Thursday, May 07, 2020




Did we just witness one of the nuttiest foreign policy blunders in American history?
Matthew Walther The Week•May 7, 2020


I cannot be the only American who somehow missed the news that on March 26 Secretary of State Mike Pompeo announced the United States would offer bounties of a combined $55 million for the capture of President Nicolás Maduro of Venezuela and four of his top associates. By the end of March, most of the country was living under some sort of mandatory lockdown. People were fighting for toilet paper and stocking up on bags of rice and making plans for aspirational quarantine reading. Millions of us were preparing for Mad Max.

It now appears that we were thinking of the wrong '80s action flick. Last weekend it was reported that a group of more than 100 American mercenaries, including two former Green Berets and one ex-agent from the Drug Enforcement Administration, had failed in some kind of apparent coup attempt and that some of them were being detained by the Maduro government. What was being called "Operation Gideon" perhaps unsurprisingly failed to bring about regime change, much less result in the apprehension of the country's socialist dictator. Reports suggest that 50 of the mercenaries stormed Venezuela by sea, joining up with around the same number of fellow soldiers of fortune already waiting behind enemy lines. The Venezuelan army (and Maduro's own paramilitary loyalist forces) outmatched them by around 350,000. A small ragtag band of American warriors attempts to force the commies out of South America against all odds? This is basically the plot of Predator if the Predator hadn't shown up.

Pompeo maintains that the United States government was not involved in this offensive. For what it's worth, he is probably telling the truth. Instead it appears that the plot was launched long ago by a bunch of former Venezuelan military officials who have been training deserters from the Maduro regime in secret Colombian camps for a year. One of the principals, a retired general named Cliver Alcalá, was arrested in the United States back in March for drug smuggling and is imprisoned in New York.

Operation Gideon was, not to put too fine a point on it, at odds with both federal social distancing guidelines and current recommendations from the World Health Organization. It was also absolutely insane. Convincing Maduro, whose presidency is considered illegitimate by the United States and around 80 other countries, to release captured Americans is going to be an enormous hassle for everyone involved. Pompeo says that the Trump administration is prepared "to use every tool" to secure their freedom. This includes, presumably, the threat of military force. What other options are realistically on the table? Official recognition of the Maduro regime? The imposition of additional economic sanctions upon what is arguably the worst economy in the Western hemisphere during the middle of a global public health crisis? A nice handwritten apology note saying, "Sorry, next time we want to encourage bored ex-servicemen to collaborate with your own generals in a revolutionary plot on the pretext that you are involved in high-level drug trafficking, we will, well, there won't be a next time?"

Under virtually any other circumstances a story like this one would be a foreign policy blunder worthy of the failed Bay of Pigs invasion in terms of the lunatic scope of its ambition, if not, thankfully, in the number of lives lost, American or otherwise. Instead it is likely to be forgotten amid the pandemic. This does not mean that it is lacking in significance.

The main lesson of Operation Gideon is that whatever the Trump administration claims about the importance of Venezuela to American foreign policy, they have no serious interest in doing anything about Maduro, much less in helping ordinary citizens for whom a carton of eggs now costs more than a month's wages. It is easy to rail against the undeniable wickedness of the communist dictatorship there; it is harder to displace it. Sounder heads would leave off talk of gazillion-dollar bounties and hope that the worldwide collapse in oil prices might force Maduro out of power, at which time the United States would be better positioned to help a new government.

The other lesson is that, whatever we owe the people of Latin America after a half century of destroying their economies through unfair trade arrangements and our addiction to vile drugs, we lack the national will to help them, just as we failed to move the needle against the Taliban in Afghanistan despite 20 years of trying. This is why, no matter how illogical it seems, one of our nation's two major political parties has committed itself to the principle that virtually unlimited immigration is the only feasible solution. So far, no one is proving them wrong.



American captured over alleged Venezuelan coup plot says Donald Trump ordered plan


Telegraph reporters
The Telegraph•May 6, 2020

An alleged US mercenary captured in Venezuela has said he was part of a plan ordered by Donald Trump to kidnap president Maduro.

In an apparent confession on state TV, Luke Denman, who was arrested alongside other alleged mercenaries, said he had been sent across the border from Colombia to secure an airport to fly Mr Maduro America.

In a separate televised address, Mr Maduro said Donald Trump was behind the alleged plot to oust him, and ordered the US nationals to be tried in Venezuela.

