Monday, October 17, 2022

Digital transformation in construction industry requires more support, study shows

Researchers identify the main obstacles preventing efficient digital transformation in the engineering and construction industry

Peer-Reviewed Publication

XI'AN JIAOTONG-LIVERPOOL UNIVERSITY

Digital transformation in the engineering and construction industry. 

IMAGE: IN A RECENT STUDY, RESEARCHERS HAVE IDENTIFIED THE MAIN OBSTACLES PREVENTING EFFICIENT DIGITAL TRANSFORMATION IN THE ENGINEERING AND CONSTRUCTION INDUSTRY. view more 

CREDIT: XJTLU

In recent years, the engineering and construction industries have been exploring the use of digital technologies to boost productivity and improve safety, quality, and sustainability. However, digital transformation in this industry has been slow compared to other sectors due to certain obstacles.

In a paper recently published in the journal Engineering, Construction, and Architectural Management, researchers from Xi’an Jiaotong-Liverpool University and the University of Lincoln identify, classify, and rank the main obstacles preventing digital transformation in this sector.

The researchers identified barriers through a systematic literature review and expert validation, then surveyed 192 construction professionals in China on the impact of the obstacles. They found that the three main problems are a lack of laws and regulations, a lack of support and leadership, and a lack of resources and professionals.

Changing legislation

The lack of laws and regulations is the most significant among the barriers identified, according to Dr Fangyu Guo, assistant professor at XJTLU’s Department of Civil Engineering and corresponding author of the paper.

“The lack of laws and regulations has a negative effect on digital transformation because construction companies need governmental regulations as guidelines to determine their strategies and adapt their organisational structure.

“Well-established standards and regulations are critical for directing an effective digital transformation and motivating stakeholders to invest more in various digital technologies and tools,” Guo says.

Leadership and resources

A lack of support and leadership also negatively influences digital transformation. Most employees may be unfamiliar with the new technologies, and insufficient support from senior management will reduce their willingness to adapt to the change.

“It is important for senior management in construction firms to give ongoing support and motivation to employees during the implementation of digital transformation,” says Dr Guo.

The lack of resources and professionals is another obstacle. There is currently a large digital skills gap in the industry, so developing the next generation of digital skills and relevant talents is crucial to digital transformation.

The researchers suggest firms must develop strategic plans and training programmes to obtain potential talents who can use digital technologies and possess long-term business intelligence.

The study offers insights for governments and construction companies to improve their understanding of these barriers and their impacts. The findings will help to establish policies that can use digital transformation to enhance construction project management.

The research team consists of Kaiyang Wang, Dr Fangyu Guo, and Dr Cheng Zhang from XJTLU, and Professor Dirk Schaefer from the University of Lincoln.

 

Back to the future of photosynthesis

Resurrecting billon-year-old enzymes reveals how photosynthesis adapted to the rise of oxygen

Peer-Reviewed Publication

MAX-PLANCK-GESELLSCHAFT

Rubisco complexes 

IMAGE: CRYO-ELECTRON MICROSCOPE IMAGE OF TWO RUBISCO COMPLEXES INTERACTING WITH EACH OTHER. IF A SUBUNIT ESSENTIAL FOR SOLUBILITY IS MISSING, INDIVIDUAL ENZYME COMPLEXES CAN INTERACT WITH EACH OTHER IN THIS WAY AND FORM THREAD-LIKE STRUCTURES, SO-CALLED FIBRILS. UNDER NORMAL CONDITIONS, HOWEVER, RUBISCO DOES NOT FORM SUCH FIBRILS. view more 

CREDIT: MPI F. TERRESTRIAL MICROBIOLOGY/ L. SCHULZ

The central biocatalyst in photosynthesis, Rubisco, is the most abundant enzyme on earth. By reconstructing billion-year-old enzymes, a team of Max Planck researchers has deciphered one of the key adaptations of early photosynthesis. Their results not only provide insights into the evolution of modern photosynthesis but also offer new impulses for improving it.

Present day life fully depends on photosynthetic organisms like plants and algae that capture and convert CO2. At the heart of these processes lies an enzyme called Rubisco that captures more than 400 billion tons CO2 annually. Organisms alive today make staggering amounts of it: the mass of Rubisco on our planet outweighs that of all humans. In order to assume such a dominant role in the global carbon cycle, Rubisco had to adapt constantly to changing environmental conditions.

Using a combination of computational and synthetic approaches, a team from the Max Planck Institute for Terrestrial Microbiology in Marburg, Germany, in collaboration with the University of Singapore has now successfully resurrected and studied billion-year-old enzymes in the lab. In this process, which they describe as “molecular paleontology”, the researchers found that instead of direct mutations in the active center, an entirely new component prepared photosynthesis to adapt to rising oxygen levels.

