Wednesday, July 23, 2025

 

Children’s Hospital of Philadelphia researchers analyze best methods to minimize risk of pediatric vehicular heatstroke



A combination of interventions is optimal to prevent children from dying in overheated cars




Children's Hospital of Philadelphia






Philadelphia, July 23, 2025 – Different technologies have been developed to help parents and caregivers address pediatric vehicular heatstroke (PVH), or scenarios where a child dies from overheating in an unattended motor vehicle. In a new study, researchers from Children’s Hospital of Philadelphia (CHOP) identified exemplar PVH scenarios that have occurred during recent years and studied the different technologies designed to prevent them from occurring. The study found that while certain technologies may be effective for different scenarios, no single technology is effective in preventing all the scenarios that lead to pediatric vehicular heatstroke, suggesting a combination of interventions is required to achieve the best prevention strategy.

The findings were recently published by the American Journal of Public Health.

Since 1998, more than 1,000 children have died due to PVH, with an average of 37 children in the United States each year. Since these are preventable deaths, in addition to continued awareness campaigns for caregivers, a variety of vehicle, child restraint, mobile-app and after-market technologies have been designed to help address this issue. These include indirect detection technologies (Bluetooth device connection, GPS-based reminders), direct detection technologies (pressure sensors and radio frequency sensors that detect breathing and heartbeat), alerting technology (warning chimes/noises, primary contacts notified) and intervention features (air conditioning on, doors unlocking).

To determine the effectiveness of these technological interventions, researchers at the Center for Injury Research and Prevention (CIRP) at CHOP, along with co-lead study author Emma Sartin, PhD, MPH now of the University of Alabama at Birmingham, systematically reviewed cases of children dying in hot vehicles to identify “exemplar” scenarios, or cases that were distinct from others in terms of circumstances, and whether the various technological interventions available would have prevented these deaths.

“When we considered the variety of scenarios in our study, we found that no single technology would have prevented all cases we identified,” said co-lead study author Jalaj Maheshwari, MSE, a research staff scientist with CIRP at CHOP. “This tragic situation can happen to anyone, and we feel that multiple technologies working in tandem are the best way to reduce the number of vehicular heatstroke deaths that occur. Members of the automotive industry recognize the threat to children’s safety that pediatric vehicular heatstroke poses, and we have seen these mitigating technologies being built into vehicles, which is encouraging progress.”

The researchers identified 10 exemplar scenarios across 354 recent instances of vehicular heatstroke and found that the technologies’ effectiveness varied drastically. For example, carbon dioxide, optical, pressure, ultrasonic, and radar/radio-frequency detection technologies would have been successful in detecting the children in 80% to 90% of cases, whereas child seat chest restraint sensors would have only protected children in one of the exemplar scenarios.

Notifying a secondary contact was the only technology that would have effectively brought intervention to every child across scenarios, assuming that the cases of overheating were due to children being left behind intentionally or unintentionally by caregivers, with a call to 911 or emergency medical services being the best-case scenario. Alerting by sounding the vehicle’s horn may also have been effective but only if the vehicle was in proximity to people who could intervene, which was not always the case. Leaving the air conditioning on in the car would have prevented 80% of cases identified.

The researchers noted that the study only focused on vehicular heatstroke deaths, the most serious cases, but did not investigate the potentially hundreds or thousands of “near miss” incidents that may put children at risk.

“We have a responsibility to children around the country for making sure these completely preventable deaths never happen,” said senior study author Kristy Arbogast, PhD, scientific director of CIRP at CHOP. “In addition to technology, we need to continue to make sure caregivers are educated about the real danger posed to children by overheating vehicles, and how quickly that danger can build. We need to ensure these life-saving technologies have the support of the automotive industry, policymakers and a variety of stakeholders who can make a difference.”

This study was supported by the National Science Foundation (NSF)-founded Center for Child Injury Prevention Studies (CChIPS) at Children’s Hospital of Philadelphia (CHOP) and The Ohio State University (OSU).

Maheshwari et al, “Preventing Real-World Pediatric Vehicular Heatstroke Events With Technology.” Am J Public Health. Online June 18, 2025. DOI: 10.2105/AJPH.2025.308109.

About Children’s Hospital of Philadelphia: 
A non-profit, charitable organization, Children’s Hospital of Philadelphia was founded in 1855 as the nation’s first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, the hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. The institution has a well-established history of providing advanced pediatric care close to home through its CHOP Care Network, which includes more than 50 primary care practices, specialty care and surgical centers, urgent care centers, and community hospital alliances throughout Pennsylvania and New Jersey. CHOP also operates the Middleman Family Pavilion and its dedicated pediatric emergency department in King of Prussia, the Behavioral Health and Crisis Center (including a 24/7 Crisis Response Center) and the Center for Advanced Behavioral Healthcare, a mental health outpatient facility. Its unique family-centered care and public service programs have brought Children’s Hospital of Philadelphia recognition as a leading advocate for children and adolescents. For more information, visit https://www.chop.edu.

