of cobalt and nickel demand by 2040.

“Without effective control mechanisms, the very targets designed to protect the planet can accelerate water, and health, and injustice crises in the communities least responsible for causing climate change,” says Prof. Madani, recently named the Stockholm Water Prize Laureate for 2026. “The world is rushing to build a cleaner energy future, and we support that urgency. But our investigation proves that the mining operations powering that transition are contaminating drinking water, destroying agricultural livelihoods, and exposing children to toxic heavy metals in some of the world's most vulnerable communities.”

Demand for graphite and other minerals essential to the energy and digital transition is projected to rise four or five times by 2050.

Referring to critical minerals as the ‘oil of the 21st century,’ the report draws a sobering parallel to the fossil fuel era, noting that the benefits of past resource extraction rarely reached the communities that bore its costs. Without deliberate policy intervention, it warns, the energy transition risks repeating that pattern, creating new "sacrifice zones" in mineral-rich but economically-marginalised regions.

Health burden falls hardest on women and children

Mining-related water contamination is creating serious public health emergencies. In the Democratic Republic of Congo (DRC), for example, a major cobalt producer, 72% of people living near mining sites reported skin diseases, and 56% of women and girls reported gynecological problems.

Birth defect rates in maternal wards near DRC mining areas are markedly elevated compared to those farther away, including neural tube defects (which can lead to serious infant brain and spine defects) at a rate of 10.9 per 10,000 births and lower limb defects at 8.8 per 10,000 births.

The psychosocial toll is also documented. Residents of mining communities in Calama, Chile and Mibanze, DRC describe living in constant fear, anxiety, and a sense of being 'sacrificed' so that wealthier regions can advance. Studies link water insecurity and chronic pollution exposure to elevated rates of anxiety, depression, and in extreme cases, suicide.

And approximately 30% of mining sites in the DRC employ children, who typically lack basic health and safety protections.

In the DRC, more than 80% of mineral output is controlled by foreign industrial mines, limiting local economic gains. Despite the country's vast mineral wealth, over 70% of the DRC's population lives on less than $2.15 per day.

“The green energy transition is among the most important undertakings of our time. But the evidence we've gathered shows that the communities doing the actual digging, breathing the dust, and losing access to clean water are largely excluded from its benefits,” says UNU-INWEH scientist Dr. Abraham Nunbogu, the report’s lead author. “If we don't correct the governance failures driving this, we will have built the clean energy economy of the future on the same extractive injustices as the fossil fuel economy of the past.”

Urgent policy action required

The report calls for a fundamental shift in how the global community governs critical mineral supply chains.

Key recommendations include mandatory international due diligence standards to replace voluntary compliance, legally binding mechanisms for ethical sourcing and environmental justice, strict pollution and wastewater controls including zero-discharge systems, and independent monitoring of water use and heavy metal contamination.

The report also calls for investment in circular economy solutions, including advanced recycling of batteries, electronics, and renewable energy components, to reduce pressure on primary extraction.

The report notes that the issues bear directly on progress towards UN Sustainable Development Goals 6 (clean water and sanitation), 3 (good health and well-being), 1 (no poverty), 7 (affordable and clean energy), and 10 (reduced inequalities).

“This rigorous, evidence-based investigation by UNU scientists addresses a problem the world urgently needs to confront,” says Prof. Tshilidzi Marwala, UN Under-Secretary-General and Rector of the United Nations University. “A transition that deepens poverty, undermines access to clean water, and concentrates health burdens on the world's most marginalized communities is not a transition toward the UN’s Sustainable Development Goals. It is a step away from them. We cannot give up on the digital transition but we need to do it right.”

Drawing on empirical analyses, scientific studies, and field evidence from the Lithium Triangle, the Democratic Republic of the Congo, and other high-risk extraction regions, the report presents what the authors describe as one of the most overlooked injustices of the global sustainability transition.

Importantly, the report makes clear this is not exclusively a problem of distant or developing regions. The Thacker Pass lithium mine in Nevada, the largest known lithium deposit in the United States, would require up to 3.5 billion litres of water annually, largely by diverting water rights from farming communities in the Quinn River Valley.