Rubisco's early confusion

Rubisco is ancient: it emerged approximately four billion years ago in primordial metabolism prior to the presence of oxygen on earth. However, with the invention of oxygen-producing photosynthesis and rise of oxygen in the atmosphere, the enzyme started catalyzing an undesired reaction, in which it mistakes O2 for CO2 and produces metabolites that are toxic to the cell. This confused substrate scope still scars Rubiscos to date and limits photosynthetic efficiency. Even though Rubiscos that evolved in oxygen-containing environments became more specific for CO2 over time, none of them could get completely rid of the oxygen capturing reaction.

The molecular determinants of increased CO2 specificity in Rubisco remain largely unknown. However, they are of great interest to researchers aiming to improve photosynthesis. Interestingly, those Rubiscos that show increased CO2 specificity recruited a novel protein component of unknown function. This component was suspected to be involved in increasing CO2 specificity, however, the true reason for its emergence remained difficult to determine because it already evolved billions of years ago.

Studying evolution by resurrecting ancient proteins in the lab

To understand this key event in the evolution of more specific Rubiscos, collaborators at the Max Planck Institute for Terrestrial Microbiology in Marburg and Nanyang Technological University in Singapore used a statistical algorithm to recreate forms of Rubiscos that existed billions of years ago, before oxygen levels began to rise. The team led by Max Planck researchers Tobias Erb and Georg Hochberg resurrected these ancient proteins in the lab to study their properties. In particular, the scientists wondered whether Rubisco’s new component had anything to do with the evolution of higher specificity.

The answer was surprising, as doctoral researcher Luca Schulz explains: “We expected the new component to somehow directly exclude oxygen from Rubisco catalytic center. That is not what happened. Instead, this new subunit seems to act as a modulator for evolution: recruitment of the subunit changed the effect that subsequent mutations had on Rubisco’s catalytic subunit. Previously inconsequential mutations suddenly had a huge effect on specificity when this new component was present. It seems that having this new subunit completely changed Rubisco’s evolutionary potential.”

An enzyme's addiction to its new subunit

This function as an “evolutionary modulator” also explains another mysterious aspect of the new protein component: Rubiscos that incorporated it are completely dependent on it, even though other forms of Rubisco can function perfectly well without. The same modulating effect explains why: When bound to this small protein component, Rubisco become tolerant to mutations that would otherwise be catastrophically detrimental. With the accumulation of such mutations, Rubisco effectively became addicted to its new subunit.

Altogether, the findings finally explain the reason why Rubisco kept this new protein component around ever since it encountered it. Max Planck Research Group Leader Georg Hochberg explains: “The fact that this connection was not understood until now highlights the importance of evolutionary analysis for understanding the biochemistry that drives life around us. The history of biomolecules like Rubisco can teach us so much about why they are the way they are today. And there are still so many biochemical phenomena whose evolutionary history we really have no idea about. So it’s a very exciting time to be an evolutionary biochemist: almost the entire molecular history of the cell is still waiting to be discovered.”

Scientific journeys back in time can provide invaluable insights for the future

The study also has important implications for how photosynthesis might be improved, says Max Planck Director Tobias Erb: “Our research taught us that traditional attempts to improve Rubisco might have been looking in the wrong place: for years, research focused solely on changing amino acids in Rubisco itself to improve it. Our work now suggests that adding entirely new protein components to the enzyme could be more productive and may open otherwise impossible evolutionary paths. This is uncharted land for enzyme engineering.”

Building the tools to make environmental data more accessible and forecasts more accurate

Virginia Tech ecological forecaster Quinn Thomas will lead Virginia Tech’s efforts in a newly-funded NSF project that will accelerate ongoing environmental research and benefit future researchers and scientific communities

Grant and Award Announcement

VIRGINIA TECH

Photo by Krista Timney for Virginia Tech. 

IMAGE: THE NATIONAL SCIENCE FOUNDATION-FUNDED DECODER PLATFORM WILL ACCELERATE WORK ON CURRENT VIRGINIA TECH FORECASTING PROJECTS RELATED TO CARBON STORAGE, WATER QUALITY, AND FALL COLORS, SUCH AS THIS LAKESHORE LANDSCAPE AT HUNGRY MOTHER STATE PARK IN MARION, VIRGINIA. PHOTO BY KRISTA TIMNEY FOR VIRGINIA TECH. view more 

CREDIT: VIRGINIA TECH

Before you start your next Google search, stop for just a minute. You may not know it, but whether you’re looking for the latest Hokie football score or cheap airline tickets, you’re about to unleash a powerful data discovery, retrieval, and organizing process made possible by the agreed-upon rules for defining information that drive search engines.

