Saturday, May 17, 2025

 

Digital reconstruction reveals 80 steps of prehistoric life



University of Queensland
An image from the reconstruction of the dinosaur's movements. 

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An image from the reconstruction of the dinosaur's movements.

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Credit: Dr Anthony Romilio UQ





A dinosaur’s 40-second journey more than 120 million years ago has been brought back to life by a University of Queensland-led research team using advanced digital modelling techniques.

Dr Anthony Romilio from UQ’s Dinosaur Lab analysed and reconstructed the Phoenix Trackway, the longest documented set of footprints made by a predator walking on two legs in East Asia.

“For the first time this dinosaur’s movements have been reconstructed step by step, revealing how it walked, changed pace and responded to its environment,” Dr Romilio said.

“This sequence of 80 consecutive footprints extends for 70 metres in Sichuan Province, China and is a fleeting moment frozen in stone.

“Through digital animation, we can observe that moment as it unfolded, getting unprecedented insights into the animal’s behaviour and biomechanics.”

Using trackway measurements, the research team has revealed the dinosaur walked on two legs, stood 1.13 metres tall at the hip and weighed up to 292 kilograms.

“The footprints show this dinosaur moved at a steady 5.3 km/h which is equivalent to a brisk human walk and then briefly accelerated into a light trot before returning to its regular pace,” Dr Romilio said.

“This wasn’t just a dinosaur wandering aimlessly, it was moving with purpose in a nearly perfectly straight line.”

Local folklore once attributed the footprints to a mythical phoenix, but scientific analysis reveals it was an ancient predator, similar in size to the feathered Yutyrannus which lived in northeastern China in the early Cretaceous period.

“Trackways can reveal behavioural information and stories that fossilised bones alone cannot provide,” Dr Romilio said.

“But long trackways such as this have historically been understudied due to the logistical difficulties of measuring them in detail in the field.

“Our entirely digital approach allows us to capture, interpret and preserve all the measurements and calculations of fossil track sites on computer to provide a glimpse into the dynamic life of an ancient creature.”

The study was co-authored by Dr Lida Xing of China University of Geosciences, Beijing.

The research is published in Geosciences.  Video of the reconstruction is available via YouTube.

Australia’s oldest prehistoric tree frog hops 22 million years back in time




University of New South Wales





Newly discovered evidence of Australia’s earliest species of tree frog challenges what we know about when Australian and South American frogs parted ways on the evolutionary tree.

Previously, scientists believed Australian and South American tree frogs separated from each other about 33 million years ago.

But in a study published today in Journal of Vertebrate Palaeontology, palaeontologists from UNSW Sydney say the new species, Litoria tylerantiqua, is now at about 55 million years old, the earliest known member of the pelodryadid family of Australian tree frogs.

The study is based on fossils unearthed from Murgon on the traditional lands of the Waka Waka people of south-eastern Queensland. The new species, Litoria tylerantiqua, is named in honour of the late Michael Tyler, a renowned Australian herpetologist globally celebrated for his research on frogs and toads.

“It is only fitting to name Australia’s earliest tree frog in honour of a man who was a giant in Australian frog research and in particular the first to explore the fossil record for Australian frogs,” says study lead author Dr Roy Farman, an adjunct associate lecturer with UNSW School of Biological, Earth & and Environmental Sciences.

Evolutionary history of Australian tree frogs

Around 55 million years ago, Australia, Antarctica and South America were linked together as the last remnants of the southern supercontinent Gondwana. Global climates were warmer during this period, while a forested corridor linked South America and Australia.

Up until now, it was thought the earliest Australian tree frogs came from the Late Oligocene (about 26 million years ago) and the Early Miocene (23 million years ago). Fossils of the Late Oligocene were found at Kangaroo Well in the Northern Territory and Etadunna Formation at Lake Palankarinna, South Australia, while the Riversleigh World Heritage Area in Queensland revealed tree frogs from the Early Miocene.