In a video broadcast Mr Deman admitted his role in the alleged plot. "I was helping Venezuelans take back control of their country,” he told an interviewer hidden from the camera.

The veracity of the comments is unclear, as was the conditions under which the video had been made. Mr Denman is being held by the Venezuelan authorities.

Speaking after the Denman video was played, Mr Maduro said: “Donald Trump is the direct chief of this invasion.”

The US government has denied any involvement. Last night Russia said the US denial over the alleged plot was "unconvincing".

Researchers study Gulf of Mexico in international collaboration


Researchers study Gulf of Mexico in international collaboration
Rachel Kalin, left, an alumna of Eckerd College, and FSU research assistant Samantha Bosman transferring a core sample during a research cruise. Credit: Devon Firesinger

When the Deepwater Horizon oil rig suffered a blowout in 2010 and began spilling oil into the Gulf of Mexico, scientists got to work understanding the effects of that disaster.

But limited data on the typical conditions in the Gulf made understanding the potential changes from the spill more difficult. To make sure scientists weren't caught unaware in the future, Florida State University and partner universities investigated current baseline conditions in the southern Gulf to create a series of maps and guides that detail the distribution of carbon, nitrogen and the carbon-14 isotope.
These elements are all important ecological factors that contribute to the  supporting untold number of plants, fish and other marine life.
The study was published in the journal PLOS ONE.
"The Gulf of Mexico is a productive system that is important both in ecology—by providing unique habitats for various species— and economy, for industries such as tourism, fishing and the oil industry," said Samantha Bosman, a research assistant in the Department of Earth, Ocean and Atmospheric Science and the paper's lead author. "The ecosystem may not go back to its pre-spill or pre-disturbance conditions, so having a baseline makes it easier to determine how much has changed after the disturbance. That helps you determine if conditions are returning to what was observed prior to a spill or if they are changing to a 'new normal.'"
Florida State researchers worked with colleagues from the University of South Florida, Eckerd College and the National Autonomous University of Mexico to complete fieldwork for the project in 2015 and 2016.
"This joint collaboration of Mexican and U.S. scientists brought together people with unique skill sets and significant local knowledge," said Jeff Chanton, a Robert O. Lawton professor of oceanography in the Department of Earth, Ocean and Atmospheric Science and a co-author of the paper. "They were able to access the environmental health of the southern Gulf, which is subject to significant oil and gas recovery."
The researchers surveyed the southern Gulf of Mexico, an area that had been home to the Ixtoc 1 well, which suffered a blowout and massive oil spill in 1979. Along with measuring the typical distribution of elements, the study looked for evidence of oil within the sediment that could have come from that spill, but they didn't find any signs of that disturbance remaining.
The oil industry and fishing industry exist side-by-side in the Gulf of Mexico. Millions of people live around its coast. An understanding of the baseline conditions in the ecosystem will help scientists looking at the impacts and recovery of the environment in the event of any future oil spills.
One particular area of interest to scientists was the composition of sediment on the seafloor. To understand typical conditions in the region, the researchers measured how much carbon, nitrogen and carbon-14 were in the sediment.
Before this research, there was limited data on the sediment composition in the southern Gulf. Understanding the composition provides scientists greater insight into when fossil fuels might have entered the environment.
For example, scientists can measure the carbon-14 found in organic material. Younger material has higher levels of the isotope, and older materials have lower levels. Right after an oil spill, scientists should find very low levels of carbon-14. As the oil degrades and the ecosystem recovers, the level will increase.
"In the event of an oil spill, that's a big slug of carbon emitted to the surface of the Earth," Chanton said. "And everything in the surface of the Earth has carbon-14 in it because it's pretty modern. Sediments have a modern date. When you add petroleum or some petroleum product to the sediments, they look older, and that's because they're being diluted with fossil fuel."
But that analysis is most useful when scientists know what the typical measurement is for a particular location, allowing them to understand when conditions have returned to normal.
As their sampling sites moved from near the coastline to further out to sea, the researchers found that the amount of carbon increased but the amount of carbon-14 decreased. This information showed them the sediment they were pulling up was older.
"The better you know the pre-existing conditions, the better off you are when something happens," Chanton said.
More information: Samantha H. Bosman et al, The southern Gulf of Mexico: A baseline radiocarbon isoscape of surface sediments and isotopic excursions at depth, PLOS ONE (2020). DOI: 10.1371/journal.pone.023167
Journal information: PLoS ONE 
Provided by Florida State University 
Hong Kong customs seize 38,500 endangered shark fins

MAY 7, 2020
A record 26 tonnes of shark fin were seized by customs officers in Hong Kong

Hong Kong has seized 26 tonnes of smuggled shark fins, sliced from some 38,500 endangered animals, in the largest bust of its kind in the southern Chinese city.

