Wednesday, September 17, 2025

 

Bronze and Iron Age cultures in the Middle East were committed to wine production




Durham University

Mozan olive 

image: 

Scanning electron microscopic (SEM)-image of transverse section of an olive charcoal sample dating to around 1900 BC from Tell Mozan (NE Syria).

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Credit: Dr Katleen Deckers




-With pictures-

Farmers in the Middle East were more committed to wine production over olive growing during times of climatic change in the Bronze and Iron Ages, according to new research.

Archaeologists who analysed the charred remains of ancient plant samples found that irrigation was used to maintain grape cultivation as people prioritised viticulture.

Their findings provide evidence of the importance of wine production for cultural and economic purposes during that period.

The research, led by the University of Tübingen, Germany, and involving Durham University, UK, is published in the journal PLOS One.

The team looked at over 1,500 seed and wood samples from grape and olive plants from the Early Bronze Age to the Iron Age (5,000 to 2,600 years before today).

The samples came from the Levant region and northern Mesopotamia, which today includes Lebanon, Jordan, Israel, Palestine, Syria, Turkey, and northern Iraq.

The researchers analysed the ratios of stable carbon isotopes – non-radioactive forms of carbon that do not decay over time – in the samples to see how much water was available as the plants grew.

During the Early Bronze Age evidence of water stress matched seasonal variations in moisture.

During later periods there was greater variability in water stress, while the presence of grapes and olives in drier regions indicated more widespread use of irrigation.

The analysis also showed evidence for intensive irrigation of grape crops since the Middle Bronze Age, as well as the presence of cultivated grapes in areas poorly-suited to growing the fruit.

This suggests that grapes and wine were of particular cultural and economic value, confirming the findings of previous archaeological research.

Research senior author Professor Dan Lawrence, in the Department of Archaeology, Durham University, said: “Olive and grape were key crops, providing both food for locals and exportable commodities which facilitated trade between the Levant and Mesopotamia, and beyond with Egypt, Turkey and the wider Mediterranean.

“Our research demonstrates that farmers in the Middle East thousands of years ago were making decisions about which crops to plant and how to manage them, balancing the risk of harvest failure with the effort needed to irrigate, and the likely demand for their products.

“It reminds us that people in the past were just as smart as people today, and that seemingly modern issues like resilience to climate change and the need to allocate resources carefully have long histories.”

As well as Durham University’s Department of Archaeology, the research involved Durham’s Department of Earth Sciences, alongside the Senckenberg Centre for Human Evolution and Palaeoenvironment and the Institute for Archaeological Sciences, at the University of Tübingen.

The research was funded by the European Research Council through the European Union’s Horizon 2020 research and innovation programme, the German Research Foundation and the Fritz Thyssen Foundation.

ENDS

Olive trees in Central Lebanon, showing the types of wood and olive fruits used in the study.



Olive trees in Central Lebanon, showing the types of wood and olive fruits used in the study.


Credit
Dr Kamal Badreshany

A bunch of grapes sitting on top of a metal table.

Credit

Photo by Jason Leung on Unsplash.

 

Indian adolescents are mostly starting their periods at an earlier age than 25 years ago




PLOS





Indian adolescents are mostly starting their periods at an earlier age than 25 years ago - likely because of demographic factors such as improved education, and possibly even climate change.

 

Article URL: https://plos.io/4nqfag7  

Article Title: Understanding age at menarche: Environmental and demographic influences over a quarter century in India

Author Countries: Bangladesh

Funding: The author(s) received no specific funding for this work.

 

Temporary medical centers in Gaza known as "Medical Points" (MPs) treat an average of 117 people daily with only about 7 staff per MP



PLOS






Temporary medical centers in Gaza known as "Medical Points" (MPs) treat an average of 117 people daily with only about 7 staff per MP, filling a critical role despite severe staffing and supply shortages (with insulin and cancer treatments unavailable in over 90% of cases, for instance).