In Canada, the 2014 Mount Polley copper/gold mine disaster in British Columbia released roughly 25 million cubic metres of toxic waste into rivers and lakes, contaminating drinking water sources and devastating Indigenous communities. The report calls it one of Canada's worst mining-related environmental failures.

“Water insecurity is not a side effect of critical mineral mining, it is a systemic outcome of how the global supply chain is currently designed and governed,” says Prof. Madani. “Without binding international standards, mandatory disclosure, and genuine community co-governance, the demand surge projected for the coming decades will make the current situation dramatically worse.”

The report argues that without binding global rules, the current system will continue to externalize environmental and health costs.

Key recommendations include:

Mandatory international due diligence standards to replace voluntary compliance, with legally binding mechanisms for ethical sourcing and environmental justice
Strict pollution and wastewater controls, including zero-discharge systems, and independent monitoring of water use and heavy metal contamination
Investment in circular economy solutions -- including advanced recycling of batteries, electronics, and renewable energy components -- to reduce pressure on primary extraction
Legally mandated benefit-sharing agreements that direct a fair share of mining revenues to affected communities for health, water, and education services
Legal enshrinement of Free, Prior and Informed Consent (FPIC) for Indigenous communities whose lands are affected by extraction
Robust public health systems and mandatory Health Impact Assessments in mining regions, with companies required to contribute financially
Investment in low-water extraction technologies such as direct lithium extraction (DLE) to reduce freshwater consumption

“The data collected for this report makes a stark case, documenting severe health and environmental outcomes in communities that will probably never own an electric vehicle or benefit from the technologies their land is being destroyed to build, in the foreseeable future” says Dr. Nunbogu. “These hidden costs of the energy transition remain largely invisible to regulators and the public because reliable, publicly accessible data on water usage and pollution at specific mining sites remains scarce. Without open and verifiable data, we cannot hold supply chains accountable, and we cannot ensure that the transition is equitable. That is not a technical failure, it is a governance failure.”

By the numbers

Demand

Demand for critical minerals tripled between 2010 and 2023
Lithium demand rose 30% in 2022 alone; cobalt and nickel demand grew 70% and 40% respectively from 2017 to 2022
Total global trade value of critical minerals exceeded USD 320 billion by 2022
Demand projected to more than double by 2030 and quadruple by 2050
Graphite, lithium, and cobalt demand could rise by nearly 500% by 2050 relative to 2020 levels
Meeting Paris Agreement targets would require a ninefold increase in lithium demand and a doubling of cobalt and nickel demand by 2040

Water

1.9 million litres of water required to produce one tonne of lithium
An average lithium mine producing 11,000 tonnes annually uses roughly 20 billion litres of water -- enough to cover the annual domestic water needs of 2.8 million people in sub-Saharan Africa
2024 global lithium output (excluding US): ~240,000 tonnes, requiring an estimated 456 billion litres of water -- equivalent to the annual domestic water needs of 62 million people in sub-Saharan Africa
Lithium mining accounts for up to 65% of regional water usage in Chile's Salar de Atacama
Thacker Pass mine (Nevada, USA) would require up to 3.5 billion litres of water annually
Water table in Atacama brine-well areas dropped by up to 9 metres from 1990 to 2015
16% of critical mineral mining sites are in areas already classified as water-stressed
54% of energy transition mineral projects are on or near indigenous peoples' lands

Toxic waste

Each tonne of rare earth elements produced generates ~2,000 tonnes of toxic waste overall, plus 1 tonne of radioactive residue and 75 cubic metres of wastewater
2024 global rare earth production generated an estimated 707 million metric tonnes of toxic waste -- equivalent to ~59 million loaded garbage trucks, or the annual municipal waste of approximately 1.4 billion people
~70% of that waste (490 million metric tonnes) was generated in China

Concentration of reserves and production

Africa holds 30% of the world's critical mineral reserves
DRC, Madagascar, and Morocco hold over 50% of global cobalt deposits; DRC's global cobalt production share has remained above 60% from 2020 to 2024
South Africa holds ~90% of global platinum reserves and accounts for ~70% of global production
The Lithium Triangle (Argentina, Bolivia, Chile) holds over 50% of world lithium reserves
Indonesia holds 42% of global nickel reserves and in 2023 accounted for 51% of global nickel production
Over 80% of DRC mineral output is controlled by foreign industrial mines; Indonesian companies control less than 10% of national nickel production