Now pause again and imagine if every website used a different set of rules and search engines weren’t available. Given the mind-boggling amount of information on the internet that is at our fingertips, how would you ever find what you need to make decisions and plan your life? Take that query up a couple notches for scientists navigating a plethora of environmental data scattered across the web, and you’ll understand the impact of a new Virginia Tech research project.

Quinn Thomas, who holds dual appointments in the College of Natural Resources and Environment and the College of Science, is the principal investigator for Virginia Tech’s part of a $3.2 million research project funded by the National Science Foundation’s (NSF) Office of Advanced Cyberinfrastructure.

The Democratized Cyberinfrastructure for Open Discovery to Enable Research (DeCODER) aims to standardize and facilitate how environmental data and model predictions are described and shared so that, ultimately, more individual researchers and scientific communities can utilize these resources.

Data is the key driver for the project and for the ecological forecasting research of Thomas, an associate professor in the Department of Forest Resource and Environmental Conservation, an affiliated faculty member of the Global Change Center, and the Data Science Faculty Fellow in the College of Science. He is a researcher with a bold objective: predicting the natural environment just like we predict the weather through the use of shared data tools and a computational infrastructure.

As the project lead for Virginia Tech, Thomas will put the university’s $535,000 share of the NSF grant to work to aid researchers interested in predicting environmental change. “My portion of the project is to advance the discoverability of ecological forecasts through the development of protocols and software to archive and document model predictions of ecological dynamics,” Thomas said. “Much like we use internet search engines (like Google) to find information, our work will help a researcher ask questions and initiate searches like ‘Find forecasts of algae in lakes across the U.S.’ in order to find current forecasts to help guide decision making and support environmental management.”  

This grant advances work already done on the EarthCube GeoCODES platform. EarthCube is an NSF-funded environment that improves access, sharing, and visualization of data. GeoCODES is a program specifically for researchers working in the field of geoscience that offers evolving methods for organizing data so it can be easily accessed, as well as a framework for new computational tools, a registry, and best practices for the user community.

The new DeCODER platform will build upon and leverage the work that has already been done as part of the EarthCube effort. Thomas will take the next steps to help researchers working specifically in ecological forecasting to more easily access data and create better models.

Again, considering the example of researchers needing to forecast algae growth across the U.S., the DeCODER platform will allow researchers to not only gather data and forecasts, but also to “then compare these predictions to actual measurements of algae to quantify the strengths and weakness of the forecasts that have been generated to date.”

In addition, Thomas said, “Rather than requiring all ecological forecasters to use a single archive location on the internet, the technology we are developing allows for many archiving locations to be used, thus democratizing the storage and discovery of the results of the forecasting expertise.”

This new platform is especially valuable to researchers, like Thomas, whose work involves utilizing data and modeling because it will allow them to more easily discover what has already been done in the field in order to improve models over time.

“Think about weather forecasts,” said Thomas. “They have been getting better over time. A 10-day forecast is as good as an eight- or nine-day forecast was a decade ago. We know this improvement has occurred by comparing past forecasts to data. Now we want to do this evaluation of other environmental forecasts, and we can’t do that if we can’t find all the historical data.”

He also said individual scientists are producing incredible amounts of data about the environment, but, unfortunately, it’s not all in one centralized place. This new technology will allow data to be discovered wherever it is and enable researchers to determine if they are getting better at forecasting environmental change.

Thomas will be working closely with Associate Professor Carl Boettiger of the University of California at Berkeley (UCB) on the application of the DeCODER platform to ecological forecasting. A primary focus will be developing the software and protocols that will allow people to discover needed data. “The DeCODER project will democratize research pipelines such as the production and assessment of ecological forecasts, helping to bridge scientific communities and better inform decision makers,” Boettiger said.

To meet this ambitious goal, the project involves a collaborative research effort between several teams with specific areas of expertise. In addition to the Virginia Tech and UCB focus on ecological forecasting data, the University of Illinois Urbana-Champaign (the lead institution) and the University of California San Diego (UCSD) are developing the cyberinfrastructure used by all the teams to tie the work together. Syracuse University and Texas A&M University are working on low-temperature geochemistry data, and the Scripps Institution of Oceanography, along with UCSD, is focusing on deep ocean science data.

According to Thomas, this newly-funded NSF grant project will both complement and advance the ongoing research agenda in ecological forecasting at Virginia Tech. The DeCODER platform will ultimately accelerate work on current forecasting projects related to water quality, forest carbon storage, fall colors, and environmental dynamics in the context of a changing environment.

“By focusing on a democratized approach to data and forecast discovery, the advances are designed to outlive the duration of the project. This places Virginia Tech’s ecological forecasting research at the vanguard of the field,” said Thomas.