The record haul was discovered in two containers from Ecuador, and highlights the continued demand for shark fin, which is served at wedding banquets in many Chinese communities.

The city's customs department unveiled the haul on Wednesday and said it smashed previous records.

"Each consignment consisting of 13 tonnes broke the previous record seizure of 3.8 tonnes of controlled shark fins made in 2019," customs official Danny Cheung told reporters.

Most of the fins came from thresher and silky sharks, both endangered species. A 57-year-old man was arrested but has been released on bail pending further enquiries.

Some of the ocean's most vital apex predators, shark populations have been decimated over the last few decades with finning and industrial long line fishing the main culprits.

Fishing fleets often cut the fin from the shark and then and throw the fatally maimed animal back in the sea to maximise profit.

The dried fins sell for considerable sums and are usually served in a glutinous soup at banquets.

The sale and consumption of shark fin is not illegal in Hong Kong, but must be licensed.

Years of campaigning by environmentalists and celebrities like Chinese basketball star Yao Ming have led to the dish becoming less fashionable among younger consumers in China, Macau, Hong Kong and Taiwan.

But it remains stubbornly popular among older generations and many prominent hotels and restaurants still offer it.

A 2018 survey by the World Wildlife Fund (WWF) found seven out of 10 Hong Kongers had eaten shark fin that year.

"There is still strong cultural value placed on consuming shark fin, particularly at weddings, business events and family gatherings like the upcoming Mother's Day," senior conservation officer Gloria Lai Pui-yin told AFP.

Some restaurants and hotels had signed WWF's "no shark fin" pledge but many continued to offer the dish, she added.

Wild Aid estimates some 73 million sharks are killed every year for the trade.

Their research says consumption has dropped significantly on the Chinese mainland but there is growing appetite for the dish in Thailand, Vietnam and Indonesia.

With its busy port and international connections, Hong Kong has long been a major trafficking route for wildlife and drug smugglers.

Importing endangered species without a licence is illegal and carries a maximum penalty of 10 years in jail and a HK$10 million ($1.3 million)

© 2020 AFP
MONOPOLY CAPITALISM IS M&A   

Virgin Media, O2 plan merger to create new UK telecoms giant

Internet supplier Virgin Media and mobile phone carrier O2 plan to merge and create a big new telecommunications provider in the U.K., the brands' parent companies announced Thursday.
Virgin Media's owner, Anglo-Dutch-American firm Liberty Global, and Spain's Telefonica, which owns O2, valued the new company at 31 billion pounds ($38 billion).
Telefonica chief executive Jose Maria Alvarez-Pallete said that "combining O2′s number one  with Virgin Media's superfast broadband network and entertainment services will be a game-changer in the U.K."
The new firm would be a rival to BT PLC, currently the U.K.'s main provider of combined internet and phone services.
O2 is the U.K.'s largest phone company with about 34 million users. Virgin has more than 5 million subscribers to its broadband and cable television service

© 2020 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission

Hastily introduced 'fake news' laws could damage efforts to counter disinformation, UNESCO reports warn