Health impacts in DRC

72% of respondents near DRC mining sites reported skin diseases
56% of women and girls reported gynecological issues; 14% reported similar issues among teenage girls
Neural tube defects near DRC mining areas: 10.9 per 10,000 births
Lower limb defects: 8.8 per 10,000 births; cleft lip/palate: 7.2 per 10,000; abdominal wall defects: 6.4 per 10,000
Cobalt concentrations found to be higher in umbilical cord blood than in maternal blood at delivery
~30% of DRC mining sites employ children, often without basic health or safety protections; children as young as seven work without protective equipment

Poverty and inequality

73.5% of DRC's population lives on less than $2.15 per day
64% of DRC's population lacked basic drinking water access in 2024 -- despite the country holding more than 50% of Africa's freshwater reserves
Namibia, Zambia, and DRC hold over 30% of world critical mineral deposits, but most profits flow to multinational corporations and mining companies in the Global North
Indonesia: domestic companies control less than 10% of national nickel production

Report Information

Nunbogu, A., Farsi, A., Matin, M., Madani, K. (2026). Critical Minerals, Water Insecurity and Injustice. United Nations University Institute for Water, Environment, and Health (UNU-INWEH), Richmond Hill, Ontario, Canada, doi: 10.53328/INR25ABN002

* * * * *

About UNU-INWEH

Marking its 30th anniversary of operation in 2026, the United Nations University Institute for Water, Environment and Health (UNU-INWEH) is one of 13 institutions that comprise the United Nations University (UNU), the academic arm of the UN.

Known as 'The UN’s Think Tank on Water', UNU-INWEH addresses critical water, environmental, and health challenges around the world. Through research, training, capacity development, and knowledge dissemination, the institute contributes to solving pressing global sustainability and human security issues of concern to the UN and its Member States.

Headquartered in Richmond Hill, Ontario, UNU-INWEH has been hosted and supported by the Government of Canada since 1996. With a global mandate and extensive partnerships across UN entities, international organizations, and governments, UNU-INWEH operates through its UNU Hubs in Calgary, Hamburg, New York, Lund, and Pretoria, and an international network of affiliates.

unu.edu/inweh

* * * * *

DOI

10.53328/INR25ABN002

Article Title

Critical Minerals, Water Insecurity and Injustice

Article Publication Date

29-Apr-2026

Tuesday, December 23, 2025

V0TE NO!

'Independent state?' Proposed referendum question approved on Alberta separation

Story by Jack Farrell

EDMONTON — Alberta's election agency announced Monday it has approved a proposed referendum question on the province separating from Canada.

The question seeks a yes or no answer to: "Do you agree that the province of Alberta should cease to be a part of Canada to become an independent state?"

Elections Alberta said the proponents — the Alberta Prosperity Project and its chief executive officer, Mitch Sylvestre — have until early January to appoint a financial officer for its petition campaign, after which signature collection can begin.

TINY GROUP OF SEPERATISTS WHO LOVE USA MORE THAN CANADA

People gather in support of Alberta becoming a 51st state during a rally at the legislature in Edmonton, on Saturday, May 3, 2025. THE CANADIAN PRESS/Jason Franson© The Canadian Press JUST MOVE SOUTH

Sylvestre, a constituency association president for Premier Danielle Smith's United Conservative Party, has four months to collect just under 178,000 signatures. If he does so, the question would be put to Albertans in a referendum.

The Alberta Prosperity Project said on social media Monday that the approval is a "huge victory" for the province.

"This is the breakthrough we've been fighting for," it said.

Sylvestre, in an interview, said he thought Alberta needs to go it alone because of Ottawa's restrictions on oil production and dim prospects for federal electoral change.

"This last election when the Liberals won after 10 years of absolute brutal government, as far as I was concerned, I believe that there's absolutely no way that we'll ever win another election in Alberta," he said.

"It's up to us to decide what to do about that."

Sylvestre said the group already has 2,000 people signed up internally to collect signatures, and more than 240,000 people who have previously pledged their willingness to sign.

"This is very non-partisan as far as I'm concerned," he said.