But the new species extends the fossil record of pelodryadids by approximately 30 million years, to a time potentially close to the divergence of Australian tree frogs from the South American tree frogs.

Previous estimates based on molecular clock studies – a method scientists use to figure out when different species split from a common ancestor by looking at the rate of genetic changes over time – suggested that Australian and South American tree frogs separated from each other at about 33 million years ago.

“Our research indicates that that date is at least 22 million years too young,” Dr Farman says.

“While molecular studies are important for understanding the evolutionary relationships of different groups of animals, these studies should be calibrated using knowledge from the fossil record and in this case the fossil record provides a more accurate time for separation of the southern world’s tree frogs.”

Using new technology to study ancient frogs

To conduct this research, the authors used CT scans of spirit-preserved frogs from Australian museum collections to compare the three-dimensional shape of the fossil bones with those of living species. The technique – called three-dimensional geometric morphometrics – has only been used on fossil frogs once before. Using these new methods, they were able to unravel the relationships of these fossils to all other groups of frogs living and extinct.   

“We had a real problem at the start of this study because the pelvic bones of most living frogs were invisible inside whole pickled frogs rather than available for study as skeletons,” Dr Farman says.

“Museums understandably want to ensure these often unique or rare pickled specimens remain intact for molecular studies because DNA can be obtained from their soft tissues. This meant that instead of skeletonising these specimens, we needed instead to make CT scans of them, enabling us to create 3D models of their otherwise invisible skeletons.

“Using these cutting-edge investigative methods, we were able to determine from the shape of the fossil ilia – one of three bones that make up each side of the pelvis – that this new Murgon species of frog is more closely related to the Australian tree frogs (pelodryadids) than the South American tree frogs (phyllomedusids).”

Seasoned survivors that outlasted the dinosaurs

Litoria tylerantiqua joins the only other Murgon frog, the ground-dwelling Platyplectrum casca (previously described as Lechriodus casca), as the oldest frogs known from Australia. Both have living relatives in Australia and New Guinea demonstrating remarkable resilience over time.

“Despite their delicate nature, frogs have been surprisingly successful at surviving several mass extinction events since their origins about 250 million years ago, including the mass extinction 66 million years ago that took out the non-flying dinosaurs,” Dr Farman says.

“Although global extinction events triggered by human activities – such as rapid climate change and the spread of chytrid fungus – may be among the worst challenges frogs have had to face, the fossil record could reveal how some frog groups overcame previous challenges, perhaps by adapting to new, less-threatening habitats. This could provide clues about how we might be able to help by translocating some threatened frogs into more future-secure habitats.”

Frogs such as the southern corroboree frog are threatened in their current habitats which have become more hostile due to climate change. The authors say that if the fossil record shows physically similar frogs living in very different habitats, today’s frogs may benefit by being reintroduced into similar environments.

 

Study reveals why women tend to have faster heartbeats, men more irregular rhythms


Comprehensive research of the heart’s natural pacemaker may lead to targeted treatments



Ohio State University Wexner Medical Center





COLUMBUS, Ohio – For decades, doctors and researchers have puzzled over a basic heart rhythm mystery: Why do women tend to have faster heartbeats while men are more likely to develop irregular rhythms like atrial fibrillation (AFib)? Now a new study from The Ohio State University Wexner Medical Center provides some insight.

The research shows that the sinoatrial node (SAN) — a small but powerful structure in the human heart that serves as its natural pacemaker and initiates every normal heartbeat — runs on different gene blueprints in men and women. The study found that women have genes that help their hearts beat faster while men have gene networks that may lead to heart problems like AFib. The research was recently published in the American Heart Association’s Circulation: Arrythmia and Electrophysiology.

“We found for the first time that the genes controlling how the SAN works are influenced by sex,” said Vadim Fedorov, PhD, professor of physiology and cell biology, Corrine Frick Research Chair in Heart Failure and Arrhythmia at the Ohio State University College of Medicine and senior author of the study. “That helps explain why women generally have faster heart rates and are more likely to experience inappropriate sinus tachycardia, while men face a greater risk of heart rate disorders like conduction block and atrial fibrillation.”