social media
Credit: CC0 Public Domain
Measures designed to curb the spread of disinformation related to the coronavirus could criminalize legitimate journalism, reports published by UNESCO have warned.
The research, produced in collaboration with the International Center for Journalists (ICFJ), by experts attached to the University of Sheffield's Centre for Freedom of the Media, showed so-called ' laws' could undermine freedom of expression and critical journalism designed to ensure that  reaches the public, and that governments are held to account for their management of the pandemic.
Instead, the researchers suggest incentives and empowerment measures to strengthen the role of independent news media to counter disinformation, as false rumors and conspiracy theories about the origins of and potential cures for COVID-19 spread online.
Dr. Julie Posetti and Professor Kalina Bontcheva's two policy briefs on the 'disinfodemic' are calling on governments around the world to provide publicly-funded, no-strings-attached 'rescue packages' for independent journalism and news outlets to ensure the sustainability of journalism as a public good, as the pandemic adds to financial pressures on media organizations.
The UNESCO-commissioned reports also highlight the need for transparency from governments, recommending they release open data sources on rates of infection, mortality and recovery, and on issues such as equipment shortages. Such an approach would encourage  and support the work of fact-checkers, according to the experts.
The policy briefs also call on tech and social media corporations to extend programmes designed to compensate independent media organizations for the revenues social sites make from news content. WhatsApp, Facebook, Google and Twitter have pledged some funding to fact-checking organizations and local journalism—but the experts are urging them to go further and support independent journalism projects focused on investigating the themes and networks behind COVID-19 disinformation, ensuring that funds are offered with 'no strings attached."
The researchers urge social media and other internet communications companies to apply the lessons learned during the urgent response to the COVID-19 disinfodemic and apply them with the same level of urgency and thoroughness to political disinformation that threatens democracy internationally.
Dr. Posetti and Professor Bontcheva were commissioned to produce the reports as part of the United Nations' response to the coronavirus crisis, with the aim of helping the UN, governments, journalists, civil society and internet communications companies respond, while protecting freedom of expression rights in the process.
The experts use the term 'disinfodemic' to describe the falsehoods being spread about the pandemic because of the huge 'viral load' of potentially deadly disinformation. The disinfodemic often sees falsehoods hidden amid true information, and concealed under the guise of familiar formats. Fake news is shared via well-known distribution methods—ranging from false or misleading memes and fake sources, through to trapping people into clicking on links connected to criminal phishing expeditions. It can be shared by individuals, organized groups, some news media and official channels—wittingly or unwittingly.
Dr. Julie Posetti, Global Director of Research at the International Center for Journalists, said: "There is a grave risk that laws designed to curtail COVID-19 disinformation could also damage the ability of free and quality journalism to counter the disinfodemic.
"Instead, governments around the world must use their  and economic recovery packages to empower legitimate journalism to help prevent the spread of potentially deadly misinformation and disinformation."
Professor Kalina Bontcheva, Head of the Natural Language Processing Research Group at the Department of Computer Science at the University of Sheffield, said: "Before it is too late, policy actions are vital to ensure that independent journalism is considered an essential service in the public interest, that journalists are recognized as key workers, and that they are given all necessary assistance and protection under national emergency conditions.
"The tech and social media giants have a key role to play in supporting the spread of accurate information by providing no-strings-attached funding for independent news media and fact-checking organizations both during and after the pandemic."
Guy Berger, Director for Policies and Strategies regarding Communication and Information at UNESCO, said that free and professional journalism should be considered "an ally in the fight against disinformation, especially because the news media works openly in the public sphere, whereas much disinformation is under the radar, on social messaging apps."
He added: "As a power against  even when it publicizes verified information and informed opinion that annoys those in power, the  deserves to be recognized and supported by governments as an essential service at this time."

Provided by University of Sheffield 

Uber cuts 3,700 jobs amid pandemic slump

Uber is cutting 14 percent of its workforce as part of its response to the pandemic-induced economic slump
Uber is cutting 14 percent of its workforce as part of its response to the pandemic-induced economic slump
Uber said Wednesday it was cutting 3,700 jobs amid a huge slump in its ride-hailing operations during the pandemic.
The cuts amount to around 14 percent of Uber's global workforce, which does not include its contract drivers.
The company made the announcement in a regulatory filing, which also said chief executive Dara Khosrowshahi would waive his base salary for the remainder of the year.
The move comes a day ahead of Uber's earnings report, and follows a 17 percent staff cut by its US rival Lyft.
"Today's cost cutting move ahead of tomorrow's earnings is a painful, but unfortunately a necessary, move for Dara & co. to make in this unprecedented COVID-19 environment," said Daniel Ives at Wedbush Securities.
"On the other side of this dark valley, the Uber business model will likely look a lot different for the next few years (at least) and the company must rationalize costs and a smaller operation to focus on attaining profitability in this 'new normal' backdrop."
Uber cuts marketing staff to reduce costs

© 2020 AFP
Canadian team first in world to treat COVID-19 with specialized dialysis
by Lawson Health Research Institute 
MAY 7, 2020
This modified dialysis device gently removes a patient's blood, 'reprograms' white blood cells and returns them to fight hyperinflammation. Credit: Lawson Health Research Institute
As part of a randomized controlled trial, a team from Lawson Health Research Institute is the first in the world to treat a patient with COVID-19 using a modified dialysis device. The device gently removes a patient's blood, modifies white blood cells and returns them to fight hyperinflammation. It is being tested with critically ill patients at London Health Sciences Centre (LHSC).