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Ecosystem-based fisheries management restores western Baltic fish stocks

First western Baltic Sea ecosystem model shows that ecosystem-based management increases catches of cod and herring as well as food web resilience to ocean warming

Peer-Reviewed Publication

HELMHOLTZ CENTRE FOR OCEAN RESEARCH KIEL (GEOMAR)

Decades of overfishing, together with nutrient pollution, rapid increase in hypoxia, ocean warming and acidification have put fish and harbour porpoise (Phocoena phocoena) in the western Baltic Sea at risk of collapse. But the commercially relevant stocks of cod (Gadus morhua), herring (Clupea harengus) and sprat (Sprattus sprattus) can be restored and prospects for marine mammals be improved, according to a team of marine scientists from GEOMAR Helmholtz Centre for Ocean Research Kiel (Germany), the German Federal Agency for Nature Conservation (Bundesamt für Naturschutz, BfN, Germany) and the Institute of Biosciences and Bioresources at the National Research Council (CNR) of Italy.

Using model simulations, the researchers tested five scenarios from no fishing to ecosystem-based fisheries management. This approach accounts for the roles of species within their ecosystem and adjusts catches accordingly to keep fish stocks in a healthy, productive and resilient condition. A study now published in the scientific magazine Frontiers in Marine Science concludes: Ecosystem-based fisheries management would allow the endangered harbour porpoise population to recover and increase catches of herring and cod significantly within a decade. The food web would become less susceptible to eutrophication and climate change and, in addition, more able to support carbon sequestration than in a business-as-usual scenario that assumes today’s fisheries practices continue.

The study benefits from years of data collection at GEOMAR. Building on a first prototype and a huge amount of data, the researchers now developed the first model for the western Baltic Sea that includes top predators such as harbour porpoise and seals, various fish species and other marine animals, plankton, algae and seaweeds, as well as their interactions under different scenarios. “Looking at the big picture of the food web helps to identify management options that sustain important food resources and dependant businesses”, emphasises Dr. Marco Scotti, marine ecologist at GEOMAR and CNR, lead author of the recent publication.

Ecosystem-based fisheries management would imply to stop catching juvenile cod, reduce catches of herring and sprat to half of the maximum sustainable yield – the highest possible harvest per year that can be sustained over time – and catches of adult cod and flatfish to 80 per cent of the maximum sustainable yield. This approach was compared to a business-as-usual scenario characterised by average fishing mortalities for all exploited stocks during the years 2015 to 2019.

In the business-as-usual scenario, cod stocks decline slightly below the numbers of 2019 and herring stocks to almost half their 2019 sizes by 2050. Sprat and flatfish increase to some degree, suggesting a substantial regime shift. Ecosystem-based fisheries management, in contrast, would lead to an increase of almost 70 per cent in cod and 50 per cent in herring catches by 2050, compared to the period 2015 to 2019. Catches in flatfish would increase by almost 20 per cent, but with largely reduced fishing effort and costs. Potential for carbon sequestration would be more than three times greater under ecosystem-based fisheries management compared to business-as-usual.

“The Common Fisheries Policy of Europe demands an end to overfishing by 2020 and rebuilding of healthy and resilient ecosystems thereafter”, says Dr. Rainer Froese, fisheries biologist at GEOMAR and co-author of the study. “Past and present overfishing – not climate change – was the main cause of the recent collapse of herring, cod, and profitable western Baltic fisheries in general. Continued business-as-usual would in addition push the highly endangered harbour porpoise to the brink of extinction. In contrast, ecosystem-based management would rebuild healthy stocks and fisheries and even help us to fight climate change. Saving the western Baltic requires to stop fishing of cod and herring for a few years, until these stocks have recovered. During this time, fishers need to be compensated for their losses. Fishing for plaice and other flatfish can meanwhile continue.”

Original publications:

Scotti M., Opitz S., MacNeil L., Kreutle A., Pusch C. and Froese R. (2022): Ecosystem-based fisheries management increases catch and carbon sequestration through recovery of exploited stocks: The western Baltic Sea case study. Frontiers in Marine Science 9, 879998. https://doi.org/10.3389/fmars.2022.879998

Opitz, S. and Froese R. (2019): Ecosystem Based Fisheries Management for the Western Baltic Sea. Extended Report. https://www.fishbase.de/rfroese/WBS_ComFish_Report_Final.pdf

Project funding:

The work has been funded by the German Federal Ministry of Education and Research through the Adaptation of the Western Baltic Coastal Fishery to Climate Change (balt_ADAPT) project (grant number 03F0863), the EcoScope Project of the Horizon 2020 Research and Innovation Programme of the European Commission (grant agreement number 101000302), as well as by the Federal Ministry of the Environment, Nature Conservation and Nuclear Safety (FKZ 3521532201).