About the Center for Child Injury Prevention Studies: 

The Center for Child Injury Prevention Studies (CChIPS) is a child injury research consortium focused on advancing the safety of children and adolescents. Co-hosted by the Children's Hospital of Philadelphia (CHOP) Research Institute and The Ohio State University (OSU), CChIPS was founded by the National Science Foundation in 2005 as an Industry/University Cooperative Research Center. CChIPS researchers from CHOP and OSU – with expertise in bioengineering, mechanical engineering, epidemiology, behavioral science, public health, and psychology – work side by side with member company representatives on the Industry Advisory Board (IAB) to conduct translational research that is practical to industry. CChIPS has completed over 215 projects.

 

Collaborative initiative highlights successes and challenges in global bioethics training






University of Pennsylvania School of Nursing





PHILADELPHIA (July 23, 2025) – A new Penn Nursing initiative explores the impact of federally funded international bioethics training programs. The collaborative initiative, published in the Journal of Empirical Research on Human Research Ethics, highlights both the significant achievements and ongoing challenges in building bioethics research capacity in low- and middle-income countries (LMICs).

The collaboration, led by Connie M. Ulrich, PhD, RN, FAAN, the Lillian S. Brunner Chair in Medical and Surgical Nursing in Penn Nursing’s Department of Biobehavioral Health Sciences and Professor of Medical Ethics and Health Policy in the Perelman School of Medicine, examines seven doctoral and postdoctoral bioethics training programs supported by the National Institutes of Health (NIH) Fogarty International Center’s D43 mechanism. These programs, primarily located in African countries, Central Asia, and Ukraine, aim to prepare scholars for independent bioethics research, teaching, and advising on complex ethical issues.

Key findings and successes include:

  • Advancing doctoral and postdoctoral international bioethics training is essential for addressing healthcare needs in LMICs.
  • Graduates from these programs have attained leadership positions in their home countries and have a strong record of publications.
  • The programs foster cross-disciplinary collaboration and enhance the ethical conduct of research.

However, the study also identifies several challenges:

  • The COVID-19 pandemic significantly disrupted in-person activities and data collection.
  • Trainees often face communication difficulties, heavy employment duties, and gaps in advanced research skills.
  • Administrative hurdles in funding transfers and university degree granting processes can cause delays.

"Our study clearly demonstrates that advancing international bioethics training is not just beneficial, but absolutely essential for addressing global healthcare needs. The success of our graduates in leadership roles and their contributions to ethical research underscore the profound impact of these programs. It is vital that we continue to invest in and support these initiatives to build robust bioethics capacity worldwide, ensuring we can effectively tackle complex ethical challenges in health."

The findings advocate for continued investment in these training programs, emphasizing the need for sustained financial support from NIH and other funders, institutional capacity development, and the creation of dedicated research ethics posts in LMICs. This continued investment is crucial for establishing and upholding ethical research standards globally and addressing emerging ethical dilemmas in health.

About the University of Pennsylvania School of Nursing

The University of Pennsylvania School of Nursing (Penn Nursing) is one of the world’s leading nursing schools. It has been ranked the #1 nursing school in the U.S. by QS University for a decade. Our Bachelor of Science in Nursing (BSN) is among the top-ranked programs in the nation, according to the 2025 U.S. News & World Report’s Best Colleges rankings. Penn Nursing also consistently earns high rankings in U.S. News & World Report’s annual list of best graduate schools and is a top recipient of National Institutes of Health (NIH) funding for nursing research. Penn Nursing prepares nurse scientists and nurse leaders to meet the health needs of a global society through innovation in research, education, and practice. Follow Penn Nursing on: FacebookXLinkedInYouTube, & Instagram.

 

A device developed at the EHU makes it simple to obtain platelet-rich plasma



Researchers in the Microfluidics Cluster on the Alava campus design a portable, cost-effective system for generating high-quality, platelet-rich plasma



University of the Basque Country

plasma separator 

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plasma separator

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Credit: EHU





Platelet-rich plasma (PRP) is a fraction of blood plasma; its concentration of platelets is of great value in regenerative medicine as they are essential in accelerating healing and repairing tissue. Until now, obtaining them has been based on centrifugation techniques which, in addition to being expensive, could activate the platelets prematurely and reduce their effectiveness.

“We realised that our device not only separated the plasma, but also obtained very high-quality PRP, with functional and minimally activated platelets,” explained the Ikerbasque Research Professor Lourdes Basabe.