Evidence suggests that COVID-19 causes a heightened immune response, termed a 'cytokine storm,' in the most severely ill patients. Treatment options to address this hyperinflammatory state are currently limited and there are concerns about global drug shortages.

"Working in the intensive care unit (ICU), I was aware that more treatment options were needed in the fight against COVID-19," says Dr. Chris McIntyre, lead researcher, Lawson Scientist and LHSC Nephrologist. "This led to the idea of treating a patient's blood outside of the body. We could reprogram white blood cells associated with inflammation to alter the immune response."

The research uses a modified version of a standard dialyzer called an extracorporeal leukocyte modifying device. It gently removes blood in a much slower circuit than standard dialysis. Through a process using specific levels of biochemical components, it targets and transforms white blood cells associated with inflammation before releasing them back into circulation. The hope is that these 'reprogrammed' cells will now fight hyperinflammation—rather than promoting it—in affected organs like the lungs.
Dr. Chris McIntyre, Scientist at Lawson Health Research Institute, is the first in the world to treat a patient with COVID-19 using a modified dialysis device. Credit: Lawson Health Research Institute

The clinical trial will include up to 40 critically ill patients with COVID-19 at LHSC's Victoria Hospital and University Hospital. Research participants will be randomized to receive either standard supportive care or standard supportive care in combination with this novel treatment. The research team will compare patient outcomes to determine if the treatment is effective.

"The ultimate goal is to improve patient survival and lessen their dependency on oxygen and ventilation," explains Dr. McIntyre. "If effective, it's possible that this treatment could be combined with other therapies. For example, this could be used to modulate inflammatory consequences while an antiviral drug is used to reduce the viral load."

Led by Lawson's Kidney Clinical Research Unit, this new trial was accelerated from initial conception to treatment of the first patient in only 40 days. It represents an important research collaboration with a multidisciplinary team. The trial is leveraging insights gained from another local study led by Dr. Douglas Fraser which is analyzing blood samples from COVID-19 patients at LHSC to better understand the cytokine storm.

"We're identifying which cytokines or biomarkers are important to the hyperinflammatory response seen in COVID-19 patients," says Dr. Fraser, Scientist at Lawson and Paediatric Critical Care Physician at LHSC. "With the knowledge we're gaining, we can study a patient's blood to determine whether this extracorporeal treatment is making a difference."

If successful, the treatment also has potential to be used with other conditions like sepsis.
Antioxidant reverses damage to fertility caused by exposure to bisphenol A