 

ICYMI

Study reveals new insights into how fast-moving glaciers may contribute to sea level rise

Peer-Reviewed Publication

UNIVERSITY OF OXFORD

Greenland glacier 

IMAGE: ASSOCIATE PROFESSOR LAURA STEVENS (RIGHT) AND CO-AUTHOR PROFESSOR MEREDITH NETTLES (LEFT, COLUMBIA UNIVERSITY) APPROACH A GREENLAND SUPRAGLACIAL LAKE VIA HELICOPTER. PHOTO BY MARIANNE OKAL (UNAVCO, INC.). view more 

CREDIT: PHOTO BY MARIANNE OKAL (UNAVCO, INC.).

Climate change is resulting in sea level rise as ice on land melts and oceans expand. How much and how fast sea levels will rise in the near future will depend, in part, on the frequency of glacier calving events. These occur when large chunks of ice detach from glaciers that terminate in the ocean (known as tidewater glaciers), and fall into coastal fjords as icebergs. The faster these glaciers flow over the ground towards the ocean, the more ice enters the ocean, increasing the rate of sea level rise.

During the warmer summer months, the surface of Greenland’s glaciers can melt and form large lakes that may then drain through to the base of the glacier. Studies on the inland Greenland ice sheet have shown that this reduces friction between the ice and ground, causing the ice to slide faster for a few days. Up to now, however, it has been unclear whether such drainage events affect the flow speed of tidewater glaciers, and hence the rate of calving events.

To investigate this, a research team from Oxford University’s Earth Sciences department, the Oxford University Mathematical Institute, and Columbia University used Global Positioning System (GPS) observations of the flow speed of Helheim Glacier—the largest single-glacier contributor to sea level rise in Greenland. The GPS captured a near perfect natural experiment: high-temporal-resolution observations of the glacier’s flow response to lake drainage.

The results found that Helheim Glacier behaved very differently to the inland ice sheet, which shows a fast, downhill movement during lake drainage events. In contrast, Helheim Glacier exhibited a relatively small ‘pulse’ of movement where the glacier sped up for a short amount of time and then moved slower, resulting in no net increase in movement.

Using a numerical model of the subglacial drainage system, the researchers discovered that this observation was likely caused by Helheim glacier having an efficient system of channels and cavities along its bed. This allows the draining waters to be quickly evacuated from the glacier bed without causing an increase in the total net movement.

Although this appears positive news in terms of sea level rise implications, the researchers suspected that a different effect may occur for glaciers without an efficient drainage system where surface melt is currently low but will increase in future due to climate change (such as in Antarctica).

They ran a mathematical model based on the conditions of colder, Antarctic tidewater glaciers. The results indicated that lake drainages under these conditions would produce a net increase in glacier movement. This was largely due to the less efficient winter-time subglacial drainage system not being able to evacuate flood waters quickly. As of yet, however, there are no in situ observations of Antarctic tidewater glacier responses to lake drainage.

The study calls into question some common approaches for inferring glacial drainage systems based on glacier velocities recorded using satellite observations (which are currently used in sea level rise models).

Lead author Associate Professor Laura Stevens (Department of Earth Sciences, Oxford University) said: ‘What we've observed here at Helheim is that you can have a big input of meltwater into the drainage system during a lake drainage event, but that melt input doesn’t result in an appreciable change in glacier speed when you average over the week of the drainage event.’

With the highest temporal resolution of satellite-derived glacier speeds currently available being roughly one week, lake drainage events like the one captured in the Helheim GPS data usually go unnoticed.

‘These tidewater glaciers are tricky,’ Associate Professor Stevens added. ‘We have a lot more to learn about how meltwater drainage operates and modulates tidewater-glacier speeds before we can confidently model their future response to atmospheric and oceanic warming.’

Notes to editors:

The study ‘Tidewater-glacier response to supraglacial lake drainage’ is published in Nature Communications: https://www.nature.com/articles/s41467-022-33763-2.

For media inquiries contact Professor Laura Stevens, Earth Sciences Department, University of Oxford: laura.stevens@earth.ox.ac.uk.

About the University of Oxford

Oxford University has been placed number 1 in the Times Higher Education World University Rankings for the seventh year running, and ​number 2 in the QS World Rankings 2022. At the heart of this success are the twin-pillars of our ground-breaking research and innovation and our distinctive educational offer.

Oxford is world-famous for research and teaching excellence and home to some of the most talented people from across the globe. Our work helps the lives of millions, solving real-world problems through a huge network of partnerships and collaborations. The breadth and interdisciplinary nature of our research alongside our personalised approach to teaching sparks imaginative and inventive insights and solutions.