"Every Albertan will benefit from this, and it'll give Alberta children and my grandchildren and my kids a much brighter future as far as I'm concerned, or I wouldn't be doing it.

The group's approved question is similar to one it had previously submitted: “Do you agree that the province of Alberta shall become a sovereign country and cease to be a province in Canada?”

That question was held up in court for a review of its constitutionality.

The delay prompted Smith's government to change the rules for citizen-initiated referendums earlier this month.

The changes rendered the court review moot, as it allowed Sylvestre to reapply at no charge while also preventing Alberta's chief electoral officer from rejecting referendum proposals should they be unconstitutional or not factually accurate.

Justice Colin Feasby, who issued his decision on the original question despite the government vetoing the result, deemed the proposal to be unconstitutional, but only under the previous rules.

Feasby, in his decision, wrote that Alberta separating from Canada would violate certain Charter and treaty rights, as there are no guarantees Albertans would keep their right to vote federally or maintain mobility rights if the province were to become its own nation.

He also noted that those rights would need to be accounted for in any negotiation undertaken to amend the Constitution, something that would be required should Alberta actually look to quit confederation.

"Alberta chose not to give citizens the power to propose to take away Charter and Treaty rights through the citizen initiative process," Feasby wrote.

But he added: "Alberta seems to regret this decision now."

Justice Minister Mickey Amery's press secretary, Heather Jenkins, said in an email that it's a democratic right for people to participate in citizen initiated referendums and bring forward questions they deem important.

"If those seeking independence believe that they have the support for it, this is their chance to prove it," she said.

Sylvestre said he was excited at the prospect that Albertans could soon decide their own fate.

"In spite of the fact that this has been a roller-coaster up and down ride, I think it's going to be well worth it no matter what happens," he said.

"The people are going to be able to decide based on the information that they get what they want to do with their future, and I think this is what democracy should be all about."

This report by The Canadian Press was first published Dec. 22, 2025.

— With files from Dayne Patterson in Calgary.

Jack Farrell, The Canadian Press

Alberta Next Panel recommends ditching RCMP, referendum to quit CPP

Story by Lisa Johnson

Premier Danielle Smith speaks to the media at the Legislature in Edmonton, on Wednesday, Dec. 10, 2025. THE CANADIAN PRESS/Amber Bracken© The Canadian Press

EDMONTON — Alberta Premier Danielle Smith’s hand-picked panel re-examining the province's relationship with Ottawa says it’s time to ditch the RCMP and hold a provincewide referendum on quitting the Canada Pension Plan.

The Alberta Next panel, in a report with findings and recommendations, says creating a provincial pension plan was the most hotly debated topic among citizens and one that needs to proceed to a vote.

“Replacing the CPP with an (Alberta plan) is the most financially meaningful initiative Albertans have the right to pursue on our own to enhance our sovereignty and financial independence within a united Canada,” says the report from the panel, which was headed up by Smith.

But the panel stresses such a vote should only be held after residents receive more information on the pros and cons of the province going it alone.

And it says a vote would be contingent on an Alberta pension plan matching or improving the payouts and premiums of the federal system.

The report was issued Friday afternoon without a news conference, and Smith was not made available for an interview.

Her office, asked if she would support a CPP referendum, pointed to Smith's earlier comments that it would be tight to get the issue on any ballot for next fall.

The next general election is set for October 2027.

Related video: RCMP official says police force's future in Alberta uncertain (CBC)

The report comes after months of public town halls across the province and survey feedback.

It also recommends continuing work to create an Alberta police force to replace the RCMP when the latest contract with the national force ends in 2032.

Smith’s government has long questioned whether the province is getting value for money on the Mountie contract, while saying a provincial force can bolster accountability.

The panel acknowledged a provincial force was also a polarizing topic in debates but said it heard concerns about police staffing levels, particularly in smaller communities, with hundreds of contracted policing positions going unfilled.

“Some, like Cypress County, have been paying the RCMP with zero officers provided,” says the report.

The panel also called for referendums on more provincial control over immigration and on specific constitutional questions, such as abolishing the "unelected Senate."

It suggested doing a cost-benefit analysis of Alberta running its own tax system.