 

Article URL: https://plos.io/4nn4PRX

Article Title: Resilience amid chaos: The role of Gaza medical points

Author Countries: Jordan, Palestine, United States

Funding: The author(s) received no specific funding for this work.

 

US Rates of alcohol-induced deaths among the general population nearly doubled from 1999 to 2024



With females aged 25-34 showing a 255 percent surge in alcohol-related deaths during this time period




PLOS




In an analysis by race, sex, age, and geography, alcohol-induced death rates in 2024 are nearly double those in 1999, with a sharp increase at the onset of the COVID-19 pandemic. Although rates are higher for men, the largest increase in alcohol-induced deaths over the full 25-year period occurred in females aged 25-34, according to a study published on September 17 by Dr. Tony Wong and colleagues at UCLA in the open-access journal PLOS Global Public Health.

Alcohol-induced deaths have been increasing over the past two decades. Particularly concering are increases between 2019 and 2021, when the population was under significant stress from isolation due to the COVID-19 pandemic, and people with alcohol-use disorders were less able to access treatment. Quantifying mortality trends and determining whether alcohol-induced deaths have returned to pre-pandemic levels is essential for understanding long-term temporal patterns and dynamics. To examine these trends, the authors of this study analyzed data from the Centers for Disease Control and Prevention’s National Vital Statistics System, focusing on 14 specific alcohol-induced causes of death.

Wong et al. found that rates of alcohol-induced deaths in the United States nearly doubled between 1999 and 2024, reaching their highest level in 2021. Most deaths are due to alcoholic liver disease and, to a lesser degree, alcohol-related mental and behavioral disorders. The largest overall increase in alcohol-induced mortality across all race, sex, age groups occurred in 2021 when fatalities peaked at 54,258 deaths overall. By 2024, fatalities had declined, but the average alcohol-induced mortality rate across U.S. counties remained approximately 25% higher than in 2019.

American Indian/Alaska Native populations (AIAN) remain the most affected, with male AIAN rates of alcohol-induced mortality three times higher than that of white males, and female AIAN mortality rates four times higher than that of white females, over the entire period of investigation.

The largest increase by demographic was among females aged 25-34, which rose from 0.9 deaths per 100,000 in 1999 to 3.2 per 100,000 in 2024 — a 255 percent increase. The second largest increase was in males aged 25-34, from 2.3 fatalities per 100,000 in 1999 to 6.5 in 2024 — a 188 percent increase. As deaths from chronic diseases related to alcohol use, such as certain cancers or cardiovascular events, were not included in this study, the overall fatality counts may be underestimated. These findings underscore the critical need for targeted policies to reduce excessive alcohol consumption and improve access to treatment for those who need it most.

Senior author Maria R D’Orsogna adds: "The rapid rise of alcohol-induced deaths among women is particularly concerning. Although men still die at higher rates, the gender gap appears to be closing. Notably, for the population aged 25-34, the male-to-female mortality ratio has decreased from three-to-one in 1999 to two-to-one in 2024."

The authors conclude: "The rise in alcohol-induced mortality is widespread and affects the entire country, with particularly large surges arising during the COVID-19 pandemic. In the early months of the pandemic, alcohol-induced deaths among AIAN males increased by as much as 40% in a single month and remained unusually high for nearly four years. Similar trends were observed among AIAN and Black females, whose alcohol-induced death rates rose by over 30% in one month."