Innovation from sedimentation

Unlike traditional methods, the system developed at the University of the Basque Country (EHU) uses gravity sedimentation (a physical separation process in which the solid particles, which are denser than the fluid, settle at the bottom of a container due to the force of gravity, a routine method for removing solids suspended in liquids). The system comprises laser-cut acrylic sheets and special adhesives, which means it can be manufactured at a low cost. In just 40 minutes, it can extract around 300 micro-litres of PRP from 1 millilitre of blood, thereby minimising handling.

The results obtained with this new system are very interesting indeed. Platelet activation could be significantly reduced, reaching a level of 8.2 % as opposed 31 % seen in traditional methods. What is more, the mean platelet volume (MPV) was maintained, which is essential for maintaining the therapeutic efficacy of PRP. It was also possible to eliminate 98% of red blood cells and 96% of white blood cells. Another significant advantage is that this method can be adjusted to process a higher or lower quantity of blood, thus maintaining its effectiveness at all times.

A finding produced by years of research

This development is the result of the ongoing work of the team, which has spent over a decade researching what are known as Lab-on-a-Chip technologies. In other words, ones that concentrate and automate various functions that normally require large, complex equipment into a single, small device, even the size of a chip. In other words, it is like having an entire laboratory operating in a space that fits into the palm of one’s hand. During the course of this research, the scientists observed that the composition of the plasma separated in their devices was particularly rich in low-activated platelets. Based on this observation, they redesigned the system for therapeutic purposes. The result is a disposable, portable, low-cost, and easy-to-use device with the potential for use in resource-limited clinical settings, personalised treatments, or even home healthcare.

The lead author of the work is Dr Pablo Enrique Guevara-Pantoja, post-PhD researcher in the Microfluidics Cluster EHU research group thanks to a prestigious Marie Curie COFUND grant. With a solid international track record in microfluidics and biomedical engineering, he has been the lead author of multiple high-impact publications and is the co-inventor of several patents in the field of diagnostics and bioengineering.

Intellectual property protection and transfer

The technology has been protected by a Spanish patent and the group is currently seeking clinical, industrial or investment partnerships to scale up the system and facilitate its release onto the market and into healthcare settings.

The full, open-access article can be consulted in the journal Lab on a Chip: https://pubs.rsc.org/en/content/articlehtml/2025/lc/d5lc00362h


Fernando Benito, permanent doctoral researcher, Pablo Guevara, predoctoral researcher and Lurdes Basabe, Ikerbasque professor. 

Credit

Nuria González. EHU

 

Healthy European peatlands require specific temperature and water level parameters



Peat accumulation, key for carbon sequestration, is highest in Baltic countries




PLOS

Climate and water-table levels regulate peat accumulation rates across Europe 

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Photo of blanket peatland in western Ireland.

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Credit: Richard Fewster, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)





Efforts to enhance peat accumulation in European peatlands, which contain around half of Europe’s soil carbon, will require a combination of warm temperatures and a specific depth of the water table, according to a study published July 23, 2025 in the open-access journal PLOS One by Graeme Swindles of Queen’s University Belfast, U.K. and colleagues.

Peatlands form via the buildup of plant matter, and they serve an important role in carbon sequestration, containing around half of Europe’s soil organic carbon and five times more carbon than its forests. In recent decades, European peatlands have been damaged by human activities, including pollution, draining, and climate change itself. Efforts are underway to restore these environments, but the factors that influence peatland accumulation are poorly understood. In this study, Swindles and colleagues calculate peat accumulation rates over the past 2,000 years from cores taken from 28 peat bogs across Europe.

Among the studied sites, the fastest peat accumulation, up to nearly 0.5 centimeters per year, occurred around the Baltic Sea, at sites in Denmark, Poland, Sweden, and Finland which experience warm and humid summers. The slowest peat accumulation was measured in northern Sweden, which experiences cold winters and a short growing season. Across all sites, peat accumulated fastest in regions with warm summer temperatures, which improves plant growth, and a water table around 10 centimeters below the surface. If the water table is too high, plants struggle to grow, and if the water table is too low, decomposers can rapidly break down peat as it develops.

These results show that rapid peat growth relies on a delicate combination of climate and water conditions, with important implications for peatland restoration efforts. The authors suggest that previous peatland restoration programs should be evaluated to determine if their relative successes or deficiencies corroborate these findings.

The authors add: “Our work demonstrates that European peatlands function most effectively under specific climatic and hydrological conditions.”

“Our study suggests that warmer summer temperatures could boost growth rates in European peatlands – but only if the water table stays high enough. We also found that maintaining a water table around 10 cm below the surface is key to allowing peat to grow quickly and store carbon over the long term. These findings strengthen current evidence and have important implications for how we restore and rewet peatlands as part of global efforts to tackle climate change.”