Through its research commercialisation arm, Oxford University Innovation, Oxford is the highest university patent filer in the UK and is ranked first in the UK for university spinouts, having created more than 200 new companies since 1988. Over a third of these companies have been created in the past three years. The university is a catalyst for prosperity in Oxfordshire and the United Kingdom, contributing £15.7 billion to the UK economy in 2018/19, and supports more than 28,000 full time jobs.

 

Too much motivation affects our decision-making

A team from the UNIGE, in collaboration with the EPFL, reveals how motivation influences the neural circuits of perception and impacts decision-making

Peer-Reviewed Publication

UNIVERSITÉ DE GENÈVE

Too much motivation affects our decision-making 

IMAGE: THE PROFILE OF THIS MOUND, CLIMBED BY THE MOUSE TO QUENCH ITS THIRST, MIRRORS THE CURVE OF THE YERKES-DODSON LAW, WHICH DESCRIBES THE RELATIONSHIP BETWEEN BEHAVIOURAL PERFORMANCE AND MOTIVATION. THE MOUSE PERFORMS THIS TASK WITH THE HELP OF ITS WHISKERS, WHICH ARE ESSENTIAL FOR EXPLORING THE WORLD IN RODENTS. view more 

CREDIT: © GENERATED BY DALL-E

In a good or a bad mood, focused or distracted, in dire or no need: our internal states directly influence our perceptions and decision-making. While the role of motivation on the performance of behavioural tasks has been known for more than a century - thanks to the work of psychologists Robert Yerkes and John Dilligham Dodson - its precise effect on the brain remains unclear. A team from the University of Geneva (UNIGE), in collaboration with the EPFL, has revealed how motivation alters the neural circuits responsible for sensory perception preceding decision-making in mice. This study reveals why a level of motivation that is too high or too low can affect our perception and therefore our choices. These results, featured in the journal Neuron, open up new perspectives in learning methods. 


Going to work early in the morning, choosing a restaurant at lunchtime: many of our decisions are motivated by needs, such as earning a living or satisfying our hunger. However, decision-making is a complex process, which can also be influenced by external factors, such as the environment or other individuals, and by our internal states, such as our mood, our level of attention or our degree of motivation.


The laboratory of Sami El-Boustani, Assistant Professor in the Department of Basic Neurosciences at the Faculty of Medicine of the UNIGE and recipient of an Eccellenza fellowship (SNSF), is studying the neural circuits involved in decision-making. In recent work, carried out in collaboration with Professor Carl Petersen’s team at EPFL, his lab has studied the role played by a specific internal state - motivation - in perception and decision-making. For more than a century it has been known that a relationship between motivation and performance exists thanks to the work of American psychologists Robert Yerkes and John Dilligham Dodson. Too much or too little motivation is detrimental to performance. However, the way in which this impacts our neural circuits remains unclear. ‘‘We wanted to observe how sensory information transmitted by neurons in the cortex is altered by the degree of motivation and to what extent the latter can have an effect on learning and performance in a decision-making task,’’ explains Sami El-Boustani, the lead author of the study.


The research team developed a behavioral paradigm involving mice in a controlled water consumption regime. They first trained these rodents to respond to tactile stimuli via two whiskers (A and B) and to produce an action - licking a spout - only for whisker A in order to obtain a drop of water. Following this training, these mice reacted mainly to the stimulation of whisker A, thus indicating their ability to discriminate between these two sensations. Finally, the researchers conducted these experiments at decreasing levels of thirst in order to vary the motivation of the rodents to participate in the task.


State of hyper-motivation blurs sensory information

In a state of great thirst - therefore of great motivation - rodents performed poorly. They licked the spout indiscriminately, without distinguishing between the whiskers stimulated. In contrast, in a state of moderate thirst, the choice of their action became optimal. They mainly licked the spout when whisker A was stimulated. Finally, when they were not very thirsty, their performance in the task dropped again.


By observing the activity of neuronal populations responsible for perceptual decision-making in these mice, the researchers discovered that neurons in these circuits were flooded with electrical signals when mice were hyper-motivated. Conversely, in a state of low-motivation, the signals were too weak. ‘‘Hyper-motivation leads to strong stimulation of cortical neurons, which causes a loss of precision in the perception of tactile stimuli,’’ says Giulio Matteucci, a Postdoctoral Fellow in Sami El-Boustani’s laboratory and the study’s first author.


In contrast, in the low-motivation state, the accuracy of the sensory information was recovered, but the strength of the signal was too low for it to be transferred correctly. As a result, the perception of the stimuli was also impaired.


A new understanding of learning

These results open up new perspectives. They provide a possible neural basis for the Yerkes-Dodson Law. ‘‘They also reveal that the level of motivation does not only impact decision-making but also the perception of sensory information, which leads to the decision’’, explains Carl Petersen, Full Professor at the Brain Mind Institute of EPFL and co-senior author in the study.