Researchers at Ohio State University’s Dorothy M. Davis Heart and Lung Research Institute and Bob and Corrine Frick Center for Heart Failure and Arrhythmia examined donated human hearts to unmask unique gene sets in the SAN pacemaker cells responsible for the generation and maintenance of heart rates. They analyzed genes and pathways involved in pacing, metabolism, inflammation and fibrotic remodeling and discovered distinct patterns tied to biological sex. The hearts were donated for research by organ donor families through Lifeline of Ohio.

“Women showed higher levels of TBX3 and HCN1, which are two key genes that help drive faster heart rhythms,” said Ning Li, MD, PhD, Ohio State research assistant professor and co-author of the study. “In contrast, male hearts had more activity in gene networks related to inflammation and collagen production, which can interfere with electrical signaling and increase the risk of arrhythmias.”

The findings could help lay the groundwork for more personalized, patient-specific approaches to treating heart rhythm disorders, Fedorov said. The study builds on Ohio State’s broader efforts to understand and prevent the most common cardiac arrhythmias that can lead to dangerously slow or fast heart rates and often require interventions such as medication or pacemaker implantation. According to the American Heart Association, more than 6 million Americans are currently living with heart failure and many also suffer from rhythm disturbances originating in the SAN.

This research was supported by the National Institutes of Health, the Leducq Foundation and the Bob and Corrine Frick Center for Heart Failure and Arrhythmia, the nation's first center dedicated to treating patients with both heart failure and arrhythmia.

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Processing and reporting greenfeed emissions data just got easier with a new open-source, flexible data analysis tool



A new technical note from JDS Communications introduces greenfeedr and demonstrates how it can generate easy-to-read reports and insights using real dairy cow data



Elsevier

Processing and Reporting GreenFeed Emissions Data Just Got Easier with a New Open-Source, Flexible Data Analysis Tool 

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The greenfeedr package described in JDS Communications helps improve the management and analysis of GreenFeed data, offering a streamlined and efficient tool tailored to the needs of different teams.

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Credit: Guillermo Martinez-Boggio





Philadelphia, May 15, 2025 – The dairy and agriculture sectors’ pursuit of sustainability and efficiency has fueled a dramatic expansion in research aimed at understanding and reducing livestock greenhouse gas emissions. Central to this effort is the ability to accurately measure methane and carbon dioxide output from cattle on a large scale. GreenFeed is a popular tool helping researchers and producers measure emissions in real time.

A new open-source tool, greenfeedr—outlined in a new technical note in JDS Communications—is simplifying processing and data reporting from GreenFeed systems, making it easier to get flexible, useful, and impactful data and accelerate the work toward a sustainable future for dairy and livestock production.

GreenFeed systems are portable head chambers that measure individual animal gas production in real time, generating substantial amounts of data. Animals voluntarily use the machine, receiving pelleted feed throughout the day, meaning that the system gathers data 24 hours a day, often for weeks at a time. While all of these data are crucial for researchers and producers aiming to understand and mitigate livestock’s contribution to climate change, it comes with challenges. Managing and analyzing this high volume of data—especially across different research projects, dairy herds, and teams—are often time consuming and can lead to error and data inconsistencies.

Guillermo Martinez-Boggio, PhD, of the Department of Animal and Dairy Sciences, University of Wisconsin–Madison, and lead author of the article, said, “The sheer volume of data produced by GreenFeed systems can be really overwhelming. We set out to create an open-source tool that simplifies this process, making it more efficient and reproducible, and flexible to the variety of situations in which these systems are used.”

Motivated by the principle of “doing as little as possible by hand and as much as possible with functions,” Dr. Martinez-Boggio, of the Peñagaricano Lab, developed greenfeedr—a toolkit with functions for downloading, processing, and reporting GreenFeed data—all freely and publicly available as an R package, an open-source software and programming language. Interested users can access greenfeedr on the Comprehensive R Archive Network (CRAN) at https://cran.r-project.org/web/packages/greenfeedr and its source code on GitHub at https://github.com/GMBog/greenfeedr.