 

 

In your coverage, please use this URL to provide access to the freely available article in PLOS Onehttp://plos.io/3GrN5Ft

Citation: Swindles GT, Mullan DJ, Brannigan NT, Fewster RE, Sim TG, Gallego-Sala A, et al. (2025) Climate and water-table levels regulate peat accumulation rates across Europe. PLoS One 20(7): e0327422. https://doi.org/10.1371/journal.pone.0327422

Author countries: Canada, U.K., Poland, France, U.S., Romania, Estonia, Finland, Ireland, Switzerland, Netherlands.

Funding: We acknowledge all the organizations that have funded the data used in this analysis: Academy of Finland; Department for Employment and Learning (Northern Ireland); European Commission (Fifth Framework); INTERACT (European Community’s Seventh Framework Programme); Irish Discovery Programme; Leverhulme Trust; National Science Centre (Poland); Natural Environment Research Council (UK); Natural Sciences and Engineering Research Council of Canada; Netherlands Organization for Scientific Research; Polish National Science Centre (2021/41/B/ST10/00060 and 2021/03/Y/ST10/00093 [BIODIVRESTORE]); Quaternary Research Association; Swiss Contribution to the enlarged European Union; Swiss Federal Office for Education and Science; Swiss National Science Foundation; World University Network; Wüthrich Fund (University of Neuchâtel); and Yorkshire Water. T.G.S. was funded by the Leeds–York Natural Environment Research Council (NERC) Doctoral Training Partnership (grant no. NE/L002574/1). T.E.T. acknowledges NERC Doctoral Training Grant no. NE/G52398X/1. JMGs contribution represents NRCan contribution number/Numéro de contribution de RNCan: 20230392. This paper is a contribution to the PAGES C-PEAT group. PAGES is supported by the Swiss Academy of Sciences and Future Earth. This research was supported by a grant to G.T.S from the UK Leverhulme Trust (Grant No. RPG-2021-354) and a grant to E.M.K from UKRI NERC (Grant No. UKRI182).

 

Matches in online dating illuminated in study of Czech app



In analysis, men tended to “punch up” in pursuing more desirable women, but mutual matches mostly showed more similar desirability



PLOS

It takes two to tango: A directed two-mode network approach to desirability on a mobile dating app 

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A growing number of couples meet through online dating apps.

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Credit: amrothman, PIxabay, CC0 (https://creativecommons.org/publicdomain/zero/1.0/)





Per analysis of heterosexual users of a Czech dating app, men tended to pursue women who were more desirable than themselves, but most instances of reciprocated interest occurred between men and women with more similar levels of desirability. Renata Topinkova of the Ludwig Maximilian University of Munich, Germany, and Tomas Diviak of the University of Manchester, U.K., present these findings in the open-access journal PLOS One on July 23, 2025.

A growing number of couples meet through online dating apps. Prior research has suggested that married couples often share similar characteristics – such as age, ethnicity, or political ideology – and some similarities have also been observed among dating couples and in online dating. However, it is unclear whether these patterns are universally true, including in countries beyond the U.S. and Western Europe.

To help address this gap, Topinkova and Diviak analyzed data from a Central European dating app, specifically looking at two cities in Czechia. They applied social network analysis methods in which network nodes represented app users, and ties between nodes represented “swipes” sent between users to express interest. They extended standard methods to account for the direction of ties, which shows who pursues whom and when there is mutual interest.

Analysis of data from July 2017 on 2,321 heterosexual users in Prague and 624 in Brno showed that some users received far more swipes than others, resulting in a hierarchy of desirability. Women generally ranked more highly in this hierarchy, in large part because the app had many more male users than female users.

Men tended to express interest in women who were more desirable than themselves, while women typically pursued men of more similar desirability. However, mutual swipes—showing reciprocal interest—mostly occurred between men and women of more similar desirability. These findings suggest that similarity of desirability between couples may arise through the process of rejection by others, who are more desirable counterparts, rather than from initial preferences for similarity.

Future research could address some limitations of this study, such as by including queer users and other dating apps.

The authors add: “Our research on a Czech online dating app shows that while men often aim high when choosing whom to contact, successful matches tend to happen between people with similar levels of desirability. This pattern is largely the result of rejection, rather than an initial preference for similarity.”

“The successful matching outcomes tend to align more closely with women's preferences than with men's. This likely reflects women's stronger position in the online dating market, as men outnumber women and are often expected to make the first move.”

 

 

In your coverage, please use this URL to provide access to the freely available article in PLOS Onehttp://plos.io/4nCk36N

Citation: Topinkova R, Diviak T (2025) It takes two to tango: A directed two-mode network approach to desirability on a mobile dating app. PLoS One 20(7): e0327477. https://doi.org/10.1371/journal.pone.0327477

Author countries: Germany, Czechia, U.K.

Funding: RT was supported by the Charles University, project GAUK 602120. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.