Antioxidant reverses damage to fertility caused by exposure to bisphenol A
A study shows that administering coenzyme Q10 reverses damage done to germinative cells by BPA, a contaminant found in many kinds of plastic Credit: Maria Fernanda Hornos Carneiro & Nara Shin
Exposure to bisphenol A (BPA), an industrial chemical used to make certain plastics and resins, inner coatings for food cans and bottle tops, thermal paper used in store receipts, dental sealants and other products is a concern because of possible adverse health effects, including a reduction in fertility.
A study performed at Harvard Medical School (HMS) in the United States by Maria Fernanda Hornos Carneiro and her research group shows that the harmful effects of BPA can be reversed by administering a supplement known as CoQ10 (coenzyme Q10), a substance naturally produced by the human body and found in beef and fish. Hornos Carneiro is a former SĂŁo Paulo Research Foundation—FAPESP scholarship awardee.
The article published in the journal Genetics is the first to present this strategy for reversing the effects of BPA in the organism. In this study, the researchers tested the antioxidant action of CoQ10 in nematodes of the species Caenorhabditis elegans exposed to BPA.
As an excellent antioxidant, CoQ10 is an . By donating its electrons, it stabilizes free radicals, reducing the oxidative stress and  caused by BPA.
"BPA has oxidation potential as it's chemically unstable and produces reactive oxygen and nitrogen species. When the antioxidant reserves in cells [electron donors] run out, the amount of reactive oxygen and nitrogen increases. Because of their chemical instability, they 'poach' electrons from mitochondria and other cellular organelles, cell membranes, proteins, and even DNA, damaging cells significantly and potentially causing cell death. If this problem becomes extensive, it poses a major threat to the organism," Hornos Carneiro told.
The study measured the number of fertilized eggs laid and hatched and the number of progeny that reached adulthood. The problems detected can be compared to difficulty in becoming pregnant, miscarriages and chromosome anomalies in humans.
"BPA is a chemical contaminant that acts as an endocrine disruptor, causing cellular oxidative stress [an imbalance between oxidant and antioxidant molecules], which results in damage to gametes and embryos," said Hornos Carneiro, who conducted the study under the supervision of HMS Professor Monica Paola Colaiácovo. "In the study, the worms exposed to BPA and given CoQ10 displayed lower egg cell death rates, less DNA breakage and fewer abnormalities in chromosomes during cell division, as well as less cellular oxidative stress."
In the experiment, worms were exposed to different combinations of BPA, CoQ10 and a solvent (DMSO): solvent only, solvent and CoQ10, BPA only, and BPA plus CoQ10.
The amount of exposure to BPA mimicked the estimated amount in humans. "We know it's practically impossible to avoid exposure to BPA and similar contaminants in this day and age, so we looked for a strategy to minimize the harm done. Many studies have shown that age reduces fertility in women, and because exposure to BPA [and other endocrine disruptors] occurs throughout life, it's not yet possible to estimate separately the extent to which observed infertility is due to exposure to toxic chemicals in the external environment and how much is due to aging," Hornos Carneiro said.
The nematodes used in the study were transgenic, with a fluorescent protein sequence inserted into their DNA to enable in vivo observation of protein expression. Fluorescent antibodies were also used, as well as advanced microscopy and molecular biology techniques. The researchers were thereby able to observe in real time the effects produced at the cellular and molecular levels during the process of cell division (meiosis) and embryo formation in the worms.
Estrogen mimic
According to Hornos Carneiro, BPA's chemical structure is similar to that of estrogen, a female sex hormone that plays a key role in ovulation. As a result, BPA can bind to estrogen receptors in humans, leading to a number of significant effects. "Depending on the tissue, the effects may be pro-estrogenic or anti-estrogenic, with an impact not just on the reproductive system but also on other systems and processes that are important to a person's health," she said.
Hornos Carneiro is currently a professor in the School of Chemistry and Pharmacy at the Pontifical Catholic University of Chile. She conducted the study at the University of SĂŁo Paulo's RibeirĂŁo Preto School of Pharmaceutical Sciences (FCFRP-USP) in Brazil with the support of a FAPESP scholarship for postdoctoral research internship abroad.
DNA breakage and mitochondrial dysfunction
According to Hornos Carneiro, exposure of the worms to BPA alone resulted in more DNA breaks. "This was potentially due to the action of reactive oxygen species formed as a result of the presence of the contaminant in the organism," she said. "We found that the breaks were not correctly repaired in this group of worms."
The damage was observed by monitoring a protein involved in DNA breakage and repair when genetic material is exchanged between homologous chromosomes during meiosis.
This exchange of genetic material, known as crossing over, is important for increasing genetic diversity and driving evolution. "One hypothesis is that the increase in DNA breakage [and inefficient repair] was due to a rise in gonad oxidative stress caused by BPA," she said.
Another finding was that mitochondrial dysfunction increased. Mitochondria are energy-producing organelles in . "Because of , mitochondrial membrane potential was significantly altered in the worms exposed only to BPA, while in the group that received the CoQ10 supplement, this marker was much improved," Hornos Carneiro said.
Effect on embryos
The effect of BPA on embryos was also studied in this experiment. As a hermaphrodite, C. elegans self-fertilizes, and it is therefore possible to observe in its gonads all stages of germinative cell development in meiosis up to the polar corpuscle and embryo formation.
"In the study, we observed embryo formation in vivo using a technique called live imaging," Hornos Carneiro explained. "The benchmark for analysis of the occurrence of defects was the first cell division [the precise moment at which the unicellular embryo divides in two]. In the group exposed only to BPA, a larger number of defects were observed, such as formation of chromatin bridges and cell division cessation."
Antioxidant reverses BPD-induced fertility damage in worms

More information: Maria Fernanda Hornos Carneiro et al, Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline, Genetics (2019). DOI: 10.1534/genetics.119.302939
Journal information: Genetics 
Provided by FAPESP 

Clay layers and distant pumping trigger arsenic contamination in Bangladesh groundwater

by Columbia University
Workers install a monitoring well near the study site in Bangladesh. Credit: Rajib Mozumder

Well water contaminated by arsenic in Bangladesh is considered one of the most devastating public health crises in the world. Almost a quarter of the country's population, an estimated 39 million people, drink water naturally contaminated by this deadly element, which can silently attack a person's organs over years or decades, leading to cancers, cardiovascular disease, developmental and cognitive problems in children, and death. An estimated 43,000 people die each year from arsenic-related illness in Bangladesh.