This work also suggests that it is necessary to decouple acquisition and expression of new knowledge. ‘‘We observed that mice understood the rule very quickly but could only express this learning much later, depending on an altered perception linked to their level of motivation.’’ This unraveling of the role of motivation in learning opens the way to new adaptive methods that aim to maintain an optimal level of motivation during learning.

US life expectancy drops as Europe shows signs of recovery post-COVID, study finds

Adrianna Rodriguez, USA TODAY
Mon, October 17, 2022 



In 2020, most countries around the world experienced a shocking decline in life expectancy as COVID-19 wreaked havoc on society. But as some countries show signs of recovery, a new study found the United States continues to see its life expectancy in free-fall.

Researchers looked at data from 29 countries around the world and found seven countries in western Europe saw a significant increase in life expectancy in 2021, according to the study published Monday in Nature Human Behavior. Four of those countries – France, Belgium, Switzerland and Sweden – returned to pre-pandemic levels.

Meanwhile, the U.S. reported the third-largest decline in life expectancy, following closely behind Bulgaria and Slovakia.

The study is the latest example of how issues relating to the U.S. health care system, policies and public behavior, which impacted life expectancy before COVID-19, were exacerbated by the pandemic, experts say.

“Most of the developed countries experienced some recovery during 2021 ... whereas the U.S. was among the countries that had the largest decreases in life expectancy that year,” said Dr. Steven Woolf, director emeritus of the Center on Society and Health at Virginia Commonwealth University in Richmond, who is not affiliated with the study.

Study authors said life expectancy in France, Belgium, Switzerland and Sweden returned to pre-pandemic levels by reducing mortality in people 60 and over. They attributed life expectancy declines in other countries to continued mortality in this age group.

But the U.S. was the only country that continued to see life expectancy losses because of increasing mortality in people under 60, explaining for “more than half of the loss in U.S. life expectancy since the start of the pandemic,” study authors said.

The study suggests vaccine uptake may be partly to blame. Researchers analyzed the proportion of the population that was fully vaccinated as of October 2021 and found reduced life expectancy was associated with lower vaccination uptake.

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"Everyone was hit in 2020 ... 2020 was about policy response and 2021 becomes a story of vaccination, and the U.S. was not a success story," said Theresa Andrasfay, postdoctoral scholar at the University of Southern California’s Leonard Davis School of Gerontology, who is not affiliated with the study.

Study authors also note the country’s proportion of people with comorbid conditions – which is comparatively larger than European counterparts – may have increased mortality in the working-age population.

The study tracks with previous reporting showing U.S. life expectancy decreased from 78.86 years in 2019 to 76.99 years in 2020, and then to 76.60 years in 2021 – accumulating a net loss of 2.26 years, according to a study authored by Woolf and published in April.

Other research also shows life expectancy losses disproportionately affected Black and Latino Americans. A 2021 study found estimated reductions for these populations are 3 to 4 times that for white people, reversing over 10 years of progress made in closing the life expectancy gap.

Experts say it may take a while for American life expectancy to return to pre-pandemic levels, but even then, the U.S. would still fall behind Europe.

“The U.S. has a series of systemic problems different than what exists in Europe,” Woolf said. “Those systemic problems aren’t going away as quickly as we would like.”

Follow Adrianna Rodriguez on Twitter: @AdriannaUSAT.

Health and patient safety coverage at USA TODAY is made possible in part by a grant from the Masimo Foundation for Ethics, Innovation and Competition in Healthcare. The Masimo Foundation does not provide editorial input.

This article originally appeared on USA TODAY: As US life expectancy drops, Europe shows signs of recovery post-COVID

Life expectancies diverged in pandemic's second year: study

MONDAY, OCTOBER 17, 2022 
AUTHOR: AFP



There was a dramatic divergence in the average life expectancy of people in different global regions during the second year of the pandemic, a study found Monday, as higher vaccination rates helped some nations recover far more quickly than others.. - 'Protect both old and young' - Countries that had a higher percentage of their population fully vaccinated by October 2021 had a smaller drop in life expectancy, the study found.

There was a dramatic divergence in the average life expectancy of people in different global regions during the second year of the pandemic, a study found Monday, as higher vaccination rates helped some nations recover far more quickly than others.

Because governments have counted Covid statistics in different ways, researchers have sought to give a clearer picture of the pandemic's true impact by measuring a country's total number of annual deaths from all causes and comparing it to the number from before the pandemic.

Last year, researchers at Oxford University's Leverhulme Centre for Demographic Science said that in 2020 the pandemic caused the biggest decrease in life expectancy since World War II.

But in 2021, a "sudden divergence appears," said Ridhi Kashyap, a professor of demography at Oxford and co-author of the latest study, published in the journal Nature Human Behaviour.