  

In your coverage please use this URL to provide access to the freely available article in PLOS Global Public Healthhttps://plos.io/4nra5UI

Citation: Wong T, Böttcher L, Chou T, D’Orsogna MR (2025) Alcohol-induced deaths in the United States across age, race, gender, geography, and the COVID-19 pandemic. PLOS Glob Public Health 5(9): e0004623. https://doi.org/10.1371/journal.pgph.0004623

Author Countries: United States

Funding: This work was supported by the ARO through a grant [W911NF-23-1-0129 to LB and MRD], and by the U.S. National Science Foundation through a grant [OAC-2320846 to MRD]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

END ANIMAL TESTING

PLOS One study: In adolescent lab animals exposed to cocaine, High-Intensity Interval Training boosts aversion to the drug



Findings show that exercise is dose-dependent in mitigating drug use behaviors




University at Buffalo





BUFFALO, N.Y. — People with substance use disorder who participate in recovery running programs have shown improved success in maintaining their sobriety and reducing their risk for relapse.

Those observations led Panayotis Thanos, a University at Buffalo neuroscientist who studies the brain’s reward system, to try to figure out the brain mechanisms behind that phenomenon.

In a new study published today in PLOS One, Thanos, PhD, senior research scientist in the Clinical and Research Institute on Addictions in the Jacobs School of Medicine and Biomedical Sciences at UB, and co-authors reveal that high-intensity interval training (HIIT) was more effective than moderate exercise in making adolescent lab animals avoid cocaine.

The researchers used adolescent lab animals because this is the age when most people who develop substance use disorder begin their exposure. The study focused on male rats only because previous observations have revealed some gender differences in drug-seeking behaviors between males and females. The researchers plan a future study on how HIIT affects females with regard to cocaine. 

HIIT as personalized medicine

“The study shows that HIIT exercise, rather than moderate exercise, during adolescence may protect against cocaine abuse,” says Thanos, a faculty member in the Department of Pharmacology and Toxicology in the Jacobs School. The findings provide evidence that HIIT could become a personalized medicine tool in drug abuse intervention.

“The key take-home is that not all exercise is created equal in terms of outcome,” Thanos says. “Exercise is not a binary therapeutic tool but rather we need to think about exercise as dose-dependent, the way we think of medicine as dose-dependent.”

In the study, rats exposed to HIIT exercise on a treadmill were compared to rats exposed to moderate treadmill exercise. Both groups then underwent a behavioral test called cocaine place preference, which trains the animal to discriminate between two chambers: one where they can access cocaine and one where they can access saline. Cocaine preference is when the animal spends more time in the cocaine chamber, while cocaine aversion is when the animal chooses to spend more time in the saline chamber.

The findings were significant, Thanos explains, because not only did the HIIT animals exhibit a preference for the saline chamber, they exhibited a clear aversion to the cocaine chamber.

Increase in a molecular switch for addiction

“We believe that the increase in aversion to cocaine happens in the HIIT animals,” Thanos says, “because of this exercise dose-dependent effect on the brain’s reward circuit that involves an increase we observed in ΔFosB.” ΔFosB is a transcription factor commonly referred to as a molecular switch for addiction and known to boost sensitivity to drugs of abuse. “Our study showed that HIIT increased Î”FosB levels causing an aversion to consuming cocaine,” he adds.

The findings reveal new avenues that Thanos and his colleagues plan to explore, including how HIIT may affect brain metabolism.

“We know from recent studies in our lab with steady, moderate treadmill running that compared to sedentary animals, exercise decreased metabolism in the somatosensory cortex of the brain while activating other brain regions involved in planning and decision,” he says. “That activation may help dampen various aspects of cocaine abuse and relapse.”

The paper also discusses the need to better understand gender differences in preference for cocaine. “Future studies need to explore how HIIT affects cocaine preference in female rats,” Thanos says, adding that the literature in the field includes evidence that females seem to be more vulnerable to certain phases of addiction.

UB co-authors are Teresa Quattin, MD, UB Distinguished Professor in the Department of Pediatrics and senior associate dean for research integration in the Jacobs School; Nikki Hammond, a former graduate student; and Nabeel Rahman and Sam Zhan, former undergraduate students in Thanos’ lab. Other co-authors are from Washington University School of Medicine and Western University of Health Sciences.

The study was supported by the SUNY Research Foundation (RIAQ0940).