The R package has functions for downloading GreenFeed data (get_gfdata), for generating daily and final reports (report_gfdata), for processing daily and final records (process_gfdata), and extra functions that help to extract information regarding pellet intakes and daily visits (pellin and viseat).

After development, the team demonstrated the package’s capabilities using data from 32 lactating dairy cows. The article demonstrates how greenfeedr can generate comprehensive reports and efficiently process large datasets, allowing for a detailed analysis of methane and carbon dioxide emissions. The package also permits user-defined parameters to allow the best use of each research group’s datasets.

Dr. Martinez-Boggio explained, “We wanted the tool to be as versatile as possible, so it was designed to be used with all livestock species and housing systems, including freestall, tiestall, and pasture based.

This important advancement allows teams to automate routine processes as they gather data with GreenFeed systems, simplifying formerly complex workflows, saving time, and creating insightful outputs that can inform study results and farm management decisions. 

This tool is expected to benefit researchers and producers by enhancing the efficiency and accuracy of GreenFeed data analysis, ultimately contributing to a better understanding of livestock emissions and the development of mitigation strategies.

 

 

People with more nature in their neighbourhood smoke and drink less, study finds





University of Exeter





People who live in greener neighbourhoods smoke and drink less on average, and those who make regular visits to nature tend not to smoke.

A new international collaboration led by the University of Exeter has found residential greenspace is associated with a significant reduction in health risk behaviours such as smoking and everyday drinking. The study found people living in the greenest neighbourhoods were 13 per cent less likely to be current smokers and 31 per cent less likely to drink alcohol every day than those in less green areas.

This research - which is part of the BlueHealth project funded by the EU’s Horizon 2020 and published in Health & Place - has for the first time analysed data across multiple countries and different types of nature contact and highlights the potential of greenspaces as a public health intervention.

The findings are consistent across different countries, household income and educational attainment. Therefore, the presence of green spaces near someone’s home lowering health risk behaviours appears to be beneficial to all and not limited to particular groups.

Researchers also found that people who make intentional visits to nature away from their home at least once a week are less likely to smoke.

Lead author Dr Leanne Martin at the European Centre for Environment and Human Health at the University of Exeter said: “Our finding that nature seems to be beneficial to all in society is hugely important because it goes some way to levelling the playing field in terms of reducing health inequalities. We've accounted for a wide range of socioeconomic factors in our research and found the benefits are not determined by things like having a higher income or living in more affluent areas. For those people who don’t live in areas with high green space, we’ve found those intentional visits to nature also have huge benefits.”

The study defines residential greenspace as land comprised of vegetation and natural elements within 250 metres of someone’s home, including private gardens. Data was used from the BlueHealth International Survey, a cross-sectional survey of 18,838 adults (9,645 females) from 18 countries and across various socio-demographic groups.

The findings suggest that the positive effects of residential greenspaces in reducing smoking and everyday drinking could be harnessed as a public health intervention. This could involve nature-based interventions for people looking to quit smoking, or to treat alcohol misuse.

Co-author Dr Mat White at the University of Vienna said: “We don’t think it’s simply a coincidence those who are exposed to nature smoke and drink less. A growing number of studies are showing that when people are exposed to nature, they have fewer cravings for substances like alcohol and nicotine. In part we think this is because they tend to be calmer and don’t need that “hit”, which helps them give up smoking, for instance.”

The study provides a starting point for even more detailed research looking into whether improved access and maintenance of urban greenspaces could offer public health providers viable strategies for reducing multiple health risk behaviours.

The paper titled ‘Nature Contact and Health Risk Behaviours: Results from an 18 Country Study’ was published in Health & Place.

ENDS  

 

One in ten asthma cases can be avoided with a better urban environment



Karolinska Institutet
Erik Melén 

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Erik Melén

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Credit: Andreas Andersson





The combination of air pollution, dense urban development and limited green spaces increases the risk of asthma in both children and adults. This is shown by a new study conducted as part of a major EU collaboration led by researchers from Karolinska Institutet.