"Some countries start showing signs of a recovery," while others have "worsening, compounding losses," he told AFP.

The researchers analysed mortality data across 29 European countries, the United States and Chile since 2015.

Many countries in Western Europe saw their life expectancy bounce back to near pre-pandemic levels. France, Belgium, Switzerland and Sweden even managed to fully return to 2019's number.

However in Eastern Europe, life expectancy dropped to a level not seen since the collapse of the Soviet Union, the study said.

In Bulgaria, life expectancy fell by 25 months in 2021 after dropping 18 months the year before, meaning it plunged more than three and a half years since the start of the pandemic.

Bulgaria has the lowest vaccination rate in the European Union.

- 'Protect both old and young' -

Countries that had a higher percentage of their population fully vaccinated by October 2021 had a smaller drop in life expectancy, the study found.

"This suggests that clearly there is a link," Kashyap said.

The age of people dying from Covid also shifted younger, with the life expectancy of over-80s returning to normal in many places.

This was "partly a sign of vaccines really protecting the old," Kashyap said.

In the US, deaths of people aged over 80 bounced back to pre-pandemic levels, but fatalities soared for the middle-aged and younger, resulting in the country's life expectancy falling by nearly three months.

Jonas Schoeley, a study co-author from Germany's Max Planck Institute for Demographic Research, said countries such as "Sweden, Switzerland, Belgium and France, managed a recovery to pre-pandemic levels of life expectancy because they managed to protect both the old and the young."

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'No conventional studio wanted my film': Oscar-winner Inarritu














Inarritu won Oscars for 'Birdman' and 'The Revenant' but struggled to find backers for his return to Mexico
 ISABEL INFANTES AFP

Issued on: 17/10/2022 -

Paris (AFP) – He was the first director in 60 years to win back-to-back Oscars, but Alejandro Gonzalez Inarritu said he still struggled to generate interest in Hollywood for his return to Mexico with new film "Bardo".

"Birdman" and "The Revenant" earned Inarritu an Oscar for best picture and two for best director in 2015 and 2016.

But only Netflix was interested in the follow-up, which means "Bardo" will only get a short theatrical run in some countries next month, before landing on the streaming service in December.

"This film was not wanted by any conventional studio," Inarritu told AFP during a visit to Paris.

"It's a personal film, a film in Spanish, a film that doesn't have big stars, and it's a film that... needed considerable funding.

"Only Netflix dared to let me make this film with absolute freedom and financial support."
'Profoundly Mexican'

The dream-like movie follows a journalist -- a thinly fictionalised version of Inarritu himself -- who returns to Mexico after finding success in the United States.

When it premiered at the Venice Film Festival last month, some critics felt the nearly three-hour film was, in the words of The Guardian, "outrageously narcissistic".

Inarritu did not take kindly to some of the reviews -- particularly the constant comparisons to Italian legend Federico Fellini (whose renowned "8 1/2" similarly focused on himself) -- which he said bordered on "racism".

"(Bardo) is profoundly Mexican," he told AFP. "We have our own, ancestral references, of great richness and of a very particular style.

"Fellini was beautiful and great, but as far as I know, Fellini didn't leave Rome, he was never an immigrant and he had no children. And my film is about fatherhood and immigrants. What does this have to do with '8 1/2'?

"Fuck -- don't we have our own filmmakers and literature? Our own imagination?"

But Inarritu does seem to have agreed with critics who felt the original cut was too long, having now shaved some 20 minutes off the running time.

He insists this was not a response to the reviews, however.

"Many of the visual effects came very late... I finished the film literally two days before I left for Venice, and the first time I saw it with an audience was in Venice with 2,000 people," he said.

"(During the screening) I realised there were opportunities to get to the point a little faster in some scenes."

'Fractured identity'

"Bardo" is Mexico's official entry for the Oscars, hoping for more of the country's huge success in the 2010s.

Alfonso Cuaron also won two directing Oscars (for "Gravity" and "Roma"), while Guillermo Del Toro won best picture and best director for "The Shape of Water".

But there is still a long way to go in redressing the imbalance of cultural knowledge between the two countries, Inarritu said.

"I have a total knowledge of American literature, history and music. But the vast majority (of Americans) don't know our culture, our history. They don't even know about the (US) invasion of Mexico" in 1846, he said.

"Bardo" is an attempt to discuss the strange relationship between the two nations -- "there are no countries more different than the United States and Mexico," he said -- as well as the Spanish heritage of California with its millions of Hispanic immigrants.

"At my age (59), it was a need to try to put these contradictory things in order... to be able to learn from them," Inarritu said.

"It was brewing for a long time and it was only now that I had the courage and ability and freedom to talk about them the way I did."

© 2022 AF