To avoid arsenic contamination, many Bangladeshi households access water via private wells drilled to 300 feet or less, beneath impermeable clay layers. Such clay layers have been thought to protect groundwater in the underlying aquifers from the downward flow of contaminants. However, a study published in Nature Communications this week suggests that such clay layers do not always protect against arsenic, and could even be a source of contamination in some wells.

Clay layers had previously been suspected of contaminating groundwater with arsenic in parts of Bangladesh, the Mekong delta of Vietnam and the Central Valley of California, but the new paper provides the most direct evidence so far.

"Our findings challenge a widely held view, namely that impermeable clay layers necessarily protect an aquifer from perturbation," said Alexander van Geen, a research professor at Columbia University's Lamont-Doherty Earth Observatory who has been studying arsenic contamination of drinking water for two decades. "In this context, we show from several different angles—failed attempts to lower local exposure, high-resolution drilling, monitoring, and groundwater dating—that this is actually not the case for groundwater arsenic, because distant municipal pumping can trigger remotely the release of arsenic below such a clay layer."

The researchers were inspired to conduct the study after two manually pumped community wells drilled to intermediate depths in the vicinity of Dhaka, the capital of Bangladesh, suddenly failed, producing water with elevated concentrations of arsenic after having generated clean water for many months.

Most sand contains arsenic, but it is not a problem until the arsenic is released into drinking water in some way, typically through response to reactive carbon. The sources of this reactive carbon remain poorly understood, despite decades of study. One possibility is that it travels into the sediment with the downward flowing of surface waters, but the researchers showed with groundwater dating that such flow was not responsible in the case of their study area. Another is that reactive carbon is released as plant matter breaks down underground. The third theory, demonstrated for the first time in the new paper, is that excessive municipal pumping can compress the clay layers, squeezing out reactive carbon, which then releases arsenic from local sediments.


Indeed, the researchers found that the recent changes in arsenic near Dhaka were the result of pumping from deeper aquifers to satisfy the municipal supply of the city. Because of this deep municipal pumping, water levels under Dhaka itself are a hundred meters below what they would naturally be—the aquifer just doesn't refill fast enough. This depressed area is called the Dhaka "cone of depression," and it extends approximately 20 kilometers around the city.
Samples of clay and aquifer sand cuttings collected at five-foot intervals near the study site in Bangladesh. Grey sand is often associated with elevated arsenic in groundwater and orange sand consistently with low arsenic in groundwater. Credit: Rajib Mozumder

"In Dhaka, the pumping probably accelerated the release of arsenic and allowed us to document the changes within a decade," said van Geen. "We wouldn't have figured this out without having been there monitoring wells for at least 10 years. Monitoring is not very exciting, but because of the monitoring we discovered something fascinating."

The research team's findings are especially worrisome for local households on the outskirts of Dhaka that have been privately re-installing wells to access relatively shallow aquifers beneath the impermeable clay layer.

Even in the absence of deep pumping for municipal needs, long-term diffusion of dissolved organic carbon from clay layers could explain why private wells screened just below a clay layer in other sedimentary aquifers are more likely to be contaminated with arsenic than deeper wells, according to the paper.

While the geochemical conditions surrounding every aquifer are different, the problem of arsenic and other contaminants leaking into deep aquifer groundwater is not unique to Dhaka. "It's a warning and it means that in some areas you need to probably test wells more frequently than others," said van Geen.

The problem is not unique to Bangladesh, either. With groundwater pumping from aquifers expected to continue throughout the world, more global monitoring for contamination by arsenic from compacting clay layers may be necessary, according to the paper's authors.

The dilemma of how to provide Bangladesh's population with clean water remains. Deep wells are currently supplying some of the safest water in Bangladesh, said Charles Harvey, a professor of civil engineering at MIT who has long studied arsenic in drinking water but did not contribute to this research. "Most of them seem to be fine, but this raises the alarm that maybe they won't stay fine."

The research question van Geen would like to address next occupies the realm of behavioral economics: "How can you encourage people who have wells that are high in arsenic to do something about it?"