The study covers nearly 350,000 people of different ages, from 14  cohorts in seven European countries. Information on home addresses of each individual made it possible to link data on various environmental risks in the urban environment to individual people. The environmental exposures included were air pollution, outdoor temperatures, and the level of urban density. The assessment was partly based on satellite images showing grey, green, or blue areas, i.e., where there were buildings, green spaces, or water.

“Previous studies have typically calculated the risk of one environmental factor at a time. We have combined several environmental factors and described how they together affect the risk of developing asthma. This provides a better picture of environmental risks, as life in a city usually involves exposure to several environmental risk factors at the same time,” says first author Zhebin Yu, researcher and assistant professor at the Institute of Environmental Medicine at Karolinska Institutet.

During the study period, nearly 7,500 of the study participants developed asthma as children or adults. The researchers found that 11.6 per cent of asthma cases could be explained by the combination of environmental factors. Or, to put it another way, in a favourable environment, approximately one in ten people with asthma would not have developed the disease. The combination of air pollution, lack of green spaces, and dense urban development was most relevant for the development of asthma.

“This is useful for politicians and others involved in urban planning. The method makes it possible to identify risk areas in existing urban areas, but it can also be used when planning future urban environments,” says Erik Melén, professor at the Department of Clinical Research and Education, Södersjukhuset, and last author of the study.

The next step for the researchers is to examine blood samples from some of the study participants. The aim is to identify their metabolome, i.e., a composite picture of the body's metabolism and breakdown products. The purpose is to understand how external environmental factors affect the body, which could provide a better understanding of how asthma develops.

The study was conducted in collaboration between various research groups within the framework of the EU project EXPANSE. The researchers involved in the project are also investigating how the risk of other diseases such as stroke, heart attack, COPD and diabetes, is affected by individual exposomes, i.e., the total exposure to many environmental factors.

The study was funded by the EU's Horizon 2020 programme (EXPANSE, No 874627), the Swedish Research Council, Forte (the Swedish Research Council for Health, Working Life and Welfare), the Swedish Heart-Lung Foundation and Region Stockholm, among others.

Read more about the EXPANSE project here.

Publication: ‘External exposome and incident asthma across the life course in 14 European cohorts: a prospective analysis within the EXPANSE project’, Zhebin Yu, Sara Kress, Natalia Blay, Petr Gregor, Hanna-Maria Kukk, Miriam Leskien, Renata Majewska, Max J. Oosterwegel, Daniel Szabó, Margreet ten Have, Jana Klánová, OndÅ™ej MikeÅ¡, Anna Bergström, Alonso Bussalleu, Rafael de Cid, Andrea Dalecka, Payam Dadvand, Saskia van Dorsselaer, Krista Fischer, Kees de Hoogh, Gerard H. Koppelman, Jaanika Kronberg, Estonian Biobank Research Team, Jeroen Lakerveld, Petter Ljungman, Simon Kebede Merid, Pawel Macek, Marta Manczuk, Anne-Sophie Merritt, Agnieszka Pac, Priit Palta, Göran Pershagen, Annette Peters, Hynek Pikhart, Apolline Saucy, Tamara Schikowski, Youchen Shen, Marie Standl, Cathryn Tonne, Roel Vermeulen, Jelle Vlaanderen, Judith M Vonk, Kathrin Wolf, Carl Henrik Ek, Olena Gruzieva, Ulrike Gehring, Erik Melén, Lancet Regional Health-Europe, online May 15, 2025, doi: 10.1016/j.lanepe.2025.101314

 

Air pollution may increase epilepsy risk, new study suggests




London Health Sciences Centre Research Institute





LONDON, ON - A new study reveals air pollution may contribute to the development of epilepsy, a brain condition that causes seizures. Published in Epilepsia, researchers at London Health Sciences Centre Research Institute (LHSCRI) and Western University’s Schulich School of Medicine & Dentistry found an association between long-term exposure to air pollution with new cases of epilepsy in adults in Ontario.