And it urged Alberta to push harder for equalization reform, saying that on balance Albertans are OK with subsidizing smaller provinces but “the vast majority strongly oppose their federal tax dollars subsidizing provinces with the fiscal and economic strength to deliver such services on their own.”

Opposition NDP Leader Naheed Nenshi labelled the Alberta Next project a stage-managed distraction from government failures on health care and education.

He said Smith didn't campaign on any of the issues prioritized in the report, which he noted was released on the Friday before Christmas.

"The government has spent millions of taxpayer dollars on a sham consultation, where they actively silenced anyone who dared to disagree with them,” Nenshi said in an interview.

“(They) are now pretending that that was the voice of Albertans to justify spending millions of dollars more on referenda on things that Albertans don't want.

Nenshi said the CPP issue is a stalking horse to create a government controlled piggy bank.

“They want to create a large asset fund that is under the control of the government to invest in things the government wants to invest in," he said.

Debate in Alberta over whether to quit the more than $777-billion CPP has been ebbing and flowing for more than two years under Smith. The premier has linked a standalone plan to long-standing concerns that Albertans are paying more into Confederation than they deservedly get back.

In 2023, her government issued a report estimating Alberta is entitled to more than half the money in the national nest egg should it go its own way.

That number was hotly contested. Absent a clear exit figure, Smith put formal consultations on hold and the issue faded into the background.

As late as this spring, Smith said no firm bottom line number coupled with a lack of public “appetite” for leaving the CPP precluded any referendum for the time being.

However, the panel said a straw vote of people at its town halls supported the idea, as did a slim majority of those in its poll. But it noted a “clear majority” of those who sent online feedback opposed leaving the CPP.

The panel said it heard concerns about what would happen if a provincial fund was mismanaged or if Alberta’s strong economic advantage didn't continue, not to mention questions about portability.

The panel said all those details – contribution rates, management structure, benefits and more — need to spelled out for Albertans ahead of any referendum.

This report by The Canadian Press was first published Dec. 19, 2025.

Lisa Johnson, The Canadian Press

Alberta increases referendum petition fees to $25,000 — a 5,000 per cent hike

Story by Lisa Johnson

Alberta Premier Danielle Smith and Minister of Justice Mickey Amery announce proposed changes to several pieces of democratic process legislation, in Edmonton on Tuesday April 29, 2025. THE CANADIAN PRESS/Jason Franson© The Canadian Press

EDMONTON — Alberta Premier Danielle Smith's government is hiking the cost to apply for a citizen-initiated referendum by 5,000 per cent, saying it's about making sure applicants are serious.

It’s the latest in a series of rule changes that one petitioner – country singer Corb Lund – characterizes as exhausting.

A cabinet order released late Wednesday afternoon upped the fee to $25,000 from $500.

Heather Jenkins, press secretary to Justice Minister Mickey Amery, says the cost will be refundable if the applicant meets the required threshold of signatures and completes reporting requirements.

"Citizen initiative petitions are costly,” Jenkins said Thursday in a statement.

“That is why a higher application fee was chosen, to discourage frivolous applications and protect Alberta taxpayers.”

The move comes despite previous efforts by Smith's United Conservative Party government to make it easier for citizens to apply for a policy initiative or a constitutional referendum, including efforts to put Alberta separation on the ballot.

Lund may not have to pay the higher fee.

Elections Alberta confirmed Thursday his prior application to launch a referendum to stop new coal mining in Alberta's Rockies will have a grace period

The new fee would be waived if Lund files his paperwork by Jan. 11.

Lund, in an interview, said it’s disturbing to see Smith’s government make sudden rule changes for what he views as "random, self-serving reasons.”

"The chaos and confusion and exhaustion is very similar to the same confusion, chaos and exhaustion that we've seen from the government on how they've been handling the coal situation for the last six years," Lund said.

"It just keeps changing."

He said no matter what else might shift, he won't be deterred from completing a process that's already been cancelled by recent election law changes, forcing him to start again.

"We'll fill out as many forms as they make us fill out if it means we can keep the coal mines out of the headwaters of the rivers that provide our drinking water."

Premier Smith has long championed the merits of direct democracy.

In late November, when asked about Lund's petition, she said, "I support citizen-initiated referenda. I think it's really important that people have their say. The rules are out there, and I will watch with great interest.”