Explore furtherStudy zeroes in on source of arsenic in Bengal Basin's deep wells
More information: Nature Communications (2020). DOI: 10.1038/s41467-020-16104-z
Journal information: Nature Communications

Provided by Columbia University

Carbon footprint hotspots: Mapping China's export-driven emissions


Carbon footprint hotspots: Mapping China's export-driven emissions
i Map shows sources of Chinese carbon dioxide emissions tied to products consumed overseas in 2012. Orange and red locations are hotspots for Chinese emissions that are tied to exports. A new University of Michigan-led study tracked Chinese emissions to a small number of coastal manufacturing hubs and showed that about 1% of the country’s land area is responsible for 75% of the export-linked CO2 emissions. Credit: From Yang et al., Nature Communications 2020The coronavirus pandemic has highlighted just how reliant the United States and other countries are on Chinese manufacturing, with widespread shortages of protective medical gear produced there.
But U.S. dependence on China extends far beyond surgical masks and N95 respirators. China is the largest producer of many industrial and  shipped worldwide, and about one-quarter of the country's  comes from exports.
It is also the world's largest emitter of climate-altering , generated by the burning of fossil fuels. A new study details the links between China's exports and its emissions by mapping the in-country sources of carbon dioxide emissions tied to products consumed overseas.
University of Michigan researchers and their Chinese collaborators tracked these emissions to a small number of coastal manufacturing hubs and showed that about 1% of the country's land area is responsible for 75% of the export-linked CO2 emissions.
The study, scheduled for publication May 7 in Nature Communications, provides the most detailed mapping of China's export-driven CO2 emissions to date, according to corresponding author Shen Qu of the U-M School for Environment and Sustainability. The findings, which are based on 2012 emissions data, offer insights that can guide policymakers, he said.
"Developing localized climate mitigation strategies requires an understanding of how global consumption drives local carbon dioxide emissions with a fine spatial resolution," said Qu, a Dow Sustainability Postdoctoral Fellow at SEAS who combines the tools of input-output analysis and network analysis to uncover the role of international trade in global environmental impacts.
"The carbon footprint hotspots identified in this study are the key places to focus on collaborative mitigation efforts between China and the downstream parties that drive those emissions," he said.
The study found that the manufacturing hubs responsible for most of the foreign-linked emissions are in the Yangtze River Delta (including Shanghai, China's top CO2-emitting city), the Pearl River Delta (including Dongguan) and the North China Plain (including Tianjin). These cities have, or are close to, ports for maritime shipping.
The modeling study uses data from large-scale emissions inventories derived from 2012 surveys of individual firms in all Chinese industries that generate carbon dioxide emissions. Emissions levels have likely changed in response to recent U.S.-China trade disputes and the COVID-19 pandemic, which has significantly impacted Chinese manufacturing and exports.


Chinese CO2 emissions driven by foreign consumption totaled 1.466 megatons in 2012, accounting for 14.6% of the country's industrial-related carbon dioxide emissions that year. If the Chinese manufacturing hubs identified in the U-M study constituted a separate country, their CO2 emissions in 2012 would have ranked fifth in the world behind China, the United States, India and Russia, according to the authors.
The study also found that:
  • Exports to the United States, Hong Kong and Japan were responsible for the biggest chunks of Chinese foreign-linked CO2 emissions, contributing about 23%, 10.8% and 9%, respectively.
  • About 49% of the U.S.-linked CO2 emissions were driven by the production of consumer goods for the household.
  • About 42% of the export-driven CO2 emissions in China are tied to , with notable hotspots in the cities of Shanghai, Ningbo, Suzhou (Jiangsu Province) and Xuzhou. Much of that electricity is produced at coal-fired power plants.
  • China is the world's largest steel producer and exporter. Cities that manufacture large amounts of iron and steel—and that use large amounts of coal in the process—were hotspots for export-driven CO2 emissions. Cement plants and petroleum refineries were also big contributors.
In the study, U-M researchers and their collaborators used carbon footprint accounting—i.e., consumption-based accounting—to track greenhouse gas emissions driven by global supply chains. They mapped those emissions at a spatial resolution of 10 kilometers by 10 kilometers, a level of detail that enabled them to identify specific source cities.
"Previous studies have linked greenhouse gas emissions to final consumption of products, but primarily at national or regional levels," said study co-author Ming Xu of the U-M School for Environment and Sustainability and the Department of Civil and Environmental Engineering.
"Given the increasing importance of non-—provinces, states, cities and companies—in climate mitigation, it becomes increasingly important to be able to explicitly link the final consumers of products to the subnational actors that have direct control over greenhouse gas ."
Coronavirus outbreak slashes China carbon emissions: study

More information: Mapping global carbon footprint in China, Nature Communications (2020). doi.org/10.1038/s41467-020-15883-9