The study utilized data from the Canadian Urban Environmental Health Research Consortium which was linked to Ontario’s health administrative databases and analyzed at ICES. It began with the population of Ontario residents with a health card as of January 1, 2010. After focusing on adults without other major health conditions like brain cancer, researchers found 24,761 new epilepsy cases over six years. The study found that higher exposure to fine particulate matter, a component of air pollution, increased the likelihood of developing epilepsy by 5.5 per cent, while ozone, another component of air pollution, increased it by 9.6 per cent.

The study is the first time databases were used to make a direct connection between new cases of epilepsy in adults in Ontario and long-term exposure to air pollution. “Our hope is that this research can help inform environmental policy and ensure there are adequate resources and health care for epilepsy in areas that have significant air pollution,” says Dr. Jorge Burneo, Scientist at LHSCRI, Neurologist at London Health Science Centre (LHSC) and Professor at Schulich School of Medicine & Dentistry.

According to the World Health Organization (WHO), 99 per cent of the world’s population breathes air that exceeds WHO air quality limits. Scientific studies have linked air pollution to a wide variety of health issues and now there is additional evidence on its association with new onset epilepsy.

Epilepsy is one of the most common neurological disorders worldwide, affecting about six in every 1,000 people at any given time. People with epilepsy are three times more likely to die earlier in life and some do not respond to anti-seizure medications.

“This research is important because it has the potential to drive changes that could ultimately reduce the number of new epilepsy cases,” says Tresah Antaya, PhD, Postdoctoral Associate at Western University in the Department of Clinical Neurological Sciences. “We know seizures can significantly affect quality of life — limiting a person’s ability to work in certain industries, drive, or live independently. Our hope is that this work will contribute to a future where fewer people are affected by epilepsy.”

As a next step in this work, the research team plans to explore the effects that forest fires may have on health, including epilepsy.

"Our environment plays a big role in our health," adds Dr. Burneo. "Our research aims to better understand these connections with a goal of improving both planetary and human health."

 

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MEDIA CONTACTS:  
Celine Zadorsky, Senior Media Relations Consultant, London Health Sciences Centre, (226) 927-2309, media@lhsc.on.ca    

Cynthia Fazio, Media Relations Officer, Schulich Medicine & Dentistry, (226) 376-4924 (mobile), cynthia.fazio@uwo.ca

About London Health Sciences Centre Research Institute:
At London Health Sciences Centre Research Institute (LHSCRI), our teams pioneer discoveries that transform the health of adult and paediatric patients around the world. As the research institute of London Health Sciences Centre (LHSC), we conduct research where patient care is delivered, working alongside patients, families, health-care providers and academic partners like Western University. We are leaders in advancing the understanding, diagnosis, treatment and management of diseases and health conditions through a diverse research program that ranges from laboratory-based science to clinical trials. Our research has a global impact as we build on LHSC’s 150-year legacy of health innovation and drive forward medical breakthroughs that make a difference in the lives of patients and their families. Find us online at www.lhscri.ca and on social media @LHSCRI. 

ABOUT WESTERN
Western University delivers an academic experience second to none. Since 1878, The Western Experience has combined academic excellence with life-long opportunities for intellectual, social and cultural growth in order to better serve our communities. Our research excellence expands knowledge and drives discovery with real-world application. Western attracts individuals with a broad worldview, seeking to study, influence and lead in the international community. For more information, visit https://uwo.ca/

ABOUT ICES

ICES houses a vast, secure array of large, population-based databases that capture health-care system use over time and across Ontario, Canada. The ICES data repository includes health administrative datasets, demographic datasets, population-based surveys, disease registries, validated chronic condition cohorts, electronic medical records, and a growing number of other non-health administrative data. These record-level, coded data are linkable, encompassing over 30 years of health service interactions for over 21 million people eligible for publicly-funded health care in Ontario.