Earlier this year, Smith's government significantly lowered the thresholds for citizens to apply for a referendum, including the number of signatures required.

Earlier this month, her government passed a new law to clear further legal hurdles faced by those aiming to hold a separation referendum.

A pro-Confederation petition organized by former Alberta deputy premier Thomas Lukaszuk is not affected. Elections Alberta has already certified that petition as having the required signatures. Lukaszuk seeks to spike separatist sentiment by forcing a decision to reaffirm Alberta staying in Canada.

Another application has already received the green light to proceed. It seeks to gather signatures to ask whether Alberta should end spending public money on independent schools.

Alberta NDP justice critic Irfan Sabir says the fee increase shows the UCP government doesn't have any respect for the democratic process.

"This change is clearly meant to stifle democratic action,” Sabir said in a statement.

Chief electoral officer Gordon McClure told a legislative committee earlier this month it cost $340,000 to verify Lukaszuk’s petition and that the cost to prepare for a subsequent provincewide referendum would be more than $3 million.

This report by The Canadian Press was first published Dec. 18, 2025.

Lisa Johnson, The Canadian Press

Monday, October 06, 2025

New Canadian study reveals where HIV hides in different parts of the body

University of Western Ontario

image:
A new study, co-led by Western University’s Stephen Barr, reveals that HIV cloaks itself in the DNA of infected cells using unique DNA patterns in the brain, blood and parts of the digestive tract.
view more
Credit: Frank Neufeld

New Canadian study reveals where HIV hides in different parts of the body

Researchers at Western University and the University of Calgary have discovered how HIV hides in different parts of the body by embedding itself into the DNA of cells in a tissue-specific manner, offering new insights into why the virus is so difficult to eliminate and cure – even decades after infection and treatment.

The study, led by Western University’s Stephen Barr and UCalgary’s Guido van Marle, reveals that HIV cloaks itself in the DNA of infected cells using unique DNA patterns in the brain, blood and parts of the digestive tract. For example, in the brain, the virus avoids genes and hides in less active parts of the DNA.

The findings were published by the high impact journal Communications Medicine.

“We found that HIV doesn’t integrate randomly. Instead, it follows unique patterns in different tissues, possibly shaped by the local environment and immune responses,” said Barr, microbiology and immunology professor at Western’s Schulich School of Medicine & Dentistry. “This helps explain how HIV manages to persist in the body for decades, and why certain tissues may act as reservoirs of infection.”

For the study, Barr, van Marle and their collaborators at the Southern Alberta HIV Clinic and University of Alberta used rare tissue samples from people living with the virus during the early years of the HIV/AIDS pandemic (around 1993), before modern treatment existed. This gave the researchers a unique opportunity to look at how the virus behaved in its natural state across different organs – all within the same individuals.

“Our study is a powerful example of how we can learn from historic samples to better understand a virus that continues to affect tens of millions of people worldwide,” said Barr.

The research team acknowledges the individuals who volunteered to participate in studies during the early, uncertain days of the HIV/AIDS pandemic.

“Their willingness to contribute samples, at a time of stigma, fear and with limited treatment options, was an act of bravery, foresight and generosity that continues to advance scientific understanding of HIV and save lives today,” said van Marle, microbiology, immunology and infectious diseases professor at UCalgary’s Cumming School of Medicine.

New targeted attack

For this novel Canadian approach to understanding HIV, the researchers investigated historic samples taken from the esophagus, blood, stomach, small intestine and colon of individuals with unmatched brain tissue from other individuals. They evaluated how often the virus integrated into specific regions of the genome and compared these patterns across various tissues from different individuals.

“Knowing where the virus hides in our genomes will help us identify ways to target those cells and tissues with targeted therapeutic approaches – either by eliminating these cells or ‘silencing’ the virus,” said van Marle.

The research was supported by the Canadian Institutes of Health Research and the National Health Research and Development Program and builds on years of collaborative work between Western, UCalgary, the Southern Alberta HIV Clinic and UAlberta.

“Studies like this are highly collaborative and only possible when many of us work together,” said Barr.

Journal

Communications Medicine

TWO

10.1038/s43856-025-01146-5

Method of Research

Experimental study

Subject of Research

People